{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:02:26Z","timestamp":1791201746720,"version":"4.2.0"},"reference-count":258,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is an age-related progressive neurodegenerative disorder that represents the leading cause of dementia worldwide, affecting over 50 million people. This global burden is expected to rise dramatically over the coming decades because of global population aging, representing a public health concern. Despite significant advances in understanding AD pathophysiology, early diagnosis remains challenging, emphasizing the urgent need for novel, reliable diagnostic and predictive biomarkers capable of identifying individuals at risk of progression during the preclinical stages of the disease. Growing evidence indicates that epigenetics constitutes a dynamic interface through which aging and environmental exposures influence gene expression and cellular homeostasis, thereby contributing to AD susceptibility and progression. The present review summarizes current knowledge on the epigenetic landscape of AD, from canonical epigenetic mechanisms, including aberrant DNA methylation, histone modifications, and non-coding RNAs (ncRNAs), to the emerging role of mitoepigenetics and RNA methylation in disease-associated molecular mechanisms. Finally, we discuss the potential of epigenetic alterations as promising innovative biomarkers of AD, providing insights into novel avenues for diagnostic and therapeutic intervention.<\/jats:p>","DOI":"10.3389\/fnagi.2026.1959361","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:34:25Z","timestamp":1791200065000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Epigenetics in Alzheimer\u2019s disease: from molecular mechanisms to emerging novel biomarkers"],"prefix":"10.3389","volume":"18","author":[{"given":"Elisabetta","family":"D\u2019Aversa","sequence":"first","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara","place":["Ferrara, Italy"]},{"name":"Center for Hemostasis and Thrombosis, University of Ferrara","place":["Ferrara, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriana","family":"Grisafi","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara","place":["Ferrara, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Pernagallo","sequence":"additional","affiliation":[{"name":"Department of Environmental Sciences and Prevention, University of Ferrara","place":["Ferrara, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Salvatori","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara","place":["Ferrara, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay V.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR)","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Nucciarone","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara","place":["Ferrara, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Tisato","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara","place":["Ferrara, Italy"]},{"name":"Center for Hemostasis and Thrombosis, University of Ferrara","place":["Ferrara, Italy"]},{"name":"University Strategic Centre for Studies on Gender Medicine, University of Ferrara","place":["Ferrara, Italy"]},{"name":"LTTA Center, University of Ferrara","place":["Ferrara, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Gemmati","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara","place":["Ferrara, Italy"]},{"name":"Center for Hemostasis and Thrombosis, University of Ferrara","place":["Ferrara, Italy"]},{"name":"University Strategic Centre for Studies on Gender Medicine, University of Ferrara","place":["Ferrara, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"14645","DOI":"10.1523\/JNEUROSCI.1327-13.2013","article-title":"MiR-26b, upregulated in Alzheimer\u2019s disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons.","volume":"33","author":"Absalon","year":"2013","journal-title":"J. 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