{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:14:24Z","timestamp":1778649264485,"version":"3.51.4"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Parkinson\u2019s disease (PD) is characterized by progressive dopaminergic neurodegeneration, neuroinflammation, and emerging evidence of gut microbiota dysbiosis. Although nicotine has been implicated in neuroprotection, whether its enantiomers exert stereoselective effects on the gut-brain axis remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically compared the effects of S-nicotine and R-nicotine in an MPTP-induced mouse model of PD. Motor function, nigrostriatal dopaminergic neuronal loss, neuroinflammatory responses, intestinal barrier integrity, and gut microbiota composition were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both enantiomers ameliorated motor deficits, attenuated nigrostriatal dopaminergic neuronal loss, and suppressed neuroinflammatory responses, yet exhibited markedly different efficacy profiles. S-nicotine produced robust neuroprotection at a lower effective dose (1 mg\/kg), associated with improved motor performance, reduced central and peripheral inflammation, preservation of intestinal barrier integrity, and coordinated remodeling of the gut microbiota characterized by enrichment of Akkermansiaceae (notably\n                      <jats:italic>Akkermansia<\/jats:italic>\n                      ). In contrast, R-nicotine required a higher dose (3 mg\/kg) to achieve comparable neuroprotection and induced weaker and more heterogeneous microbiota alterations. Correlation analyses further revealed that S-nicotine-associated enrichment of\n                      <jats:italic>Akkermansia<\/jats:italic>\n                      was closely linked to improvements in motor function, reduced inflammatory status, and enhanced intestinal integrity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings demonstrate pronounced stereoselective and dose-dependent effects of nicotine enantiomers on neuroimmune modulation and identify gut microbiota remodeling as a functionally relevant correlate of nicotine-mediated neuroprotection in PD. Our results highlight the therapeutic potential of targeting the microbiota-gut-brain axis through chiral interventions and support S-nicotine as a promising candidate for neuroprotective strategies in aging-related neurodegenerative disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1823372","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:47:35Z","timestamp":1778647655000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Stereoselective effects of nicotine enantiomers on the gut-brain axis and neuroinflammation in a mouse model of Parkinson\u2019s disease"],"prefix":"10.3389","volume":"18","author":[{"given":"Ruixia","family":"Liu","sequence":"first","affiliation":[{"name":"Hefei Institutes of Physical Science, Chinese Academy of Sciences","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]},{"name":"Beijing Life Science Academy","place":["Beijing, China"]},{"name":"Key Laboratory of Tobacco Biological Effects, China National Tobacco Quality Supervision & Test Center","place":["Zhengzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunu","family":"Ma","sequence":"additional","affiliation":[{"name":"Beijing Life Science Academy","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingyan","family":"Li","sequence":"additional","affiliation":[{"name":"Hefei Institutes of Physical Science, Chinese Academy of Sciences","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]},{"name":"Beijing Life Science Academy","place":["Beijing, China"]},{"name":"Key Laboratory of Tobacco Biological Effects, China National Tobacco Quality Supervision & Test Center","place":["Zhengzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Gao","sequence":"additional","affiliation":[{"name":"Beijing Life Science Academy","place":["Beijing, China"]},{"name":"Key Laboratory of Tobacco Biological Effects, China National Tobacco Quality Supervision & Test Center","place":["Zhengzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Wang","sequence":"additional","affiliation":[{"name":"Hefei Institutes of Physical Science, Chinese Academy of Sciences","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]},{"name":"Beijing Life Science Academy","place":["Beijing, China"]},{"name":"Key Laboratory of Tobacco Biological Effects, China National Tobacco Quality Supervision & Test Center","place":["Zhengzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutao","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Life Science Academy","place":["Beijing, China"]},{"name":"Key Laboratory of Tobacco Biological Effects, China National Tobacco Quality Supervision & Test Center","place":["Zhengzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanglin","family":"Liu","sequence":"additional","affiliation":[{"name":"Hefei Institutes of Physical Science, Chinese Academy of Sciences","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]},{"name":"Beijing Life Science Academy","place":["Beijing, China"]},{"name":"Key Laboratory of Tobacco Biological Effects, China National Tobacco Quality Supervision & Test Center","place":["Zhengzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Life Science Academy","place":["Beijing, China"]},{"name":"Key Laboratory of Tobacco Biological Effects, China National Tobacco Quality Supervision & Test Center","place":["Zhengzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Ji","sequence":"additional","affiliation":[{"name":"Hefei Institutes of Physical Science, Chinese Academy of Sciences","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Hou","sequence":"additional","affiliation":[{"name":"Beijing Life Science Academy","place":["Beijing, China"]},{"name":"Key Laboratory of Tobacco Biological Effects, China National Tobacco Quality Supervision & Test Center","place":["Zhengzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"270","DOI":"10.17305\/bjbms.2020.5016","article-title":"Dysbiosis of gut microbiota in inflammatory bowel disease: current therapies and potential for microbiota-modulating therapeutic approaches","volume":"21","author":"Alshehri","year":"2021","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1056\/NEJMra0809890","article-title":"Nicotine addiction","volume":"362","author":"Benowitz","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"115008","DOI":"10.1016\/j.physbeh.2025.115008","article-title":"Gut microbial dysbiosis aggravated Parkinson-like pathology induced by MPTP\/probenecid","volume":"299","author":"Chen","year":"2025","journal-title":"Physiol. Behav."