{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T07:03:44Z","timestamp":1784617424669,"version":"3.55.0"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Low education, hearing loss, traumatic brain injury, hypertension, alcohol abuse, obesity, smoking, depression, social isolation, physical inactivity, air pollution, and diabetes are modifiable lifestyle and experiential factors associated with an increased risk of developing dementia. This study introduces the 12-item Risk Factor Questionnaire (RF12), a brief checklist designed to capture these modifiable dementia risk factors. We present a preliminary investigation of criterion-related, cross-sectional associations between RF12 scores and cognitive\/affective measures in a community-dwelling Italian cohort, comparing three scoring methods: self-report, informant-report, and a weighted score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A sample of 563 community-dwelling, cognitively healthy adults (326 females; mean age\u202f=\u202f61.79\u202f\u00b1\u202f10.19\u202fyears, range\u202f=\u202f27\u201391; years of education\u202f=\u202f11.76\u202f\u00b1\u202f4.60, range\u202f=\u202f3\u201330) completed the RF12 alongside standard cognitive assessments (MMSE, MoCA, SATURN, FAB) and a depression scale (GDS). Hierarchical regression analyses were conducted to examine the proportion of variance in cognitive and affective outcomes explained by RF12 scores, controlling for age, sex, and education.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A moderate correlation was observed between self- and informant-reported RF12 scores (Spearman\u2019s\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u202f=\u202f0.408,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). Hierarchical regression analyses indicated that each RF12 scoring method accounted for unique, albeit small, portions of variance in cognitive and affective outcomes (incremental \u0394\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      ranging from 0.8 to 2.3%, even after controlling for age, sex, and education.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The RF12 captures relevant dementia-related risk factors in a low-burden format, although the proportion of variance explained is modest. The tool may be useful for research, epidemiological applications, and prevention efforts. Further longitudinal studies are needed to evaluate its predictive validity in clinical populations and its potential utility in primary care and public health settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1862742","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:26:32Z","timestamp":1784615192000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A brief checklist of modifiable dementia risk factors (RF12): associations with cognitive and affective measures in an Italian cohort"],"prefix":"10.3389","volume":"18","author":[{"given":"Francesco","family":"Giaquinto","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine - Lab of Applied Psychology and Intervention, University of Salento, P.zza Tancredi","place":["Lecce, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Assecondi","sequence":"additional","affiliation":[{"name":"Department of Psychology and Cognitive Science - DiPSCo, University of Trento, Corso Bettini","place":["Rovereto, TN, Italy"]},{"name":"Center for Mind\/Brain Sciences - CIMeC, University of Trento, Corso Bettini","place":["Rovereto, TN, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Vanacore","sequence":"additional","affiliation":[{"name":"National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, Via Giano Della Bella","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Psychology and Milan Center for Neuroscience (NeuroMi), University of Milano-Bicocca, P.zza dell\u2019Ateneo Nuovo","place":["Milano, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Angelelli","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine - Lab of Applied Psychology and Intervention, University of Salento, P.zza Tancredi","place":["Lecce, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.3389\/fpsyg.2022.1031871","article-title":"Diagnostic properties of the frontal assessment battery (FAB) in Italian healthy adults","volume":"34","author":"Aiello","year":"2022","journal-title":"Aging Clin. 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Prev Alzheimers Dis."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e12336","DOI":"10.1002\/dad2.12336","article-title":"Development of the CogDrisk tool to assess risk factors for dementia","volume":"14","author":"Anstey","year":"2022","journal-title":"Alzheimers Dement (Amst)."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"765454","DOI":"10.3389\/fneur.2021.765454","article-title":"Dementia risk scores and their role in the implementation of risk reduction guidelines","volume":"12","author":"Anstey","year":"2022","journal-title":"Front. Neurol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s10072-005-0443-4","article-title":"The frontal assessment battery (FAB): normative values in an Italian population sample","volume":"26","author":"Apollonio","year":"2005","journal-title":"Neurol. Sci."