{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:07:08Z","timestamp":1784786828228,"version":"3.55.0"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The well-documented bidirectional relationship between Alzheimer\u2019s disease (AD) and epilepsy suggests that seizures are not merely a complication of AD but may also contribute to disease progression. Emerging evidence indicates that antiseizure medications (ASMs) could potentially slow the disease course and act as disease-modifying agents if initiated early.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We investigated the long-term cognitive and functional effects of ASMs when introduced at the prodromal stage of AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-two sporadic epileptic prodromal AD patients (epADs) and 21 matched subjects without epilepsy (nepADs) were followed for a median of 7\u202fyears. Baseline cognition, daily functioning, clinical\/paraclinical features, and pharmacological profiles were compared. Annual assessments included cognition, pharmacological burden, and functional impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the final follow-up, epADs evidenced more preserved cognition than nepADs, reflecting a significantly slower annual rate of cognitive decline (\u22121.2\u202f\u00b1\u202f0.9 vs. \u22122.7\u202f\u00b1\u202f2.4 points\/year on the MMSE score, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.01). They were also less likely to require neuroleptics (9.1% vs. 47.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.01) or memantine (0% vs. 28.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.01). However, epADs and nepADs had the same proportion of Alzheimer\u2019s dementia at the final follow-up visit (90.9% vs. 90.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.96). Despite being significant, these results had low statistical power due to our small sample size and should be considered exploratory.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings support the idea that early ASM treatment may attenuate cognitive decline in sporadic prodromal AD patients with comorbid epilepsy. However, these benefits were not accompanied by a lower dementia rate at the final follow-up visit, suggesting that ASMs alone are insufficient for sustained disease modification. Combinatorial therapeutic strategies may be needed to achieve long-term neuroprotection in AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1786247","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:41:04Z","timestamp":1784785264000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of long-term antiseizure treatment on cognitive decline in late-onset epileptic prodromal Alzheimer\u2019s disease: an exploratory study"],"prefix":"10.3389","volume":"18","author":[{"given":"Benjamin","family":"Cretin","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Neuropsychologie, Service de Neurologie et H\u00f4pital de Jour de G\u00e9riatrie, P\u00f4le de G\u00e9riatrie, H\u00f4pitaux Universitaires de Strasbourg","place":["Strasbourg, France"]},{"name":"Centre M\u00e9moire, de Ressources et de Recherche d\u2019Alsace (Strasbourg-Colmar)","place":["Strasbourg, France"]},{"name":"ICube Laboratory UMR 7357 and FMTS (F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg), University of Strasbourg and CNRS, Team IMIS\/Neurocrypto","place":["Strasbourg, France"]},{"name":"Centre de Comp\u00e9tences des D\u00e9mences Rares des H\u00f4pitaux Universitaires de Strasbourg","place":["Strasbourg, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Philippi","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Neuropsychologie, Service de Neurologie et H\u00f4pital de Jour de G\u00e9riatrie, P\u00f4le de G\u00e9riatrie, H\u00f4pitaux Universitaires de Strasbourg","place":["Strasbourg, France"]},{"name":"Centre M\u00e9moire, de Ressources et de Recherche d\u2019Alsace (Strasbourg-Colmar)","place":["Strasbourg, France"]},{"name":"ICube Laboratory UMR 7357 and FMTS (F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg), University of Strasbourg and CNRS, Team IMIS\/Neurocrypto","place":["Strasbourg, France"]},{"name":"Centre de Comp\u00e9tences des D\u00e9mences Rares des H\u00f4pitaux Universitaires de Strasbourg","place":["Strasbourg, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Bousiges","sequence":"additional","affiliation":[{"name":"University Hospital of Strasbourg, Laboratory of Biochemistry and Molecular Biology, and CNRS, Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), UMR7364","place":["Strasbourg, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Dibitonto","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Neuropsychologie, Service de Neurologie et H\u00f4pital de Jour de G\u00e9riatrie, P\u00f4le de G\u00e9riatrie, H\u00f4pitaux Universitaires de Strasbourg","place":["Strasbourg, France"]},{"name":"Centre M\u00e9moire, de Ressources et de Recherche d\u2019Alsace (Strasbourg-Colmar)","place":["Strasbourg, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Blanc","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Neuropsychologie, Service de Neurologie et H\u00f4pital de Jour de G\u00e9riatrie, P\u00f4le de G\u00e9riatrie, H\u00f4pitaux Universitaires de Strasbourg","place":["Strasbourg, France"]},{"name":"Centre M\u00e9moire, de Ressources et de Recherche d\u2019Alsace (Strasbourg-Colmar)","place":["Strasbourg, France"]},{"name":"ICube Laboratory UMR 7357 and FMTS (F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg), University of Strasbourg and CNRS, Team IMIS\/Neurocrypto","place":["Strasbourg, France"]},{"name":"Centre de Comp\u00e9tences des D\u00e9mences Rares des H\u00f4pitaux Universitaires de Strasbourg","place":["Strasbourg, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e26650","DOI":"10.1016\/j.heliyon.2024.e26650","article-title":"Differential effects of antiseizure medications on neurogenesis: evidence from cells to animals","volume":"10","author":"Alavi","year":"2024","journal-title":"Heliyon"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1002\/(SICI)1099-1166(199910)14:10<858::AID-GPS35>3.0.CO;2-8","article-title":"Short versions of the geriatric depression scale: a study of their validity for the diagnosis of a major depressive episode according to ICD-10 and DSM-IV","volume":"14","author":"Almeida","year":"1999","journal-title":"Int. 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