{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:59:51Z","timestamp":1790315991846,"version":"4.1.0"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"\n Background<\/jats:title>\n Postmenopausal women are at increased risk of mild cognitive impairment (MCI). Vascular and cerebrovascular dysfunction may contribute to this increased vulnerability. Tai Chi has been shown to benefit cognitive function, but its effects on cerebrovascular health in this high-risk population remain poorly defined. This study aimed to evaluate the impact of a 12-week Tai Chi intervention on cognitive performance, cerebral perfusion, and circulating vasomotor and Alzheimer\u2019s disease (AD)-related biomarkers in postmenopausal women with MCI.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This single-center, parallel-group, open-label exploratory randomized controlled trial was conducted from June 2023 to September 2024 in Fuzhou, China. Forty postmenopausal women with MCI were randomized in a 1:1 ratio using block randomization to either a 12-week supervised 24-form Tai Chi program or a health education control group. Primary and secondary outcomes included Montreal Cognitive Assessment (MoCA) total and domain-specific scores, cerebral blood flow in cognition-related brain regions, circulating vasomotor factors, and serum AD-related biomarkers.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared with the health education control group, the Tai Chi group showed greater improvement in MoCA total score (\n \u03b2<\/jats:italic>\n \u202f=\u202f4.95,\n p<\/jats:italic>\n \u202f&lt;\u202f0.001) and in delayed recall (\n \u03b2<\/jats:italic>\n \u202f=\u202f1.50), visuospatial\/executive function (\n \u03b2<\/jats:italic>\n \u202f=\u202f1.10), and attention (\n \u03b2<\/jats:italic>\n \u202f=\u202f1.05) (all\n p<\/jats:italic>\n \u202f&lt;\u202f0.001). Tai Chi was also associated with greater increases in global and regional CBF, including a significant group-by-time interaction for global CBF (\n \u03b2<\/jats:italic>\n \u202f=\u202f15.29,\n p<\/jats:italic>\n \u202f&lt;\u202f0.001), as well as increased plasma NO (\n \u03b2<\/jats:italic>\n \u202f=\u202f10.41,\n p<\/jats:italic>\n \u202f&lt;\u202f0.001), a lower ET-1\/NO ratio (\n \u03b2<\/jats:italic>\n \u202f=\u202f\u22120.97,\n p<\/jats:italic>\n \u202f=\u202f0.004), and greater reductions in circulating T-tau (\n \u03b2<\/jats:italic>\n \u202f=\u202f\u2212255.45,\n p<\/jats:italic>\n \u202f&lt;\u202f0.001), P-tau (\n \u03b2<\/jats:italic>\n \u202f=\u202f\u2212135.67,\n p<\/jats:italic>\n \u202f&lt;\u202f0.001), and A\u03b2\n 1\u201342<\/jats:sub>\n (\n \u03b2<\/jats:italic>\n \u202f=\u202f\u2212169.41,\n p<\/jats:italic>\n \u202f&lt;\u202f0.001). No intervention-related adverse events occurred.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n A 12-week program of standardized 24-form Tai Chi was associated with improvements in overall cognitive performance as assessed by the MoCA in postmenopausal women with MCI. These cognitive changes were accompanied by increased cerebral perfusion, a more favorable vasomotor profile, and reductions in circulating AD-related biomarkers. Tai Chi appears to be a feasible and well-tolerated non-pharmacological intervention for this vulnerable population.<\/jats:p>\n <\/jats:sec>\n \n Clinical trial registration<\/jats:title>\n ChiCTR2300068871.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1880915","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:31:50Z","timestamp":1790314310000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of 12-week 24-form Tai Chi on cognitive function, cerebral perfusion, and vascular function in postmenopausal women with mild cognitive impairment: an exploratory randomized controlled trial"],"prefix":"10.3389","volume":"18","author":[{"given":"Yan","family":"Zheng","sequence":"first","affiliation":[{"name":"Health Management Center, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifen","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of General Practice, Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Health Management Center, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbei","family":"Chen","sequence":"additional","affiliation":[{"name":"Health Management Center, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoling","family":"Hu","sequence":"additional","affiliation":[{"name":"Health Management Center, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Chen","sequence":"additional","affiliation":[{"name":"Health Management Center, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuling","family":"Ni","sequence":"additional","affiliation":[{"name":"Health Management Center, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojin","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Health Management Center, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianhua","family":"Yin","sequence":"additional","affiliation":[{"name":"Health Management Center, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine","place":["Fuzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/bcpt.14035","article-title":"Regulation of mitochondrial dysfunction by estrogens and estrogen receptors in Alzheimer's disease: A focused review","volume":"135","author":"Arjmand","year":"2024","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1502417","DOI":"10.3389\/fnins.2025.1502417","article-title":"Physical activity and neuroplasticity in neurodegenerative disorders: a comprehensive review of exercise interventions, cognitive training, and AI applications","volume":"19","author":"Ben Ezzdine","year":"2025","journal-title":"Front. Neurosci."