{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:53:06Z","timestamp":1785912786930,"version":"3.56.0"},"reference-count":293,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Cognitive decline and neurodegenerative diseases are progressive, multifactorial conditions that may begin years before overt clinical diagnosis and reflect interactions among biological vulnerability, modifiable exposures, environmental determinants, and reduced brain resilience. This structured narrative review examines how artificial intelligence (AI) and machine learning (ML) can integrate clinical, biological, behavioral, and digital data to support earlier, personalized, and clinically actionable strategies for preserving cognitive health. Drawing on evidence from aging neuroscience, biomarker research, digital medicine, lifestyle prevention, natural-product pharmacology, and translational AI, we propose an AI-enabled framework for precision prevention and early management of cognitive decline. Within this framework, AI may support multimodal data integration, individualized risk prediction, digital phenotyping, biomarker-based stratification, intervention selection, natural-compound prioritization, and longitudinal monitoring. Lifestyle interventions and natural medicines are considered complementary components of personalized care whose value depends on biological plausibility, standardization, target engagement, and measurable cognitive or biomarker effects. However, translation from benchmark datasets to clinical practice remains limited by insufficient prospective and external validation, poor interpretability, dataset bias, limited generalizability, inadequate calibration and clinical-utility assessment, and incomplete integration into real-world workflows. Overall, AI may provide the integrative architecture needed to combine multimodal biomarkers, modifiable risk profiles, lifestyle interventions, and natural-product pharmacology within dynamic, person-centered precision-prevention pathways. Its clinical value will depend on transparent reporting, representative datasets, prospective evaluation, and demonstrable improvement in clinical decisions and patient outcomes.<\/jats:p>","DOI":"10.3389\/fnagi.2026.1924338","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:33:40Z","timestamp":1785911620000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Artificial intelligence and machine learning for precision prevention of cognitive decline: integrating multimodal biomarkers, lifestyle interventions, and natural medicines from prediction to clinical practice"],"prefix":"10.3389","volume":"18","author":[{"given":"Erika","family":"Smeriglio","sequence":"first","affiliation":[{"name":"Department of Cognitive, Psychological and Pedagogical Sciences, and Cultural Studies (COSPECS), University of Messina","place":["Messina, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Imbesi","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (CHIBIOFARAM), University of Messina","place":["Messina, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Xiao","sequence":"additional","affiliation":[{"name":"Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Instituto de Agroecolox\u00eda e Alimentaci\u00f3n (IAA)-CITEXVI, Universidade de Vigo","place":["Vigo, Spain"]},{"name":"Research Group on Food, Nutritional Biochemistry and Health, Universidad Europea del Atl\u00e1ntico","place":["Santander, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Smeriglio","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (CHIBIOFARAM), University of Messina","place":["Messina, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Trombetta","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (CHIBIOFARAM), University of Messina","place":["Messina, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1347987","DOI":"10.3389\/fnagi.2024.1347987","article-title":"The role of neuroinflammation in neurodegenerative diseases: Current understanding and future therapeutic targets.","volume":"16","author":"Adamu","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"176706","DOI":"10.1016\/j.ejphar.2024.176706","article-title":"A marine-derived antioxidant astaxanthin as a potential neuroprotective and neurotherapeutic agent: A review of its efficacy on neurodegenerative conditions.","volume":"977","author":"Ad\u0131g\u00fczel","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"9583","DOI":"10.3390\/ijms22179583","article-title":"Deciphering the potential neuroprotective effects of luteolin against A\u03b21\u201342-induced Alzheimer\u2019s disease.","volume":"22","author":"Ahmad","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1002\/ptr.8430","article-title":"Berberine inhibits the disruption of the blood\u2013brain barrier and glial cell activation in a rat model of acute hepatic encephalopathy.","volume":"39","author":"Ali","year":"2025","journal-title":"Phytotherapy Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1016\/j.clnu.2022.09.012","article-title":"The gut microbiome, mild cognitive impairment, and probiotics: A randomized clinical trial in middle-aged and older adults.","volume":"41","author":"Aljumaah","year":"2022","journal-title":"Clin. Nutr."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.3390\/nu17071108","article-title":"Omega-3 EPA supplementation shapes the gut microbiota composition and reduces major histocompatibility complex class II in aged wild-type and APP\/PS1 Alzheimer\u2019s mice: A pilot experimental study.","volume":"17","author":"Altendorfer","year":"2025","journal-title":"Nutrients"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X251367650","article-title":"Metabolomics-driven standardization of herbal medicine: Advances, applications, and sustainability considerations.","volume":"20","author":"Alum","year":"2025","journal-title":"Nat. Prod. Commun."},{"key":"B8","unstructured":"The Ethical Issues Linked to the Perceptions and Portrayal of Dementia and People With Dementia.\n          \n          2013"},{"key":"B9","unstructured":"Dementia in Europe Yearbook 2025: Transport and accEss to Cultural Life, Recreation, Leisure and Sport."},{"key":"B10","unstructured":"AI-Mind supplement to Dementia in Europe issue 48, June 2025."},{"key":"B11","unstructured":"AI4HOPE."},{"key":"B12","unstructured":"Alzheimer Europe Public Involvement Pool."},{"key":"B13","unstructured":"PROMINENT."},{"key":"B14","unstructured":"Discussion Paper and Guidelines for the Ethical Use of Technology for and by People With Dementia.\n          \n          2026"},{"key":"B15","unstructured":"World Alzheimer Report 2019: Attitudes to dementia.\n          \n          2019"},{"key":"B16","volume-title":"Diagnostic and Statistical Manual of Mental Disorders: DSM-5","year":"2013"},{"key":"B17","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2022"},{"key":"B18","doi-asserted-by":"publisher","first-page":"5262","DOI":"10.1002\/alz.13886","article-title":"Prediction of Alzheimer\u2019s disease progression within 6 years using speech: A novel approach leveraging language models.","volume":"20","author":"Amini","year":"2024","journal-title":"Alzheimer\u2019s Dement."},{"key":"B19","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/S1474-4422(17)30040-6","article-title":"Effect of long-term omega-3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): A randomised, placebo-controlled trial.","volume":"16","author":"Andrieu","year":"2017","journal-title":"Lancet Neurol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"3505","DOI":"10.1007\/s00204-025-04091-3","article-title":"The neurotoxic threat of micro- and nanoplastics: Evidence from in vitro and in vivo models.","volume":"99","author":"Ara\u00fajo","year":"2025","journal-title":"Arch. Toxicol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2555","DOI":"10.1038\/s41591-022-02074-w","article-title":"Differential roles of A\u03b242\/40, p-tau231 and p-tau217 for Alzheimer\u2019s trial selection and disease monitoring.","volume":"28","author":"Ashton","year":"2022","journal-title":"Nat. Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1144636","DOI":"10.3389\/fpubh.2023.1144636","article-title":"A scoping review of different monitoring-technology devices in caring for older adults with cognitive impairment.","volume":"11","author":"Asiri","year":"2023","journal-title":"Front. Public Health"},{"key":"B23","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.dadm.2017.03.007","article-title":"Resting-state network dysfunction in Alzheimer\u2019s disease: A systematic review and meta-analysis.","volume":"8","author":"Badhwar","year":"2017","journal-title":"Alzheimer\u2019s Dement. Diagnosis Assess. Dis. Monit."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.3390\/nu16121952","article-title":"Efficacy and safety of Panax ginseng sprout extract in subjective memory impairment: A randomized, double-blind, placebo-controlled clinical trial.","volume":"16","author":"Baek","year":"2024","journal-title":"Nutrients"},{"key":"B25","doi-asserted-by":"publisher","first-page":"e2273","DOI":"10.1002\/brb3.2273","article-title":"Omega-3 fatty acids are associated with blood\u2013brain barrier integrity in a healthy aging population.","volume":"11","author":"Barnes","year":"2021","journal-title":"Brain Behav."},{"key":"B26","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer\u2019s disease.","volume":"367","author":"Bateman","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"101266","DOI":"10.1016\/S2542-5196(25)00118-4","article-title":"Long-term air pollution exposure and incident dementia: A systematic review and meta-analysis.","volume":"9","author":"Best Rogowski","year":"2025","journal-title":"Lancet Planetary Health"},{"key":"B28","doi-asserted-by":"publisher","first-page":"884345","DOI":"10.3389\/fnins.2022.884345","article-title":"Natural therapeutics in aid of treating Alzheimer\u2019s disease: A green gateway toward ending quest for treating neurological disorders.","volume":"16","author":"Bhat","year":"2022","journal-title":"Front. