{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:31:06Z","timestamp":1786516266358,"version":"build-2736575974"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Orthostatic hypotension (OH) is common in Parkinson\u2019s disease (PD), but what is known of its clinical associations comes from ambulatory or population-based cohorts assessed under protocolised or tilt-table conditions. The patients whom a routine bedside screen identifies on a general ward have not been described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterise the modified Hoehn\u2013Yahr (H\u2013Y) stage distribution of hospitalized PD patients with a positive bedside OH screen, and to describe how clinical burden is distributed across stage within that group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cross-sectional analysis of 125 consecutive adults admitted to a Chinese tertiary neurology department (January 2021 to March 2025) with idiopathic PD and a positive bedside OH screen, defined as a fall of \u226520\u202fmmHg systolic or \u226510\u202fmmHg diastolic at 1 or at 3\u202fmin upright. No OH-negative comparator was available. The primary outcome was the H\u2013Y stage distribution; secondary outcomes were motor severity (MDS-UPDRS Part III), motor complications, fracture history, physician-documented sleep disturbance and length of stay. Stage groups were compared using rank-based tests with effect sizes, with multivariable and Firth penalized logistic regression for the two principal binary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Screen-positive inpatients spanned the whole H\u2013Y spectrum: 42.4% (95% CI 34.1\u201351.2) were at H\u2013Y 1.0\u20132.0, before postural instability. One third (33.6%, 95% CI 25.9\u201342.3) met the criterion at 1\u202fmin only and would not have been detected by a 3-min-only rule. Motor severity rose steeply across stage (median MDS-UPDRS Part III 18, 35 and 62.5;\n                      <jats:italic>\u03b5<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u202f=\u202f0.65), as did motor complications (\n                      <jats:italic>\u03b5<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u202f=\u202f0.52), fracture history (5.3%, 37.9%, 30.0%) and length of stay (\n                      <jats:italic>\u03b5<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u202f=\u202f0.10). Physician-documented sleep disturbance instead peaked at the middle stage (30.3%, 58.6%, 45.0%), persisting after adjustment (odds ratio 2.44, 95% CI 1.01\u20135.92).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A bedside OH screen identifies a clinically heterogeneous inpatient group that is not confined to advanced disease, and a third of it is detectable only at 1\u202fmin. Because all participants were screen-positive, these comparisons describe that group and cannot establish that the screening result marks burden independently of stage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1894279","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:56:50Z","timestamp":1786514210000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Stage-dependent clinical burden in hospitalized Parkinson\u2019s disease with a positive bedside orthostatic hypotension screen: a retrospective cross-sectional analysis"],"prefix":"10.3389","volume":"18","author":[{"given":"Hengzhang","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Neurology, Mindong Hospital","place":["Ningde, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mindong Hospital","place":["Ningde, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mindong Hospital","place":["Ningde, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mindong Hospital","place":["Ningde, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaohui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mindong Hospital","place":["Ningde, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenkun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mindong Hospital","place":["Ningde, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1007\/s13311-020-00889-4","article-title":"Medical management and prevention of motor complications in Parkinson's disease","volume":"17","author":"Aradi","year":"2020","journal-title":"Neurotherapeutics"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1783953","DOI":"10.3389\/fneur.2026.1783953","article-title":"Association of neurogenic orthostatic hypotension with cognitive decline in Parkinson's disease: a longitudinal cohort study","volume":"17","author":"Bagheri","year":"2026","journal-title":"Front. 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