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1632365","DOI":"10.3389\/fnagi.2025.1632365","article-title":"Exercise-mediated cerebrovascular repair in Alzheimer's disease: from pathophysiology to therapeutic precision","volume":"17","author":"Cai","year":"2025","journal-title":"Front. Aging Neurosci."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"226","DOI":"10.3390\/ejihpe15110226","article-title":"Clinical effectiveness of treatments for mild cognitive impairment in adults: A systematic review","volume":"15","author":"Cepeda-Pineda","year":"2025","journal-title":"Eur. J. Investig. Health Psychol. Educ."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e237004","DOI":"10.1001\/jamanetworkopen.2023.7004","article-title":"Effects of tai Chi Chuan on cognitive function in adults 60 years or older with type 2 diabetes and mild cognitive impairment in China: A randomized clinical trial","volume":"6","author":"Chen","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1080\/13803395.2023.2167942","article-title":"Predicting conversion of patients with mild cognitive impairment to Alzheimer's disease using bedside cognitive assessments","volume":"44","author":"Clarke","year":"2022","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12987-023-00496-3","article-title":"Sex, hormones and cerebrovascular function: from development to disorder","volume":"21","author":"Collignon","year":"2024","journal-title":"Fluids Barriers CNS"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/s41467-026-68374-8","article-title":"The glymphatic system clears amyloid beta and tau from brain to plasma in humans","volume":"17","author":"Dagum","year":"2026","journal-title":"Nat. Commun."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"15333175241272025","DOI":"10.1177\/15333175241272025","article-title":"A review of the role of Estrogens in olfaction, sleep and glymphatic functionality in relation to sex disparity in Alzheimer's disease","volume":"39","author":"Ekanayake","year":"2024","journal-title":"Am. J. Alzheimers Dis. Other Dement."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"815668","DOI":"10.3389\/fcvm.2022.815668","article-title":"Why are women predisposed to intracranial aneurysm?","volume":"9","author":"Fr\u00e9neau","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1161\/strokeaha.123.044841","article-title":"Effect of menopause status on brain perfusion Hemodynamics","volume":"55","author":"Guo","year":"","journal-title":"Stroke"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s13195-024-01524-6","article-title":"Quantitative transport mapping of multi-delay arterial spin labeling MRI detects early blood perfusion alterations in Alzheimer's disease","volume":"16","author":"Guo","year":"","journal-title":"Alzheimers Res. Ther."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e067293","DOI":"10.1136\/bmjopen-2022-067293","article-title":"Effects of different aerobic exercises on the global cognitive function of the elderly with mild cognitive impairment: a meta-analysis","volume":"13","author":"Han","year":"2023","journal-title":"BMJ Open"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1152\/japplphysiol.00565.2022","article-title":"The role of exerkines on brain mitochondria: a mini-review","volume":"134","author":"Heo","year":"2023","journal-title":"J. Appl. Physiol."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1016\/j.jval.2022.06.003","article-title":"Access to disease-modifying Alzheimer's therapies: addressing possible challenges using innovative payment models","volume":"25","author":"Hl\u00e1vka","year":"2022","journal-title":"Value Health"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"fcaf249","DOI":"10.1093\/braincomms\/fcaf249","article-title":"Cerebral blood flow is associated with plasma and PET biomarkers of tau pathology in middle age","volume":"7","author":"Houck","year":"2025","journal-title":"Brain Commun."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1444716","DOI":"10.3389\/fnagi.2024.1444716","article-title":"The impact of physical exercise on neuroinflammation mechanism in Alzheimer's disease","volume":"16","author":"Hu","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s13643-023-02358-3","article-title":"Effects and mechanisms of tai Chi on mild cognitive impairment and early-stage dementia: a scoping review","volume":"12","author":"Jasim","year":"2023","journal-title":"Syst. Rev."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"e661","DOI":"10.1016\/s2468-2667(20)30185-7","article-title":"Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study","volume":"5","author":"Jia","year":"2020","journal-title":"Lancet Public Health"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1177\/1073191116654217","article-title":"Changes in Montreal cognitive assessment scores over time","volume":"24","author":"Krishnan","year":"2017","journal-title":"Assessment"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"943","DOI":"10.17219\/acem\/171379","article-title":"Lecanemab (Leqembi) is not the right drug for patients with Alzheimer's disease","volume":"32","author":"Kurkinen","year":"2023","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"glaf133","DOI":"10.1093\/gerona\/glaf133","article-title":"Exercise and cognitive aging: a meta-analysis of macrovascular cerebral blood flow and cognitive function in older adults","volume":"80","author":"Li","year":"","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s40520-025-03218-x","article-title":"Two-year follow-up assessment of a randomized controlled trial evaluating the durability of tai Chi on cognitive function in older adults with type 2 diabetes and mild cognitive impairment","volume":"37","author":"Li","year":"","journal-title":"Aging Clin. Exp. Res."