{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T06:03:37Z","timestamp":1784527417880,"version":"3.55.0"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Subjective cognitive decline (SCD) is a preclinical condition associated with an increased risk of dementia and Alzheimer\u2019s disease, with no consensus regarding effective therapeutic interventions to date. As the global burden of aging-related neurodegenerative diseases continues to rise, early intervention has become increasingly critical. Cognitive training has been proposed as a promising behavioral intervention; however, few studies have integrated multimodal assessments to elucidate its underlying neurobiological and psychological mechanisms, particularly within the educational system that shapes cognitive reserve and learning strategies across the lifespan. This pilot study aims to estimate effect sizes for future definitive trials, assess the feasibility and acceptability of the intervention and multimodal evaluations, and generate hypotheses regarding the relationship between recitation practice and clinical biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 60 individuals with subjective cognitive decline will be enrolled in a randomized, assessor-blinded, controlled pilot study. Participants will be randomly assigned to either an intervention group or a non-active control group prior to baseline assessment. The intervention group will undergo a six-month structured recitation training program. Both groups will undergo short-term follow-up after the intervention, and long-term follow-up annually post-intervention. Multimodal assessments will include neuropsychological testing, functional magnetic resonance imaging (fMRI), electroencephalography (EEG), blood biomarker profiling, gut microbiota analysis, and fecal metabolomics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study protocol outlines a randomized, assessor-blinded, controlled pilot study designed to advance understanding of the feasibility of Chinese Classics recitation training on both physiological and psychological outcomes in individuals with subjective cognitive decline. The findings are expected to provide mechanistic insights into non-pharmacological interventions and to address the current underrepresentation of Asian populations in neuroscience research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      We registered this randomized controlled trial on\n                      <jats:ext-link>ClinicalTrials.gov<\/jats:ext-link>\n                      on March 11, 2026, under the identifier NCT07463391.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1830299","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T05:35:00Z","timestamp":1784525700000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Memory training through Chinese classics recitation for individuals with subjective cognitive decline: study protocol for a pilot study"],"prefix":"10.3389","volume":"18","author":[{"given":"Tz-Syuan","family":"Su","sequence":"first","affiliation":[{"name":"School of Medicine, College of Medicine, Kaohsiung Medical University","place":["Kaohsiung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Pin","family":"Su","sequence":"additional","affiliation":[{"name":"Office of Research and Development, Asia University","place":["Taichung, Taiwan"]},{"name":"An-Nan Hospital, China Medical University","place":["Tainan, Taiwan"]},{"name":"School of Medicine, College of Medicine, China Medical University","place":["Taichung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Ren","family":"Hsueh","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, China Medical University","place":["Taichung, Taiwan"]},{"name":"Department of Laboratory Medicine, China Medical University Hospital, China Medical University","place":["Taichung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Lun","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, China Medical University Hospital, China Medical University","place":["Taichung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, China Medical University Hospital","place":["Taichung, Taiwan"]},{"name":"Neuroscience and Brain Disease Center, College of Medicine, China Medical University","place":["Taichung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chun","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, China Medical University Hospital","place":["Taichung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Sin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Immunology, University of Pittsburgh","place":["Pittsburgh, PA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Nian","sequence":"additional","affiliation":[{"name":"Yellow Flower Meditation Academy","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Wen","family":"Chang","sequence":"additional","affiliation":[{"name":"School of Nursing, College of Nursing, Asia University","place":["Taichung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Ta","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, China Medical University","place":["Taichung, Taiwan"]},{"name":"Neuroscience and Brain Disease Center, College of Medicine, China 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