{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:05:03Z","timestamp":1789452303800,"version":"build-2803163510"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Evidence on the association between physical activity (PA) and incident dementia among individuals with hypertension remains limited. This study examined the associations between different PA types and intensities and dementia risk in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from questionnaire-based and accelerometer-based cohorts were analyzed. PA was categorized into quartiles of light-intensity (LPA), moderate-intensity (MPA), vigorous-intensity (VPA), moderate-to-vigorous-intensity PA (MVPA), and total PA (TPA). PA domains included leisure time, housework, transportation, and occupational activities. Incident dementia was identified using hospital inpatient and death records, which may not capture milder dementia cases and classified as early- or late-onset by age at diagnosis. Cox proportional hazards models were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the accelerometer-based cohort of 47,861 hypertensive participants, 574 (1.2%) developed dementia over a median of 8.1 years. Compared with the lowest quartile, the highest quartile of MPA (HR 0.41, 95% CI 0.31\u20130.54), VPA (HR 0.34, 95% CI 0.25\u20130.46), MVPA (HR 0.43, 95% CI 0.32\u20130.57), and TPA (HR 0.63, 95% CI 0.49\u20130.82) had lower risks of incident dementia. In the questionnaire-based cohort, 5,647 (2.5%) cases occurred over a median of 13.7 years. Higher PA levels, particularly leisure-time and housework-related PA, were consistently tied to a lower risk estimate. MPA showed a more pronounced risk reduction for early-onset than late-onset dementia (ratio of HR 0.69, 95% CI 0.50\u20130.96).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher levels of MPA, MVPA, VPA, and TPA are associated with a lower risk profile for dementia among individuals with hypertension, with variations observed across activity domains and age of onset. However, the reliance on hospital and death records for dementia ascertainment may underestimate the true burden by missing milder cases. These findings demonstrate associations rather than causal effects and require confirmation in intervention studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1833102","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:36:18Z","timestamp":1789450578000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between physical activity and incident dementia among individuals with hypertension"],"prefix":"10.3389","volume":"18","author":[{"given":"Chenguang","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yejing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingkuo","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubi","family":"Lei","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Clinical and Epidemiologic Research, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XuYang","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences","place":["Beijing, China"]},{"name":"Department of Gerontology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChenXi","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences","place":["Beijing, China"]},{"name":"Department of Gerontology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"B1","first-page":"136","article-title":"Reducing sugar, fat, and salt for prevention and control of noncommunicable diseases (n.d.) as an adopted health policy in Iran.","volume":"34","author":"Amerzadeh","year":"2020","journal-title":"Med. 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