{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:36:45Z","timestamp":1788349005450,"version":"build-2803163510"},"reference-count":61,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neuroanat."],"DOI":"10.3389\/fnana.2017.00065","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T03:48:36Z","timestamp":1501645716000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Pseudotyped Lentiviral Vectors for Retrograde Gene Delivery into Target Brain Regions"],"prefix":"10.3389","volume":"11","author":[{"given":"Kenta","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soshi","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Takada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,8,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e76310","DOI":"10.1371\/journal.pone.0076310","article-title":"Analysis of transduction efficiency, tropism and axonal transport of AAV serotypes 1, 2, 5, 6, 8 and 9 in the mouse brain","volume":"8","author":"Aschauer","year":"2013","journal-title":"PLoS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/nature02544","article-title":"VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model","volume":"429","author":"Azzouz","year":"2004","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/jnr.20696","article-title":"1-Methyl-4-phenylpyridinium neurotoxicity is attenuated by adenoviral gene transfer ofhuman Cu\/Zn superoxide dismutase","volume":"83","author":"Barkats","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1006\/exnr.1998.6878","article-title":"Neuroprotection of spinal motoneurons following targeted transduction with an adenoviral vector carrying the gene for glial cell line-derived neurotrophic factor","volume":"153","author":"Baumgartner","year":"1998","journal-title":"Exp. Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1038\/sj.mt.6300159","article-title":"Comparison of HIV-derived lentiviral and MLV-based gammaretroviral vector integration sites in primate repopulating cells","volume":"15","author":"Beard","year":"2007","journal-title":"Mol. Ther."},{"key":"B6","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.cell.2015.07.015","article-title":"Circuit architecture of VTA dopamine neurons revealed by systematic input-output mapping","volume":"162","author":"Beier","year":"2015","journal-title":"Cell"},{"key":"B7","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/cne.22003","article-title":"Inputs to serotonergic neurons revealed by conditional viral transneuronal tracing","volume":"514","author":"Braz","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2134","DOI":"10.3390\/v2092134","article-title":"An update on canine adenovirus type 2 and its vectors","volume":"2","author":"Bru","year":"2010","journal-title":"Viruses"},{"key":"B9","doi-asserted-by":"publisher","first-page":"3739","DOI":"10.1128\/jvi.76.8.3739-3747.2002","article-title":"Human immunodeficiency virus cDNA metabolism: notable stability of two-long terminal repeat circles","volume":"76","author":"Butler","year":"2002","journal-title":"J. Virol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.conb.2009.03.007","article-title":"Transneuronal circuit tracing with neurotropic viruses","volume":"18","author":"Callaway","year":"2008","journal-title":"Curr. Opin. Neurobiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"8979","DOI":"10.1523\/JNEUROSCI.0409-15.2015","article-title":"Monosynaptic circuit tracing with glycoprotein-deleted rabies viruses","volume":"35","author":"Callaway","year":"2015","journal-title":"J. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"387","DOI":"10.2174\/1566523054546224","article-title":"Altering the tropism of lentiviral vectors through pseudotyping","volume":"5","author":"Cronin","year":"2005","journal-title":"Curr. Gene Ther."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1749-6632.2003.tb07458.x","article-title":"Description of Parkinson\u2019s disease as a clinical syndrome","volume":"991","author":"Fahn","year":"2003","journal-title":"Ann. N Y Acad. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1479-0556-7-1","article-title":"Comparative analysis of HIV-1-based lentiviral vectors bearing lyssavirus glycoproteins for neuronal gene transfer","volume":"7","author":"Federici","year":"2009","journal-title":"Genet. Vaccines Ther."},{"key":"B15","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/nmeth.2996","article-title":"Targeting cells with single vectors using multiple-feature Boolean logic","volume":"11","author":"Fenno","year":"2014","journal-title":"Nat. Methods"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1016\/j.neuron.2016.04.043","article-title":"Endocannabinoid modulation of orbitostriatal circuits gates habit formation","volume":"90","author":"Gremel","year":"2016","journal-title":"Neuron"},{"key":"B17","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1126\/science.1088547","article-title":"LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1","volume":"302","author":"Hacein-Bey-Abina","year":"2003","journal-title":"Science"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e39149","DOI":"10.1371\/journal.pone.0039149","article-title":"Immunotoxin-mediated tract targeting in the primate brain: selective elimination of the cortico-subthalamic \u201chyperdirect\u201d pathway","volume":"7","author":"Inoue","year":"2012","journal-title":"PLoS One"},{"key":"B19","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1523\/JNEUROSCI.2399-15.2016","article-title":"Causal link between the cortico-rubral pathway and functional recovery through forced impaired limb use in rats with stroke","volume":"36","author":"Ishida","year":"2016","journal-title":"J. Neurosci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1385\/1-59259-650-9:367","article-title":"Gene delivery by lentivirus vectors an overview","volume":"246","author":"Kafri","year":"2004","journal-title":"Methods Mol. Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1089\/hum.2007.082","article-title":"Efficient gene transfer via retrograde transport in rodent and primate brains using a human immunodeficiency virus type 1-based vector pseudotyped with rabies virus glycoprotein","volume":"18","author":"Kato","year":"2007","journal-title":"Hum. Gene Ther."},{"key":"B24","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1089\/hum.2009.179","article-title":"A lentiviral strategy for highly efficient retrograde gene transfer by pseudotyping with fusion envelope glycoprotein","volume":"22","author":"Kato","year":"","journal-title":"Hum. Gene Ther."},{"key":"B25","doi-asserted-by":"publisher","first-page":"17169","DOI":"10.1523\/JNEUROSCI.4005-11.2011","article-title":"Selective neural pathway targeting reveals key roles of thalamostriatal projection in the control of visual discrimination","volume":"31","author":"Kato","year":"","journal-title":"J. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1089\/hum.2011.111","article-title":"Neuron-specific gene transfer through retrograde transport of lentiviral vector pseudotyped with a novel type of fusion envelope glycoprotein","volume":"22","author":"Kato","year":"","journal-title":"Hum. Gene Ther."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1515\/revneuro-2012-0043","article-title":"Dissecting circuit mechanisms by genetic manipulation of specific neural pathways","volume":"24","author":"Kato","year":"2013","journal-title":"Rev. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jneumeth.2014.02.015","article-title":"Improved transduction efficiency of a lentiviral vector for neuron-specific retrograde gene transfer by optimizing the junction of fusion envelope glycoprotein","volume":"227","author":"Kato","year":"2014","journal-title":"J. Neurosci. Methods"},{"key":"B27","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/mt.2011.213","article-title":"AAV transduction of dopamine neurons with constitutively active Rheb protects from neurodegeneration and mediates axon regrowth","volume":"20","author":"Kim","year":"2012","journal-title":"Mol. Ther."},{"key":"B29","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/978-1-4939-3271-9_12","article-title":"Altering entry site preference of lentiviral vectors into neuronal cells by pseudotyping with envelope glycoproteins","volume":"1382","author":"Kobayashi","year":"","journal-title":"Methods Mol. Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.neulet.2016.07.020","article-title":"Survival of corticostriatal neurons by Rho\/Rho-kinase signaling pathway","volume":"630","author":"Kobayashi","year":"","journal-title":"Neurosci. Lett."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-016-1674-7","article-title":"Genetic manipulation of specific neural circuits by use of a viral vector system","author":"Kobayashi","year":"2017","journal-title":"J. Neural Transm."},{"key":"B31","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1002\/(sici)1097-4547(19970815)49:4<485::aid-jnr9>3.3.co;2-n","article-title":"Factors that contribute to the transneuronal spread of herpes simplex virus","volume":"49","author":"LaVail","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1126\/science.1068893","article-title":"Murine leukemia induced by retroviral gene marking","volume":"296","author":"Li","year":"2002","journal-title":"Science"},{"key":"B33","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1089\/hum.2012.174","article-title":"Direct and retrograde transduction of nigral neurons with AAV6, 8, and 9 and intraneuronal persistence of viral particles","volume":"24","author":"L\u00f6w","year":"2013","journal-title":"Hum. Gene Ther."},{"key":"B34","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nm.1863","article-title":"Development of a novel mouse glioma model using lentiviral vectors","volume":"15","author":"Marumoto","year":"2009","journal-title":"Nat. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.neuroscience.2011.06.080","article-title":"Local and retrograde gene transfer into primate neuronal pathways via adeno-associated virus serotype 8 and 9","volume":"193","author":"Masamizu","year":"2011","journal-title":"Neuroscience"},{"key":"B36","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/nn.4463","article-title":"Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ","volume":"20","author":"Matsuda","year":"2017","journal-title":"Nat. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.jneumeth.2006.04.011","article-title":"Transduction of motor neurons and muscle fibers by intramuscular injection of HIV-1-based vectors pseudotyped with select rabies virus glycoproteins","volume":"157","author":"Mentis","year":"2006","journal-title":"J. Neurosci. Methods"},{"key":"B38","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/nature09714","article-title":"Cortical representations of olfactory input by trans-synaptic tracing","volume":"472","author":"Miyamichi","year":"2011","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/nm.2165","article-title":"Missing pieces in the Parkinson\u2019s disease puzzle","volume":"16","author":"Obeso","year":"2010","journal-title":"Nat. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"510","DOI":"10.15252\/emmm.201404610","article-title":"Combined Nurr1 and Foxa2 roles in the therapy of Parkinson\u2019s disease","volume":"7","author":"Oh","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"344","DOI":"10.3389\/neuro.01.032.2009","article-title":"Untangling neural networks with dual retrograde transsynaptic viral infection","volume":"3","author":"Ohara","year":"2009","journal-title":"Front. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3389\/fnana.2014.00086","article-title":"Long-term Cre-mediated retrograde tagging of neurons using a novel recombinant pseudorabies virus","volume":"8","author":"Oyibo","year":"2014","journal-title":"Front. Neuroanat."