{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:18:08Z","timestamp":1783491488941,"version":"3.55.0"},"reference-count":85,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Fidelity of detailed information retrieved from long-term memory (LTM) declines in aging due to changes affecting learning and remembering processes. Such behavioral deficits correspond with functional alterations in the hippocampal formation. However, it is unclear whether age-related decline in high-fidelity retrieval alters functional connections between hippocampal and cortical regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-two cognitively intact older adults (69.4\u202f\u00b1\u202f4.4\u202fyears) completed mnemonic discrimination tasks during fMRI indicating, whether previously encoded targets, lures, or novel objects were old or new.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants\u2019 high-fidelity memory, measured by the lure discrimination index (the proportion of \u201cnew\u201d responses to lures minus the proportion of \u201cold\u201d responses to novel objects), was 0.45\u202f\u00b1\u202f0.04 \u2013 lower than previously reported scores in young adults. High-fidelity LTM in older adults engaged a hippocampal formation region in the left entorhinal cortex with trial-wise beta-series connections to the right angular gyrus and the left precuneus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Taken together, we characterize the distribution of medial temporal lobe (MTL)-cortical networks in older adults that underlies high-fidelity memory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1788092","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:53:38Z","timestamp":1783490018000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hippocampal formation\u2013cortical high-fidelity memory networks in healthy older adults during the mnemonic discrimination task"],"prefix":"10.3389","volume":"18","author":[{"given":"Joseph C. C.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology, Neuroscape, University of California","place":["San Francisco, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Gazzaley","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neuroscape, University of California","place":["San Francisco, CA, United States"]},{"name":"Departments of Physiology and Psychiatry, University of California","place":["San Francisco, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Wais","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neuroscape, University of California","place":["San Francisco, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"8742","DOI":"10.1523\/JNEUROSCI.1165-22.2022","article-title":"Entorhinal-hippocampal circuit integrity is related to mnemonic discrimination and amyloid-\u03b2 pathology in older adults","volume":"42","author":"Adams","year":"2022","journal-title":"J. Neurosci."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1016\/j.cortex.2012.10.002","article-title":"Differential effects of aging on the neural correlates of recollection and familiarity","volume":"49","author":"Angel","year":"2013","journal-title":"Cortex"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1016\/j.neuroimage.2010.09.025","article-title":"A reproducible evaluation of ANTs similarity metric performance in brain image registration","volume":"54","author":"Avants","year":"2011","journal-title":"NeuroImage"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.neuron.2005.07.023","article-title":"Dissociable controlled retrieval and generalized selection mechanisms in ventrolateral prefrontal cortex","volume":"47","author":"Badre","year":"2005","journal-title":"Neuron"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1126\/science.1152882","article-title":"Pattern separation in the human hippocampal CA3 and dentate gyrus","volume":"319","author":"Bakker","year":"2008","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.neuron.2012.03.023","article-title":"Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment","volume":"74","author":"Bakker","year":"2012","journal-title":"Neuron"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1093\/cercor\/bht291","article-title":"Ventral Fronto-temporal pathway supporting cognitive control of episodic memory retrieval","volume":"25","author":"Barredo","year":"2015","journal-title":"Cereb. Cortex"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"4590","DOI":"10.1038\/s41467-020-18364-1","article-title":"Prior knowledge promotes hippocampal separation but cortical assimilation in the left inferior frontal gyrus","volume":"11","author":"Bein","year":"2020","journal-title":"Nat. Commun."