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"7710","DOI":"10.1073\/pnas.0910723107","article-title":"EGCG remodels mature \u03b1-synuclein and amyloid-\u03b2 fibrils and reduces cellular toxicity.","volume":"107","author":"Bieschke","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B30","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s13195-023-01304-8","article-title":"Systematic review: Fluid biomarkers and machine learning methods to improve the diagnosis from mild cognitive impairment to Alzheimer\u2019s disease.","volume":"15","author":"Blanco","year":"2023","journal-title":"Alzheimer\u2019s Res. Therapy"},{"key":"B31","doi-asserted-by":"publisher","first-page":"4800","DOI":"10.3390\/ijms26104800","article-title":"Fungal bioactive compounds as emerging therapeutic options for age-related neurodegenerative disorders.","volume":"26","author":"Bonetto","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1055\/a-2744-9871","article-title":"Review of artificial intelligence for clinical use in Alzheimer\u2019s disease and related dementias.","volume":"46","author":"Breithaupt","year":"2025","journal-title":"Semin. Neurol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1038\/nn.3850","article-title":"Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults.","volume":"17","author":"Brickman","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1017\/S095925980400108X","article-title":"What is person-centred care in dementia?","volume":"13","author":"Brooker","year":"2004","journal-title":"Rev. Clin. Gerontol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"127392","DOI":"10.1016\/j.envpol.2025.127392","article-title":"Qualitative and quantitative analysis of microplastics and nanoplastics in healthy human central nervous system and its blood\u2013brain barrier transmission efficiency: A pilot study.","volume":"388","author":"Bu","year":"2026","journal-title":"Environ. Pollut."},{"key":"B36","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1089\/jmf.2021.0084","article-title":"The role of resveratrol in mild cognitive impairment and Alzheimer\u2019s disease: A systematic review.","volume":"25","author":"Buglio","year":"2022","journal-title":"J. Med. Food"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1177271920950319","DOI":"10.1177\/1177271920950319","article-title":"Fluid biomarkers for synaptic dysfunction and loss.","volume":"15","author":"Camporesi","year":"2020","journal-title":"Biomarker Insights"},{"key":"B38","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1016\/j.jamda.2016.06.020","article-title":"Spontaneous reversion of mild cognitive impairment to normal cognition: A systematic review of literature and meta-analysis.","volume":"17","author":"Canevelli","year":"2016","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"B39","doi-asserted-by":"publisher","first-page":"601","DOI":"10.3390\/nu17040601","article-title":"Impact of polyphenol-rich nutraceuticals on cognitive function and neuroprotective biomarkers: A randomized, double-blind, placebo-controlled clinical trial.","volume":"17","author":"Carrillo","year":"2025","journal-title":"Nutrients"},{"key":"B40","doi-asserted-by":"publisher","first-page":"5144","DOI":"10.1038\/s41598-024-56001-9","article-title":"Automated detection of Alzheimer\u2019s disease: A multi-modal approach with 3D MRI and amyloid PET.","volume":"14","author":"Castellano","year":"2024","journal-title":"Sci. Rep."},{"key":"B41","doi-asserted-by":"publisher","first-page":"D634","DOI":"10.26434\/chemrxiv-2024-fxq2s-v2","article-title":"COCONUT 2.0: A comprehensive overhaul and curation of the collection of open natural products database.","volume":"53","author":"Chandrasekhar","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"7652","DOI":"10.1038\/s41467-022-35157-w","article-title":"Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia.","volume":"13","author":"Charpignon","year":"2022","journal-title":"Nat. Commun."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.3233\/JAD-231100","article-title":"The effects of pomegranate seed oil on mild cognitive impairment.","volume":"97","author":"Chatzikostopoulos","year":"2024","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"B44","doi-asserted-by":"publisher","first-page":"937","DOI":"10.17219\/acem\/171565","article-title":"Recent advances in the study of the neurobiological mechanisms behind the effects of physical activity on mood, resilience and emotional disorders","volume":"32","author":"Chen","year":"2023","journal-title":"Adv. Clin. Exp. Med"},{"key":"B45","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1001\/jamapsychiatry.2023.0800","article-title":"Association of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet with the risk of dementia.","volume":"80","author":"Chen","year":"2023","journal-title":"JAMA Psychiatry"},{"key":"B46","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/s41574-022-00641-2","article-title":"Exerkines in health, resilience and disease.","volume":"18","author":"Chow","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"e36728","DOI":"10.1016\/j.heliyon.2024.e36728","article-title":"Prediction of future dementia among patients with mild cognitive impairment (MCI) by integrating multimodal clinical data.","volume":"10","author":"Cirincione","year":"2024","journal-title":"Heliyon"},{"key":"B48","doi-asserted-by":"publisher","first-page":"112283","DOI":"10.1016\/j.fct.2021.112283","article-title":"Resveratrol attenuates manganese-induced oxidative stress and neuroinflammation through SIRT1 signaling in mice.","volume":"153","author":"Cong","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"3513","DOI":"10.3390\/app15073513","article-title":"Natural health products in the prevention and management of Alzheimer\u2019s disease: A systematic review of randomized clinical trials.","volume":"15","author":"Conti","year":"2025","journal-title":"Appl. Sci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.1093\/brain\/awae142","article-title":"Parkinson\u2019s disease variant detection and disclosure: PD GENEration, a North American study.","volume":"147","author":"Cook","year":"2024","journal-title":"Brain"},{"key":"B51","doi-asserted-by":"publisher","first-page":"2986796","DOI":"10.1155\/2016\/2986796","article-title":"Mechanisms of neuroprotection by quercetin: Counteracting oxidative stress and more.","volume":"2016","author":"Costa","year":"2016","journal-title":"Oxidative Med. Cell. Longevity"},{"key":"B52","doi-asserted-by":"publisher","first-page":"293","DOI":"10.57643\/lsadj.2023.26.2_12","article-title":"Virtual reality for the assessment and treatment of cognitive impairment in the elderly: A scoping review.","volume":"26","author":"Costanzo","year":"2023","journal-title":"Life Span Disabil."},{"key":"B53","doi-asserted-by":"publisher","first-page":"155101","DOI":"10.1016\/j.phymed.2023.155101","article-title":"Natural products for the treatment of neurodegenerative diseases.","volume":"121","author":"Cui","year":"2023","journal-title":"Phytomedicine"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1038\/s41467-025-56690-4","article-title":"Drug repurposing for Alzheimer\u2019s disease and other neurodegenerative disorders.","volume":"16","author":"Cummings","year":"2025","journal-title":"Nat. Commun."},{"key":"B55","doi-asserted-by":"publisher","first-page":"362","DOI":"10.14283\/jpad.2023.30","article-title":"Lecanemab: Appropriate use recommendations.","volume":"10","author":"Cummings","year":"2023","journal-title":"J. Prevent. Alzheimer\u2019s Dis."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1287750","DOI":"10.3389\/fphar.2023.1287750","article-title":"Neuroprotective effects and possible mechanisms of berberine in animal models of Alzheimer\u2019s disease: A systematic review and meta-analysis.","volume":"14","author":"Dan","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B57","first-page":"141","article-title":"Future road map in neurodegenerative disease management with natural product: Roadmap 2024","volume-title":"Annual Reports in Medicinal Chemistry","author":"Das","year":"2024"},{"key":"B58","doi-asserted-by":"publisher","first-page":"100213","DOI":"10.1016\/j.medidd.2025.100213","article-title":"Generative AI for drug discovery and protein design: The next frontier in AI-driven molecular science.","volume":"27","author":"Das","year":"2025","journal-title":"Med. Drug Discov."},{"key":"B59","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3390\/antiox10020223","article-title":"Carotenoids and cognitive outcomes: A meta-analysis of randomized intervention trials.","volume":"10","author":"Davinelli","year":"2021","journal-title":"Antioxidants"},{"key":"B60","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/jgs.16228","article-title":"Relationship of cigarette smoking and time of quitting with incident dementia and cognitive decline.","volume":"68","author":"Deal","year":"2020","journal-title":"J. Am. Geriatr. Soc."},{"key":"B61","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1002\/gps.4245","article-title":"Target risk factors for dementia prevention: A systematic review and Delphi consensus study on the evidence from observational studies.","volume":"30","author":"Deckers","year":"2015","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"B62","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s40478-018-0650-x","article-title":"Amyloid-beta and phosphorylated tau in post-mortem Alzheimer\u2019s disease retinas.","volume":"6","author":"den Haan","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"B63","doi-asserted-by":"publisher","first-page":"e374","DOI":"10.1212\/WNL.0000000000009816","article-title":"Healthy lifestyle and the risk of Alzheimer dementia: Findings from two prospective cohort studies.","volume":"95","author":"Dhana","year":"2020","journal-title":"Neurology"},{"key":"B64","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1161\/CIRCRESAHA.116.308426","article-title":"Vascular cognitive impairment.","volume":"120","author":"Dichgans","year":"2017","journal-title":"Circulation Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1002\/ana.24954","article-title":"Serum neurofilament light: A biomarker of neuronal damage in multiple sclerosis.","volume":"81","author":"Disanto","year":"2017","journal-title":"Ann. Neurol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1001\/jamaneurol.2014.803","article-title":"The preclinical Alzheimer cognitive composite: Measuring amyloid-related decline.","volume":"71","author":"Donohue","year":"2014","journal-title":"JAMA Neurol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"889226","DOI":"10.3389\/fphar.2022.889226","article-title":"Curcumin restrains oxidative stress after intracerebral hemorrhage in rat by activating the Nrf2\/HO-1 pathway.","volume":"13","author":"Duan","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/nu16010009","article-title":"Berberine mediates the production of butyrate to ameliorate cerebral ischemia via the gut microbiota in mice.","volume":"16","author":"Duan","year":"2023","journal-title":"Nutrients"},{"key":"B69","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1038\/s43588-024-00699-0","article-title":"The future of machine learning for small-molecule drug discovery will be driven by data.","volume":"4","author":"Durant","year":"2024","journal-title":"Nat. Comput. Sci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"e00624","DOI":"10.1016\/j.neurot.2025.e00624","article-title":"Applications of artificial intelligence in drug discovery for neurological diseases.","volume":"22","author":"Ekins","year":"2025","journal-title":"Neurotherapeutics"},{"key":"B71","doi-asserted-by":"publisher","first-page":"e34","DOI":"10.1056\/NEJMoa1800389","article-title":"Primary prevention of cardiovascular disease with a Mediterranean diet.","volume":"378","author":"Estruch","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"B72","unstructured":"Guideline on the Assessment of Clinical Safety and Efficacy in the Preparation of EU Herbal Monographs for Well-Established and Traditional Herbal Medicinal Products (EMA\/HMPC\/104613\/2005 Rev. 1).