{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:15:12Z","timestamp":1783318512790,"version":"3.54.6"},"reference-count":135,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is the most common cause of dementia and major public-health challenge in aging societies worldwide. Accumulating evidence suggests that olfactory and visual deficits can precede overt cognitive symptoms and are closely associated with amyloid-\u03b2 deposition, pathological tau phosphorylation, and disease progression. Early sensory abnormalities in AD likely arise from converging pathological processes. Among these, chronic neuroinflammation marked by microglial and astrocytic reactivity, inflammasome activation and increased pro-inflammatory mediators might play a pivotal role linking sensory-circuit injury to neurodegeneration. A coherent synthesis of the inflammatory mechanisms underlying early olfactory and visual impairment in AD remains limited, and putative molecular pathways and interventions have not been fully integrated. We aimed to identify AD-related olfactory and visual or retinal abnormalities, combine core inflammatory pathways and their interactions with amyloid-\u03b2 and tau pathology, and summarize actionable targets and candidate interventions along a \u201creceptor\u2013intracellular signaling-inflammasome-effector\u201d axis, to inform earlier-stage detection and mechanism-guided intervention in AD.<\/jats:p>","DOI":"10.3389\/fnagi.2026.1838634","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T05:37:17Z","timestamp":1783316237000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroinflammation in Alzheimer\u2019s disease-associated sensory dysfunction: mechanistic links, actionable targets and therapeutic strategies"],"prefix":"10.3389","volume":"18","author":[{"given":"Yanjiao","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Neurology, First Hospital of Jilin University, Jilin University","place":["Changchun, Xinmin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guimei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, First Hospital of Jilin University, Jilin University","place":["Changchun, Xinmin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Neurology, First Hospital of Jilin University, Jilin University","place":["Changchun, Xinmin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology, First Hospital of Jilin University, Jilin University","place":["Changchun, Xinmin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e14433","DOI":"10.1002\/alz.14433","article-title":"Retinal dysfunction in APOE4 knock-in mouse model of Alzheimer's disease","volume":"21","author":"Abhyankar","year":"2025","journal-title":"Alzheimers Dement."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3390\/cells13070581","article-title":"Nf-\u03baB and Jak\/Stat signaling pathways as crucial regulators of neuroinflammation and astrocyte modulation in spinal cord injury","volume":"13","author":"Ageeva","year":"2024","journal-title":"Cells"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"5431","DOI":"10.3390\/ijms21155431","article-title":"Functional alterations in the olfactory neuronal circuit occur before hippocampal plasticity deficits in the P301S mouse model of tauopathy: implications for early diagnosis and translational research in Alzheimer's disease","volume":"21","author":"Ahnaou","year":"","journal-title":"Int. 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Sci."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1703969","DOI":"10.1155\/2020\/1703969","article-title":"Aging alters olfactory bulb network oscillations and connectivity: relevance for aging-related neurodegeneration studies","volume":"2020","author":"Ahnaou","year":"","journal-title":"Neural Plast."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"103266","DOI":"10.1016\/j.redox.2024.103266","article-title":"Metformin ameliorates neuroinflammatory environment for neurons and astrocytes during in vitro and in vivo stroke and tobacco smoke chemical exposure: role of Nrf2 activation","volume":"75","author":"Akter","year":"2024","journal-title":"Redox Biol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/s41398-025-03788-4","article-title":"The safety and efficacy of gamma frequency auditory and visual stimulation in the treatment of Alzheimer's disease: a systematic review and meta-analysis","volume":"15","author":"Ang","year":"2025","journal-title":"Transl. 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Neuroinflammation"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"ENEURO.0403","DOI":"10.1523\/ENEURO.0403-19.2020","article-title":"Differential effects of nasal inflammation and odor deprivation on layer-specific degeneration of the mouse olfactory bulb","volume":"7","author":"Hasegawa-Ishii","year":"2020","journal-title":"eNeuro"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.55563\/clinexprheumatol\/pjs6eh","article-title":"Real-world safety and effectiveness of canakinumab in patients with cryopyrin-associated periodic fever syndrome: a long-term observational study in Japan","volume":"40","author":"Hosono","year":"2022","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3238\/arztebl.m2022.0411","article-title":"Olfactory dysfunction: etiology, diagnosis, and treatment","volume":"120","author":"Hummel","year":"2023","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"6293","DOI":"10.1007\/s12035-019-1512-7","article-title":"Hesperetin confers neuroprotection by regulating Nrf2\/Tlr4\/Nf-\u03baB signaling in an a\u03b2 mouse model","volume":"56","author":"Ikram","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/s41419-017-0153-x","article-title":"Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration","volume":"9","author":"Ising","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/s41586-019-1769-z","article-title":"Nlrp3 inflammasome activation drives tau pathology","volume":"575","author":"Ising","year":"2019","journal-title":"Nature"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/s12967-024-05008-x","article-title":"Modulation of hippocampal protein expression by a brain penetrant biologic TNF-\u03b1 inhibitor in the 3xTg Alzheimer's disease mice","volume":"22","author":"Jagadeesan","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"138300","DOI":"10.1016\/j.neulet.2025.138300","article-title":"Masitinib attenuates neuropathological changes in acrolein-induced sad mouse model via NF-\u03baB\/NLRP3\/caspase-1 signaling pathway","volume":"862","author":"Jia","year":"2025","journal-title":"Neurosci. Lett."