{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T08:38:07Z","timestamp":1775032687655,"version":"3.50.1"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically map the global and domestic research landscape of sepsis-associated encephalopathy (SAE) and to identify current hotspots and future trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Relevant articles published from 1 January 2000, to 1 August 2025 were retrieved from the Web of Science (WoS) Core Collection and the China National Knowledge Infrastructure (CNKI). Bibliometric software including CiteSpace V6.3. R1, VOSviewer V1.6.20 and Bibliometrix R V4.1.3 were employed to extract and visualize annual publications, distribution of research fields, countries\/regions, authors, institutions, average citations per publication and keywords.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1,097 articles were included in this study. Over the past 25\u202fyears, the annual articles and annual citations in the field of SAE have shown an overall upward trend. Among various sepsis-related organ complications, SAE has undergone rapid development and gained an increasingly prominent research status. Studies in this field are characterized by multidisciplinary integration, involving neuroscience, immunology, pharmacology and pharmacy, emergency medicine, neurology, and other disciplines. China ranks first in publication volume, followed by the United States and Brazil. Tianjin Medical University is the most productive institution, while Nanjing University holds the highest average citations per paper. Core research groups led by \u201cXie Keliang\u201d and \u201cYang Jianjun\u201d have been formed at home and abroad. Burst keyword analysis shows a shift from early mechanistic terms such as \u201cnitric oxide synthase\u201d, \u201ccerebral blood flow\u201d and \u201ctumor necrosis factor\u201d to recent intervention-oriented terms including \u201ccells\u201d, \u201cinhibition\u201d, \u201ctreatment\u201d and \u201celectroacupuncture\u201d, indicating a transition from basic mechanism exploration to clinical application and targeted intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SAE research continues to gain momentum. Future work should focus on the neuroinflammation-blood\u2013brain barrier axis. Researchers may explore interactions among microglial activation, oxidative stress, and barrier damage, as well as the role of the vagal-immune metabolic pathway. Within a consensus-based framework, efforts can advance new prevention and treatment strategies. These strategies may combine multi-organelle targeted inhibition with multi-component interventions from traditional Chinese medicine (TCM).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1780681","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:43:59Z","timestamp":1775022239000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["New trends and hotspots in Sepsis-associated encephalopathy research: a bibliometric and visualization analysis"],"prefix":"10.3389","volume":"18","author":[{"given":"Younian","family":"Wang","sequence":"first","affiliation":[{"name":"Hubei University of Arts and Science","place":["Xiangyang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Hubei University of Arts and Science","place":["Xiangyang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science","place":["Xiangyang, China"]},{"name":"Institute of Neuroscience and Brain Science, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science","place":["Xiangyang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"115495","DOI":"10.1016\/j.intimp.2025.115495","article-title":"Sepsis-induced ALI\/ARDS beyond supportive care: molecular mechanisms and cutting-edge therapies","volume":"166","author":"Barkat","year":"2025","journal-title":"Int. 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