\n          \n          2017"},{"key":"B73","unstructured":"Guideline on Quality of Herbal Medicinal Products\/Traditional Herbal Medicinal Products (EMA\/HMPC\/CHMP\/CVMP\/201116\/2005 Rev. 3)."},{"key":"B74","unstructured":"Guideline on Specifications: Test Procedures and Acceptance Criteria for Herbal Substances, Herbal Preparations and Herbal Medicinal Products\/Traditional Herbal mediCinal Products (EMA\/HMPC\/CHMP\/CVMP\/162241\/2005 Rev. 3)."},{"key":"B75","volume-title":"Regulation (EU) 2024\/1689 of the European Parliament and of the Council of 13 June 2024 Laying Down Harmonised Rules on Artificial Intelligence (Artificial Intelligence Act).","year":"2024"},{"key":"B76","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.neuroscience.2024.12.011","article-title":"Ginsenoside Rg1 attenuates A\u03b21\u201342-induced microglial cell apoptosis and inflammation in Alzheimer\u2019s disease via the GATA4\/PDE4A\/PI3K\/AKT axis.","volume":"565","author":"Fang","year":"2025","journal-title":"Neuroscience"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1038\/s43587-021-00138-z","article-title":"Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer\u2019s disease.","volume":"1","author":"Fang","year":"2021","journal-title":"Nat. Aging"},{"key":"B78","doi-asserted-by":"publisher","first-page":"b3869","DOI":"10.1136\/bmj.b3869","article-title":"Adherence to a Mediterranean diet, cognitive decline, and risk of dementia.","volume":"339","author":"F\u00e9art","year":"2009","journal-title":"BMJ"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.jalz.2019.06.3914","article-title":"The Alzheimer\u2019s disease exposome.","volume":"15","author":"Finch","year":"2019","journal-title":"Alzheimer\u2019s Dement."},{"key":"B80","doi-asserted-by":"publisher","first-page":"364","DOI":"10.7326\/0003-4819-144-5-200603070-00013","article-title":"Reporting randomized, controlled trials of herbal interventions: An elaborated CONSORT statement.","volume":"144","author":"Gagnier","year":"2006","journal-title":"Ann. Internal Med."},{"key":"B81","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1080\/13607863.2015.1132677","article-title":"Computer-based cognitive interventions for people living with dementia: A systematic literature review and meta-analysis.","volume":"21","author":"Garc\u00eda-Casal","year":"2017","journal-title":"Aging Mental Health"},{"key":"B82","doi-asserted-by":"publisher","first-page":"e13573","DOI":"10.1111\/obr.13573","article-title":"Assessing adipokines as potential biomarkers of dementia, Alzheimer\u2019s disease, and mild cognitive impairment: A systematic review and meta-analysis.","volume":"24","author":"Garc\u00eda-Garc\u00eda","year":"2023","journal-title":"Obesity Rev."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1581109","DOI":"10.3389\/fneur.2025.1581109","article-title":"A novel risk factor for dementia: Chronic microplastic exposure.","volume":"16","author":"Gecegelen","year":"2025","journal-title":"Front. Neurol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"e745","DOI":"10.1016\/S2589-7500(21)00208-9","article-title":"The false hope of current approaches to explainable artificial intelligence in health care.","volume":"3","author":"Ghassemi","year":"2021","journal-title":"Lancet Digit. Health"},{"key":"B85","doi-asserted-by":"publisher","first-page":"643","DOI":"10.3233\/JAD-231391","article-title":"Sildenafil as a candidate drug for Alzheimer\u2019s disease: Real-world patient data observation and mechanistic observations from patient-induced pluripotent stem cell-derived neurons.","volume":"98","author":"Gohel","year":"2024","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"B86","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","article-title":"Vascular contributions to cognitive impairment and dementia: A statement for healthcare professionals from the American Heart Association\/American Stroke Association.","volume":"42","author":"Gorelick","year":"2011","journal-title":"Stroke"},{"key":"B87","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s12986-024-00800-4","article-title":"Natural products in the management of neurodegenerative diseases.","volume":"21","author":"Goyal","year":"2024","journal-title":"Nutr. Metab."},{"key":"B88","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1038\/s41591-025-03605-x","article-title":"Blood-based biomarkers of Alzheimer\u2019s disease and incident dementia in the community.","volume":"31","author":"Grande","year":"2025","journal-title":"Nat. Med."},{"key":"B89","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s44163-025-00494-4","article-title":"Blood brain barrier permeability prediction with artificial intelligence and machine learning: A meta-review and future directions.","volume":"5","author":"Grant","year":"2025","journal-title":"Discov. Artif. Intell."},{"key":"B90","doi-asserted-by":"publisher","first-page":"19409","DOI":"10.1038\/s41598-020-76160-9","article-title":"Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults.","volume":"10","author":"Gratton","year":"2020","journal-title":"Sci. Rep."},{"key":"B91","doi-asserted-by":"publisher","first-page":"10388","DOI":"10.18632\/oncotarget.23737","article-title":"Astaxanthin is neuroprotective in an aged mouse model of Parkinson\u2019s disease.","volume":"9","author":"Grimmig","year":"2018","journal-title":"Oncotarget"},{"key":"B92","doi-asserted-by":"publisher","first-page":"4227","DOI":"10.1038\/s41467-019-12242-1","article-title":"Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer\u2019s disease.","volume":"10","author":"Hadoux","year":"2019","journal-title":"Nat. Commun."},{"key":"B93","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1016\/j.neuron.2023.05.017","article-title":"Blood-based biomarkers for Alzheimer\u2019s disease: Current state and future use in a transformed global healthcare landscape.","volume":"111","author":"Hampel","year":"2023","journal-title":"Neuron"},{"key":"B94","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s disease: The amyloid cascade hypothesis.","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"B95","doi-asserted-by":"publisher","first-page":"2778","DOI":"10.1093\/jn\/nxac228","article-title":"Mixed tree nuts, cognition, and gut microbiota: A 4-week, placebo-controlled, randomized crossover trial in healthy nonelderly adults.","volume":"152","author":"Haskell-Ramsay","year":"2022","journal-title":"J. Nutr."},{"key":"B96","doi-asserted-by":"publisher","first-page":"138748","DOI":"10.1016\/j.jhazmat.2025.138748","article-title":"Association of microplastics in human cerebrospinal fluid with Alzheimer\u2019s disease-related changes.","volume":"494","author":"He","year":"2025","journal-title":"J. Hazardous Mater."},{"key":"B97","doi-asserted-by":"publisher","first-page":"102848","DOI":"10.1016\/j.redox.2023.102848","article-title":"Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor \u03b3-dependent mechanism in Alzheimer\u2019s disease.","volume":"66","author":"He","year":"2023","journal-title":"Redox Biol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease.","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"3310","DOI":"10.3390\/nu14163310","article-title":"Quercetin increases mitochondrial biogenesis and reduces free radicals in neuronal SH-SY5Y cells.","volume":"14","author":"Ho","year":"2022","journal-title":"Nutrients"},{"key":"B100","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1001\/jama.279.2.119","article-title":"Cigarette smoking and progression of atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) study","volume":"279","author":"Howard","year":"1998","journal-title":"JAMA"},{"key":"B101","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3390\/md21010043","article-title":"Application of marine natural products against Alzheimer\u2019s disease: Past, present and future.","volume":"21","author":"Hu","year":"2023","journal-title":"Mar. Drugs"},{"key":"B102","doi-asserted-by":"publisher","first-page":"109929","DOI":"10.1016\/j.neuropharm.2024.109929","article-title":"Ginsenoside Rd enhances blood\u2013brain barrier integrity after cerebral ischemia\/reperfusion by alleviating endothelial cell ferroptosis via activation of NRG1\/ErbB4-mediated PI3K\/Akt\/mTOR signaling pathway.","volume":"251","author":"Hu","year":"2024","journal-title":"Neuropharmacology"},{"key":"B103","doi-asserted-by":"publisher","first-page":"e1967","DOI":"10.1002\/wnan.1967","article-title":"The development of nanocarriers for natural products.","volume":"16","author":"Huang","year":"2024","journal-title":"Wiley Interdisciplinary Rev. Nanomed. Nanobiotechnol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/s43587-025-00844-y","article-title":"A systematic review with a burden of proof meta-analysis of health effects of long-term ambient fine particulate matter (PM2.5) exposure on dementia.","volume":"5","author":"Huang","year":"2025","journal-title":"Nat. Aging"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.3389\/fphar.2019.01699","article-title":"Sensing technology to monitor behavioral and psychological symptoms and to assess treatment response in people with dementia: A systematic review.","volume":"10","author":"Husebo","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1001\/jama.2017.11295","article-title":"Digital phenotyping: Technology for a new science of behavior.","volume":"318","author":"Insel","year":"2017","journal-title":"JAMA"},{"key":"B107","doi-asserted-by":"publisher","first-page":"e2354285","DOI":"10.1001\/jamanetworkopen.2023.54285","article-title":"Physical activity and cognitive decline among older adults: A systematic review and meta-analysis.","volume":"7","author":"Iso-Markku","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"B108","doi-asserted-by":"publisher","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of Alzheimer\u2019s disease: Alzheimer\u2019s Association Workgroup.","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimer\u2019s Dement."