},{"key":"ref24","article-title":"APOE4 and chronic health risk factors are associated with sex-specific preclinical Alzheimer's disease neuroimaging biomarkers","volume-title":"medRxiv","author":"Losinski","year":"2024"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"42766","DOI":"10.31083\/rcm42766","article-title":"Endothelial dysfunction in sex-specific disparities in cardiovascular diseases: biological mechanisms, diagnostic-therapeutic differences, and translational medicine strategies","volume":"26","author":"Lv","year":"2025","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"11843","DOI":"10.3390\/ijms262411843","article-title":"Neurovascular dysfunction and glymphatic impairment: an unexplored therapeutic frontier in neurodegeneration","volume":"26","author":"Mansour","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1634302","DOI":"10.3389\/fmolb.2025.1634302","article-title":"Estrogen, menopause, and Alzheimer's disease: understanding the link to cognitive decline in women","volume":"12","author":"Mervosh","year":"2025","journal-title":"Front. Mol. Biosci."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"102335","DOI":"10.1016\/j.arr.2024.102335","article-title":"Overlooked cases of mild cognitive impairment: implications to early Alzheimer's disease","volume":"98","author":"Mian","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1177\/17474930241279888","article-title":"Vascular cognitive impairment and dementia: mechanisms, treatment, and future directions","volume":"19","author":"Mok","year":"2024","journal-title":"Int. J. Stroke"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"5590","DOI":"10.1002\/alz.14072","article-title":"Neurovascular coupling, functional connectivity, and cerebrovascular endothelial extracellular vesicles as biomarkers of mild cognitive impairment","volume":"20","author":"Owens","year":"2024","journal-title":"Alzheimers Dement."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"847","DOI":"10.3390\/bs13100847","article-title":"Effects of physical exercise on cerebral blood velocity in older adults: a systematic review and meta-analysis","volume":"13","author":"Prudente","year":"2023","journal-title":"Behav. Sci."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1169499","DOI":"10.3389\/fnagi.2023.1169499","article-title":"Safety and efficacy of lecanemab for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials","volume":"15","author":"Qiao","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1158001","DOI":"10.3389\/fnagi.2023.1158001","article-title":"Brain volumetric changes in menopausal women and its association with cognitive function: a structured review","volume":"15","author":"Ramli","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"225","DOI":"10.14283\/jpad.2018.34","article-title":"Female sex and Alzheimer's risk: the menopause connection","volume":"5","author":"Scheyer","year":"2018","journal-title":"J. Prev Alzheimers Dis."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1467595","DOI":"10.3389\/fnins.2024.1467595","article-title":"The effectiveness of tai Chi for patients with mild cognitive impairment: a systematic review and meta-analysis","volume":"18","author":"Shao","year":"2024","journal-title":"Front. Neurosci."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"6566","DOI":"10.3390\/ijms24076566","article-title":"Cognitive decline in early and premature menopause","volume":"24","author":"Sochocka","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1028822","DOI":"10.3389\/fnagi.2022.1028822","article-title":"Mitigating effects and mechanisms of tai Chi on mild cognitive impairment in the elderly","volume":"14","author":"Wang","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1556622","DOI":"10.3389\/fphys.2025.1556622","article-title":"Effects of Tai Chi Chuan on cognitive function in adults 60 years or older with mild cognitive impairment: a systematic review and meta-analysis","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Physiol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1568835","DOI":"10.3389\/fmed.2025.1568835","article-title":"Optimal exercise temporal parameters of traditional Chinese exercises for cognitive function of older adults with mild cognitive impairment: a systematic review and dose-response meta-analysis of randomized controlled trials","volume":"12","author":"Wen","year":"2025","journal-title":"Front. Med."},{"key":"ref101","first-page":"1294","article-title":"2018 Chinese guidelines for the diagnosis and treatment of dementia and cognitive impairment (V): diagnosis and treatment of mild cognitive impairment","volume-title":"Natl. Med. J. China","year":"2018"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"630382","DOI":"10.3389\/fnagi.2021.630382","article-title":"Altered regional cerebral blood flow and brain function across the Alzheimer's disease Spectrum: A potential biomarker","volume":"13","author":"Zhang","year":"","journal-title":"Front. Aging Neurosci."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3390\/brainsci11020205","article-title":"Effects of mind-body exercise on brain structure and function: A systematic review on MRI studies","volume":"11","author":"Zhang","year":"","journal-title":"Brain Sci."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2026.1880915\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:31:51Z","timestamp":1790314311000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2026.1880915\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":42,"alternative-id":["10.3389\/fnagi.2026.1880915"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2026.1880915","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"article-number":"1880915"}}