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"14305","DOI":"10.1038\/s41598-024-65248-1","article-title":"The impact of astrocytic Nf-\u03baB on healthy and Alzheimer's disease brains","volume":"14","author":"Jong Huat","year":"2024","journal-title":"Sci. Rep."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3389\/fncel.2020.00198","article-title":"Overview of general and discriminating markers of differential microglia phenotypes","volume":"14","author":"Jurga","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.neuron.2014.01.045","article-title":"ApoE and a\u03b2 in Alzheimer's disease: accidental encounters or partners?","volume":"81","author":"Kanekiyo","year":"2014","journal-title":"Neuron"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type associated with restricting development of Alzheimer's disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/ni.2829","article-title":"The pyrin domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses","volume":"15","author":"Khare","year":"2014","journal-title":"Nat. Immunol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/s41586-025-08852-z","article-title":"Immune checkpoint TIM-3 regulates microglia and Alzheimer's disease","volume":"641","author":"Kimura","year":"2025","journal-title":"Nature"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1056\/NEJMoa2027892","article-title":"Phase 3 trial of Interleukin-1 trap Rilonacept in recurrent pericarditis","volume":"384","author":"Klein","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/cr.2008.65","article-title":"MyD88-independent activation of a novel actin-Cdc42\/Rac pathway is required for toll-like receptor-stimulated phagocytosis","volume":"18","author":"Kong","year":"2008","journal-title":"Cell Res."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"e93621","DOI":"10.1172\/jci.insight.93621","article-title":"Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease","volume":"2","author":"Koronyo","year":"2017","journal-title":"JCI Insight"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s00401-023-02548-2","article-title":"Retinal pathological features and proteome signatures of Alzheimer's disease","volume":"145","author":"Koronyo","year":"2023","journal-title":"Acta Neuropathol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"115176","DOI":"10.1016\/j.celrep.2024.115176","article-title":"The microglial response to inhibition of colony-stimulating-factor-1 receptor by Plx3397 differs by sex in adult mice","volume":"44","author":"Le","year":"2025","journal-title":"Cell Rep."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"eadi7828","DOI":"10.1126\/scitranslmed.adi7828","article-title":"Neuroinflammation: an astrocyte perspective","volume":"15","author":"Lee","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.neuroscience.2017.07.053","article-title":"Amelioration of amyloid \u03b2-induced retinal inflammatory responses by a LXR agonist TO901317 is associated with inhibition of the NF-\u03baB signaling and NLRP3 inflammasome","volume":"360","author":"Lei","year":"2017","journal-title":"Neuroscience"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"7092","DOI":"10.1111\/ejn.15472","article-title":"Diet enriched in omega-3 fatty acids alleviates olfactory system deficits in APOE4 transgenic mice","volume":"54","author":"Lessard-Beaudoin","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"102799","DOI":"10.1016\/j.arr.2025.102799","article-title":"Trends and mechanisms of Alzheimer's disease and hearing impairment: a 20-year perspective","volume":"110","author":"Li","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1111\/jnc.13169","article-title":"Liraglutide is neurotrophic and neuroprotective in neuronal cultures and mitigates mild traumatic brain injury in mice","volume":"135","author":"Li","year":"2015","journal-title":"J. Neurochem."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/j.neuron.2018.05.008","article-title":"APOE4 causes widespread molecular and cellular alterations associated with Alzheimer's disease phenotypes in human iPSC-derived brain cell types","volume":"98","author":"Lin","year":"2018","journal-title":"Neuron"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s12264-018-0324-5","article-title":"Up-regulation of Trem2 inhibits hippocampal neuronal apoptosis and alleviates oxidative stress in epilepsy via the PI3K\/Akt pathway in mice","volume":"35","author":"Liu","year":"2019","journal-title":"Neurosci. 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Other Dement."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"01","DOI":"10.1152\/physiol.00037.2024","article-title":"Olfactory development and dysfunction: involvement of microglia","volume":"40","author":"Meller","year":"2025","journal-title":"Physiology (Bethesda)"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"7338","DOI":"10.1038\/s41467-025-62500-8","article-title":"Early locus Coeruleus noradrenergic axon loss drives olfactory dysfunction in Alzheimer's disease","volume":"16","author":"Meyer","year":"2025","journal-title":"Nat. Commun."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1073\/pnas.1215165110","article-title":"Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology","volume":"110","author":"Michaud","year":"2013","journal-title":"Proc. Natl. Acad. Sci. 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Med."},{"key":"ref107","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1159\/000110455","article-title":"Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease","volume":"20","author":"Walter","year":"2007","journal-title":"Cell. Physiol. Biochem."},{"key":"ref108","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1038\/s41401-023-01125-3","article-title":"Salvianolic acid B ameliorates retinal deficits in an early-stage Alzheimer's disease mouse model through downregulating Bace1 and a\u03b2 generation","volume":"44","author":"Wang","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"ref109","doi-asserted-by":"publisher","first-page":"e20200785","DOI":"10.1084\/jem.20200785","article-title":"Anti-human Trem2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model","volume":"217","author":"Wang","year":"","journal-title":"J. Exp. 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