},{"key":"B109","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA research framework: Toward a biological definition of Alzheimer\u2019s disease.","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimer\u2019s Dement."},{"key":"B110","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer\u2019s pathological cascade.","volume":"9","author":"Jack","year":"2010","journal-title":"Lancet Neurol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1001\/jamaneurol.2020.4201","article-title":"Associations of plasma phospho-tau217 levels with tau positron emission tomography in early Alzheimer disease.","volume":"78","author":"Janelidze","year":"2021","journal-title":"JAMA Neurol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"7407","DOI":"10.1038\/s41467-025-62590-4","article-title":"AI-driven fusion of multimodal data for Alzheimer\u2019s disease biomarker assessment.","volume":"16","author":"Jasodanand","year":"2025","journal-title":"Nat. Commun."},{"key":"B113","first-page":"1","article-title":"Prevalence and pathology of mixed dementia.","volume":"119","author":"Jellinger","year":"2010","journal-title":"Acta Neuropathol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"e2434136","DOI":"10.1001\/jamanetworkopen.2024.34136","article-title":"Flavonoid-rich foods, dementia risk, and interactions with genetic risk, hypertension, and depression.","volume":"7","author":"Jennings","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"B115","doi-asserted-by":"publisher","first-page":"1167398","DOI":"10.3389\/fphar.2023.1167398","article-title":"Protective effects of ginsenosides Rg1 and Rb1 against cognitive impairment induced by simulated microgravity in rats.","volume":"14","author":"Jiang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"42","DOI":"10.31083\/j.fbl2803042","article-title":"Protective effects of quercetin against MPP+-induced dopaminergic neuron injury via the Nrf2 signaling pathway.","volume":"28","author":"Jiang","year":"2023","journal-title":"Front. Biosci."},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1002\/alz70860_102850","article-title":"The role of diet in dementia prevention: Subjective and objective diet scores","volume":"21","author":"Johnston","year":"2025","journal-title":"Alzheimers Dement."},{"key":"B118","doi-asserted-by":"publisher","first-page":"110096","DOI":"10.1016\/j.neuropharm.2024.110096","article-title":"Revolutionizing neurotherapeutics: Nanocarriers unveiling the potential of phytochemicals in Alzheimer\u2019s disease.","volume":"259","author":"Kamath","year":"2024","journal-title":"Neuropharmacology"},{"key":"B119","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00401-017-1717-7","article-title":"Impact of multiple pathologies on the threshold for clinically overt dementia.","volume":"134","author":"Kapasi","year":"2017","journal-title":"Acta Neuropathol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1186\/s12916-019-1426-2","article-title":"Key challenges for delivering clinical impact with artificial intelligence.","volume":"17","author":"Kelly","year":"2019","journal-title":"BMC Med."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.3389\/fphar.2018.01383","article-title":"Neuroprotective effect of quercetin against the detrimental effects of LPS in the adult mouse brain.","volume":"9","author":"Khan","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B122","volume-title":"Dementia Reconsidered: The Person Comes First.","author":"Kitwood","year":"1997"},{"key":"B123","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1002\/alz.12123","article-title":"World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia.","volume":"16","author":"Kivipelto","year":"2020","journal-title":"Alzheimer\u2019s Dement."},{"key":"B124","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1038\/s41401-021-00702-8","article-title":"Luteolin alleviates cognitive impairment in Alzheimer\u2019s disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation.","volume":"43","author":"Kou","year":"2022","journal-title":"Acta Pharmacol Sin."},{"key":"B125","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41746-019-0084-2","article-title":"Digital biomarkers for Alzheimer\u2019s disease: The mobile\/wearable devices opportunity.","volume":"2","author":"Kourtis","year":"2019","journal-title":"NPJ Digit. Med."},{"key":"B126","doi-asserted-by":"publisher","first-page":"6168199","DOI":"10.1155\/2022\/6168199","article-title":"A new perspective on the treatment of Alzheimer\u2019s disease and sleep deprivation-related consequences: Can curcumin help?","volume":"2022","author":"K\u00fcpeli Akkol","year":"2022","journal-title":"Oxidative Med. Cell. Longevity"},{"key":"B127","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3390\/nu16020240","article-title":"Curcumin mitigates the high-fat high-sugar diet-induced impairment of spatial memory, hepatic metabolism, and the alteration of the gut microbiome in Alzheimer\u2019s disease-induced (3xTg-AD) mice.","volume":"16","author":"Lamichhane","year":"2024","journal-title":"Nutrients"},{"key":"B128","doi-asserted-by":"publisher","first-page":"5795","DOI":"10.3390\/ijms22115795","article-title":"Physical exercise-induced myokines in neurodegenerative diseases","volume":"22","author":"Lee","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B129","doi-asserted-by":"publisher","first-page":"12276","DOI":"10.1038\/s41598-024-60134-2","article-title":"A multimodal machine learning model for predicting dementia conversion in Alzheimer\u2019s disease.","volume":"14","author":"Lee","year":"2024","journal-title":"Sci. Rep."},{"key":"B130","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1136\/jnnp-2024-334708","article-title":"Low-density lipoprotein cholesterol levels and risk of incident dementia: A distributed network analysis using common data models.","volume":"96","author":"Lee","year":"2025","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B131","doi-asserted-by":"publisher","first-page":"2819","DOI":"10.3390\/molecules25122819","article-title":"Taurine and ginsenoside Rf induce BDNF expression in SH-SY5Y cells: A potential role of BDNF in corticosterone-triggered cellular damage.","volume":"25","author":"Lee","year":"2020","journal-title":"Molecules"},{"key":"B132","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1001\/jamaneurol.2020.0989","article-title":"Diagnostic performance of RO948 F 18 tau positron emission tomography in the differentiation of Alzheimer disease from other neurodegenerative disorders.","volume":"77","author":"Leuzy","year":"2020","journal-title":"JAMA Neurol."},{"key":"B133","first-page":"102189","article-title":"The impact of environmental pollutants on brain aging: A review of the evidence.","volume":"95","author":"Li","year":"2024","journal-title":"Aging Res. Rev."},{"key":"B134","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1021\/acschemneuro.0c00808","article-title":"Berberine improves behavioral and cognitive deficits in a mouse model of Alzheimer\u2019s disease via regulation of \u03b2-amyloid production and endoplasmic reticulum stress.","volume":"12","author":"Liang","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"B135","doi-asserted-by":"publisher","first-page":"695117","DOI":"10.3389\/fnagi.2021.695117","article-title":"Hearing loss and dementia: A meta-analysis of prospective cohort studies","volume":"13","author":"Liang","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"B136","doi-asserted-by":"publisher","first-page":"e13599","DOI":"10.2196\/13599","article-title":"Using technology to facilitate fidelity assessments: The Tele-STAR caregiver intervention.","volume":"21","author":"Lindauer","year":"2019","journal-title":"J. Med. Internet Res."},{"key":"B137","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1021\/acs.jcim.1c01476","article-title":"RetroGNN: Fast estimation of synthesizability for virtual screening and de novo design by learning from slow retrosynthesis software.","volume":"62","author":"Liu","year":"2022","journal-title":"J. Chem. Information Modeling"},{"key":"B138","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.bbi.2021.04.005","article-title":"Mannan oligosaccharide attenuates cognitive and behavioral disorders in the 5xFAD Alzheimer\u2019s disease mouse model via regulating the gut microbiota\u2013brain axis.","volume":"95","author":"Liu","year":"2021","journal-title":"Brain Behav. Immunity"},{"key":"B139","doi-asserted-by":"publisher","first-page":"5044","DOI":"10.3390\/ijms26115044","article-title":"Resveratrol attenuates CSF markers of neurodegeneration and neuroinflammation in individuals with Alzheimer\u2019s disease.","volume":"26","author":"Liu","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B140","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1142\/S0192415X24500101","article-title":"Berberine alleviates ischemic brain injury by enhancing autophagic flux via facilitation of TFEB nuclear translocation.","volume":"52","author":"Liu","year":"","journal-title":"Am. J. Chinese Med."},{"key":"B141","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.3233\/JAD-180121","article-title":"Sedentary behavior and risk of dementia: A systematic review and meta-analysis.","volume":"64","author":"Liu","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1358992","DOI":"10.3389\/fnagi.2024.1358992","article-title":"Cognitive reserve over the life course and risk of dementia: a systematic review and meta-analysis","volume":"16","author":"Liu","year":"","journal-title":"Front. Aging Neurosci."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1358992","DOI":"10.3389\/fnagi.2024.1358992","article-title":"Cognitive reserve over the life course and risk of dementia: A systematic review and meta-analysis.","volume":"16","author":"Liu","year":"","journal-title":"Front. Aging Neurosci."