{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:01:22Z","timestamp":1790168482350,"version":"4.1.0"},"reference-count":91,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"<jats:p>\n                    Alzheimer\u2019s disease (AD) is characterized by amyloid-\n                    <jats:italic>\u03b2<\/jats:italic>\n                    (A\u03b2) deposition, tau pathology, synaptic injury, neuroinflammation, oxidative stress, and disrupted organellar homeostasis. Peroxisomes maintain lipid and redox balance through very-long-chain fatty acid (VLCFA)\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -oxidation, plasmalogen biosynthesis, and reactive oxygen species (ROS) metabolism. This Review evaluates how peroxisomal alterations may modulate APP processing and A\u03b2 clearance, tau kinase\/phosphatase balance, neuroinflammation, oxidative stress, and peroxisome-mitochondria crosstalk. We distinguish human correlational evidence from intervention studies in AD models and mechanistic extrapolation from primary peroxisomal disorders. Current evidence supports a context-dependent vulnerability or amplifier model rather than a universal causal pathway. Peroxisome-targeted interventions remain investigational, and no validated biomarker currently identifies an AD subgroup for such treatment.\n                  <\/jats:p>","DOI":"10.3389\/fnagi.2026.1960320","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:07:51Z","timestamp":1790165271000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Peroxisomes in Alzheimer\u2019s disease: emerging mechanistic insights and therapeutic opportunities"],"prefix":"10.3389","volume":"18","author":[{"given":"Tao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medical Sciences, Hunan Normal University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Hunan Normal University, Health Science Center","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Basic Medical Sciences, Hunan Normal University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Basic Medical Sciences, Hunan Normal University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Basic Medical Sciences, Hunan Normal University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujun","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medical Sciences, Hunan Normal University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Han","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of New Pharmaceutical Preparation, Changsha Medical University","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of New Pharmaceutical Preparation, Changsha Medical University","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Basic Medical Sciences, Hunan Normal University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Affiliated Hengyang Hospital of Hunan Normal University and Hengyang Central Hospital","place":["Hengyang, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiqing","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medical Sciences, Hunan Normal University","place":["Changsha, China"]},{"name":"Department of Physiology, School of Basic Medical Sciences, Hunan Normal University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.3390\/nu18091392","article-title":"Long-chain fatty acids at the intersection of mitochondrial dysfunction, lipid peroxidation, ferroptosis and neuroinflammation in neurodegenerative disease","volume":"18","author":"Alam","year":"2026","journal-title":"Nutrients"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1089\/ars.2009.2996","article-title":"Peroxisomes are oxidative organelles","volume":"13","author":"Antonenkov","year":"2009","journal-title":"Antioxid. 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