{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:56:02Z","timestamp":1790754962650,"version":"4.1.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T00:00:00Z","timestamp":1546819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008880","name":"Kanae Foundation for the Promotion of Medical Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003263","name":"Pioneer Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012378","name":"Kavli Institute for Brain and Mind, University of California, San Diego","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012378","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011671","name":"G. Harold and Leila Y. Mathers Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011671","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007457","name":"JPB Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000006","name":"Office of Naval Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neuroanat."],"DOI":"10.3389\/fnana.2018.00115","type":"journal-article","created":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T01:26:33Z","timestamp":1546824393000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":60,"title":["Centrifugal Inputs to the Main Olfactory Bulb Revealed Through Whole Brain Circuit-Mapping"],"prefix":"10.3389","volume":"12","author":[{"given":"Krishnan","family":"Padmanabhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumitaka","family":"Osakada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Tarabrina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Kizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Callaway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred H.","family":"Gage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrence J.","family":"Sejnowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,1,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/nmeth.2434","article-title":"Whole-brain functional imaging at cellular resolution using light-sheet microscopy","volume":"10","author":"Ahrens","year":"2013","journal-title":"Nat. Methods"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1016\/j.neuron.2014.07.035","article-title":"Sparseness and expansion in sensory representations","volume":"83","author":"Babadi","year":"2014","journal-title":"Neuron"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1038\/s41593-018-0241-y","article-title":"Integration of gene expression and brain-wide connectivity reveals the multiscale organization of mouse hippocampal networks","volume":"21","author":"Bienkowski","year":"2018","journal-title":"Nat. Neurosci"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.neuron.2012.10.020","article-title":"Cortical feedback control of olfactory bulb circuits","volume":"76","author":"Boyd","year":"2012","journal-title":"Neuron"},{"key":"B5","doi-asserted-by":"publisher","first-page":"8979","DOI":"10.1523\/JNEUROSCI.0409-15.2015","article-title":"Monosynaptic circuit tracing with glycoprotein-deleted rabies viruses","volume":"35","author":"Callaway","year":"2015","journal-title":"J. Neurosci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.neuron.2011.02.047","article-title":"Neural circuit mechanisms for pattern detection and feature combination in olfactory cortex","volume":"70","author":"Davison","year":"2011","journal-title":"Neuron"},{"key":"B7","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/cne.901810202","article-title":"The afferent connections of the main and the accessory olfactory bulb formations in the rat: an experimental HRP-study","volume":"181","author":"de Olmos","year":"1978","journal-title":"J. Comp. Neurol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.neuron.2009.11.031","article-title":"Are the dorsal and ventral hippocampus functionally distinct structures?","volume":"65","author":"Fanselow","year":"2010","journal-title":"Neuron"},{"key":"B9","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.neuron.2013.04.033","article-title":"Temporal processing in the olfactory system: can we see a smell?","volume":"78","author":"Gire","year":"2013","journal-title":"Neuron"},{"key":"B10","volume-title":"Digital Image Processing Using MATLAB","author":"Gonzalez","year":"2004"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1152\/jn.01075.2009","article-title":"Directional coupling from the olfactory bulb to the hippocampus during a go\/no-go odor discrimination task","volume":"103","author":"Gour\u00e9vitch","year":"2010","journal-title":"J. Neurophysiol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1002\/cne.901780408","article-title":"Association and commissural fiber systems of the olfactory cortex of the rat","volume":"178","author":"Haberly","year":"1978","journal-title":"J. Comp. Neurol"},{"key":"B13","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0361-9230(90)90044-Z","article-title":"Hippocampal pathway to the amygdala and stress ulcer development","volume":"25","author":"Henke","year":"1990","journal-title":"Brain Res. Bull"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jneumeth.2010.05.017","article-title":"A simple method of in vitro electroporation allows visualization, recording, and calcium imaging of local neuronal circuits","volume":"191","author":"Hovis","year":"2010","journal-title":"J. Neurosci. Methods"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1038\/14801","article-title":"Odor- and context-dependent modulation of mitral cell activity in behaving rats","volume":"2","author":"Kay","year":"1999","journal-title":"Nat. Neurosci"},{"key":"B16","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/nature06281","article-title":"Innate versus learned odour processing in the mouse olfactory bulb","volume":"450","author":"Kobayakawa","year":"2007","journal-title":"Nature"},{"key":"B17","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1038\/nn.4303","article-title":"Spatially segregated feedforward and feedback neurons support differential odor processing in the lateral entorhinal cortex","volume":"19","author":"Leitner","year":"2016","journal-title":"Nat. Neurosci"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1016\/j.celrep.2016.06.060","article-title":"Three-dimensional study of Alzheimer's disease hallmarks using the idisco clearing method","volume":"16","author":"Liebmann","year":"2016","journal-title":"Cell Rep"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.neuron.2012.10.028","article-title":"Functional properties of cortical feedback projections to the olfactory bulb","volume":"76","author":"Markopoulos","year":"2012","journal-title":"Neuron"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.1152\/jn.00524.2007","article-title":"An