{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:27:47Z","timestamp":1770326867768,"version":"3.49.0"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neuroanat."],"DOI":"10.3389\/fnana.2019.00038","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T07:56:46Z","timestamp":1556092606000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Dendritic and Synaptic Degeneration in Pyramidal Neurons of the Sensorimotor Cortex in Neonatal Mice With Kaolin-Induced Hydrocephalus"],"prefix":"10.3389","volume":"13","author":[{"given":"Omowumi M.","family":"Femi-Akinlosotu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew T.","family":"Shokunbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thajasvarie","family":"Naicker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1159\/000442212","article-title":"Myelin sheath injury in kaolin-induced hydrocephalus: a light and electron microscopy study","volume":"51","author":"Ayannuga","year":"2016","journal-title":"Pediatr. Neurosurg."},{"key":"B2","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/0165-3806(93)90009-y","article-title":"Synaptophysin and synaptoporin expression in the developing rat olfactory system","volume":"74","author":"Bergmann","year":"1993","journal-title":"Dev. Brain Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2801","DOI":"10.1523\/JNEUROSCI.13-07-02801.1993","article-title":"Changes of synaptic density in the primary visual cortex of the macaque monkey from fetal to adult stage","volume":"13","author":"Bourgeois","year":"1993","journal-title":"J. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1080\/02699050410001672332","article-title":"Structural patterns of injured mitochondria in human oedematous cerebral cortex","volume":"18","author":"Castej\u00f3n","year":"2004","journal-title":"Brain Inj."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e40844","DOI":"10.1371\/journal.pone.0040844","article-title":"Cranial irradiation alters dendritic spine density and morphology in the hippocampus","volume":"7","author":"Chakraborti","year":"2012","journal-title":"PLoS One"},{"key":"B7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3389\/fnana.2015.00014","article-title":"The dendritic spine story: an intriguing process of discovery","volume":"9","author":"DeFelipe","year":"2015","journal-title":"Front. Neuroanat."},{"key":"B8","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1159\/000056016","article-title":"Future directions for therapy of childhood hydrocephalus: a view from the laboratory","volume":"34","author":"Del Bigio","year":"2001","journal-title":"Pediatr. Neurosurg."},{"key":"B9","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/j.1750-3639.2004.tb00071.x","article-title":"Cellular damage and prevention in childhood hydrocephalus","volume":"14","author":"Del Bigio","year":"2004","journal-title":"Brain Pathol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/ddrr.94","article-title":"Neuropathology and structural changes in hydrocephalus","volume":"16","author":"Del Bigio","year":"2010","journal-title":"Dev. Disabil. Res. Rev."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1097\/00005072-199709000-00010","article-title":"Myelination delay in the cerebral white matter of immature rats with kaolin-induced hydrocephalus is reversible","volume":"56","author":"Del Bigio","year":"1997","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/s0006-8993(98)00404-1","article-title":"Monoamine neurotransmitters and amino acids in the cerebrum and striatum of immature rats with kaolin-induced hydrocephalus","volume":"798","author":"Del Bigio","year":"1998","journal-title":"Brain Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1006\/exnr.1998.6922","article-title":"Cell death, axonal damage, and cell birth in the immature rat brain following induction of hydrocephalus","volume":"154","author":"Del Bigio","year":"1998","journal-title":"Exp. Neurol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1192\/bjp.176.3.236","article-title":"Synaptophysin gene expression in schizophrenia. Investigation of synaptic pathology in the cerebral cortex","volume":"176","author":"Eastwood","year":"2000","journal-title":"Br. J. Psychiatry"},{"key":"B14","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/s0361-9230(01)00530-5","article-title":"Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins","volume":"55","author":"Eastwood","year":"2001","journal-title":"Brain Res. Bull."