{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:04:34Z","timestamp":1789452274988,"version":"build-2803163510"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Ischemic stroke is a leading cause of mortality and disability, but the effect of statins on survival in critically ill patients, especially those with dementia, remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study analyzed 1,964 patients from MIMIC-IV and validated findings in 4,255 external cases. Time-dependent Cox, IPTW, and PSM were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Statin use was significantly associated with reduced mortality at 30, 90, 180 days, and 1 year, though the effect attenuated over time. A significant statin-dementia interaction was observed, with greater benefit in dementia patients (adjusted HR = 0.548; NNT = 7 vs. 13). The strongest protection occurred immediately post-admission (74.1% risk reduction) and waned by 1 year. Results were robust in sensitivity and external validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>In conclusion, statin therapy improves short-to-medium-term survival in critically ill ischemic stroke patients, with potential additional benefits observed in those with dementia. These findings support early statin use and suggest dementia as a potential effect modifier, though prospective validation with standardized cognitive assessments is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1866416","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:36:13Z","timestamp":1789450573000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Statin use and all-cause mortality in critically ill ischemic stroke patients: a time-dependent Cox analysis with external validation highlighting enhanced survival benefits in dementia subgroups"],"prefix":"10.3389","volume":"18","author":[{"given":"Danyu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Jinhua Hospital Affiliated to Zhejiang University, Jinhua","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Jinhua Hospital Affiliated to Zhejiang University, Jinhua","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua Municipal Central Hospital","place":["Jinhua, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Jinhua Hospital Affiliated to Zhejiang University, Jinhua","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Jinhua Hospital Affiliated to Zhejiang University, Jinhua","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Jinhua Hospital Affiliated to Zhejiang University, Jinhua","place":["Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1056\/NEJMoa1910355","article-title":"A comparison of two LDL cholesterol targets after ischemic stroke.","volume":"382","author":"Amarenco","year":"2020","journal-title":"N. 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