{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T03:16:20Z","timestamp":1778555780280,"version":"3.51.4"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501025&81803233"],"award-info":[{"award-number":["81501025&81803233"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2016JJ3174&2018JJ3834"],"award-info":[{"award-number":["2016JJ3174&2018JJ3834"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neuroanat."],"DOI":"10.3389\/fnana.2019.00005","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T23:25:00Z","timestamp":1548890700000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Non-destructive 3D Microtomography of Cerebral Angioarchitecture Changes Following Ischemic Stroke in Rats Using Synchrotron Radiation"],"prefix":"10.3389","volume":"13","author":[{"given":"Yonghong","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianzhen","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shupeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuolu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,1,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s00401-009-0483-6","article-title":"Angiogenesis after cerebral ischemia","volume":"117","author":"Beck","year":"2009","journal-title":"Acta Neuropathol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1088\/0031-9155\/58\/1\/R1","article-title":"X-ray phase-contrast imaging: from pre-clinical applications towards clinics","volume":"58","author":"Bravin","year":"2013","journal-title":"Phys. Med. Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1089\/neu.2016.4697","article-title":"Three dimensional quantification of microarchitecture and vessel regeneration by synchrotron radiation microcomputed tomography in a rat model of spinal cord injury","volume":"34","author":"Cao","year":"2017","journal-title":"J. Neurotr."},{"key":"B4","doi-asserted-by":"publisher","first-page":"7688","DOI":"10.1002\/adma.201402956","article-title":"X-ray imaging for non-destructive microstructure analysis at SSRF","volume":"26","author":"Chen","year":"2014","journal-title":"Adv. Mater."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1364\/OL.36.001719","article-title":"Phase retrieval in quantitative x-ray microtomography with a single sample-to-detector distance","volume":"36","author":"Chen","year":"2011","journal-title":"Opt. Lett."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.2741\/e513","article-title":"Focal cerebral ischemia activates neurovascular restorative dynamics in mouse brain","volume":"4","author":"Chu","year":"2012","journal-title":"Front. Biosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.semcdb.2015.11.001","article-title":"Light-sheet imaging of mammalian development","volume":"55","author":"de Medeiros","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1016\/j.neuroimage.2006.12.040","article-title":"Three-dimensional cerebral vasculature of the CBA mouse brain: a magnetic resonance imaging and micro computed tomography study","volume":"35","author":"Dorr","year":"2007","journal-title":"Neuroimage"},{"key":"B9","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1161\/STROKEAHA.111.642710","article-title":"Angiogenesis: a harmonized target for recovery after stroke","volume":"43","author":"Ergul","year":"2012","journal-title":"Stroke"},{"key":"B10","doi-asserted-by":"publisher","first-page":"238","DOI":"10.2174\/157340310791658802","article-title":"Angiogenesis, neurogenesis and neuroplasticity in ischemic stroke","volume":"6","author":"Font","year":"2010","journal-title":"Curr. Cardiol. Rev."},{"key":"B11","doi-asserted-by":"crossref","DOI":"10.1007\/BFb0056195","volume-title":"Multiscale Vessel Enhancement Filtering.","author":"Frangi","year":"1998"},{"key":"B12","doi-asserted-by":"publisher","first-page":"8514","DOI":"10.1038\/srep08514","article-title":"Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord","volume":"5","author":"Fratini","year":"2015","journal-title":"Sci. Rep."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1007\/s00330-015-4173-6","article-title":"Assessment of fibrotic tissue and microvascular architecture by in-line phase-contrast imaging in a mouse model of liver fibrosis","volume":"26","author":"Fu","year":"2016","journal-title":"Eur. Radiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"102005","DOI":"10.1063\/1.3115402","article-title":"Refracting R\u00f6ntgen's rays: Propagation-based x-ray phase contrast for biomedical imaging","volume":"105","author":"Gureyev","year":"2009","journal-title":"J. Appl. Phys."},{"key":"B15","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.neuroimage.2006.03.043","article-title":"Hierarchical microimaging for multiscale analysis of large vascular networks","volume":"32","author":"Heinzer","year":"2006","journal-title":"Neuroimage"},{"key":"B16","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/sc.2015.49","article-title":"3D angioarchitecture changes after spinal cord injury in rats using synchrotron radiation phase-contrast tomography","volume":"53","author":"Hu","year":"2015","journal-title":"Spinal Cord"},{"key":"B17","doi-asserted-by":"publisher","first-page":"E883","DOI":"10.1097\/BRS.0000000000002110","article-title":"Comparison of synchrotron radiation-based propagation phase contrast imaging and conventional micro-computed tomography for assessing intervertebral discs and endplates in a murine model","volume":"42","author":"Hu","year":"2017","journal-title":"Spine"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e0124143","DOI":"10.1371\/journal.pone.0124143","article-title":"Signs analysis and clinical assessment: phase-contrast computed tomography of human breast tumours","volume":"10","author":"Jian","year":"2015","journal-title":"PLoS ONE"},{"key":"B19","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.mvr.2012.07.002","article-title":"Three-dimensional quantification of capillary networks in healthy and cancerous tissues of two mice","volume":"84","author":"Lang","year":"2012","journal-title":"Microvasc. Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1126\/science.1191776","article-title":"Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain","volume":"330","author":"Li","year":"2010","journal-title":"Science"},{"key":"B21","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1159\/000337155","article-title":"New vessels after stroke: postischemic neovascularization and regeneration","volume":"33","author":"Liman","year":"2012","journal-title":"Cerebrovasc. Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e0121438","DOI":"10.1371\/journal.pone.0121438","article-title":"Grating-based phase-contrast imaging of tumor angiogenesis in lung metastases","volume":"10","author":"Lin","year":"2015","journal-title":"PLoS ONE"},{"key":"B23","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1002\/jemt.23020","article-title":"Three-dimensional visualization of rat retina by X-ray differential phase contrast tomographic microscopy","volume":"81","author":"Liu","year":"2018","journal-title":"Microsc. Res. Tech."},{"key":"B24","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1097\/00004647-200110000-00011","article-title":"Angiogenesis after stroke is correlated with increased numbers of macrophages: the clean-up hypothesis","volume":"21","author":"Manoonkitiwongsa","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B26","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1097\/00019052-200412000-00010","article-title":"The functional relevance of cerebral hemodynamics: why blood flow matters to the injured and recovering brain","volume":"17","author":"Marshall","year":"2004","journal-title":"Curr. Opin. Neurol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.neuroscience.2012.03.034","article-title":"Repeated longitudinal in vivo imaging of neuro-glio-vascular unit at the peripheral boundary of ischemia in mouse cerebral cortex","volume":"212","author":"Masamoto","year":"2012","journal-title":"Neuroscience"},{"key":"B28","doi-asserted-by":"publisher","first-page":"3754","DOI":"10.1161\/STR.0000000000000046","article-title":"Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"45","author":"Meschia","year":"2014","journal-title":"Stroke"},{"key":"B29","doi-asserted-by":"publisher","first-page":"3258494","DOI":"10.1155\/2016\/3258494","article-title":"Synchrotron radiation X-ray phase-contrast tomography visualizes microvasculature changes in mice brains after ischemic injury","volume":"2016","author":"Miao","year":"2016","journal-title":"Neural. Plast."},{"key":"B30","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S1361-8415(98)80009-1","article-title":"Three-dimensional multi-scale line filter for segmentation and visualization of curvilinear structures in medical images","volume":"2","author":"Sato","year":"1998","journal-title":"Med. Image Anal."},{"key":"B31","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/B978-012547638-6\/50034-1","article-title":"CHAPTER 33 - Cerebral Vascular System","volume-title":"The Rat Nervous System, 3","author":"Scremin","year":"2004"},{"key":"B32","first-page":"209","article-title":"Synchrotron radiation imaging for advancing our understanding of cardiovascular function","volume-title":"Circ Res.","author":"Shirai","year":"2013"},{"key":"B33","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/nmeth.3690","article-title":"Inverted light-sheet microscope for imaging mouse pre-implantation development","volume":"13","author":"Strnad","year":"2016","journal-title":"Nat Methods"},{"key":"B34","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1107\/S090904951200310X","article-title":"Synchrotron-radiation phase-contrast imaging of human stomach and gastric cancer: in vitro studies","volume":"19","author":"Tang","year":"2012","journal-title":"J. Synchr. Radiat."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3032","DOI":"10.1161\/STROKEAHA.107.488445","article-title":"Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke","volume":"38","author":"Thored","year":"2007","journal-title":"Stroke"},{"key":"B36","doi-asserted-by":"publisher","first-page":"e109562","DOI":"10.1371\/journal.pone.0109562","article-title":"X-ray phase-contrast tomography of renal ischemia-reperfusion damage","volume":"9","author":"Velroyen","year":"2014","journal-title":"PLoS ONE"},{"key":"B37","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1146\/annurev.physiol.70.113006.100434","article-title":"Advances in biological structure, function, and physiology using synchrotron X-ray imaging*","volume":"70","author":"Westneat","year":"2008","journal-title":"Annu. Rev. Physiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-4939-0320-7_1","article-title":"Cerebral angiogenesis during development: who is conducting the orchestra?","volume":"1135","author":"Wittko-Schneider","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"E504","DOI":"10.1097\/BRS.0000000000002408","article-title":"Morphometric analysis of rat spinal cord angioarchitecture by phase contrast radiography: from 2D to 3D visualization","volume":"43","author":"Wu","year":"2018","journal-title":"Spine"},{"key":"B40","doi-asserted-by":"publisher","first-page":"3436","DOI":"10.1161\/STROKEAHA.111.642686","article-title":"In vivo imaging of neurovascular remodeling after stroke","volume":"43","author":"Yanev","year":"2012","journal-title":"Stroke"},{"key":"B41","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/1475-925X-13-62","article-title":"3D cardiac microvessels embolization imaging based on X-ray phase contrast imaging","volume":"13","author":"Zhang","year":"","journal-title":"Biomed. Eng. Online"},{"key":"B42","doi-asserted-by":"publisher","first-page":"031907","DOI":"10.1118\/1.4865784","article-title":"Synchrotron radiation imaging is a powerful tool to image brain microvasculature","volume":"41","author":"Zhang","year":"","journal-title":"Med. Phys."},{"key":"B43","doi-asserted-by":"publisher","first-page":"14982","DOI":"10.1038\/srep14982","article-title":"Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"key":"B44","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1172\/JCI9369","article-title":"VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain","volume":"106","author":"Zhang","year":"2000","journal-title":"J. Clin. Invest."},{"key":"B45","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1053\/j.gastro.2017.07.022","article-title":"Three-Dimensional cross-sectional light-sheet microscopy imaging of the inflamed mouse gut","volume":"153","author":"Zundler","year":"2017","journal-title":"Gastroenterology"}],"container-title":["Frontiers in Neuroanatomy"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnana.2019.00005\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T23:25:03Z","timestamp":1548890703000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnana.2019.00005\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,31]]},"references-count":45,"alternative-id":["10.3389\/fnana.2019.00005"],"URL":"https:\/\/doi.org\/10.3389\/fnana.2019.00005","relation":{},"ISSN":["1662-5129"],"issn-type":[{"value":"1662-5129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,31]]},"article-number":"5"}}