{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:18:06Z","timestamp":1788265086908,"version":"build-2803163510"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Age-related hearing loss (ARHL) is the most common sensory disorder in older adults. Current hearing interventions, including hearing aids and cochlear implants, face limitations in accessibility and adherence. Therefore, efforts have been devoted to elucidating the molecular mechanisms underlying cochlear aging and identifying effective therapeutic targets for ARHL. This review summarizes several molecular mechanisms implicated in cochlear aging and ARHL, including autophagy dysregulation, oxidative stress, stereocilia degeneration, and dysregulation of mitochondrial dynamics. We further discuss recent advances in potential therapeutic targets and intervention strategies associated with these pathways, and provide theoretical support for targeted interventions for ARHL.<\/jats:p>","DOI":"10.3389\/fnagi.2026.1924937","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:44:37Z","timestamp":1788263077000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in the treatment of age-related hearing loss: from molecular mechanisms to targeted interventions"],"prefix":"10.3389","volume":"18","author":[{"given":"Le","family":"Mao","sequence":"first","affiliation":[{"name":"The First Clinical Medical College, Lanzhou University, Lanzhou","place":["Gansu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Second Hospital of Lanzhou University, Lanzhou","place":["Gansu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhu","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Lanzhou University, Lanzhou","place":["Gansu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Feng","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Lanzhou University, Lanzhou","place":["Gansu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Lanzhou University, Lanzhou","place":["Gansu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangli","family":"Yang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Lanzhou University, Lanzhou","place":["Gansu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoli","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery & Audiology and Neurotology, Karolinska University Hospital","place":["Stockholm, Sweden"]},{"name":"ENT Division, Department of Clinical Science, Intervention and Technology, Karolinska Institute","place":["Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The First Hospital of Lanzhou University, Lanzhou","place":["Gansu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e99","DOI":"10.1128\/MCB.00099-20","article-title":"The molecular mechanisms regulating the KEAP1-NRF2 pathway.","volume":"40","author":"Baird","year":"2020","journal-title":"Mol. 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