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"100055","DOI":"10.1016\/j.tjpad.2024.100055","article-title":"Preventing dementia in Italy: estimations of modifiable risk factors and public health implications","volume":"12","author":"Asta","year":"2025","journal-title":"J. Prev Alzheimers Dis."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s10072-023-06958-8","article-title":"A new national survey of centers for cognitive disorders and dementias in Italy","volume":"45","author":"Bacigalupo","year":"2024","journal-title":"Neurol. Sci."},{"key":"ref10","first-page":"9","article-title":"The role of general practitioners in prevention and management of patients affected by dementia","volume":"35","author":"Bellomo","year":"2022","journal-title":"Not Ist Super Sanit\u00e0."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e12116","DOI":"10.1002\/trc2.12116","article-title":"Validation of SATURN, a free, electronic, self-administered cognitive screening test","volume":"6","author":"Bissig","year":"2020","journal-title":"Alzheimer's & Dementia: Translational Research & Clinical Interventions"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14992027.2017.1355073","article-title":"Validation of self-reported hearing loss among adult Croatians: the performance of the hearing self-assessment questionnaire against audiometric evaluation","volume":"57","author":"Bonetti","year":"2018","journal-title":"Int. J. Audiol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1002\/gps.1167","article-title":"Characteristics of the GPCOG, a screening tool for cognitive impairment","volume":"19","author":"Brodaty","year":"2004","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1080\/13854046.2017.1334830","article-title":"Outer and inner tolerance limits: their usefulness for the construction of norms and the standardization of neuropsychological tests","volume":"31","author":"Capitani","year":"2017","journal-title":"Clin. Neuropsychol."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s40520-019-01250-2","article-title":"Mini-mental state examination: new normative values on subjects in southern Italy","volume":"32","author":"Carpinelli Mazzi","year":"2020","journal-title":"Aging Clin. Exp. 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Psychiatry"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.jalz.2013.05.1772","article-title":"Midlife risk score for the prediction of dementia four decades later","volume":"10","author":"Exalto","year":"2013","journal-title":"Alzheimers Dement."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d: a practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e0194735","DOI":"10.1371\/journal.pone.0194735","article-title":"Predicting dementia from primary care records: a systematic review and meta-analysis","volume":"13","author":"Ford","year":"2018","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"717","DOI":"10.3233\/JAD-190495","article-title":"The LIBRA index in relation to cognitive function, functional independence, and psycho-behavioral symptoms in seniors at risk of dementia","volume":"72","author":"Franchini","year":"2019","journal-title":"J. Alzheimer's Dis"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"6583","DOI":"10.1017\/S0033291722003968","article-title":"Contributions of modifiable risk factors to increased dementia risk in depression","volume":"53","author":"Geraets","year":"2023","journal-title":"Psychol. 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Alzheimer's Dis"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/jnp.12323","article-title":"The indirect effect of cognitive reserve on the relationship between age and cognition in pathological ageing: a cross-sectional retrospective study in an unselected and consecutively enrolled sample","volume":"17","author":"Giaquinto","year":"2023","journal-title":"J. Neuropsychol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1002\/gps.4751","article-title":"The frontal assessment battery in clinical practice: a systematic review","volume":"33","author":"Hurtado-Pomares","year":"2018","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref29","year":"2024"},{"key":"ref30","year":"2024"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s41687-022-00457-8","article-title":"Agreement between older adult patient and caregiver proxy symptom reports","volume":"6","author":"Kroenke","year":"2022","journal-title":"J. Patient Rep. Outcomes"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the lancet standing commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the lancet commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1016\/S0140-6736(17)31363-6","article-title":"Dementia prevention, intervention, and care","volume":"390","author":"Livingston","year":"2017","journal-title":"Lancet"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"e10525","DOI":"10.1016\/S2468-2667(21)00249-8","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the global burden of disease study 2019","volume":"7","author":"Nichols","year":"2022","journal-title":"Lancet"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1001\/archneurol.2010.115","article-title":"Validation of the new interpretive guidelines for the clinical dementia rating scale sum of boxes score in the National Alzheimer's coordinating center database","volume":"67","author":"O\u2019Bryant","year":"2010","journal-title":"Arch. Neurol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1146\/annurev.psych.59.103006.093656","article-title":"The adaptive brain: aging and neurocognitive scaffolding","volume":"60","author":"Park","year":"2009","journal-title":"Annu. Rev. Psychol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3758\/s13428-018-01193-y","article-title":"PsychoPy2: experiments in behavior made easy","volume":"51","author":"Peirce","year":"2019","journal-title":"Behav. Res. Methods"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s11065-014-9270-9","article-title":"How does it STAC up? Revisiting the scaffolding theory of aging and cognition","volume":"24","author":"Reuter-Lorenz","year":"2014","journal-title":"Neuropsychol. Rev."