{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:31:12Z","timestamp":1787725872649,"version":"build-2784847793"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rapid infarct growth in acute ischemic stroke (AIS) due to large artery occlusion (LAO) is associated with poor clinical outcomes despite successful recanalization. The hypersensitive C-reactive protein (hsCRP)-triglyceride-glucose (TyG) index (CTI), a novel biomarker integrating insulin resistance and systemic inflammation, may reflect a meta-inflammatory state that exacerbates ischemic injury. However, its relationship with early infarct growth rate (IGR) remains unexplored. This study aimed to investigate whether CTI is independently associated with early IGR in patients with anterior circulation LAO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective cross-sectional study of 247 patients with AIS due to anterior circulation LAO. CTI was calculated as the product of the TyG index and high-sensitivity CRP from fasting blood samples. Early IGR was defined as the baseline infarct core volume (rCBF &amp;lt;30%) divided by the time from symptom onset to imaging. Patients were categorized into fast (\u226510 mL\/h) or slow (&amp;lt;10 mL\/h) IGR groups. Multivariable logistic regression was used to assess the independent association between CTI and fast IGR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The fast IGR group had significantly higher CTI levels (median 5.396 vs. 5.177,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002). Spearman\u2019s correlation revealed a positive association between CTI and IGR (r = 0.348,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001). After adjusting for confounders, CTI remained an independent predictor of fast IGR (adjusted OR = 1.635, 95% CI: 1.072\u20132.493,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.022). Subgroup analyses confirmed the consistency of this association. ROC analysis showed an AUC of 0.613 (95% CI: 0.543\u20130.683) for CTI in discriminating fast IGR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated CTI is independently associated with faster early infarct growth in LAO stroke, suggesting its potential role as an adjunctive biomarker that may complement clinical and imaging assessment for risk stratification. However, the modest discriminative performance (AUC = 0.613) underscores the need for integration with established predictors rather than standalone use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1917540","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:01:38Z","timestamp":1787724098000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of the hsCRP- triglyceride-glucose index (CTI) with early infarct growth rate in acute ischemic stroke due to large artery occlusion"],"prefix":"10.3389","volume":"18","author":[{"given":"Haiping","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Neurology, Binghai County People\u2019s Hospital, Yancheng","place":["Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People\u2019s Hospital of Yancheng, Yancheng","place":["Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People\u2019s Hospital of Yancheng, Yancheng","place":["Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangfei","family":"You","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People\u2019s Hospital of Yancheng, Yancheng","place":["Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People\u2019s Hospital of Yancheng, Yancheng","place":["Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songjie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People\u2019s Hospital of Yancheng, Yancheng","place":["Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People\u2019s Hospital of Yancheng, Yancheng","place":["Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqing","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People\u2019s Hospital of Yancheng, Yancheng","place":["Jiangsu, 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