},{"key":"B144","doi-asserted-by":"publisher","first-page":"310","DOI":"10.3390\/antiox13030310","article-title":"Ginsenosides Rg1 and Rg2 activate autophagy and attenuate oxidative stress in neuroblastoma cells overexpressing A\u03b21\u201342.","volume":"13","author":"Liu","year":"","journal-title":"Antioxidants"},{"key":"B145","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission.","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"key":"B146","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","article-title":"Alzheimer disease: An update on pathobiology and treatment strategies.","volume":"179","author":"Long","year":"2019","journal-title":"Cell"},{"key":"B147","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.14283\/jpad.2024.103","article-title":"Digital health technologies for Alzheimer\u2019s disease and related dementias: Initial results from a landscape analysis and community collaborative effort.","volume":"11","author":"Lott","year":"2024","journal-title":"J. Prevent. Alzheimer\u2019s Dis."},{"key":"B148","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/s41591-018-0275-4","article-title":"Exercise-linked FNDC5\/irisin rescues synaptic plasticity and memory defects in Alzheimer\u2019s models.","volume":"25","author":"Lourenco","year":"2019","journal-title":"Nat. Med."},{"key":"B149","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1001\/jama.2019.9879","article-title":"Association of lifestyle and genetic risk with incidence of dementia.","volume":"322","author":"Lourida","year":"2019","journal-title":"JAMA"},{"key":"B150","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1097\/EDE.0b013e3182944410","article-title":"Mediterranean diet, cognitive function, and dementia: A systematic review.","volume":"24","author":"Lourida","year":"2013","journal-title":"Epidemiology"},{"key":"B151","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.1002\/ptr.8192","article-title":"Phytomedicine for neurodegenerative diseases: The road ahead.","volume":"38","author":"Madhubala","year":"2024","journal-title":"Phytotherapy Res."},{"key":"B152","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1136\/jnnp-2012-304792","article-title":"Mediterranean diet improves cognition: The PREDIMED-NAVARRA randomised trial.","volume":"84","author":"Mart\u00ednez-Lapiscina","year":"2013","journal-title":"J. Neurolo. Neurosurg. Psychiatry"},{"key":"B153","doi-asserted-by":"publisher","first-page":"1437939","DOI":"10.3389\/fphar.2024.1437939","article-title":"Targeting the NRF2 pathway for disease modification in neurodegenerative diseases: Mechanisms and therapeutic implications.","volume":"15","author":"Mayer","year":"2024","journal-title":"Front. Pharmacol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"483","DOI":"10.2174\/1567205016666190506141733","article-title":"Connected speech deficit as an early hallmark of CSF-defined Alzheimer\u2019s disease and correlation with cerebral hypoperfusion pattern.","volume":"16","author":"Mazzon","year":"2019","journal-title":"Curr. Alzheimer Res."},{"key":"B155","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/ene.13413","article-title":"Huntington\u2019s disease: A clinical review.","volume":"25","author":"McColgan","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium.","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"key":"B157","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: Recommendations from the National Institute on Aging\u2013Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease.","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimer\u2019s Dement."},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2022.104236","article-title":"Multidomain lifestyle interventions for cognition and the risk of dementia: A systematic review and meta-analysis.","volume":"130","author":"Meng","year":"2022","journal-title":"Int. J. Nurs. Stud."},{"key":"B159","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/s41582-022-00714-w","article-title":"Gene\u2013environment interactions in Alzheimer disease: The emerging role of epigenetics.","volume":"18","author":"Migliore","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"617588","DOI":"10.3389\/fnagi.2021.617588","article-title":"Mitochondrial dysfunction and oxidative stress in Alzheimer\u2019s disease.","volume":"13","author":"Misrani","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"B161","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/j.1600-0447.2008.01326.x","article-title":"Rate of progression of mild cognitive impairment to dementia: Meta-analysis of 41 robust inception cohort studies.","volume":"119","author":"Mitchell","year":"2009","journal-title":"Acta Psychiatr. Scand."},{"key":"B162","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/S0140-6736(16)30950-3","article-title":"Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): A cluster-randomised controlled trial.","volume":"388","author":"Moll van Charante","year":"2016","journal-title":"Lancet"},{"key":"B163","doi-asserted-by":"publisher","first-page":"5406","DOI":"10.1038\/s41598-023-32515-6","article-title":"A randomized, open-label clinical trial in mild cognitive impairment with EGb 761 examining blood markers of inflammation and oxidative stress.","volume":"13","author":"Morat\u00f3","year":"2023","journal-title":"Sci. Rep."},{"key":"B164","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.jalz.2014.11.009","article-title":"MIND diet associated with reduced incidence of Alzheimer\u2019s disease.","volume":"11","author":"Morris","year":"2015","journal-title":"Alzheimer\u2019s Dement."},{"key":"B165","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.jamda.2017.03.018","article-title":"Use of a robotic seal as a therapeutic tool to improve dementia symptoms: A cluster-randomized controlled trial.","volume":"18","author":"Moyle","year":"2017","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"B166","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/s41573-023-00774-7","article-title":"Artificial intelligence for natural product drug discovery.","volume":"22","author":"Mullowney","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"B167","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/s41582-020-0377-8","article-title":"Applications of machine learning to diagnosis and treatment of neurodegenerative diseases.","volume":"16","author":"Myszczynska","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"B168","doi-asserted-by":"publisher","first-page":"1529194","DOI":"10.3389\/fphar.2025.1529194","article-title":"Natural products in neurodegenerative diseases: Recent advances and future outlook.","volume":"16","author":"Nahar","year":"2025","journal-title":"Front. Pharmacol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/nature25456","article-title":"High performance plasma amyloid-\u03b2 biomarkers for Alzheimer\u2019s disease.","volume":"554","author":"Nakamura","year":"2018","journal-title":"Nature"},{"key":"B170","volume-title":"Nutritional Interventions and Natural Products Research-Information for Researchers","year":"2024"},{"key":"B171","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3233\/NHA-1615","article-title":"High-flavonoid intake induces cognitive improvements linked to changes in serum brain-derived neurotrophic factor: Two randomised, controlled trials.","volume":"4","author":"Neshatdoust","year":"2016","journal-title":"Nutr. Healthy Aging"},{"key":"B172","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","article-title":"A 2-year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people: The FINGER randomised controlled trial.","volume":"385","author":"Ngandu","year":"2015","journal-title":"Lancet"},{"key":"B173","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1093\/bioinformatics\/btaa921","article-title":"GraphDTA: Predicting drug\u2013target binding affinity with graph neural networks.","volume":"37","author":"Nguyen","year":"2021","journal-title":"Bioinformatics"},{"key":"B174","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1038\/s41467-024-46116-y","article-title":"Effect of gut microbiome modulation on muscle function and cognition: The PROMOTe randomised controlled trial.","volume":"15","author":"Ni Lochlainn","year":"2024","journal-title":"Nat. Commun."},{"key":"B175","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1038\/s41591-024-03453-1","article-title":"Bioaccumulation of microplastics in decedent human brains.","volume":"31","author":"Nihart","year":"2025","journal-title":"Nat. Med."},{"key":"B176","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1093\/brain\/awae032","article-title":"Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum of neurodegenerative diseases.","volume":"147","author":"Nilsson","year":"2024","journal-title":"Brain"},{"key":"B177","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s40520-024-02718-6","article-title":"Association between Mediterranean diet and dementia and Alzheimer disease: A systematic review with meta-analysis.","volume":"36","author":"Nucci","year":"2024","journal-title":"Aging Clin. Exp. Res."},{"key":"B178","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1177\/07334648251314284","article-title":"Feasibility and usage of a virtual assistant device in cognitively impaired homebound older adults","volume":"44","author":"Nunez","year":"2025","journal-title":"J. Appl. Gerontol."},{"key":"B179","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1038\/s41591-022-02049-x","article-title":"Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline.","volume":"28","author":"Ossenkoppele","year":"2022","journal-title":"Nat. Med."},{"key":"B180","doi-asserted-by":"publisher","first-page":"100316","DOI":"10.1016\/j.ibmed.2025.100316","article-title":"Artificial intelligence for natural product drug discovery and development: Current landscape, applications, and future directions.","volume":"12","author":"Othman","year":"2025","journal-title":"Intelligence-Based Med."},{"key":"B181","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1038\/s41591-025-03622-w","article-title":"Plasma phospho-tau217 for Alzheimer\u2019s disease diagnosis in primary and secondary care using a fully automated platform","volume":"31","author":"Palmqvist","year":"2025","journal-title":"Nat. Med."