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.nlm.2015.06.014","article-title":"Mnemonic discrimination relates to perforant path integrity: an ultra-high resolution diffusion tensor imaging study","volume":"129","author":"Bennett","year":"2016","journal-title":"Neurobiol. Learn. Mem."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3389\/fnint.2012.00031","article-title":"Insights from neuropsychology: pinpointing the role of the posterior parietal cortex in episodic and working memory","volume":"6","author":"Berryhill","year":"2012","journal-title":"Front. Integr. Neurosci."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e775","DOI":"10.1212\/WNL.0000000000200667","article-title":"Novelty-related fMRI responses of precuneus and medial temporal regions in individuals at risk for Alzheimer disease","volume":"99","author":"Billette","year":"2022","journal-title":"Neurology"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1159\/000116984","article-title":"Staging of Alzheimer-related cortical destruction","volume":"33","author":"Braak","year":"2008","journal-title":"Eur. Neurol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s41583-018-0068-2","article-title":"Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing","volume":"19","author":"Cabeza","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/nrn2459","article-title":"The parietal cortex and episodic memory: an attentional account","volume":"9","author":"Cabeza","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"ref15","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3758\/BF03200930","article-title":"Feature memory and binding in young and older adults","volume":"24","author":"Chalfonte","year":"1996","journal-title":"Mem. Cogn."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nn.4450","article-title":"Shared memories reveal shared structure in neural activity across individuals","volume":"20","author":"Chen","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"119276","DOI":"10.1016\/j.neuroimage.2022.119276","article-title":"Functional activation features of memory in successful agers across the adult lifespan","volume":"257","author":"Chen","year":"2022","journal-title":"NeuroImage"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"4943","DOI":"10.1523\/JNEUROSCI.1209-09.2010","article-title":"Top-down and bottom-up attention to memory are dissociated in posterior parietal cortex: neuroimaging and neuropsychological evidence","volume":"30","author":"Ciaramelli","year":"2010","journal-title":"J. Neurosci."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/(SICI)1099-1492(199706\/08)10:4\/5<171::AID-NBM453>3.0.CO;2-L","article-title":"Software tools for analysis and visualization of fMRI data","volume":"10","author":"Cox","year":"1997","journal-title":"NMR Biomed."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1006\/nimg.1999.0444","article-title":"The effect of Normal aging on the coupling of neural activity to the Bold hemodynamic response","volume":"10","author":"D\u2019Esposito","year":"1999","journal-title":"NeuroImage"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1093\/cercor\/bhm155","article-title":"Que PASA? The posterior-anterior shift in aging","volume":"18","author":"Davis","year":"2008","journal-title":"Cereb. Cortex"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1093\/cercor\/bhr123","article-title":"The architecture of cross-hemispheric communication in the aging brain: linking behavior to functional and structural connectivity","volume":"22","author":"Davis","year":"2012","journal-title":"Cereb. Cortex"},{"key":"ref23","volume-title":"Delis-Kaplan Executive Function System: Examiner\u2019s manual","author":"Delis","year":"2001"},{"key":"ref24","volume-title":"The California Verbal Learning test- Research edition adult version","author":"Delis","year":"1987"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1037\/0278-7393.33.1.169","article-title":"Aging, source memory, and misrecollections","volume":"33","author":"Dodson","year":"2007","journal-title":"J. Exp. Psychol. Learn. Mem. Cogn."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.neuroimage.2016.02.017","article-title":"Age-related changes in overcoming proactive interference in associative memory: the role of PFC-mediated executive control processes at retrieval","volume":"132","author":"Dulas","year":"2016","journal-title":"NeuroImage"},{"key":"ref27","first-page":"443","article-title":"Age differences in using source-relevant cues","volume-title":"Psychol. Aging","author":"Ferguson","year":"1992"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"e1408242024","DOI":"10.1523\/JNEUROSCI.1408-24.2024","article-title":"Precuneus activity during retrieval is positively associated with amyloid burden in cognitively normal older APOE4 carriers","volume":"45","author":"Fischer","year":"2025","journal-title":"J. Neurosci."