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.tips.2004.04.006","article-title":"Nicotinic acetylcholine receptors and the regulation of neuronal signalling","volume":"25","author":"Dajas-Bailador","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e28032","DOI":"10.1371\/journal.pone.0028032","article-title":"Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease","volume":"6","author":"Forsyth","year":"2011","journal-title":"PLoS One"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s12672-024-01393-3","article-title":"Gut commensal Alistipes as a potential pathogenic factor in colorectal cancer","volume":"15","author":"Fu","year":"2024","journal-title":"Discov. Oncol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1002\/ana.10277","article-title":"A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease","volume":"52","author":"Hern\u00e1n","year":"2002","journal-title":"Ann. Neurol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/s1474-4422(09)70062-6","article-title":"Neuroinflammation in Parkinson's disease: a target for neuroprotection?","volume":"8","author":"Hirsch","year":"2009","journal-title":"Lancet Neurol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41531-016-0002-0","article-title":"The gut-brain axis: is intestinal inflammation a silent driver of Parkinson's disease pathogenesis?","volume":"3","author":"Houser","year":"2017","journal-title":"NPJ Parkinson's Dis."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"5253","DOI":"10.1021\/acs.jcim.4c00591","article-title":"Nicotine enantioselectively targets myeloid differentiation protein 2 and inhibits the toll-like receptor 4 signaling","volume":"64","author":"Jiang","year":"2024","journal-title":"J. Chem. Inf. Model."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1002\/mds.26307","article-title":"Colonic bacterial composition in Parkinson's disease","volume":"30","author":"Keshavarzian","year":"2015","journal-title":"Mov. Disord."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1177\/1877718X251355112","article-title":"Proposed mechanisms of neuroprotection for nicotine in Parkinson's disease","volume":"15","author":"Kumari","year":"2025","journal-title":"J. Parkinsons Dis."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1007\/s11064-018-2620-x","article-title":"Intestinal pathology and gut microbiota alterations in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease","volume":"43","author":"Lai","year":"2018","journal-title":"Neurochem. Res."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/1479-5876-9-129","article-title":"Anti-inflammatory effects of nicotine in obesity and ulcerative colitis","volume":"9","author":"Lakhan","year":"2011","journal-title":"J. Transl. Med."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"145701","DOI":"10.1016\/j.ijbiomac.2025.145701","article-title":"Shared pathogenic mechanisms of Parkinson's disease and ulcerative colitis: \u03b17 nicotinic acetylcholine receptor as a potential therapeutic target","volume":"319","author":"Li","year":"","journal-title":"Int. J. Biol. Macromol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"815","DOI":"10.3390\/microorganisms13040815","article-title":"Odoribacter splanchnicus-a next-generation probiotic candidate","volume":"13","author":"Li","year":"","journal-title":"Microorganisms"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1535310","DOI":"10.3389\/fnagi.2025.1535310","article-title":"Significance of nicotine and nicotinic acetylcholine receptors in Parkinson's disease","volume":"17","author":"Lin","year":"2025","journal-title":"Front. Aging Neurosci."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.neuro.2021.08.007","article-title":"Teratogenic effects of maternal drug abuse on developing brain and underlying neurotransmitter mechanisms","volume":"86","author":"Little","year":"2021","journal-title":"Neurotoxicology"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/1742-2094-9-98","article-title":"\u03b17 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation","volume":"9","author":"Liu","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/nature11550","article-title":"Diversity, stability and resilience of the human gut microbiota","volume":"489","author":"Lozupone","year":"2012","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e2132","DOI":"10.1212\/WNL.0000000000009437","article-title":"Tobacco smoking and the risk of Parkinson disease: a 65-year follow-up of 30,000 male British doctors","volume":"94","author":"Mappin-Kasirer","year":"2020","journal-title":"Neurology"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"891","DOI":"10.3233\/JPD-219006","article-title":"Parkinson's disease drug therapies in the clinical trial pipeline: 2021 update","volume":"11","author":"McFarthing","year":"2021","journal-title":"J. Parkinsons Dis."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3233\/jpd-2011-11023","article-title":"MPTP mouse models of Parkinson's disease: an update","volume":"1","author":"Meredith","year":"2011","journal-title":"J. Parkinsons Dis."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13099-024-00635-7","article-title":"The influence of Akkermansia muciniphila on intestinal barrier function","volume":"16","author":"Mo","year":"2024","journal-title":"Gut Pathog."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0140-6736(23)01478-2","article-title":"The pathogenesis of Parkinson's disease","volume":"403","author":"Morris","year":"2024","journal-title":"Lancet"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1093\/eurheartj\/ehaf1010","article-title":"Nicotine and the cardiovascular system: unmasking a global public health threat","volume":"47","author":"Munzel","year":"2025","journal-title":"Eur. Heart J."