},{"key":"B182","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3390\/md18040213","article-title":"Laminarin pretreatment provides neuroprotection against forebrain ischemia\/reperfusion injury by reducing oxidative stress and neuroinflammation in aged gerbils.","volume":"18","author":"Park","year":"2020","journal-title":"Mar. Drugs"},{"key":"B183","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/s41582-023-00822-1","article-title":"Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration.","volume":"19","author":"Patani","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"B184","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1001\/jama.2019.22258","article-title":"Screening for cognitive impairment in older adults: Updated evidence report and systematic review for the US Preventive Services Task Force","volume":"323","author":"Patnode","year":"2020","journal-title":"JAMA"},{"key":"B185","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/s41574-019-0174-x","article-title":"The physiology of optimizing health: Exercise as medicine.","volume":"15","author":"Pedersen","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"B186","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.3389\/fpsyg.2018.01062","article-title":"Virtual reality-based interventions for the rehabilitation of older adults with cognitive impairments: A systematic review.","volume":"9","author":"Pedroli","year":"2018","journal-title":"Front. Psychol."},{"key":"B187","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3390\/antiox13020240","article-title":"Mitochondria dysfunction and neuroinflammation in neurodegeneration: Who comes first?","volume":"13","author":"Peggion","year":"2024","journal-title":"Antioxidants"},{"key":"B188","doi-asserted-by":"publisher","first-page":"3505","DOI":"10.1093\/brain\/awab223","article-title":"Plasma GFAP is an early marker of amyloid-\u03b2 but not tau pathology in Alzheimer\u2019s disease.","volume":"144","author":"Pereira","year":"2021","journal-title":"Brain"},{"key":"B189","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/joim.12190","article-title":"Mild cognitive impairment: A concept in evolution.","volume":"275","author":"Petersen","year":"2014","journal-title":"J. Internal Med."},{"key":"B190","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson\u2019s disease.","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"key":"B191","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3892\/mmr.2022.12731","article-title":"Neuroprotective effect of ginsenoside Re against neurotoxin-induced Parkinson\u2019s disease models via induction of Nrf2.","volume":"25","author":"Qiao","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"B192","doi-asserted-by":"publisher","first-page":"102776","DOI":"10.1016\/j.sbi.2024.102776","article-title":"Artificial intelligence for drug discovery and development in Alzheimer\u2019s disease.","volume":"85","author":"Qiu","year":"2024","journal-title":"Curr. Opin. Struct. Biol."},{"key":"B193","doi-asserted-by":"publisher","first-page":"100150","DOI":"10.1016\/j.tjpad.2025.100150","article-title":"Donanemab: Appropriate use recommendations.","volume":"12","author":"Rabinovici","year":"2025","journal-title":"J. Prevent. Alzheimer\u2019s Dis."},{"key":"B194","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia.","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"key":"B195","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1109\/TSMCA.2009.2025137","article-title":"Keeping the resident in the loop: Adapting the smart home to the user.","volume":"39","author":"Rashidi","year":"2009","journal-title":"IEEE Trans. Syst. Man Cybernetics\u2014Part A Syst. Hum."},{"key":"B196","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/s42256-021-00307-0","article-title":"Common pitfalls and recommendations for using machine learning to detect and prognosticate for COVID-19 using chest radiographs and CT scans.","volume":"3","author":"Roberts","year":"2021","journal-title":"Nat. Mach. Intell."},{"key":"B197","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1038\/s41467-021-21330-0","article-title":"Machine learning identifies candidates for drug repurposing in Alzheimer\u2019s disease.","volume":"12","author":"Rodriguez","year":"2021","journal-title":"Nat. Commun."},{"key":"B198","doi-asserted-by":"publisher","first-page":"1128619","DOI":"10.3389\/fnagi.2023.1128619","article-title":"The future is precision medicine-guided diagnoses, preventions and treatments for neurodegenerative diseases.","volume":"15","author":"Rossi","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"B199","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/s42256-019-0048-x","article-title":"Stop explaining black box machine learning models for high stakes decisions and use interpretable models instead.","volume":"1","author":"Rudin","year":"2019","journal-title":"Nat. Mach. Intell."},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k2927","article-title":"Alcohol consumption and risk of dementia: 23-year follow-up of Whitehall II cohort study","volume":"362","author":"Sabia","year":"2018","journal-title":"BMJ"},{"key":"B201","doi-asserted-by":"publisher","first-page":"125186","DOI":"10.1016\/j.ijpharm.2025.125186","article-title":"Advancing neurological disorders therapies: Organic nanoparticles as a key to blood\u2013brain barrier penetration.","volume":"670","author":"Sadat Razavi","year":"2025","journal-title":"Int. J. Pharm."},{"key":"B202","doi-asserted-by":"publisher","first-page":"671","DOI":"10.3233\/JAD-190083","article-title":"Neuroprotective potential of curcumin-loaded nanostructured lipid carrier in an animal model of Alzheimer\u2019s disease: Behavioral and biochemical evidence.","volume":"69","author":"Sadegh Malvajerd","year":"2019","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"B203","doi-asserted-by":"publisher","first-page":"1049464","DOI":"10.3389\/frdem.2022.1049464","article-title":"Views and experiences on the use of voice assistants by family and professionals supporting people with cognitive impairments.","volume":"1","author":"Salai","year":"2022","journal-title":"Front. Dement."},{"key":"B204","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1002\/ana.20854","article-title":"Mediterranean diet and risk for Alzheimer\u2019s disease.","volume":"59","author":"Scarmeas","year":"2006","journal-title":"Ann. Neurol."},{"key":"B205","doi-asserted-by":"publisher","first-page":"e1647","DOI":"10.1212\/WNL.0000000000008081","article-title":"High-precision plasma \u03b2-amyloid 42\/40 predicts current and future brain amyloidosis.","volume":"93","author":"Schindler","year":"2019","journal-title":"Neurology"},{"key":"B206","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1212\/01.wnl.0000271090.28148.24","article-title":"Mixed brain pathologies account for most dementia cases in community-dwelling older persons.","volume":"69","author":"Schneider","year":"2007","journal-title":"Neurology"},{"key":"B207","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41746-020-0253-3","article-title":"Presenting machine learning model information to clinical end users with model facts labels.","volume":"3","author":"Sendak","year":"2020","journal-title":"npj Digit. Med."},{"key":"B208","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/S1474-4422(20)30412-9","article-title":"APOE and Alzheimer\u2019s disease: Advances in genetics, pathophysiology, and therapeutic approaches.","volume":"20","author":"Serrano-Pozo","year":"2021","journal-title":"Lancet Neurol."},{"key":"B209","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1210\/endrev\/bnaa016","article-title":"Muscle\u2013organ crosstalk: The emerging roles of myokines.","volume":"41","author":"Severinsen","year":"2020","journal-title":"Endocrine Rev."},{"key":"B210","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/s41746-025-02105-z","article-title":"A systematic review of explainable artificial intelligence methods for speech-based cognitive decline detection.","volume":"8","author":"Shankar","year":"2025","journal-title":"NPJ Digit. Med."},{"key":"B211","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.3390\/molecules29081867","article-title":"NIMO: A natural product-inspired molecular generative model based on conditional transformer.","volume":"29","author":"Shen","year":"2024","journal-title":"Molecules"},{"key":"B212","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.smrv.2017.06.010","article-title":"Sleep disturbances and the risk of dementia: A systematic review.","volume":"37","author":"Shi","year":"2018","journal-title":"Sleep Med. Rev."},{"key":"B213","doi-asserted-by":"publisher","first-page":"e2426872","DOI":"10.1001\/jamanetworkopen.2024.26872","article-title":"\u03c9-3 PUFA for secondary prevention of white matter lesions and neuronal integrity breakdown in older adults: A randomized clinical trial.","volume":"7","author":"Shinto","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"B214","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1001\/jama.2023.13239","article-title":"Donanemab in early symptomatic Alzheimer disease: The TRAILBLAZER-ALZ 2 randomized clinical trial.","volume":"330","author":"Sims","year":"2023","journal-title":"JAMA"},{"key":"B215","doi-asserted-by":"publisher","first-page":"5228","DOI":"10.3390\/ijms26115228","article-title":"Nanoplastics and immune disruption: A systematic review of exposure routes, mechanisms, and health implications","volume":"26","author":"Skaba","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B216","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jalz.2017.09.007","article-title":"Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the vascular impairment of cognition classification consensus study.","volume":"14","author":"Skrobot","year":"2018","journal-title":"Alzheimer\u2019s Dement."},{"key":"B217","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.jagp.2017.10.010","article-title":"Memory and brain amyloid and tau effects of a bioavailable form of curcumin in non-demented adults: A double-blind, placebo-controlled 18-month trial.","volume":"26","author":"Small","year":"2018","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"B218","volume-title":"Applicazioni cliniche, attuali e future, dell\u2019AI nell\u2019ambito della demenza neurodegenerativa di Alzheimer. Atti Convegno Dottorale Menti Connesse.","author":"Smeriglio","year":""},{"key":"B219","first-page":"221","article-title":"La funzione narrativa del linguaggio nelle scienze cognitive: Teoria e applicazioni cliniche nella demenza di Alzheimer","volume-title":"Prospettive moniste nelle scienze cognitive: Esplorazioni interdisciplinari","author":"Smeriglio","year":""},{"key":"B220","volume-title":"Plasticit\u00e0 e figure del trauma nella psicopatologia contemporanea: Le modificazioni desoggettivanti delle identit\u00e0 individuali e delle strutture collettive nel morbo di Alzheimer. Atti Convegno Dottorale Interazioni.","author":"Smeriglio","year":"2025"},{"key":"B221","article-title":"New paradigms of artificial intelligence in neurodegenerative Alzheimer\u2019s dementia: A psychological perspective","volume-title":"Artificial Intelligence and Technological Innovations: Cultural Processes and Legal, Linguistic, Sociological and Psychological Perspectives","author":"Smeriglio","year":"2026"},{"key":"B222","doi-asserted-by":"publisher","first-page":"971252","DOI":"10.3389\/fneur.2022.971252","article-title":"Genetic variations in GBA1 and LRRK2 genes: Biochemical and clinical consequences in Parkinson disease.","volume":"13","author":"Smith","year":"2022","journal-title":"Front. Neurol."