},{"key":"ref29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"Mini-mental state: a practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"580","DOI":"10.3758\/CABN.4.4.580","article-title":"Functional connectivity during working memory maintenance","volume":"4","author":"Gazzaley","year":"2004","journal-title":"Cogn. Affect. Behav. Neurosci."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"fcab087","DOI":"10.1093\/braincomms\/fcab087","article-title":"Memory precision of object-location binding is unimpaired in APOE \u03b54-carriers with spatial navigation deficits","volume":"3","author":"Gellersen","year":"2021","journal-title":"Brain Commun."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/nrn3256","article-title":"The cognitive neuroscience of ageing","volume":"13","author":"Grady","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The amyloid-\u03b2 pathway in Alzheimer\u2019s disease","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1037\/0882-7974.5.1.119","article-title":"Aging and qualitative characteristics of memories for perceived and imagined complex events","volume":"5","author":"Hashtroudi","year":"1990","journal-title":"Psychol. Aging"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.neuroimage.2010.04.246","article-title":"Mapping sources of correlation in resting state FMRI, with artifact detection and removal","volume":"52","author":"Jo","year":"2010","journal-title":"NeuroImage"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.mri.2009.12.007","article-title":"Neural and vascular variability and the fMRI-BOLD response in normal aging","volume":"28","author":"Kannurpatti","year":"2010","journal-title":"Magn. Reson. Imaging"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1523\/JNEUROSCI.3219-14.2015","article-title":"Recollection-related increases in functional connectivity predict individual differences in memory accuracy","volume":"35","author":"King","year":"2015","journal-title":"J. Neurosci."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"e01560","DOI":"10.1002\/brb3.1560","article-title":"Neural substrates of mnemonic discrimination: a whole-brain fMRI investigation","volume":"10","author":"Klippenstein","year":"2020","journal-title":"Brain Behav."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.tics.2019.04.012","article-title":"Neural dedifferentiation in the aging brain","volume":"23","author":"Koen","year":"2019","journal-title":"Trends Cogn. Sci."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.neurobiolaging.2023.04.009","article-title":"Reduced memory precision in older age is associated with functional and structural differences in the angular gyrus","volume":"129","author":"Korkki","year":"2023","journal-title":"Neurobiol. Aging"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"8051","DOI":"10.1523\/JNEUROSCI.4328-13.2014","article-title":"Successful remembering elicits event-specific activity patterns in lateral parietal cortex","volume":"34","author":"Kuhl","year":"2014","journal-title":"J. Neurosci."},{"key":"ref42","volume-title":"The Preservation of Memory","author":"Leal","year":"2015"},{"key":"ref43","first-page":"xix","volume-title":"Detection Theory: A User\u2019s guide","author":"Macmillan","year":"2005"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1093\/brain\/awg157","article-title":"Aging affects the engagement of the hippocampus during autobiographical memory retrieval","volume":"126","author":"Maguire","year":"2003","journal-title":"Brain"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"e82385","DOI":"10.1371\/journal.pone.0082385","article-title":"Age-related changes in the functional network underlying specific and general autobiographical memory retrieval: a pivotal role for the anterior cingulate cortex","volume":"8","author":"Martinelli","year":"2013","journal-title":"PLoS One"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.cortex.2016.12.023","article-title":"Brain\u2013behavior relationships in source memory: effects of age and memory ability","volume":"91","author":"Meusel","year":"2017","journal-title":"Cortex"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.neuron.2024.12.008","article-title":"Toward a functional future for the cognitive neuroscience of human aging","volume":"113","author":"Mooraj","year":"2025","journal-title":"Neuron"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1002\/hipo.23299","article-title":"Pattern separation beyond the hippocampus: a high-resolution whole-brain investigation of mnemonic discrimination in healthy adults","volume":"31","author":"Nash","year":"2021","journal-title":"Hippocampus"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1037\/0278-7393.29.5.826","article-title":"Adult age differences in episodic memory: further support for an associative-deficit hypothesis","volume":"29","author":"Naveh-Benjamin","year":"2003","journal-title":"J. Exp. Psychol. Learn. Mem. Cogn."