{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:17:20Z","timestamp":1761513440577},"reference-count":37,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Behav. Neurosci."],"DOI":"10.3389\/fnbeh.2014.00113","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T12:29:44Z","timestamp":1396355384000},"source":"Crossref","is-referenced-by-count":5,"title":["The effects of valproic acid on appetitive and aversive instrumental learning in adult rats"],"prefix":"10.3389","volume":"8","author":[{"given":"John J.","family":"Orczyk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa K.","family":"Banks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preston E.","family":"Garraghty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2014,4,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1212\/wnl.47.3.626","article-title":"Reversible parkinsonism and cognitive impairment with chronic valproate use","volume":"47","author":"Armon","year":"1996","journal-title":"Neurology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/s0278-5846(00)00175-5","article-title":"The effects of carbamazepine on an appetitive-to-aversive transfer task: comparison to untreated and phenytoin","volume":"25","author":"Banks","year":"2001","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B3","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/s0091-3057(99)00019-2","article-title":"The effects of phenytoin on instrumental appetitive-to-aversive transfer in rats","volume":"63","author":"Banks","year":"1999","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1101\/lm.801108","article-title":"The histone deacetylase inhibitor valproic acid enhances acquisition, extinction and reconsolidation of conditioned fear","volume":"15","author":"Bredy","year":"2008","journal-title":"Learn. Mem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/bf02688857","article-title":"Lesions of the rat nucleus basalis magnocellularis disrupt appetitive-to-aversive transfer learning","volume":"38","author":"Butt","year":"2003","journal-title":"Integr. Physiol. Behav. Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1056\/NEJMra022308","article-title":"Mechanisms of disease: epilepsy","volume":"349","author":"Chang","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/bf02688828","article-title":"Some antiepileptic compounds impair learning by rats in a Morris water maze","volume":"38","author":"Churchill","year":"2003","journal-title":"Integr. Physiol. Behav. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1111\/j.1528-1157.1998.tb01425.x","article-title":"Phenytoin blocks the reversal of a classically conditioned discriminative eyeblink response in rabbits","volume":"39","author":"Churchill","year":"1998","journal-title":"Epilepsia"},{"key":"B9","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/S0031-6989(84)80048-X","article-title":"Effects of valproic acid derivatives on the acquisition of active avoidance behavior in the rat","volume":"16","author":"Continella","year":"1984","journal-title":"Pharmacol. Res. Commun."},{"key":"B10","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/1471-2377-6-42","article-title":"Valproic acid associated with cognitive decline in HIV-infected individuals: a clinical observational study","volume":"6","author":"Cysique","year":"2006","journal-title":"BMC Neurol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/ddr.430240106","article-title":"Pharmacological studies of a rat spatial delayed nonmatch-to-sample task as an animal model of dementia","volume":"24","author":"Deacon","year":"1991","journal-title":"Drug Develop. Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1007\/bf02734439","article-title":"The effects of estradiol on avoidance learning in ovariectomized adult rats","volume":"39","author":"Goodman","year":"2004","journal-title":"Integr. Physiol. Behav. Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1755-5949.2008.00062.x","article-title":"The aspects and mechanisms of cognitive alterations in epilepsy: the role of antiepileptic medication","volume":"15","author":"Hamed","year":"2009","journal-title":"CNS Neurosci. Ther."},{"key":"B14","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.neulet.2013.07.035","article-title":"Repeated valproate treatment facilitates fear extinction under specific stimulus conditions","volume":"552","author":"Heinrichs","year":"2013","journal-title":"Neurosci. Lett."},{"key":"B15","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1212\/01.wnl.0000252807.38124.a3","article-title":"How common are the \u00e2\u20ac\u0153common\u00e2\u20ac\u009d neurologic disorders?","volume":"68","author":"Hirtz","year":"2007","journal-title":"Neurology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.eplepsyres.2011.05.003","article-title":"Trends in the use of antiepileptic drugs in Taiwan from 2003 to 2007: a population-based national health insurance study","volume":"96","author":"Hsieh","year":"2011","journal-title":"Epilepsy Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.pediatrneurol.2012.02.019","article-title":"Utilization of antiepileptic drugs in Hong Kong children","volume":"46","author":"Kwong","year":"2012","journal-title":"Pediatr. Neurol."