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1093\/cercor\/bhg093","article-title":"Cortex, cognition and the cell: new insights into the pyramidal neuron and prefrontal function","volume":"13","author":"Elston","year":"2003","journal-title":"Cereb. Cortex"},{"key":"B16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/B0-12-370878-8\/00164-6","article-title":"Specialization of the neocortical pyramidal cell during primate evolution","volume-title":"Evolution of Nervous Systems, Volume IV","author":"Elston","year":"2007"},{"key":"B17","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3389\/fnana.2014.00078","article-title":"Pyramidal cell development: postnatal spinogenesis, dendritic growth, axon growth, and electrophysiology","volume":"8","author":"Elston","year":"2014","journal-title":"Front. Neuroanat."},{"key":"B21","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.neuroscience.2007.06.036","article-title":"Synaptophysin and PSD-95 in the human prefrontal cortex from mid-gestation into early adulthood","volume":"149","author":"Glantz","year":"2007","journal-title":"Neuroscience"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1111\/j.1460-9568.1994.tb00569.x","article-title":"Differential expression of synaptophysin and synaptoporin during pre- and postnatal development of the rat hippocampal network","volume":"6","author":"Grabs","year":"1994","journal-title":"Eur. J. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3389\/fnana.2011.00002","article-title":"Pyramidal cell in prefrontal cortex of primates: marked differences in neuronal structure among species","volume":"5","author":"Elston","year":"2011","journal-title":"Front. Neuroanat."},{"key":"B24","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1006\/exnr.1996.0161","article-title":"The effect of inherited hydrocephalus and shunt treatment on cortical pyramidal cell dendrites in the infant H-Tx rat","volume":"141","author":"Harris","year":"1996","journal-title":"Exp. Neurol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1046\/j.1471-4159.1997.68010305.x","article-title":"Neurochemical changes in the cerebral cortex of treated and untreated hydrocephalic rat pups quantified with in vitro 1H-NMR spectroscopy","volume":"68","author":"Harris","year":"1997","journal-title":"J. Neurochem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1212\/wnl.24.3.203","article-title":"Dendritic development in neocortex of children with mental defect and infantile spasms","volume":"24","author":"Huttenlocher","year":"1974","journal-title":"Neurology"},{"key":"B27","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1201\/9780203299296.pt2","article-title":"Regional dendritic variation in primate cortical pyramidal cells","volume-title":"Cortical Areas: Unity And Diversity","author":"Jacobs","year":"2002"},{"key":"B28","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/2045-8118-10-24","article-title":"Pre- and post-shunting observations in adult sheep with kaolin-induced hydrocephalus","volume":"10","author":"Johnston","year":"2013","journal-title":"Fluids Barriers CNS"},{"key":"B29","doi-asserted-by":"publisher","first-page":"398","DOI":"10.3389\/fncel.2015.00398","article-title":"Dendritic spine density of prefrontal layer 6 pyramidal neurons in relation to apical dendrite sculpting by nicotinic acetylcholine receptors","volume":"9","author":"Kang","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1093\/cercor\/1.2.189","article-title":"Environmental enrichment and cortical injury: behavioral and anatomical consequences of frontal cortex lesions","volume":"1","author":"Kolb","year":"1991","journal-title":"Cereb. Cortex"},{"key":"B31","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/s0006-8993(01)03320-0","article-title":"Alterations in brain metabolism, CNS morphology and CSF dynamics in adult rats with kaolin-induced hydrocephalus","volume":"8","author":"Kondziella","year":"2002","journal-title":"Brain Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"30","DOI":"10.4236\/ojmn.2018.81002","article-title":"Surgical treatment for neonatal hydrocephalus: catheter-based cerebrospinal fluid diversion or endoscopic intervention?","volume":"8","author":"Krause","year":"2018","journal-title":"Open J. Mod. Neurosurg."},{"key":"B34","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1006\/exnr.1993.1009","article-title":"The microstructure of cortical neuropil before and after decompression in experimental infantile hydrocephalus","volume":"119","author":"Kriebel","year":"1993","journal-title":"Exp. Neurol."},{"key":"B35","first-page":"3","article-title":"Dendritic changes in the hippocampus of aged rats","volume":"37","author":"Lolova","year":"1989","journal-title":"Acta Morpholog. Hung."