{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:24:06Z","timestamp":1787293446839,"version":"build-2736575974"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mental health problems among older adults with cognitive impairment have attracted increasing attention. Although non-pharmacological interventions (NPIs) are considered safe and feasible, evidence regarding their effects on older adults with suspected cognitive impairment in Southwest China remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This intervention study was conducted in an urban district of Chongqing, China, including older adults with suspected cognitive impairment. A total of 159 individuals were assigned to the intervention group and 161 to the control group. The intervention group received routine health education in addition to a 2-month multidomain NPIs, while the control group received routine health education only. The multidomain NPIs included multiple components, such as music, physical exercise, and sensory stimulation. Data were collected through face-to-face interviews using validated assessment tools, including the Generalized Anxiety Disorder Scale and the 15-item Geriatric Depression Scale. Propensity score matching (PSM) was used to balance baseline characteristics, and difference-in-differences (DID) models estimated the net intervention effect. Difference-in-Difference-in-Differences (DDD) models further examined whether baseline cognitive status modified the effects on anxiety and depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this study, the prevalence of anxiety and depressive symptoms was 24.38% and 10.94%, respectively. After PSM, 202 participants were included in the analysis. DID results showed that the multidomain NPIs significantly reduced anxiety symptoms (\u03b2 = \u22121.44, 95% CI: \u22122.22, \u22120.65,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001) and depressive symptoms (\u03b2 = \u22122.04, 95% CI: \u22122.83, \u22121.25,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001) among older adults with suspected cognitive impairment. Model 3 of the DDD analysis indicated that baseline cognitive status significantly moderated the effect of the multidomain NPIs on depressive symptoms (Treatment \u00d7 Time \u00d7 Cognitive status: \u03b2 = 2.14, 95% CI: 0.25\u20134.04,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.027). These findings suggest that, compared with older adults with baseline cognitive impairment, the intervention showed a greater effect on reducing depressive symptoms among older adults without objective cognitive impairment at baseline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The multidomain NPIs may reduce anxiety and depressive symptoms in older adults with suspected cognitive impairment, with effects on depressive symptoms potentially moderated by baseline cognitive status. Integrating the multidomain NPIs into early cognitive impairment management may improve emotional well-being.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1921356","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T05:35:10Z","timestamp":1787290510000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of the multidomain non-pharmacological interventions on anxiety symptoms and depressive symptoms in older adults with suspected cognitive impairment: a propensity score matching and difference-in-differences analysis"],"prefix":"10.3389","volume":"18","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[{"name":"Office of Party Affairs, Chongqing Jiulongpo District Center for Disease Control and Prevention","place":["Chongqing, China"]},{"name":"School of Public Health, Chongqing Medical University","place":["Chongqing, China"]},{"name":"Research Center for Medicine and Social Development, Chongqing Medical University","place":["Chongqing, China"]},{"name":"Research Center for Public Health Security, Chongqing Medical University","place":["Chongqing, China"]},{"name":"Nutrition Innovation Platform-Sichuan and Chongqing, School of Public Health, Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Li","sequence":"additional","affiliation":[{"name":"Office of Party Affairs, Chongqing Jiulongpo District Center for Disease Control and Prevention","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Public Health, Chongqing Medical University","place":["Chongqing, China"]},{"name":"Research Center for Medicine and Social Development, Chongqing Medical University","place":["Chongqing, China"]},{"name":"Research Center for Public Health Security, Chongqing Medical University","place":["Chongqing, China"]},{"name":"Nutrition Innovation Platform-Sichuan and Chongqing, School of Public Health, Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Health Education and Health Promotion, Chongqing Jiulongpo District Center for Disease Control and Prevention","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Public Health, Chongqing Medical University","place":["Chongqing, China"]},{"name":"Research Center for Medicine and Social Development, Chongqing Medical University","place":["Chongqing, China"]},{"name":"Research Center for Public Health Security, Chongqing Medical University","place":["Chongqing, China"]},{"name":"Nutrition Innovation Platform-Sichuan and Chongqing, School of Public Health, Chongqing Medical University","place":["Chongqing, China"]},{"name":"Chongqing Key Laboratory of Child Nutrition and Health, Children\u2019s Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"B1","unstructured":"The Healthy Brain Initiative: The Public Health Road Map for State and National Partnerships, 2013\u20132018\n          \n          \n          2025"},{"key":"B2","volume-title":"Diagnostic and Statistical Manual of Mental Disorders: American Psychiatric Association.","year":"2013"},{"key":"B3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fpsyt.2013.00027","article-title":"Effects of exercise and physical activity on anxiety.","volume":"4","author":"Anderson","year":"2013","journal-title":"Front. Psychiatry"},{"key":"B4","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1136\/hrt.2005.064600","article-title":"Cardiovascular, cerebrovascular, and respiratory changes induced by different types of music in musicians and non-musicians: The importance of silence.","volume":"92","author":"Bernardi","year":"2006","journal-title":"Heart"},{"key":"B5","doi-asserted-by":"publisher","first-page":"9493623","DOI":"10.1155\/2020\/9493623","article-title":"Integrated role of nonpharmacological interventions for rehabilitation of individuals with musculoskeletal disorders.","volume":"2020","author":"Bernardo-Filho","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"B6","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1055\/s-2004-818530","article-title":"[Anxiety in elderly people \u2013 epidemiology, diagnostic features and therapeutic options].","volume":"72","author":"Boerner","year":"2004","journal-title":"Fortschr. Neurol. Psychiatr."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1093\/aje\/kwj149","article-title":"Variable selection for propensity score models.","volume":"163","author":"Brookhart","year":"2006","journal-title":"Am. J. Epidemiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.3390\/nu16111741","article-title":"Exercise and nutrition in the mental health of the older adult population: A randomized controlled clinical trial.","volume":"16","author":"Carcel\u00e9n-Fraile","year":"2024","journal-title":"Nutrients"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1021\/acschemneuro.5b00007","article-title":"Top-Down control of serotonin systems by the prefrontal cortex: A path toward restored socioemotional function in depression.","volume":"6","author":"Challis","year":"2015","journal-title":"ACS Chem. Neurosci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1159\/000066672","article-title":"Validity and applicability of the Chinese version of community screening instrument for dementia.","volume":"15","author":"Chan","year":"2003","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"B11","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.jad.2018.04.110","article-title":"Prevalence of anxiety in patients with mild cognitive impairment: A systematic review and meta-analysis.","volume":"236","author":"Chen","year":"2018","journal-title":"J. Affect. Disord."},{"key":"B12","doi-asserted-by":"publisher","first-page":"100309","DOI":"10.1016\/j.conctc.2018.100309","article-title":"Comparing different ways of calculating sample size for two independent means: A worked example.","volume":"13","author":"Clifton","year":"2019","journal-title":"Contemp. Clin. Trials Commun."},{"key":"B13","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3109\/09638288.2010.503835","article-title":"Reporting on psychological well-being of older adults with chronic aphasia in the context of unaffected peers.","volume":"33","author":"Cruice","year":"2011","journal-title":"Disabil. Rehabil."},{"key":"B14","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/wps.20346","article-title":"How effective are cognitive behavior therapies for major depression and anxiety disorders? A meta-analytic update of the evidence.","volume":"15","author":"Cuijpers","year":"2016","journal-title":"World Psychiatry"},{"key":"B15","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nrn3027","article-title":"Neural mechanisms of the cognitive model of depression.","volume":"12","author":"Disner","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"119406","DOI":"10.1016\/j.jad.2025.119406","article-title":"Tailored internet-delivered cognitive behavioral therapy with therapist support for depressed older adults: Results from a randomized controlled trial with a one-year follow-up.","volume":"385","author":"Eimontas","year":"2025","journal-title":"J. Affect. Disord."},{"key":"B17","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.biopsych.2007.06.012","article-title":"Altered emotional interference processing in affective and cognitive-control brain circuitry in major depression.","volume":"63","author":"Fales","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"B18","doi-asserted-by":"publisher","first-page":"815170","DOI":"10.3389\/fpsyt.2022.815170","article-title":"Group Mindfulness-Integrated Cognitive Behavior Therapy (MiCBT) reduces depression and anxiety and improves flourishing in a transdiagnostic primary care sample compared to treatment-as-usual: A randomized controlled trial.","volume":"13","author":"Francis","year":"2022","journal-title":"Front. Psychiatry"},{"key":"B19","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1212\/01.wnl.0000172958.95282.2a","article-title":"The AD8: A brief informant interview to detect dementia.","volume":"65","author":"Galvin","year":"2005","journal-title":"Neurology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.1212\/01.wnl.0000247042.15547.eb","article-title":"Validity and reliability of the AD8 informant interview in dementia.","volume":"67","author":"Galvin","year":"2006","journal-title":"Neurology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.46234\/ccdcw2025.272","article-title":"Prevalence of depression and anxiety symptoms and the influencing factors among older adults Aged 60 Years and Over - 7 PLADs, China, 2024.","volume":"7","author":"Gao","year":"2025","journal-title":"China CDC Wkly"},{"key":"B22","first-page":"87","article-title":"Chinese expert consensus on non-pharmacological interventions for cognitive impairment disorders (2025 edition).","volume":"36","author":"Gong","year":"2026","journal-title":"Chin. J. Rehabil."