{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:59:15Z","timestamp":1785473955761,"version":"3.56.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dementia with Lewy bodies (DLB) and Alzheimer\u2019s disease (AD) are common types of dementia, however, diagnosis is challenging. An innovative MR method called neurite orientation dispersion and density imaging (NODDI) is used to assess different microstructural alterations between the conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess microstructural white matter (WM) changes in DLB and AD using NODDI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Diffusion images were acquired from 26 DLB patients, 36 AD patients, and 37 normal controls (NCs). The diffusion tensor imaging (DTI) was used to generate fractional anisotropy (FA), mean diffusivity (MD), and NODDI was used to generate neurite density index (NDI), orientation dispersion index (ODI), and volume fraction of isotropic water molecules (Viso), these parameters were compared among groups applying Tract-based spatial statistics (TBSS). We also analyzed the correlations between altered parameters and cognitive scores and investigated the diagnostic efficacy of different parameters using k-nearest neighbor (KNN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with NC, FA, ODI, and NDI significantly decreased, while MD and Viso significantly increased in both DLB and AD. Compared with DLB, ODI and NDI significantly decreased in AD. The diffusion parameters of multiple fibers were strongly correlated with cognition. NDI exhibited a relatively larger AUC value in differentiating between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Widespread disruption of white matter microstructure is evident in both DLB and AD, with differences in these alterations between the two conditions. NDI holds promise as a neuroimaging biomarker for distinguishing DLB from AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1830477","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:24:37Z","timestamp":1785471877000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Microstructural white matter alterations in dementia with lewy bodies and Alzheimer\u2019s disease: a diffusion tensor imaging and neurite orientation dispersion and density imaging study"],"prefix":"10.3389","volume":"18","author":[{"given":"Ying","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Radiology, Zhongshan Hospital, Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tianjin First Central Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlai","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tianjin Beichen Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuwei","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tianjin Medical University General Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongtong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Hospital of Hebei University","place":["Baoding, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cancer Hospital Chinese Academy of Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tianjin Huanhu Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tianjin First Central Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1002\/jnr.24584","article-title":"Neurocognitive and psychiatric disorders-related axonal degeneration in Parkinson's disease","volume":"98","author":"Andica","year":"2020","journal-title":"Journal of Neuroscience Research"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"610","DOI":"10.3109\/00016489.2010.539626","article-title":"Dendritic and spinal pathology in the acoustic cortex in Alzheimer's disease: morphological estimation in Golgi technique and electron microscopy","volume":"131","author":"Baloyannis","year":"2011","journal-title":"Acta Oto-laryngologica"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1002\/ana.25049","article-title":"Dendritic spines provide cognitive resilience against Alzheimer's disease","volume":"82","author":"Boros","year":"2017","journal-title":"Annals of Neurology"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1136\/jnnp-2018-318830","article-title":"Neurite orientation and dispersion density imaging (NODDI) detects cortical and corticospinal tract degeneration in ALS","volume":"90","author":"Broad","year":"2018","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"5016706","DOI":"10.1155\/2020\/5016706","article-title":"A Comparative Study on 5hmC Targeting Regulation of Neurons in AD Mice by Several Natural Compounds","volume":"2020","author":"Cao","year":"2020","journal-title":"BioMed research international"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.neuroimage.2015.10.043","article-title":"Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease","volume":"125","author":"Colgan","year":"2015","journal-title":"Neuroimage"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.parkreldis.2020.07.025","article-title":"Diffusion imaging in dementia with Lewy bodies: associations with amyloid burden, atrophy, vascular factors and clinical features","volume":"78","author":"Donaghy","year":"2020","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.pscychresns.2011.08.002","article-title":"Diffusion tensor imaging in Alzheimer's disease and dementia with Lewy bodies","volume":"194","author":"Firbank","year":"2011","journal-title":"Psychiatry Research"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.parkreldis.2016.01.003","article-title":"Longitudinal diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease","volume":"24","author":"Firbank","year":"2016","journal-title":"Parkinsonism Related Dis."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s00062-019-00805-0","article-title":"Microstructural white matter alterations in mild cognitive impairment and Alzheimer's disease: study based on neurite orientation dispersion and density imaging (NODDI)","volume":"30","author":"Fu","year":"2020","journal-title":"Clin. Neuroradiol."