olfacto-hippocampal network is dynamically involved in odor-discrimination learning","volume":"98","author":"Martin","year":"2007","journal-title":"J. Neurophysiol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fnana.2012.00019","article-title":"Centrifugal telencephalic afferent connections to the main and accessory olfactory bulbs","volume":"6","author":"Mohedano-Moriano","year":"2012","journal-title":"Front. Neuroanat"},{"key":"B22","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/(SICI)1098-1063(1998)8:6<608::AID-HIPO3>3.0.CO;2-7","article-title":"Functional differentiation in the hippocampus","volume":"8","author":"Moser","year":"1998","journal-title":"Hippocampus"},{"key":"B23","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nature13186","article-title":"A mesoscale connectome of the mouse brain","volume":"508","author":"Oh","year":"2014","journal-title":"Nature"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1126\/science.aaf7003","article-title":"Ventral CA1 neurons store social memory","volume":"353","author":"Okuyama","year":"2016","journal-title":"Science."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1038\/nprot.2013.094","article-title":"Design and generation of recombinant rabies virus vectors","volume":"8","author":"Osakada","year":"2013","journal-title":"Nat. Protoc"},{"key":"B26","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.neuron.2011.07.005","article-title":"New rabies virus variants for monitoring and manipulating activity and gene expression in defined neural circuits","volume":"71","author":"Osakada","year":"2011","journal-title":"Neuron"},{"key":"B27","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.jneumeth.2010.08.031","article-title":"A novel algorithm for optimal image thresholding of biological data","volume":"193","author":"Padmanabhan","year":"2010","journal-title":"J. Neurosci. Methods"},{"key":"B28","doi-asserted-by":"publisher","first-page":"7535","DOI":"10.1523\/JNEUROSCI.3358-15.2016","article-title":"Diverse representations of olfactory information in centrifugal feedback projections","volume":"36","author":"Padmanabhan","year":"2016","journal-title":"J. Neurosci"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1038\/nn.2630","article-title":"Intrinsic biophysical diversity decorrelates neuronal firing while increasing information content","volume":"13","author":"Padmanabhan","year":"2010","journal-title":"Nat. Neurosci"},{"key":"B30","volume-title":"The Mouse Brain in Stereotaxic Coordinates, 2nd ed","author":"Paxinos","year":"2004"},{"key":"B31","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1038\/nn.2335","article-title":"Serotonergic modulation of odor input to the mammalian olfactory bulb","volume":"12","author":"Petzold","year":"2009","journal-title":"Nat. Neurosci"},{"key":"B32","first-page":"215","article-title":"An experimental study of the origin and the course of the centrifugal fibres to the olfactory bulb in the rat","volume":"107","author":"Price","year":"1970","journal-title":"J. Anat"},{"key":"B33","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.tins.2009.06.001","article-title":"From the top down: flexible reading of a fragmented odor map","volume":"32","author":"Restrepo","year":"2009","journal-title":"Trends Neurosci"},{"key":"B34","doi-asserted-by":"publisher","first-page":"4654","DOI":"10.1523\/JNEUROSCI.5026-13.2014","article-title":"Cholinergic inputs from Basal forebrain add an excitatory bias to odor coding in the olfactory bulb","volume":"34","author":"Rothermel","year":"2014","journal-title":"J. Neurosci"},{"key":"B35","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.conb.2013.12.010","article-title":"The perceptual logic of smell","volume":"25","author":"Secundo","year":"2014","journal-title":"Curr. Opin. Neurobiol"},{"key":"B36","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0361-9230(84)90148-5","article-title":"The connections of the mouse olfactory bulb: a study using orthograde and retrograde transport of wheat germ agglutinin conjugated to horseradish peroxidase","volume":"12","author":"Shipley","year":"1984","journal-title":"Brain Res. Bull"},{"key":"B37","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.neuron.2009.09.005","article-title":"Representations of odor in the piriform cortex","volume":"63","author":"Stettler","year":"2009","journal-title":"Neuron"},{"key":"B38","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1002\/cne.903020308","article-title":"Extrinsic projections from area CA1 of the rat hippocampus: olfactory, cortical, subcortical, and bilateral hippocampal formation projections","volume":"302","author":"Van Groen","year":"1990","journal-title":"J. Comp. Neurol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/nrn2614","article-title":"The anatomy of memory: an interactive overview of the parahippocampal-hippocampal network","volume":"10","author":"van Strien","year":"2009","journal-title":"Nat. Rev. Neurosci"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e82","DOI":"10.1371\/journal.pbio.0060082","article-title":"Rapid encoding and perception of novel odors in the rat","volume":"6","author":"Wesson","year":"2008","journal-title":"PLoS Biol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nmeth999","article-title":"Retrograde neuronal tracing with a deletion-mutant rabies virus","volume":"4","author":"Wickersham","year":"2007","journal-title":"Nat. Methods"},{"key":"B42","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/S0166-2236(03)00076-6","article-title":"The fundamental role of memory in olfactory perception","volume":"26","author":"Wilson","year":"2003","journal-title":"Trends Neurosci"},{"key":"B43","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.neuron.2008.03.012","article-title":"Precise circuitry links bilaterally symmetric olfactory maps","volume":"58","author":"Yan","year":"2008","journal-title":"Neuron"}],"container-title":["Frontiers in Neuroanatomy"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnana.2018.00115\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T01:28:21Z","timestamp":1546824501000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnana.2018.00115\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,7]]},"references-count":43,"alternative-id":["10.3389\/fnana.2018.00115"],"URL":"https:\/\/doi.org\/10.3389\/fnana.2018.00115","relation":{},"ISSN":["1662-5129"],"issn-type":[{"value":"1662-5129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,7]]},"article-number":"115"}}