{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:56:54Z","timestamp":1792540614992,"version":"4.5.0"},"reference-count":139,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Mitochondrial complex I dysfunction, ATP depletion, and impaired autophagy are key features of Parkinson\u2019s disease (PD), but their causal relationship remains unclear. Although energy stress induces autophagy, autophagy execution requires ATP. Available evidence suggests a biphasic effect of ATP depletion on autophagy in PD, with mild early energy decline promoting autophagy and more severe ATP loss, below a critical threshold, suppressing its completion. This mechanism may contribute to the accumulation of dysfunctional mitochondria and other undegraded cargo, creating a vicious cycle in which mitochondrial dysfunction, ATP decline, and autophagy failure progressively reinforce one another in PD. Here, we review current evidence linking cellular energy status to autophagic dysfunction in PD and discuss its pathogenic and therapeutic implications.<\/jats:p>","DOI":"10.3389\/fnagi.2026.1846307","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:06:04Z","timestamp":1780466764000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The role of energy deficit in autophagy failure in Parkinson\u2019s disease"],"prefix":"10.3389","volume":"18","author":[{"given":"Mihajlo","family":"Bosnjak","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Institute of Microbiology and Immunology, University of Belgrade","place":["Belgrade, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Misirkic Marjanovic","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology, Institute for Biological Research \u201cSinisa Stankovic\u201d-National Institute of Republic of Serbia, University of Belgrade","place":["Belgrade, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Kosic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Microbiology and Immunology, University of Belgrade","place":["Belgrade, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos","family":"Mandic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Microbiology and Immunology, University of Belgrade","place":["Belgrade, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljubica","family":"Vucicevic","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology, Institute for Biological Research \u201cSinisa Stankovic\u201d-National Institute of Republic of Serbia, University of Belgrade","place":["Belgrade, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verica","family":"Paunovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Microbiology and Immunology, University of Belgrade","place":["Belgrade, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljubica","family":"Harhaji-Trajkovic","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology, Institute for Biological Research \u201cSinisa Stankovic\u201d-National Institute of Republic of Serbia, University of Belgrade","place":["Belgrade, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1001\/archneurol.2010.198","article-title":"Chaperone-mediated autophagy markers in Parkinson disease brains.","volume":"67","author":"Alvarez-Erviti","year":"2010","journal-title":"Arch. 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