},{"key":"B23","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/nrn3524","article-title":"Uncertainty and anticipation in anxiety: An integrated neurobiological and psychological perspective.","volume":"14","author":"Grupe","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jegh.2015.06.001","article-title":"The psychology of health and well-being in mass gatherings: A review and a research agenda.","volume":"6","author":"Hopkins","year":"2016","journal-title":"J. Epidemiol. Glob. Health"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/sms.12069","article-title":"The effects of physical activity and exercise on brain-derived neurotrophic factor in healthy humans: A review.","volume":"24","author":"Huang","year":"2014","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"B26","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1001\/jamapsychiatry.2016.3162","article-title":"Prevalence of depression in patients with mild cognitive impairment: A systematic review and meta-analysis.","volume":"74","author":"Ismail","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"B27","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/nrn3666","article-title":"Brain correlates of music-evoked emotions.","volume":"15","author":"Koelsch","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1176\/appi.ajgp.13.7.581","article-title":"Validity and reliability of a Taiwan Chinese version of the community screening instrument for dementia.","volume":"13","author":"Liu","year":"2005","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1038\/s41467-020-15920-7","article-title":"Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety.","volume":"11","author":"Liu","year":"2020","journal-title":"Nat. Commun."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.46234\/ccdcw2025.219","article-title":"Spatial distribution and clustering patterns of cognitive impairment among the older population - 31 PLADs, China, 2024.","volume":"7","author":"Liu","year":"2025","journal-title":"China CDC Wkly"},{"key":"B31","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the lancet standing commission.","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"key":"B32","doi-asserted-by":"publisher","first-page":"114137","DOI":"10.1016\/j.psychres.2021.114137","article-title":"Effects of music therapy on anxiety: A meta-analysis of randomized controlled trials.","volume":"304","author":"Lu","year":"2021","journal-title":"Psychiatry Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3389\/fnagi.2020.00009","article-title":"Depression, anxiety, and apathy in mild cognitive impairment: Current perspectives.","volume":"12","author":"Ma","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1176\/jnp.9.3.471","article-title":"Limbic-cortical dysregulation: A proposed model of depression.","volume":"9","author":"Mayberg","year":"1997","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1002\/gps.4406","article-title":"Depressive symptoms increase the risk of progression to dementia in subjects with mild cognitive impairment: Systematic review and meta-analysis.","volume":"31","author":"Mourao","year":"2016","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"B36","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1136\/bjsports-2025-110301","article-title":"Effect of exercise on depression and anxiety symptoms: Systematic umbrella review with meta-meta-analysis.","volume":"60","author":"Munro","year":"2026","journal-title":"Br. J. Sports Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","article-title":"A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): A randomised controlled trial.","volume":"385","author":"Ngandu","year":"2015","journal-title":"Lancet"},{"key":"B38","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3390\/geriatrics5040084","article-title":"Global cognitive impairment prevalence and incidence in community dwelling older adults-a systematic review.","volume":"5","author":"Pais","year":"2020","journal-title":"Geriatrics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1212\/01.wnl.0000260968.92345.3f","article-title":"Predictors of progression from mild cognitive impairment to Alzheimer disease.","volume":"68","author":"Palmer","year":"2007","journal-title":"Neurology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"17430","DOI":"10.1038\/s41598-024-68496-3","article-title":"Depression prevalence of the geriatric depression Scale-15 was compared to structured clinical interview for DSM using individual participant data meta-analysis.","volume":"14","author":"Parsons","year":"2024","journal-title":"Sci. Rep."