},{"key":"B36","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/s0039-9140(03)00191-7","article-title":"Study of phenolic compounds as natural antioxidants by a fluorescence method","volume":"60","author":"L\u00f3pez","year":"2003","journal-title":"Talanta"},{"key":"B37","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3389\/fnana.2017.00011","article-title":"Pyramidal neurons are not generalizable building blocks of cortical networks","volume":"11","author":"Luebke","year":"2017","journal-title":"Front. Neuroanat."},{"key":"B38","doi-asserted-by":"publisher","first-page":"776","DOI":"10.3171\/jns.1985.63.5.0776","article-title":"Neuronal effects of experimentally induced hydrocephalus in newborn rats","volume":"63","author":"McAllister","year":"1985","journal-title":"J. Neurosurg."},{"key":"B39","doi-asserted-by":"publisher","first-page":"e30159","DOI":"10.1371\/journal.pone.0030159","article-title":"Morphological and behavioural changes in the pathogenesis of a novel mouse model of communicating hydrocephalus","volume":"7","author":"McMullen","year":"2012","journal-title":"PLoS One"},{"key":"B40","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1002\/(sici)1097-4547(19990501)56:3<307::aid-jnr10>3.0.co;2-3","article-title":"Age-changes of brain synapses and synaptic plasticity in response to an enriched environment","volume":"56","author":"Nakamura","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"i9","DOI":"10.1093\/bioinformatics\/btt222","article-title":"A high-throughput framework to detect synapses in electron microscopy images","volume":"29","author":"Navlakha","year":"2013","journal-title":"Bioinformatics"},{"key":"B42","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/2045-8118-9-19","article-title":"The relationship between ventricular dilatation, neuropathological and neurobehavioural changes in hydrocephalic rats","volume":"9","author":"Olopade","year":"2012","journal-title":"Fluids Barriers CNS"},{"key":"B44","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0165-3806(93)90186-e","article-title":"Ontogeny of synaptophysin and synaptoporin in the central nervous system: differential expression in striatal neurons and their afferents during development","volume":"72","author":"Ovtscharoff","year":"1993","journal-title":"Dev. Brain Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1002\/aja.1001270402","article-title":"The small pyramidal neuron of the rat cerebral cortex. The perikaryon, dendrites and spines","volume":"127","author":"Peters","year":"1970","journal-title":"Am. J. Anat."},{"key":"B46","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3389\/fncir.2013.00097","article-title":"Comparing development of synaptic proteins in rat visual, somatosensory, and frontal cortex","volume":"7","author":"Pinto","year":"2013","journal-title":"Front. Neuroanat."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1126\/science.186.4169.1126","article-title":"Dendritic spine \u201cdysgenesis\u201d and mental retardation","volume":"186","author":"Purpura","year":"1974","journal-title":"Science"},{"key":"B47","first-page":"91","article-title":"Dendritic differentiation in human cerebral cortex: normal and aberrant development patterns","volume-title":"Advances in Neurology","author":"Purpura","year":"1975"},{"key":"B49","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/0165-3806(82)90128-6","article-title":"Microtubule disarray in cortical dendrites and neurobehavioral failure: Golgi and electron microscopic studies","volume":"281","author":"Purpura","year":"1982","journal-title":"Brain Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1590\/s1678-91992004000100005","article-title":"Immunohistochemical investigation of neuronal injury in cerebral cortex of cobra-envenomed rats","volume":"10","author":"Rahmy","year":"2004","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"B51","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1126\/science.3952506","article-title":"Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex","volume":"232","author":"Rakic","year":"1986","journal-title":"Science"},{"key":"B52","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/s0165-5728(98)00085-x","article-title":"Progressive atrophy of pyramidal neuron dendrites in autoimmune MRL-lpr mice","volume":"87","author":"Saki\u0107","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"175","DOI":"10.4103\/2152-7806.146489","article-title":"Hydrocephalus in children less than 1 year of age in northern Mozambique","volume":"5","author":"Salvador","year":"2014","journal-title":"Surg. Neurol. Int."