},{"key":"B223","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s13321-020-00478-9","article-title":"COCONUT online: Collection of open natural products database.","volume":"13","author":"Sorokina","year":"2021","journal-title":"J. Cheminformatics"},{"key":"B224","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1038\/s41593-018-0235-9","article-title":"Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.","volume":"21","author":"Soto","year":"2018","journal-title":"Nat. Neurosci."},{"key":"B225","doi-asserted-by":"publisher","first-page":"102741","DOI":"10.1016\/j.arr.2025.102741","article-title":"Use of artificial intelligence to support quality of life of people with dementia: A scoping review.","volume":"108","author":"Steijger","year":"2025","journal-title":"Aging Res. Rev."},{"key":"B226","doi-asserted-by":"publisher","first-page":"6259","DOI":"10.1021\/acs.jcim.4c00747","article-title":"Transformers for molecular property prediction: Lessons learned from the past five years.","volume":"64","author":"Sultan","year":"2024","journal-title":"J. Chem. Information Modeling"},{"key":"B227","doi-asserted-by":"publisher","first-page":"155624","DOI":"10.1016\/j.phymed.2024.155624","article-title":"Berberine alleviates Alzheimer\u2019s disease by regulating the gut microenvironment, restoring the gut barrier and brain\u2013gut axis balance.","volume":"129","author":"Sun","year":"2024","journal-title":"Phytomedicine"},{"key":"B228","doi-asserted-by":"publisher","first-page":"114550","DOI":"10.1016\/j.intimp.2025.114550","article-title":"Berberine alleviates Alzheimer\u2019s disease by activating autophagy and inhibiting ferroptosis through the JNK-p38MAPK signaling pathway.","volume":"155","author":"Sun","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"B229","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1007\/s13311-022-01310-y","article-title":"High-throughput screening assay identifies berberine and mubritinib as neuroprotection drugs for spinal cord injury via blood\u2013spinal cord barrier protection.","volume":"19","author":"Suzuki","year":"2022","journal-title":"Neurotherapeutics"},{"key":"B230","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1177\/1471301214548143","article-title":"Dementia: Stigma, language, and dementia-friendly.","volume":"13","author":"Swaffer","year":"2014","journal-title":"Dementia"},{"key":"B231","doi-asserted-by":"publisher","first-page":"628","DOI":"10.3390\/md17110628","article-title":"Effects of astaxanthin from shrimp shell on oxidative stress and behavior in animal model of Alzheimer\u2019s disease.","volume":"17","author":"Taksima","year":"2019","journal-title":"Mar. Drugs"},{"key":"B232","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/S1474-4422(21)00361-6","article-title":"Blood-based biomarkers for Alzheimer\u2019s disease: Towards clinical implementation.","volume":"21","author":"Teunissen","year":"2022","journal-title":"Lancet Neurol."},{"key":"B233","doi-asserted-by":"publisher","first-page":"102146","DOI":"10.1016\/j.arr.2023.102146","article-title":"Virtual reality and cognitive rehabilitation for older adults with mild cognitive impairment: A systematic review","volume":"93","author":"Tortora","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"B234","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1212\/WNL.0000000000002035","article-title":"A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease.","volume":"85","author":"Turner","year":"2015","journal-title":"Neurology"},{"key":"B235","unstructured":"Botanical Drug Development: Guidance for Industry.\n          \n          2020"},{"key":"B236","unstructured":"FDA Clears First Blood Test Used in Diagnosing Alzheimer\u2019s Disease.\n          \n          2025"},{"key":"B237","doi-asserted-by":"publisher","first-page":"100235","DOI":"10.1016\/j.crbiot.2024.100235","article-title":"A new frontier in neuropharmacology: Recent progress in natural products research for blood\u2013brain barrier crossing.","volume":"8","author":"Ure\u00f1a-Vacas","year":"2024","journal-title":"Curr. Res. Biotechnol."},{"key":"B238","doi-asserted-by":"publisher","first-page":"6244","DOI":"10.1038\/s41467-025-61355-3","article-title":"AI-guided patient stratification improves outcomes and efficiency in the AMARANTH Alzheimer\u2019s disease clinical trial.","volume":"16","author":"Vaghari","year":"2025","journal-title":"Nat. Commun."},{"key":"B239","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1001\/jamainternmed.2015.1668","article-title":"Mediterranean diet and age-related cognitive decline: A randomized clinical trial.","volume":"175","author":"Valls-Pedret","year":"2015","journal-title":"JAMA Internal Med."},{"key":"B240","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1186\/s12916-019-1466-7","article-title":"Calibration: The Achilles heel of predictive analytics.","volume":"17","author":"Van Calster","year":"2019","journal-title":"BMC Med."},{"key":"B241","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in early Alzheimer\u2019s disease.","volume":"388","author":"van Dyck","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"B242","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1038\/s41591-022-01772-9","article-title":"Reporting guideline for the early-stage clinical evaluation of decision support systems driven by artificial intelligence: DECIDE-AI.","volume":"28","author":"Vasey","year":"2022","journal-title":"Nat. Med."},{"key":"B243","doi-asserted-by":"publisher","first-page":"e87","DOI":"10.1016\/S2666-7568(20)30061-1","article-title":"Serum markers glial fibrillary acidic protein and neurofilament light for prognosis and monitoring in cognitively normal older people: A prospective memory clinic-based cohort study.","volume":"2","author":"Verberk","year":"2021","journal-title":"Lancet Healthy Longevity"},{"key":"B244","doi-asserted-by":"publisher","first-page":"i6","DOI":"10.1136\/bmj.i6","article-title":"Net benefit approaches to the evaluation of prediction models, molecular markers, and diagnostic tests.","volume":"352","author":"Vickers","year":"2016","journal-title":"BMJ"},{"key":"B245","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1007\/s11011-023-01160-3","article-title":"Network pharmacology and bioinformatics approach reveals the therapeutic mechanism of action of curcumin in Alzheimer disease.","volume":"38","author":"Vijh","year":"2023","journal-title":"Metabolic Brain Dis."},{"key":"B246","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid \u03b2 deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer\u2019s disease: A prospective cohort study.","volume":"12","author":"Villemagne","year":"2013","journal-title":"Lancet Neurol."},{"key":"B247","doi-asserted-by":"publisher","first-page":"1791195","DOI":"10.3389\/frdem.2026.1791195","article-title":"Artificial intelligence in dementia care: Challenges, controversies, and policy implications.","volume":"5","author":"Vilor-Tejedor","year":"2026","journal-title":"Front. Dement."},{"key":"B248","doi-asserted-by":"publisher","first-page":"l6927","DOI":"10.1136\/bmj.l6927","article-title":"Machine learning and artificial intelligence research for patient benefit: 20 critical questions on transparency, replicability, ethics, and effectiveness.","volume":"368","author":"Vollmer","year":"2020","journal-title":"BMJ"},{"key":"B249","doi-asserted-by":"publisher","first-page":"7707","DOI":"10.1038\/s41598-024-57824-2","article-title":"Neuroprotective mechanisms of luteolin in glutamate-induced oxidative stress and autophagy-mediated neuronal cell death.","volume":"14","author":"Vongthip","year":"2024","journal-title":"Scientific Rep."},{"key":"B250","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1093\/brain\/awv029","article-title":"Prevalence and prognosis of Alzheimer\u2019s disease at the mild cognitive impairment stage.","volume":"138","author":"Vos","year":"2015","journal-title":"Brain"},{"key":"B251","doi-asserted-by":"publisher","first-page":"150151","DOI":"10.1016\/j.ijbiomac.2026.150151","article-title":"Laminaria japonica fucoidan ameliorates D-galactose-induced cognitive impairment via the regulation of tryptophan metabolism along the gut\u2013brain axis.","volume":"340","author":"Wang","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"key":"B252","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1038\/nbt.3597","article-title":"Sharing and community curation of mass spectrometry data with global natural products social molecular networking.","volume":"34","author":"Wang","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"B253","doi-asserted-by":"publisher","first-page":"176750","DOI":"10.1016\/j.ejphar.2024.176750","article-title":"Pomegranate polyphenol punicalagin as a nutraceutical for mitigating mild cognitive impairment: An overview of beneficial properties.","volume":"977","author":"Wang","year":"","journal-title":"Eur. J. Pharmacol."},{"key":"B254","doi-asserted-by":"publisher","first-page":"410","DOI":"10.3390\/md21070410","article-title":"A comparative study about the neuroprotective effects of DHA-enriched phosphatidylserine and EPA-enriched phosphatidylserine against oxidative damage in primary hippocampal neurons.","volume":"21","author":"Wang","year":"2023","journal-title":"Mar. Drugs"},{"key":"B255","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/s12967-024-05025-w","article-title":"Predicting long-term progression of Alzheimer\u2019s disease using a multimodal deep learning model incorporating interaction effects.","volume":"22","author":"Wang","year":"","journal-title":"J. Transl. Med."},{"key":"B256","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/j.ajcnut.2023.04.001","article-title":"The relationship of omega-3 fatty acids with dementia and cognitive decline: Evidence from prospective cohort studies of supplementation, dietary intake, and blood markers.","volume":"117","author":"Wei","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"key":"B257","doi-asserted-by":"publisher","first-page":"902092","DOI":"10.3389\/fnagi.2022.902092","article-title":"Network pharmacology identifies intersection genes of quercetin and Alzheimer\u2019s disease as potential therapeutic targets.","volume":"14","author":"Wei","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"B258","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1097\/MOL.0000000000000862","article-title":"Omega-3 fatty acids and cognitive function.","volume":"34","author":"Welty","year":"2023","journal-title":"Curr. Opin. Lipidol."