{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:50:32Z","timestamp":1791355832301,"version":"4.3.1"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging Neurosci."],"abstract":"\n Purpose<\/jats:title>\n To characterize voxelwise degree centrality (DC) alterations and their exploratory clinical associations in severe unilateral M1-segment middle cerebral artery stenosis with ipsilateral watershed infarction.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This cross-sectional study included 40 patients with left-sided disease, 47 with right-sided disease, and 44 healthy controls. Resting-state functional magnetic resonance imaging-derived weighted DC (\n r<\/jats:italic>\n \u202f&gt;\u202f0.25) was compared using analysis of covariance with adjustment for educational attainment, Tukey\u2013Kramer testing, and Gaussian random field-corrected patient\u2013control contrasts (two-tailed voxel\n P<\/jats:italic>\n \u202f&lt;\u202f0.001; cluster\n P<\/jats:italic>\n \u202f&lt;\u202f0.05). Exploratory clinical associations were assessed using Spearman rank correlation.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mini-Mental State Examination (MMSE) scores differed among groups (\n P<\/jats:italic>\n \u202f&lt;\u202f0.001), with both patient groups scoring lower than controls; Montreal Cognitive Assessment (MoCA) scores also differed (\n P<\/jats:italic>\n \u202f&lt;\u202f0.001), with the left-sided group lowest, the right-sided group intermediate, and controls highest. The left-sided group showed lower DC predominantly in left temporal\u2013opercular and postcentral\u2013inferior parietal regions and higher DC in right medial\/subcortical and posterior-midline regions; the largest lower-DC cluster peaked at MNI coordinates \u221248, \u221218, 39 (\n Z<\/jats:italic>\n = \u22125.5420). The right-sided group showed lower DC in right putaminal\/insular, temporal, and parietal\u2013sensorimotor regions and higher DC in the left cerebellum; the largest lower-DC cluster peaked at MNI coordinates 48, \u221227, 36 (\n Z<\/jats:italic>\n = \u22126.0021). In the right-sided group, exploratory nominal associations were observed between MMSE scores and DC in the left cerebellar, right superior temporal-pole, and right parietal\u2013sensorimotor clusters (\n r<\/jats:italic>\n = \u22120.300 to 0.421; nominal\n P<\/jats:italic>\n \u202f=\u202f0.003\u20130.040). No nominal cognitive\u2013DC correlations were observed in the left-sided group, and no MoCA\u2013DC correlations in the right-sided group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Distributed DC alterations accompanied cognitive performance differences, with selective exploratory nominal MMSE associations in right-sided disease. DC may merit further evaluation as a candidate imaging feature of BOLD-based functional alterations associated with cognitive differences.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fnagi.2026.1969092","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:59:44Z","timestamp":1791352784000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Voxelwise degree centrality alterations and cognitive performance in severe unilateral M1-segment middle cerebral artery stenosis with ipsilateral watershed infarction"],"prefix":"10.3389","volume":"18","author":[{"given":"Zhilin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yude","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqian","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanmei","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanglei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunlong","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, The Second Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The People's Hospital of Chongzuo","place":["Chongzuo, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"119654","DOI":"10.1016\/j.neuroimage.2022.119654","article-title":"Reliability and sensitivity to altered hemodynamics measured with resting-state fMRI metrics: comparison with (123)i-imp SPECT","volume":"263","author":"Amemiya","year":"2022","journal-title":"NeuroImage"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1161\/strokeaha.122.041880","article-title":"Cerebrovascular reactivity has negligible contribution to hemodynamic lag after stroke: implications for functional magnetic resonance imaging studies","volume":"54","author":"Braban","year":"2023","journal-title":"Stroke"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fnsys.2010.00013","article-title":"DPARSF: a MATLAB toolbox for \"pipeline\" data analysis of resting-state fMRI","volume":"4","author":"Chao-Gan","year":"2010","journal-title":"Front. 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