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"101781","DOI":"10.1016\/j.copsyc.2023.101781","article-title":"Cognitive aging and the life course: a new look at the scaffolding theory","volume":"56","author":"Reuter-Lorenz","year":"2024","journal-title":"Curr. Opin. Psychol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"180","DOI":"10.4415\/ANN_25_03_04","article-title":"Uncovering accessibility gaps. Geospatial and diagnostic practices analysis of the Centres for cognitive disorders and dementias in Apulia and Basilicata, Italy","volume":"61","author":"Rizzi","year":"2025","journal-title":"Ann. Ist. Super. Sanita"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12955-018-0959-y","article-title":"Inter-rater agreement of the quality of life-Alzheimer\u2019s disease (QoL-AD) self-rating and proxy rating scale: secondary analysis of RightTimePlaceCare data","volume":"16","author":"R\u00f6mhild","year":"2018","journal-title":"Health Qual. Life Outcomes"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"165","DOI":"10.14283\/jpad.2020.21","article-title":"Early detection of mild cognitive impairment (MCI) in primary care","volume":"7","author":"Sabbagh","year":"2020","journal-title":"J. Prev Alzheimers Dis."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1007\/s10072-014-1995-y","article-title":"Normative data for the Montreal cognitive assessment in an Italian population sample","volume":"36","author":"Santangelo","year":"2015","journal-title":"Neurol. Sci."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"543","DOI":"10.14283\/jpad.2022.102","article-title":"Association between longitudinal cerebrospinal fluid Alzheimer\u2019s biomarkers and the lifestyle for brain health (LIBRA) index: findings from the EPAD LCS","volume":"10","author":"Saunders","year":"2023","journal-title":"J. Prev Alzheimers Dis."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1300\/J018v05n01_09","article-title":"Geriatric depression scale (GDS): recent evidence and development of a shorter version","volume":"5","author":"Sheikh","year":"1986","journal-title":"Clin. Gerontol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.14336\/AD.2021.0526","article-title":"Depression and dementia in older adults: a neuropsychological review","volume":"12","author":"Tetsuka","year":"2021","journal-title":"Aging Dis."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"e2015009","DOI":"10.1001\/jamanetworkopen.2020.15009","article-title":"Comparison of self-reported measures of hearing with an objective audiometric measure in adults in the English longitudinal study of ageing","volume":"3","author":"Tsimpida","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1037\/a0017908","article-title":"Who knows what about a person? The self\u2013other knowledge asymmetry (SOKA) model","volume":"98","author":"Vazire","year":"2010","journal-title":"J. Pers. Soc. Psychol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"537","DOI":"10.3233\/JAD-161208","article-title":"Modifiable risk factors for prevention of dementia\u2026 validation of the LIBRA index","volume":"58","author":"Vos","year":"2017","journal-title":"J. Alzheimer's Dis"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"100159","DOI":"10.1016\/j.tjpad.2025.100159","article-title":"Lifestyle and cognition: separating the effects of average lifestyle and lifestyle changes based on the LIBRA score","volume":"12","author":"Wesenhagen","year":"2025","journal-title":"J. Prev Alzheimers Dis."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression screening scale: a preliminary report","volume":"17","author":"Yesavage","year":"1982","journal-title":"J. Psychiatr. Res."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/agm2.12074","article-title":"Advances in screening instruments for Alzheimer\u2019s disease","volume":"2","author":"Zhou","year":"2019","journal-title":"Aging Med."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1525\/collabra.121243","article-title":"Assessing the transparency of methods in scientific reporting","volume":"10","author":"Zogmaister","year":"2024","journal-title":"Collabra Psychol."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2026.1862742\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:26:33Z","timestamp":1784615193000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2026.1862742\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":55,"alternative-id":["10.3389\/fnagi.2026.1862742"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2026.1862742","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]},"article-number":"1862742"}}