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1002\/nbm.1543","article-title":"Twenty-five pitfalls in the analysis of diffusion MRI data","volume":"23","author":"Jones","year":"2010","journal-title":"NMR in biomedicine"},{"key":"ref12","volume-title":"StatPearls","author":"Kumar","year":"2024"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"100158","DOI":"10.1016\/j.cccb.2023.100158","article-title":"Fornix degeneration in risk factors of Alzheimer's disease, possible trigger of cognitive decline","volume":"4","author":"Lacalle-Aurioles","year":"2023","journal-title":"Cerebral Circulation\u2014Cognition and Behavior"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"106007","DOI":"10.1016\/j.neubiorev.2025.106007","article-title":"A systematic review of diffusion tensor imaging and tractography in dementia with Lewy bodies and Parkinson's disease dementia","volume":"169","author":"Laurell","year":"2025","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s11682-021-00474-z","article-title":"Microstructural white matter alterations in Alzheimer\u2019s disease and am nestic mild cognitive impairment and its diagnostic value based on dif fusion kurtosis imaging: a tract-based spatial statistics study","volume":"16","author":"Li","year":"2022","journal-title":"Brain Imaging and Behav"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"26266","DOI":"10.1038\/s41598-025-09412-1","article-title":"Analysis of advanced diffusion models assessing white matter microstructure in Alzheimer's disease","volume":"15","author":"Lv","year":"2025","journal-title":"Sci. Rep."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41531-025-01068-y","article-title":"Cortical microstructural abnormalities in dementia with Lewy bodies and their associations with Alzheimer\u2019s disease copathologies","volume":"11","author":"Mak","year":"2025","journal-title":"NPJ Parkinson's Dis."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.neurobiolaging.2016.03.026","article-title":"Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging","volume":"43","author":"Merluzzi","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.jalz.2009.04.984","article-title":"Amyloid beta: a putative intra-spinal microtubule-depolymerizer to induce synapse-loss or dentritic spine shortening in Alzheimer's disease","volume":"114","author":"Mitsuyama","year":"2009","journal-title":"Ital. J. Anat. Embryol."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"102200","DOI":"10.1016\/j.nicl.2020.102200","article-title":"Correlation of microglial activation with white matter changes in dementia with Lewy bodies","volume":"25","author":"Nicastro","year":"2020","journal-title":"NeuroImage. Clinical"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e0172129","DOI":"10.1371\/journal.pone.0172129","article-title":"Limbic-thalamo-cortical projections and reward-related circuitry integrity affects eating behavior: A longitudinal DTI study in adolescents with restrictive eating disorders","volume":"12","author":"Olivo","year":"2017","journal-title":"PloS One"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.1016\/j.neurobiolaging.2015.05.015","article-title":"Divergent brain functional network alterations in dementia with Lewy bodies and Alzheimer's disease","volume":"36","author":"Peraza","year":"2015","journal-title":"Neurobiology of Aging"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"347","DOI":"10.3233\/JAD-190871","article-title":"Associations between microstructure, amyloid, and cognition in amnestic mild cognitive impairment and dementia","volume":"73","author":"Reas","year":"2020","journal-title":"J. Alzheimer's Dis."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1093\/brain\/awab372","article-title":"Cholinergic white matter pathways in dementia with Lewy bodies and Alzheimer\u2019s disease","volume":"145","author":"Schumacher","year":"2022","journal-title":"Brain"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"NeuroImage"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"NeuroImage"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s40478-019-0765-8","article-title":"A soluble tau fragment generated by caspase-2 is associated with demen tia in Lewy body disease","volume":"7","author":"Smith","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e12125","DOI":"10.1002\/dad2.12125","article-title":"Association between neurite metrics and tau\/inflammatory pathology in Alzheimer's disease","volume":"12","author":"Sone","year":"2020","journal-title":"Alzheimer's & Dementia (Amsterdam, Netherlands)"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/S0896-6273(03)00758-X","article-title":"Diffusion MRI of complex neural architecture","volume":"40","author":"Tuch","year":"2003","journal-title":"Neuron"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.brainresbull.2018.05.003","article-title":"Myelin injury in the central nervous system and Alzheimer\u2019s disease","volume":"140","author":"Wang","year":"2018","journal-title":"Brain Research Bulletin"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1212\/WNL.0b013e318266fc51","article-title":"Characterizing dementia with Lewy bodies by means of diffusion tensor imaging","volume":"79","author":"Watson","year":"2012","journal-title":"Neurology"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2750","DOI":"10.1002\/alz.13011","article-title":"Cortical tau is associated with microstructural imaging biomarkers of neurite density and dendritic complexity in Alzheimer's disease","volume":"19","author":"Weston","year":"2023","journal-title":"Alzheimers Dement."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"5319","DOI":"10.1111\/ejn.15815","article-title":"White matter integrity and key structures affected in Alzheimer's disease characterized by diffusion tensor imaging","volume":"56","author":"Xiao","year":"2022","journal-title":"The European Journal of Neuroscience"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.neulet.2016.01.021","article-title":"Non-Gaussian diffusion alterations on diffusion kurtosis imaging in patients with early Alzheimer\u2019s disease","volume":"616","author":"Yuan","year":"2016","journal-title":"Neurosci. Lett."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.neuroimage.2012.03.072","article-title":"NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain","volume":"61","author":"Zhang","year":"2012","journal-title":"NeuroImage"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1007\/s11682-023-00805-2","article-title":"Disentangling in-vivo microstructural changes of white and gray matter in mild cognitive impairment and Alzheimer\u2019s disease: a systematic review and meta-analysis","volume":"17","author":"Zhong","year":"2023","journal-title":"Brain Imaging Behav."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.cortex.2021.03.007","article-title":"White matter abnormalities of right hemisphere attention networks contribute to visual hallucinations in dementia with Lewy bodies","volume":"139","author":"Zorzi","year":"2021","journal-title":"Cortex"}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2026.1830477\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:24:38Z","timestamp":1785471878000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2026.1830477\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":39,"alternative-id":["10.3389\/fnagi.2026.1830477"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2026.1830477","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"article-number":"1830477"}}