{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:08:52Z","timestamp":1789711732042,"version":"4.0.1"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      People with Parkinson\u2019s disease (PwPD) may experience speech changes early in the disease process, yet it is unclear how they perceive them. Moreover, in\n                      <jats:italic>de novo<\/jats:italic>\n                      PD specifically, the relationship between speech, cognition, and swallowing is not well-established. Therefore, this study aimed to determine the association between self-perceived speech impairment, clinician-perceived speech impairment, cognitive impairment, and swallowing impairment in\n                      <jats:italic>de novo<\/jats:italic>\n                      PD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data were obtained from the Parkinson\u2019s Progressive Markers Initiative. We included baseline visit data from 1072\n                      <jats:italic>de novo<\/jats:italic>\n                      PwPD. An ordinal logistic regression was performed to determine what clinical measures were associated with self-perceived speech impairment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The ordinal logistic regression found that self-perceived speech impairments were significantly associated with clinician-perceived speech impairment (Wald \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      [3] = 44.039,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001), self-reported swallowing impairment (Wald \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      [3] = 61.863,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001), cognitive impairment (Wald \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      [4] = 32.293,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001), and being male (Wald \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      [1] = 11.520,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This preliminary work showed potential relationships between self-perceived and clinician-perceived speech impairment, swallowing impairment, and cognitive impairment, demonstrating the multidimensional nature of self-perceived speech impairment. More research using more extensive assessment methods is needed to further elucidate these relationships in\n                      <jats:italic>de novo<\/jats:italic>\n                      PD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1932141","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:36:53Z","timestamp":1789709813000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors associated with self- perceived speech impairment in de novo Parkinson\u2019s disease: a retrospective study of an international database"],"prefix":"10.3389","volume":"18","author":[{"given":"Zo\u00eb","family":"Thijs","sequence":"first","affiliation":[{"name":"Department of Communication Disorders and Occupational Therapy, University of Arkansas","place":["Fayetteville, AR, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Bain","sequence":"additional","affiliation":[{"name":"Department of Communication Sciences and Disorders, Molloy University","place":["Rockville Centre, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Dumican","sequence":"additional","affiliation":[{"name":"Department of Speech, Language, and Hearing Sciences, Western Michigan University","place":["Kalamazoo, MI, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41572-021-00280-3","article-title":"Parkinson disease-associated cognitive impairment.","volume":"7","author":"Aarsland","year":"2021","journal-title":"Nat. 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