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s40168-023-01552-8","article-title":"Using the collaborative cross to identify the role of host genetics in defining the murine gut microbiome","volume":"11","author":"Nagarajan","year":"2023","journal-title":"Microbiome"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"789037","DOI":"10.3389\/fmed.2021.789037","article-title":"Nicotine Oral administration attenuates DSS-induced colitis through upregulation of indole in the distal Colon and Rectum in mice","volume":"8","author":"Nakajima","year":"2021","journal-title":"Front. 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Pharmacol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"238","DOI":"10.3390\/brainsci14030238","article-title":"Akkermansia muciniphila is beneficial to a mouse model of Parkinson's disease, via alleviated neuroinflammation and promoted neurogenesis, with involvement of SCFAs","volume":"14","author":"Qiao","year":"2024","journal-title":"Brain Sci."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"4681","DOI":"10.1523\/jneurosci.0215-06.2006","article-title":"Chronic oral nicotine normalizes dopaminergic function and synaptic plasticity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned primates","volume":"26","author":"Quik","year":"2006","journal-title":"J. Neurosci."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1002\/mds.25594","article-title":"Nicotine reduces established levodopa-induced dyskinesias in a monkey model of Parkinson's disease","volume":"28","author":"Quik","year":"2013","journal-title":"Mov. Disord."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.4103\/1673-5374.306066","article-title":"Promising drug targets and associated therapeutic interventions in Parkinson's disease","volume":"16","author":"Rai","year":"2021","journal-title":"Neural Regen. Res."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1126\/science.aag2590","article-title":"How neuroinflammation contributes to neurodegeneration","volume":"353","author":"Ransohoff","year":"2016","journal-title":"Science"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1001\/archneur.64.7.990","article-title":"Pooled analysis of tobacco use and risk of Parkinson disease","volume":"64","author":"Ritz","year":"2007","journal-title":"Arch. Neurol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41531-021-00156-z","article-title":"Meta-analysis of the Parkinson's disease gut microbiome suggests alterations linked to intestinal inflammation","volume":"7","author":"Romano","year":"2021","journal-title":"NPJ Parkinsons Dis."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1002\/mds.26069","article-title":"Gut microbiota are related to Parkinson's disease and clinical phenotype","volume":"30","author":"Scheperjans","year":"2014","journal-title":"Mov. Disord."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.1021\/jf990089w","article-title":"Determination of the nicotine content of various edible nightshades (Solanaceae) and their products and estimation of the associated dietary nicotine intake","volume":"47","author":"Siegmund","year":"1999","journal-title":"J. Agric. Food Chem."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"474","DOI":"10.3390\/cells13060474","article-title":"Nicotinic acetylcholine receptors in glial cells as molecular target for Parkinson's disease","volume":"13","author":"Soares","year":"2024","journal-title":"Cells"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/nrmicro.2017.58","article-title":"The resilience of the intestinal microbiota influences health and disease","volume":"15","author":"Sommer","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.bbi.2018.02.005","article-title":"Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: gut microbiota, glial reaction and TLR4\/TNF-\u03b1 signaling pathway","volume":"70","author":"Sun","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/s1474-4422(21)00030-2","article-title":"Challenges in the diagnosis of Parkinson's disease","volume":"20","author":"Tolosa","year":"2021","journal-title":"Lancet Neurol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.1093\/brain\/awab156","article-title":"The role of gut dysbiosis in Parkinson's disease: mechanistic insights and therapeutic options","volume":"144","author":"Wang","year":"2021","journal-title":"Brain"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature01339","article-title":"Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation","volume":"421","author":"Wang","year":"2002","journal-title":"Nature"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"106848","DOI":"10.1016\/j.nbd.2025.106848","article-title":"Leveraging animal models to understand non-motor symptoms of Parkinson's disease","volume":"208","author":"Wichmann","year":"2025","journal-title":"Neurobiol. Dis."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s10753-024-02036-z","article-title":"Dual regulation of nicotine on NLRP3 inflammasome in macrophages with the involvement of lysosomal destabilization, ROS and \u03b17nAChR","volume":"48","author":"Wu","year":"2025","journal-title":"Inflammation"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"114374","DOI":"10.1016\/j.intimp.2025.114374","article-title":"Akkermansia muciniphila protects against dopamine neurotoxicity by modulating butyrate to inhibit microglia-mediated neuroinflammation","volume":"152","author":"Xu","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1039\/c8ra09963d","article-title":"Differences between the binding modes of enantiomers S\/R-nicotine to acetylcholinesterase","volume":"9","author":"Yang","year":"2019","journal-title":"RSC Adv."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"142815","DOI":"10.1016\/j.ijbiomac.2025.142815","article-title":"Gut commensal Lachnospiraceae bacteria contribute to anti-colitis effects of Lactiplantibacillus plantarum exopolysaccharides","volume":"309","author":"Yang","year":"2025","journal-title":"Int. J. Biol. 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