},{"key":"B259","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s43440-019-00050-9","article-title":"Hexahydrocurcumin alleviated blood\u2013brain barrier dysfunction in cerebral ischemia\/reperfusion rats.","volume":"72","author":"Wicha","year":"2020","journal-title":"Pharmacol. Rep."},{"key":"B260","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.3390\/ijms21082749","article-title":"Neuroprotective properties of resveratrol and its derivatives: Influence on potential mechanisms leading to the development of Alzheimer\u2019s disease.","volume":"21","author":"Wici\u00f1ski","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B261","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1001\/jama.2018.21442","article-title":"Effect of intensive vs standard blood pressure control on probable dementia: A randomized clinical trial.","volume":"321","author":"Williamson","year":"2019","journal-title":"JAMA"},{"key":"B262","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1016\/j.jalz.2018.01.007","article-title":"Coronary heart disease, heart failure, and the risk of dementia: A systematic review and meta-analysis","volume":"14","author":"Wolters","year":"2018","journal-title":"Alzheimers Dement."},{"key":"B263","volume-title":"Risk Reduction of Cognitive Decline and Dementia: WHO Guidelines.","year":"2019"},{"key":"B264","volume-title":"Ethics and Governance of Artificial Intelligence for Health.","year":"2021"},{"key":"B265","volume-title":"Ageism in Artificial Intelligence for Health.","year":"2022"},{"key":"B266","volume-title":"Ethics and Governance of AI for Health: Guidance on Large Multi-Modal Models.","year":"2024"},{"key":"B267","volume-title":"Dementia.","year":"2025"},{"key":"B268","doi-asserted-by":"publisher","first-page":"e37908","DOI":"10.1016\/j.heliyon.2024.e37908","article-title":"Exploring resveratrol against Alzheimer\u2019s disease and Parkinson\u2019s disease through integrating network pharmacology, bioinformatics, and experimental validation strategy in vitro.","volume":"10","author":"Wu","year":"2024","journal-title":"Heliyon"},{"key":"B269","doi-asserted-by":"publisher","first-page":"6688708","DOI":"10.1155\/2021\/6688708","article-title":"Fucoxanthin prevents 6-OHDA-induced neurotoxicity by targeting Keap1.","volume":"2021","author":"Wu","year":"2021","journal-title":"Oxidative Med. Cell. Longevity"},{"key":"B270","doi-asserted-by":"publisher","first-page":"m1328","DOI":"10.1136\/bmj.m1328","article-title":"Prediction models for diagnosis and prognosis of COVID-19: Systematic review and critical appraisal.","volume":"369","author":"Wynants","year":"2020","journal-title":"BMJ"},{"key":"B271","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s11064-020-03173-1","article-title":"Curcumin ameliorates copper-induced neurotoxicity through inhibiting oxidative stress and mitochondrial apoptosis in SH-SY5Y cells.","volume":"46","author":"Xiang","year":"2021","journal-title":"Neurochem. Res."},{"key":"B272","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1002\/ptr.6849","article-title":"Lychee seed polyphenol protects the blood\u2013brain barrier through inhibiting A\u03b225\u201335-induced NLRP3 inflammasome activation via the AMPK\/mTOR\/ULK1-mediated autophagy in bEnd.3 cells and APP\/PS1 mice.","volume":"35","author":"Xiong","year":"2021","journal-title":"Phytotherapy Res."},{"key":"B273","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1101\/gr.272484.120","article-title":"Multimodal single-cell\/nucleus RNA sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in Alzheimer\u2019s disease.","volume":"31","author":"Xu","year":"2021","journal-title":"Genome Res."},{"key":"B274","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.3390\/nu16101512","article-title":"Fucoidan improves D-galactose-induced cognitive dysfunction by promoting mitochondrial biogenesis and maintaining gut microbiome homeostasis.","volume":"16","author":"Xu","year":"2024","journal-title":"Nutrients"},{"key":"B275","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.1038\/s41591-024-03118-z","article-title":"AI-based differential diagnosis of dementia etiologies on multimodal data.","volume":"30","author":"Xue","year":"2024","journal-title":"Nat. Med."},{"key":"B276","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.brainres.2009.05.009","article-title":"Curcumin upregulates transcription factor Nrf2. HO-1 expression and protects rat brains against focal ischemia.","volume":"1282","author":"Yang","year":"2009","journal-title":"Brain Res."},{"key":"B277","doi-asserted-by":"publisher","first-page":"e74916","DOI":"10.1371\/journal.pone.0074916","article-title":"Huperzine A for Alzheimer\u2019s disease: A systematic review and meta-analysis of randomized clinical trials.","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS One"},{"key":"B278","doi-asserted-by":"publisher","first-page":"126315","DOI":"10.1016\/j.ijbiomac.2023.126315","article-title":"Neuroprotective effects of Lycium barbarum polysaccharide on light-induced oxidative stress and mitochondrial damage via the Nrf2\/HO-1 pathway in mouse hippocampal neurons.","volume":"251","author":"Yang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"B279","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3389\/fphar.2018.00386","article-title":"Anti-inflammatory effects of curcumin in microglial cells.","volume":"9","author":"Yu","year":"","journal-title":"Front. Pharmacol."},{"key":"B280","doi-asserted-by":"publisher","first-page":"8180","DOI":"10.1038\/s41467-023-43929-1","article-title":"High-throughput target trial emulation for Alzheimer\u2019s disease drug repurposing with real-world data.","volume":"14","author":"Zang","year":"2023","journal-title":"Nat. Commun."},{"key":"B281","doi-asserted-by":"publisher","first-page":"100050","DOI":"10.1016\/j.pscia.2024.100050","article-title":"Natural product databases for drug discovery: Features and applications.","volume":"2","author":"Zeng","year":"2024","journal-title":"Pharm. Sci. Adv."},{"key":"B282","doi-asserted-by":"publisher","first-page":"D1217","DOI":"10.1093\/nar\/gkx1026","article-title":"NPASS: Natural product activity and species source database for natural product research, discovery and tool development.","volume":"46","author":"Zeng","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"B283","doi-asserted-by":"publisher","first-page":"152290","DOI":"10.1016\/j.acthis.2025.152290","article-title":"Neuroprotective effect of urolithin A via downregulating VDAC1-mediated autophagy in Alzheimer\u2019s disease.","volume":"127","author":"Zhang","year":"","journal-title":"Acta Histochem."},{"key":"B284","doi-asserted-by":"publisher","first-page":"bbaf533","DOI":"10.1093\/bib\/bbaf533","article-title":"Computational toxicology in drug discovery: Applications of artificial intelligence in ADMET and toxicity prediction.","volume":"26","author":"Zhang","year":"","journal-title":"Briefings Bioinformatics"},{"key":"B285","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41591-024-03434-4","article-title":"Artificial intelligence in drug development.","volume":"31","author":"Zhang","year":"","journal-title":"Nat. Med."},{"key":"B286","doi-asserted-by":"publisher","first-page":"101696","DOI":"10.1016\/j.fbio.2022.101696","article-title":"Peptide WCPFSRSF ameliorates excitotoxicity and elevates synaptic plasticity in glutamate-damaged SH-SY5Y cells by modulating the PI3K\/mTOR\/EIF4E and BDNF\/CREB\/TrkB pathways.","volume":"47","author":"Zhang","year":"2022","journal-title":"Food Biosci."},{"key":"B287","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1111\/imj.70288","article-title":"Alcohol consumption and risk of dementia: A systematic review and meta-analysis","volume":"56","author":"Zhang","year":"2026","journal-title":"Intern. Med. J."},{"key":"B288","doi-asserted-by":"publisher","first-page":"8791832","DOI":"10.1155\/2017\/8791832","article-title":"Resveratrol attenuates microglial activation via SIRT1-SOCS1 pathway.","volume":"2017","author":"Zhang","year":"2017","journal-title":"Evid. Based Complementary Alternative Med."},{"key":"B289","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.ijbiomac.2022.11.160","article-title":"Neuroprotective effects of polysaccharide from Sparassis crispa on Alzheimer\u2019s disease-like mice: Involvement of microbiota\u2013gut\u2013brain axis.","volume":"225","author":"Zhang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"B290","doi-asserted-by":"publisher","first-page":"D1473","DOI":"10.1093\/nar\/gkac1041","article-title":"NPASS database update 2023: Quantitative natural product activity, species source and target data for natural product research and drug discovery.","volume":"51","author":"Zhao","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"B291","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12906-025-04771-8","article-title":"Network pharmacology mechanism of Rosmarinus officinalis L. (rosemary) to improve cell viability and reduces apoptosis in treating Alzheimer\u2019s disease.","volume":"25","author":"Zhao","year":"2025","journal-title":"BMC Complementary Med. Therapies"},{"key":"B292","doi-asserted-by":"publisher","first-page":"153799","DOI":"10.1016\/j.tox.2024.153799","article-title":"The effects of micro- and nanoplastics on the central nervous system: A new threat to humanity?","volume":"504","author":"Zheng","year":"2024","journal-title":"Toxicology"},{"key":"B293","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1007\/s11064-020-03078-z","article-title":"Docosahexaenoic acid protects traumatic brain injury by regulating NOX2 generation via Nrf2 signaling pathway.","volume":"45","author":"Zhu","year":"2020","journal-title":"Neurochem. Res."}],"container-title":["Frontiers in Aging Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2026.1924338\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:33:49Z","timestamp":1785911629000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2026.1924338\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":293,"alternative-id":["10.3389\/fnagi.2026.1924338"],"URL":"https:\/\/doi.org\/10.3389\/fnagi.2026.1924338","relation":{},"ISSN":["1663-4365"],"issn-type":[{"value":"1663-4365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]},"article-number":"1924338"}}