{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T05:46:06Z","timestamp":1785735966393,"version":"3.56.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Age-related hearing loss (ARHL) is increasingly recognized as a condition that involves changes in the central nervous system beyond the auditory pathway, with growing evidence showing altered large-scale brain network connectivity. However, how ARHL reshapes the temporal organization of large-scale brain networks remains poorly understood. This study aimed to investigate whether ARHL is associated with alterations in resting-state electroencephalogram (EEG) microstate dynamics and to examine the relationship between microstate features and auditory function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Resting-state EEGs were recorded in 45 older adults with ARHL and 50 age-matched normal-hearing (NH) controls. Microstate analysis was performed using a seven-class model. Group differences in microstate parameters were assessed. Correlation analyses were conducted to examine associations between microstate metrics and audiological measures, including pure-tone audiometry (PTA) thresholds and speech-in-noise (SIN) perception.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with NH controls, participants with ARHL exhibited reduced microstate G time coverage at the nominal significance level (uncorrected\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05, FDR-adjusted\n                      <jats:italic>q<\/jats:italic>\n                      \u202f\u2265\u202f0.05). In addition, the ARHL group showed significantly (FDR-adjusted\n                      <jats:italic>q<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05) increased transition probabilities (TPs) from C to F and from F to C. Conversely, the TP from D to G was significantly reduced, whereas the TP from G to D showed a reduction at the nominal significance level. Across all participants, after controlling for age and sex, microstate G time coverage and TP from D to G were negatively correlated with PTA thresholds, whereas the TPs from C to F and from F to C were positively correlated with PTA thresholds. Furthermore, microstate G time coverage showed a nominal negative correlation with the SIN threshold.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ARHL is associated with altered resting-state EEG microstate dynamics, mainly reflected by changes in TPs among sensorimotor and higher-order cognitive networks. Resting-state EEG microstate analysis provides a comprehensive and systematic framework for studying brain network temporal reorganization induced by auditory decline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1850657","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T05:31:08Z","timestamp":1785735068000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Resting-state EEG microstate dynamics indicate altered brain network temporal organization in age-related hearing loss"],"prefix":"10.3389","volume":"18","author":[{"given":"Yurun","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaohan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaran","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/MAO.0b013e318192483c","article-title":"Risk factors for hearing loss in US adults: data from the national health and nutrition examination survey, 1999 to 2002","volume":"30","author":"Agrawal","year":"2009","journal-title":"Otol. 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