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1523\/JNEUROSCI.11-05-01173.1991","article-title":"Synapsin I and synaptophysin expression during ontogenesis of the mouse peripheral vestibular system","volume":"11","author":"Scarfone","year":"1991","journal-title":"J. Neurosci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"60","DOI":"10.5114\/fn.2015.49975","article-title":"Hydrocephalus induced via intraventricular kaolin injection in adult rats","volume":"53","author":"Shaolin","year":"2015","journal-title":"Folia Neuropathol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/nrn2286","article-title":"Pyramidal neurons: dendritic structure and synaptic integration","volume":"9","author":"Spruston","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"e0149900","DOI":"10.1371\/journal.pone.0149900","article-title":"Emx1 is required for neocortical area patterning","volume":"11","author":"Stocker","year":"2016","journal-title":"PLoS One"},{"key":"B58","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/0165-3806(83)90206-7","article-title":"Fetal alcohol syn- drome and mental retardation: spine distribution of pyramidal cells in prenatal alcohol-exposed rat cerebral cortex. A Golgi study","volume":"313","author":"Stoltenburg-Didinger","year":"1983","journal-title":"Brain Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1046\/j.1440-1789.2000.00285.x","article-title":"Immunohistochemical studies of the PrP (CJD) deposition in Creutzfeldt-Jakob disease","volume":"20","author":"Tanaka","year":"2000","journal-title":"Neuropathology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1159\/000488497","article-title":"Melatonin attenuates histopathological changes in the hippocampus of infantile rats with kaolin-induced hydrocephalus","volume":"53","author":"Turgut","year":"2018","journal-title":"Pediatr. Neurosurg."},{"key":"B61","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1177\/0300985811415708","article-title":"Congenital hydrocephalus in genetically engineered mice","volume":"49","author":"Vogel","year":"2012","journal-title":"Vet. Pathol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s00441-007-0432-4","article-title":"Immunohistological markers for staging neurogenesis in adult hippocampus","volume":"329","author":"von Bohlen Und Halbach","year":"2006","journal-title":"Cell Tissue Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/j.1469-7580.2010.01274.x","article-title":"Subplate in the developing cortex of mouse and human","volume":"217","author":"Wang","year":"2011","journal-title":"J. Anat."},{"key":"B64","doi-asserted-by":"publisher","first-page":"4681","DOI":"10.1523\/JNEUROSCI.0297-09.2009","article-title":"Presynaptic defects underlying impaired learning and memory function in lipoprotein lipase-deficient mice","volume":"29","author":"Xian","year":"2009","journal-title":"J. Neurosci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"e83561","DOI":"10.1371\/journal.pone.0083561","article-title":"Changes of dendritic spine density and morphology in the superficial layers of the medial entorhinal cortex induced by extremely low-frequency magnetic field exposure","volume":"8","author":"Xiong","year":"2013","journal-title":"PLoS One"},{"key":"B66","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/76609","article-title":"From form to function: calcium compartmentalization in dendritic spines","volume":"3","author":"Yuste","year":"2000","journal-title":"Nat. Neurosci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"5167973","DOI":"10.1155\/2017\/5167973","article-title":"Alterations in cortical thickness and white matter integrity in mild-to-moderate communicating hydrocephalic school-aged children measured by whole-brain cortical thickness mapping and DTI","volume":"2017","author":"Zhang","year":"2017","journal-title":"Neural Plast."}],"container-title":["Frontiers in Neuroanatomy"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnana.2019.00038\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T14:47:53Z","timestamp":1556549273000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnana.2019.00038\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,24]]},"references-count":62,"alternative-id":["10.3389\/fnana.2019.00038"],"URL":"https:\/\/doi.org\/10.3389\/fnana.2019.00038","relation":{},"ISSN":["1662-5129"],"issn-type":[{"value":"1662-5129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,24]]},"article-number":"38"}}