{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:05:03Z","timestamp":1790661903562,"version":"4.1.0"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>\n                    Autistic adults experience lifelong motor differences and may have increased vulnerability to parkinsonism, yet behavioral and neuroanatomical correlates of motor challenges across adulthood remain poorly understood. We examined cross-sectional behavioral and motor-related brain region morphology in autistic (\n                    <jats:italic>n<\/jats:italic>\n                    = 123) and non-autistic (\n                    <jats:italic>n<\/jats:italic>\n                    = 102) adults aged 18\u201371 years using the Parkinsonism Screening Questionnaire (PSQ), Adult Repetitive Behavior Questionnaire-2 (RBQ-2A), finger tapping, and MRI-derived cortical thickness and subcortical volumes of motor-related brain regions. Replication of the questionnaire analyses was conducted in an independent cohort of middle- and older-aged autistic adults from the Simons Powering Autism Research (SPARK;\n                    <jats:italic>n<\/jats:italic>\n                    = 210; ages 42\u201380 years), whereas structural MRI and finger tapping analyses were limited to the Arizona cohort. Autistic adults reported significantly higher PSQ scores than non-autistic adults. A significant group-by-age interaction was observed for RBQ-2A Factor 1, with autistic adults showing a steeper age-related reduction in repetitive motor and sensory behaviors. RBQ-2A scores were positively correlated with PSQ scores across both cohorts. Finger tapping performance did not differ between groups. Caudate volumes were larger in autistic adults and showed a modestly stronger negative association with age that did not survive multiple comparison correction. These findings suggest that self-reported restricted, repetitive motor behaviors and interests may serve as an indicator of self-reported parkinsonism-like symptoms in autism and highlight the need for longitudinal studies to clarify mechanisms of parkinsonism risk across the lifespan.\n                  <\/jats:p>","DOI":"10.3389\/fnagi.2026.1893104","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:47:33Z","timestamp":1790660853000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Age-related differences in behavioral and brain predictors of parkinsonism in autistic adults"],"prefix":"10.3389","volume":"18","author":[{"given":"Manuela","family":"Velez Galindo","sequence":"first","affiliation":[{"name":"College of Health Solutions, Arizona State University","place":["Phoenix, AZ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goldie A.","family":"McQuaid","sequence":"additional","affiliation":[{"name":"Department of Psychology, George Mason University","place":["Fairfax, VA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Charlton","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of London","place":["Goldsmiths, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Ofori","sequence":"additional","affiliation":[{"name":"College of Health Solutions, Arizona State University","place":["Phoenix, AZ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Peterson","sequence":"additional","affiliation":[{"name":"College of Health Solutions, Arizona State University","place":["Phoenix, AZ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Q.","family":"Beversdorf","sequence":"additional","affiliation":[{"name":"Thompson Center for Autism & Neurodevelopment","place":["Columbia, MO, United States"]},{"name":"Department of Neurology, Radiology & Psychological Sciences, University of Missouri","place":["Columbia, MO, United States"]},{"name":"William & Nancy Thompson Endowed Chair in Radiology","place":["Columbia, MO, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melony","family":"Valdez","sequence":"additional","affiliation":[{"name":"College of Health Solutions, Arizona State University","place":["Phoenix, AZ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony C.","family":"Rodi","sequence":"additional","affiliation":[{"name":"College of Health Solutions, Arizona State University","place":["Phoenix, AZ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Sabri","sequence":"additional","affiliation":[{"name":"College of Health Solutions, Arizona State University","place":["Phoenix, AZ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Smith-Plata","sequence":"additional","affiliation":[{"name":"College of Health Solutions, Arizona State University","place":["Phoenix, AZ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Cervantes","sequence":"additional","affiliation":[{"name":"College of Health Solutions, Arizona State University","place":["Phoenix, AZ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory L.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Speech, Language, and Hearing Sciences, The George Washington University","place":["Washington, DC, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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