},{"key":"B41","doi-asserted-by":"publisher","first-page":"e086327","DOI":"10.1136\/bmjopen-2024-086327","article-title":"Impact of community-based multidomain preventive health program on healthcare utilisation among elderly persons in Singapore: A propensity score matched and difference-in-differences study.","volume":"14","author":"Phng","year":"2024","journal-title":"BMJ Open"},{"key":"B42","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/S0140-6736(03)12772-9","article-title":"Dementia diagnosis in developing countries: A cross-cultural validation study.","volume":"361","author":"Prince","year":"2003","journal-title":"Lancet"},{"key":"B43","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1002\/gps.2622","article-title":"A brief dementia screener suitable for use by non-specialists in resource poor settings\u2013the cross-cultural derivation and validation of the brief community screening instrument for Dementia.","volume":"26","author":"Prince","year":"2011","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"B44","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/s44220-024-00368-1","article-title":"Group arts interventions for depression and anxiety among older adults: A systematic review and meta-analysis.","volume":"3","author":"Quinn","year":"2025","journal-title":"Nat. Ment. Health"},{"key":"B45","doi-asserted-by":"publisher","first-page":"354","DOI":"10.3389\/fnins.2015.00354","article-title":"Musical neurofeedback for treating depression in elderly people.","volume":"9","author":"Ramirez","year":"2015","journal-title":"Front. Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"291","DOI":"10.2147\/TCRM.S395449","article-title":"Discontinuation of antidepressants in older adults: A literature review.","volume":"19","author":"Romdhani","year":"2023","journal-title":"Ther. Clin. Risk Manag."},{"key":"B47","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1002\/gps.2106","article-title":"Anxiety symptoms in mild cognitive impairment.","volume":"24","author":"Rozzini","year":"2009","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"B48","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1001\/archpsyc.57.10.925","article-title":"Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders.","volume":"57","author":"Sapolsky","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"key":"B49","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/npp.2009.83","article-title":"The neurocircuitry of fear, stress, and anxiety disorders.","volume":"35","author":"Shin","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"B50","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1177\/00048674221149864","article-title":"Use of psychotropic medications in adults with intellectual disability: A systematic review and meta-analysis.","volume":"57","author":"Song","year":"2023","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: The GAD-7.","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"B52","doi-asserted-by":"publisher","first-page":"e0323127","DOI":"10.1371\/journal.pone.0323127","article-title":"The impact of outpatient settlement for cross-regional medical treatment on healthcare choice by the floating population: PSM+DID evidence based on CFPS.","volume":"20","author":"Su","year":"2025","journal-title":"PLoS One"},{"key":"B53","doi-asserted-by":"publisher","first-page":"e83217","DOI":"10.1371\/journal.pone.0083217","article-title":"Prevalence and predictors of mild cognitive impairment in Xi\u2019an: A community-based study among the elders.","volume":"9","author":"Su","year":"2014","journal-title":"PLoS One"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-018-0882-7","article-title":"Barriers and facilitators to the integration of mental health services into primary health care: A systematic review.","volume":"7","author":"Wakida","year":"2018","journal-title":"Syst. Rev."},{"key":"B55","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1146\/annurev-publhealth-040617-013507","article-title":"Designing difference in difference studies: Best practices for public health policy research.","volume":"39","author":"Wing","year":"2018","journal-title":"Annu. Rev. Public Health"},{"key":"B56","volume-title":"Dementia Fact Sheet.","year":""},{"key":"B57","volume-title":"International Statistical Classification of Diseases and Related Health Problems, 10th Revision.","year":"2010"},{"key":"B58","volume-title":"Mental Health of Older Adults.","year":""},{"key":"B59","doi-asserted-by":"publisher","first-page":"22159","DOI":"10.1038\/s41598-023-49162-6","article-title":"The effect of receptive music therapy on older adults with mild cognitive impairment and depression: A randomized controlled trial.","volume":"13","author":"Xue","year":"2023","journal-title":"Sci. Rep."},{"key":"B60","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1177\/1533317510397330","article-title":"Application of AD8 questionnaire to screen very mild dementia in Taiwanese.","volume":"26","author":"Yang","year":"2011","journal-title":"Am. J. Alzheimers Dis. Other Demen."},{"key":"B61","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression screening scale: A preliminary report.","volume":"17","author":"Yesavage","year":"1982","journal-title":"J. Psychiatr. Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s40120-026-00885-4","article-title":"Thrombolysis with adjunctive tirofiban in acute non-cardioembolic posterior circulation ischemic stroke: A propensity score-matched analysis.","volume":"15","author":"Yuan","year":"2026","journal-title":"Neurol. Ther."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1080\/13607863.2023.2214091","article-title":"Does music intervention relieve depression or anxiety in people living with dementia? A systematic review and meta-analysis.","volume":"27","author":"Zhang","year":"2023","journal-title":"Aging Ment. Health"}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2026.1921356\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T05:35:12Z","timestamp":1787290512000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2026.1921356\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,21]]},"references-count":63,"alternative-id":["10.3389\/fnagi.2026.1921356"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2026.1921356","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,21]]},"article-number":"1921356"}}