},{"key":"B18","article-title":"An examination of the role of the hippocampus in the acquisition and timing of signaled barpress in appetitive and aversive conditioning","author":"Logue","year":"1994"},{"key":"B19","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1046\/j.1528-1157.42.s8.8.x","article-title":"Cognitive and behavioral effects of epilepsy treatment","volume":"42","author":"Loring","year":"2001","journal-title":"Epilepsia"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/893126","article-title":"The effects of sex and chronic restraint on instrumental learning in rats","volume":"2013","author":"McDowell","year":"2013","journal-title":"Neurosci. J."},{"key":"B21","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/bf02734169","article-title":"Discrete and contextual cue alterations eliminate the instrumental appetitive-to-aversive transfer impairment in phenytoin-treated rats","volume":"39","author":"McDowell","year":"2004","journal-title":"Integr. Physiol. Behav. Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1212\/01.wnl.0000063308.22506.19","article-title":"Differential cognitive and behavioral effects of topiramate and valproate","volume":"60","author":"Meador","year":"2003","journal-title":"Neurology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1212\/wnl.45.8.1494","article-title":"Comparative cognitive effects of phenobarbital, phenytoin and valproate in healthy adults","volume":"45","author":"Meador","year":"1995","journal-title":"Neurology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.ijdevneu.2008.03.005","article-title":"Chronic developmental exposure to phenytoin has long-term behavioral consequences","volume":"26","author":"Mowery","year":"2008","journal-title":"Int. J. Dev. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1046\/j.1471-4159.2001.00411.x","article-title":"Pentyl-4-yn-valproic acid enhances both spatial and avoidance learning and attenuates age-related NCAM-mediated neuroplastic decline within the rat medial temporal lobe","volume":"78","author":"Murphy","year":"2001","journal-title":"J. Neurochem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jad.2006.04.030","article-title":"Carbamazepine and valproate for the treatment of bipolar disorder: a review of the literature","volume":"95","author":"Nasrallah","year":"2006","journal-title":"J. Affect. Disord."},{"key":"B28","doi-asserted-by":"publisher","first-page":"36734","DOI":"10.1074\/jbc.m101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B29","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1037\/\/0735-7044.106.2.274","article-title":"Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning","volume":"106","author":"Phillips","year":"1992","journal-title":"Behav. Neurosci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1097\/fbp.0b013e32836104ea","article-title":"Exposure to histone deacetylase inhibitors during Pavlovian conditioning enhances subsequent cue-induced reinstatement of operant behavior","volume":"24","author":"Ploense","year":"2013","journal-title":"Behav. Pharmacol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/0006-8993(85)90207-0","article-title":"Therapeutic levels of sodium valproate inhibit mitotic indices in cells of neural origin","volume":"347","author":"Regan","year":"1985","journal-title":"Brain Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/bf02734185","article-title":"The effects of phenytoin on the performance of rats in a delayed match-to-place task","volume":"40","author":"Samuelson","year":"2005","journal-title":"Integr. Physiol. Behav. Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1097\/00019052-200304000-00008","article-title":"The epidemiology of epilepsy revisited","volume":"16","author":"Sander","year":"2003","journal-title":"Curr. Opin. Neurol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1002\/hipo.10103","article-title":"Neurogenesis may relate to some but not all types of hippocampal-dependent learning","volume":"12","author":"Shors","year":"2002","journal-title":"Hippocampus"},{"key":"B35","doi-asserted-by":"crossref","first-page":"73","DOI":"10.18773\/austprescr.2008.042","article-title":"Acute management of bipolar disorders","volume":"31","author":"Singh","year":"2008","journal-title":"Aust. Prescr."},{"key":"B36","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1037\/0735-7044.107.6.941","article-title":"Using signaled barpressing tasks to study the neural substrates of appetitive and aversive learning in rats: behavioral manipulations and cerebellar lesions","volume":"107","author":"Steinmetz","year":"1993","journal-title":"Behav. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1111\/j.1365-2125.1981.tb01313.x","article-title":"Sodium valproate and cognitive functioning in normal volunteers","volume":"12","author":"Thompson","year":"1981","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.neuroscience.2009.11.073","article-title":"Valproic acid reduces spatial working memory and cell proliferation in the hippocampus","volume":"166","author":"Umka","year":"2010","journal-title":"Neuroscience"}],"container-title":["Frontiers in Behavioral Neuroscience"],"original-title":[],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T10:44:27Z","timestamp":1498128267000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnbeh.2014.00113\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,1]]},"references-count":37,"URL":"https:\/\/doi.org\/10.3389\/fnbeh.2014.00113","relation":{},"ISSN":["1662-5153"],"issn-type":[{"value":"1662-5153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,1]]}}}