{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:49:21Z","timestamp":1793335761231,"version":"4.5.0"},"reference-count":92,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>\n                    <jats:italic>Pink1<\/jats:italic>\n                    (PTEN-induced kinase 1) is a key guardian of mitochondrial quality via mitophagy; its mutations are tightly linked to early-onset PD. This review synthesizes how aging, exercise, and high-fat diet (HFD) modulate\n                    <jats:italic>Pink1<\/jats:italic>\n                    activity and thereby PD risk. Aging down-regulates\n                    <jats:italic>Pink1<\/jats:italic>\n                    , impairing clearance of damaged mitochondria and promoting\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -synuclein aggregation. Exercise up-regulates\n                    <jats:italic>Pink1<\/jats:italic>\n                    -Parkin signaling, enhances PGC-1\u03b1 and brain-derived neurotrophic factor (BDNF), and protects dopaminergic neurons in humans and rodents. Conversely, chronic HFD suppresses\n                    <jats:italic>Pink1<\/jats:italic>\n                    , exacerbates oxidative stress, microglial activation and insulin resistance, accelerating Parkinson\u2019s disease pathology. Cross-species cautions (mouse vs. primate) are highlighted. Targeting\n                    <jats:italic>Pink1<\/jats:italic>\n                    -mediated mitophagy through lifestyle interventions offers a non-pharmacological strategy to delay PD onset and progression in aging populations.\n                  <\/jats:p>","DOI":"10.3389\/fnagi.2026.1738559","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:00:50Z","timestamp":1775800850000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Pink1 at the crossroads of aging, exercise, and diet in Parkinson\u2019s disease: a mechanistic review"],"prefix":"10.3389","volume":"18","author":[{"given":"Ying","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Physical Education, Ludong University","place":["Yantai, Shandong Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng-tai","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Ludong University","place":["Yantai, Shandong Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"565751","DOI":"10.3389\/fphys.2020.565751","article-title":"Berberine promotes cardiac function by upregulating Pink1\/Parkin-mediated Mitophagy in heart failure","volume":"11","author":"Abudureyimu","year":"2020","journal-title":"Front. 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