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.cub.2016.12.042","article-title":"Stimulation of the posterior cortical-hippocampal network enhances precision of memory recollection","volume":"27","author":"Nilakantan","year":"2017","journal-title":"Curr. Biol."},{"key":"ref51","doi-asserted-by":"crossref","first-page":"838","DOI":"10.3758\/BF03211328","article-title":"False recognition in younger and older adults: exploring the characteristics of illusory memories","volume":"25","author":"Norman","year":"1997","journal-title":"Mem. Cogn."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.neuropsychologia.2016.03.026","article-title":"Cortical pattern separation and item-specific memory encoding","volume":"85","author":"Pidgeon","year":"2016","journal-title":"Neuropsychologia"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1093\/scan\/nsp011","article-title":"Independence in ROI analysis: where is the voodoo?","volume":"4","author":"Poldrack","year":"2009","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"R764","DOI":"10.1016\/j.cub.2013.05.041","article-title":"Interplay of Hippocampus and prefrontal cortex in memory","volume":"23","author":"Preston","year":"2013","journal-title":"Curr. Biol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"17680","DOI":"10.1523\/JNEUROSCI.4740-11.2011","article-title":"Hippocampal hyperactivation associated with cortical thinning in Alzheimer\u2019s disease signature regions in non-demented elderly adults","volume":"31","author":"Putcha","year":"2011","journal-title":"J. Neurosci."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"E4264","DOI":"10.1073\/pnas.1411250111","article-title":"Object and spatial mnemonic interference differentially engage lateral and medial entorhinal cortex in humans","volume":"111","author":"Reagh","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.neuroimage.2004.06.035","article-title":"Measuring functional connectivity during distinct stages of a cognitive task","volume":"23","author":"Rissman","year":"2004","journal-title":"NeuroImage"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1037\/0278-7393.33.2.321","article-title":"Aging and the misinformation effect: a neuropsychological analysis","volume":"33","author":"Roediger","year":"2007","journal-title":"J. Exp. Psychol. Learn. Mem. Cogn."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1348\/174866410X504059","article-title":"The posterior parietal paradox: why do functional magnetic resonance imaging and lesion studies on episodic memory produce conflicting results?","volume":"5","author":"Schoo","year":"2011","journal-title":"J. Neuropsychol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"425.e3","DOI":"10.1016\/j.neurobiolaging.2010.10.005","article-title":"Aging and the neural correlates of source memory: over-recruitment and functional reorganization","volume":"33","author":"Spaniol","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1126\/science.1896849","article-title":"The medial temporal lobe memory system","volume":"253","author":"Squire","year":"1991","journal-title":"Science"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1016\/j.neurobiolaging.2010.11.007","article-title":"Age-related effects on the neural correlates of autobiographical memory retrieval","volume":"33","author":"St Jacques","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.tics.2019.08.003","article-title":"Mnemonic similarity task: a tool for assessing hippocampal integrity","volume":"23","author":"Stark","year":"2019","journal-title":"Trends Cogn. Sci."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.bbr.2017.06.049","article-title":"Age-related deficits in the mnemonic similarity task for objects and scenes","volume":"333","author":"Stark","year":"2017","journal-title":"Behav. Brain Res."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1037\/bne0000055","article-title":"Stability of age-related deficits in the mnemonic similarity task across task variations","volume":"129","author":"Stark","year":"2015","journal-title":"Behav. Neurosci."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1016\/j.neuropsychologia.2012.12.014","article-title":"A task to assess behavioral pattern separation (BPS) in humans: data from healthy aging and mild cognitive impairment","volume":"51","author":"Stark","year":"2013","journal-title":"Neuropsychologia, Special Issue on Functional Neuroimag. Episodic Memory"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1523\/JNEUROSCI.0564-19.2019","article-title":"Pattern separation and source memory engage distinct hippocampal and neocortical regions during retrieval","volume":"40","author":"Stevenson","year":"2020","journal-title":"J. Neurosci."