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1046\/j.1460-9568.2000.00098.x","article-title":"IAP family proteins delay motoneuron cell death in vivo","volume":"12","author":"Perrelet","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1128\/mmbr.69.3.462-500.2005","article-title":"Molecular biology of pseudorabies virus: impact on neurovirology and veterinary medicine","volume":"69","author":"Pomeranz","year":"2005","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B45","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.1038\/mt.2013.180","article-title":"Comparison of fetal mesencephalic grafts, AAV-delivered GDNF, and both combined in an MPTP-induced nonhuman primate Parkinson\u2019s model","volume":"21","author":"Redmond","year":"2013","journal-title":"Mol. Ther."},{"key":"B46","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.expneurol.2013.06.002","article-title":"AAV2-mediated striatum delivery of human CDNF prevents the deterioration of midbrain dopamine neurons in a 6-hydroxydopamine induced parkinsonian rat model","volume":"248","author":"Ren","year":"2013","journal-title":"Exp. Neurol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/gt.2012.27","article-title":"Axonal transport of adeno-associated viral vectors is serotype-dependent","volume":"20","author":"Salegio","year":"2013","journal-title":"Gene Ther."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1038\/gt.2013.48","article-title":"Adeno-associated virus type 6 is retrogradely transported in the non-human primate brain","volume":"20","author":"San Sebastian","year":"2013","journal-title":"Gene Ther."},{"key":"B49","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nature14600","article-title":"Viral-genetic tracing of the input-output organization of a central noradrenaline circuit","volume":"524","author":"Schwarz","year":"2015","journal-title":"Nature"},{"key":"B50","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.neuron.2013.11.006","article-title":"Long-range connectivity defines behavioral specificity of amygdala neurons","volume":"81","author":"Senn","year":"2014","journal-title":"Neuron"},{"key":"B51","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.neures.2017.02.007","article-title":"The use of an optimized chimeric envelope glycoprotein enhances the efficiency of retrograde gene transfer of a pseudotyped lentiviral vector in the primate brain","volume":"120","author":"Tanabe","year":"2017","journal-title":"Neurosci. Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.neuron.2016.09.021","article-title":"A designer AAV variant permits efficient retrograde access to projection neurons","volume":"92","author":"Tervo","year":"2016","journal-title":"Neuron"},{"key":"B53","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.ymthe.2005.07.358","article-title":"Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice","volume":"12","author":"Themis","year":"2005","journal-title":"Mol. Ther."},{"key":"B54","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/nrg1066","article-title":"Progress and problems with the use of viral vectors for gene therapy","volume":"4","author":"Thomas","year":"2003","journal-title":"Nat. Rev. Genet."},{"key":"B55","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1073\/pnas.1610787114","article-title":"Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys","volume":"114","author":"Tohyama","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B56","first-page":"493","article-title":"Use of rabies virus as a transneuronal tracer of neuronal connections: implications for the understanding of rabies pathogenesis","volume":"131","author":"Ugolini","year":"2008","journal-title":"Dev. Biol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1744806916681567","DOI":"10.1177\/1744806916681567","article-title":"Involvement of mesolimbic dopaminergic network in neuropathic pain relief by treadmill exercise: a study for specific neural control with Gi-DREADD in mice","volume":"12","author":"Wakaizumi","year":"2016","journal-title":"Mol. Pain"},{"key":"B58","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.neuron.2007.01.033","article-title":"Monosynaptic restriction of transsynaptic tracing from single, genetically targeted neurons","volume":"53","author":"Wickersham","year":"2007","journal-title":"Neuron"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/hum.2006.17.1","article-title":"Lentivirus-mediated gene transfer to the central nervous system: therapeutic and research applications","volume":"17","author":"Wong","year":"2006","journal-title":"Hum. Gene Ther."},{"key":"B60","doi-asserted-by":"publisher","first-page":"8048","DOI":"10.1073\/pnas.88.18.8048","article-title":"Direction of transneuronal transport of herpes simplex virus 1 in the primate motor system is strain-dependent","volume":"88","author":"Zemanick","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B61","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.molbrainres.2004.06.029","article-title":"Delayed gene therapy of glial cell line-derived neurotrophic factor is efficacious in a rat model of Parkinson\u2019s disease","volume":"134","author":"Zheng","year":"2005","journal-title":"Mol. Brain Res."}],"container-title":["Frontiers in Neuroanatomy"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnana.2017.00065\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T03:48:36Z","timestamp":1501645716000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnana.2017.00065\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,2]]},"references-count":61,"alternative-id":["10.3389\/fnana.2017.00065"],"URL":"https:\/\/doi.org\/10.3389\/fnana.2017.00065","relation":{},"ISSN":["1662-5129"],"issn-type":[{"value":"1662-5129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,2]]},"article-number":"65"}}