{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:57:18Z","timestamp":1790575038663,"version":"4.1.0"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Dual-task training is proposed as a rehabilitative strategy to mitigate motor and cognitive impairments in patients with Parkinson\u2019s disease (PD). This systematic review and meta-analysis sought to consolidate existing information regarding the impact of dual-task therapies on health-related quality of life (HRQoL) and cognitive performance in middle-aged and older persons diagnosed with PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review of randomized controlled trials (RCTs) published to May 2026 was performed utilizing PubMed, EBSCOhost, Scopus, and Web of Science. The chosen studies adhered to the PICOS framework. The Methodological quality and certainty of evidence were assessed using the Cochrane Risk of Bias 2 tool and GRADE framework, respectively. The review protocol is recorded in PROSPERO under the number CRD420251159680.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 3,037 identified records, 10 RCTs met the eligibility criteria and were included in the systematic review, of which 9 contributed data to the meta-analysis. The meta-analysis showed a statistically significant but modest effect on HRQoL measured with the Parkinson\u2019s Disease Questionnaire-39 (SMD = 0.35; 95% CI: 0.03\u20130.67;\n                      <jats:italic>p =<\/jats:italic>\n                      0.03). No significant between-group effects were observed for TMT-A (MD = 0.99; 95% CI: -3.38 to 5.37;\n                      <jats:italic>p =<\/jats:italic>\n                      0.66), TMT-B (SMD = 0.02; 95% CI: -0.24 to 0.29;\n                      <jats:italic>p =<\/jats:italic>\n                      0.86), or MoCA (SMD = 0.19; 95% CI: -0.26 to 0.64;\n                      <jats:italic>p =<\/jats:italic>\n                      0.41).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dual-task interventions may produce a modest improvement in HRQoL in people with Parkinson\u2019s disease, whereas the current evidence does not demonstrate significant benefits for the cognitive outcomes assessed. These findings should be interpreted cautiously given the limited number of studies, methodological limitations, and clinical heterogeneity across interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD420251159680<\/jats:ext-link>\n                      , identifier CRD420251159680.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1939266","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:44:57Z","timestamp":1790574297000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of dual-task training on health-related quality of life and cognitive function in people with Parkinson\u2019s disease: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"18","author":[{"given":"Leandro","family":"Cerda-P\u00e9rez","sequence":"first","affiliation":[{"name":"School of Occupational Therapy, Faculty of Psychology, Universidad de Talca","place":["Talca, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Guti\u00e9rrez-Rojas","sequence":"additional","affiliation":[{"name":"School of Occupational Therapy, Faculty of Psychology, Universidad de Talca","place":["Talca, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Retamal-Salazar","sequence":"additional","affiliation":[{"name":"School of Occupational Therapy, Faculty of Psychology, Universidad de Talca","place":["Talca, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Rodr\u00edguez-Fa\u00fandez","sequence":"additional","affiliation":[{"name":"School of Occupational Therapy, Faculty of Psychology, Universidad de Talca","place":["Talca, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javiera","family":"Venegas-Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"School of Occupational Therapy, Faculty of Psychology, Universidad de Talca","place":["Talca, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Hernandez-Martinez","sequence":"additional","affiliation":[{"name":"Department of Physical Activity Sciences, Universidad de Los Lagos","place":["Osorno, Chile"]},{"name":"Department of Education, Faculty of Humanities, Universidad de La Serena","place":["La Serena, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Sandoval-V\u00e1squez","sequence":"additional","affiliation":[{"name":"Carrera de Terapia Ocupacional, Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile","place":["Temuco, Chile"]},{"name":"Departamento de Medicina Interna, Facultad de Medicina, Universidad de La Frontera","place":["Temuco, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Vald\u00e9s-Badilla","sequence":"additional","affiliation":[{"name":"Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Cat\u00f3lica del Maule","place":["Talca, Chile"]},{"name":"Sports Coach Career, School of Education, Universidad Vi\u00f1a del Mar","place":["Vi\u00f1a del Mar, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"V\u00e1squez-Carrasco","sequence":"additional","affiliation":[{"name":"School of Occupational Therapy, Faculty of Psychology, Universidad de Talca","place":["Talca, Chile"]},{"name":"Centro de Investigaci\u00f3n en Ciencias Cognitivas, Faculty of Psychology, Universidad de Talca","place":["Talca, Chile"]},{"name":"VITALIS Longevity Center, Universidad de Talca","place":["Talca, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"992873","DOI":"10.3389\/fnagi.2022.992873","article-title":"A novel dual-task paradigm with story recall shows significant differences in gait kinematics in older adults with cognitive impairment: A cross-sectional study.","volume":"14","author":"Ali","year":"2022","journal-title":"Front. 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