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.neurobiolaging.2009.05.003","article-title":"A longitudinal study of gray matter volume decline with age and modifying factors","volume":"32","author":"Taki","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"8142","DOI":"10.1523\/JNEUROSCI.1319-17.2017","article-title":"A role for the left angular gyrus in episodic simulation and memory","volume":"37","author":"Thakral","year":"2017","journal-title":"J. Neurosci."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.neurobiolaging.2021.12.008","article-title":"Lateral entorhinal cortex dysfunction in amnestic mild cognitive impairment","volume":"112","author":"Tran","year":"2022","journal-title":"Neurobiol. Aging"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1002\/hbm.22768","article-title":"The effect of ageing on fMRI: correction for the confounding effects of vascular reactivity evaluated by joint fMRI and MEG in 335 adults","volume":"36","author":"Tsvetanov","year":"2015","journal-title":"Hum. Brain Mapp."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1093\/cercor\/bhl013","article-title":"Evidence for frontally mediated controlled processing differences in older adults","volume":"17","author":"Velanova","year":"2007","journal-title":"Cereb. Cortex"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/hipo.23393","article-title":"Intrinsic functional connectivity in the default mode network predicts mnemonic discrimination: a connectome-based modeling approach","volume":"32","author":"Wahlheim","year":"2022","journal-title":"Hippocampus"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1038\/s41598-021-82109-3","article-title":"Virtual reality video game improves high-fidelity memory in older adults","volume":"11","author":"Wais","year":"2021","journal-title":"Sci. Rep."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.neuroimage.2017.01.062","article-title":"Retrieval of high-fidelity memory arises from distributed cortical networks","volume":"149","author":"Wais","year":"2017","journal-title":"NeuroImage"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.brainres.2011.10.048","article-title":"The impact of visual distraction on episodic retrieval in older adults","volume":"1430","author":"Wais","year":"2012","journal-title":"Brain Res."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"14877","DOI":"10.1038\/s41598-018-33164-w","article-title":"Evidence of a causal role for mid-ventrolateral prefrontal cortex based functional networks in retrieving high-Fidelity memory","volume":"8","author":"Wais","year":"2018","journal-title":"Sci. Rep."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1093\/cercor\/bhu333","article-title":"The effects of age on the neural correlates of recollection success, recollection-related cortical reinstatement, and post-retrieval monitoring","volume":"26","author":"Wang","year":"2016","journal-title":"Cereb. Cortex"},{"key":"ref79","volume-title":"WAIS-III: Administration and scoring manual","author":"Wechsler","year":"1997"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.neuroimage.2018.12.012","article-title":"BOLD hemodynamic response function changes significantly with healthy aging","volume":"188","author":"West","year":"2019","journal-title":"NeuroImage"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"imag\u20132\u201300404","DOI":"10.1162\/imag_a_00404","article-title":"Pattern separation involves regions beyond the hippocampus in non-demented elderly individuals: a 7T object lure task fMRI study","volume":"2","author":"Yang","year":"2024","journal-title":"Imaging Neurosci."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"8873","DOI":"10.1073\/pnas.1101567108","article-title":"Age-related memory deficits linked to circuit-specific disruptions in the hippocampus","volume":"108","author":"Yassa","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1016\/j.neuroimage.2010.03.040","article-title":"High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic mild cognitive impairment","volume":"51","author":"Yassa","year":"2010","journal-title":"NeuroImage"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"6379","DOI":"10.1523\/JNEUROSCI.0660-18.2018","article-title":"Causal evidence for mnemonic metacognition in human Precuneus","volume":"38","author":"Ye","year":"2018","journal-title":"J. Neurosci."},{"key":"ref85","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression screening scale: a preliminary report","volume":"17","author":"Yesavage","year":"1982","journal-title":"J. Psychiatr. 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