{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:16:34Z","timestamp":1784913394438,"version":"3.55.0"},"reference-count":68,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Behav. Neurosci."],"DOI":"10.3389\/fnbeh.2015.00194","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T09:21:53Z","timestamp":1438248113000},"source":"Crossref","is-referenced-by-count":33,"title":["Pain perception in people with Down syndrome: a synthesis of clinical and experimental research"],"prefix":"10.3389","volume":"9","author":[{"given":"Brian E.","family":"McGuire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Defrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,7,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.pmn.2014.08.001","article-title":"Evaluation of pain in healthy newborns and in newborns with developmental problems (down syndrome)","volume":"16","author":"Aguilar Cordero","year":"2015","journal-title":"Pain Manage. Nurs."},{"key":"B3","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/01.NAJ.0000391236.68263.90","article-title":"Pain assessment in people with intellectual or developmental disabilities","volume":"110","author":"Baldridge","year":"2010","journal-title":"Ann. Rehabil. Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1097\/00002508-200405000-00005","article-title":"Evaluating pain induced by venipuncture in pediatric patients with developmental delay","volume":"20","author":"Benini","year":"2004","journal-title":"Clin. J. Pain"},{"key":"B5","article-title":"Analysis of facial expression in relation to stimulation intensity and self-reports of pain","author":"Benromano","year":"2015"},{"key":"B6","first-page":"619","article-title":"Incidence of significantly altered pain experience among individuals with developmental disabilities","volume":"98","author":"Biersdorff","year":"1994","journal-title":"Am. J. Mental. Retard."},{"key":"B7","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1055\/s-2007-979780","article-title":"Impaired peripheral somatosensory function in children with down syndrome","volume":"26","author":"Brandt","year":"1995","journal-title":"Neuropediatrics"},{"key":"B8","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1097\/00000542-200203000-00004","article-title":"Validation of the non-communicating children\u2019s pain checklist-postoperative version","volume":"96","author":"Breau","year":"2002","journal-title":"Anesthesiol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1097\/00002508-199812000-00011","article-title":"Agreement between child and parent reports of pain","volume":"14","author":"Chambers","year":"1998","journal-title":"Clin. J. Pain"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1080\/08035250500252609","article-title":"Sensory evoked potentials in infants with down syndrome","volume":"94","author":"Chen","year":"2005","journal-title":"Acta Paediatr."},{"key":"B11","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/s0304-3959(00)00485-1","article-title":"Pain assessment in cognitively impaired and unimpaired older adults: a comparison of four scales","volume":"92","author":"Chibnall","year":"2001","journal-title":"Pain"},{"key":"B12","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1186\/s12883-014-0229-5","article-title":"An international road map to improve pain assessment in people with impaired cognition: the development of the Pain Assessment in Impaired Cognition (PAIC) meta-tool","volume":"14","author":"Corbett","year":"2014","journal-title":"BMC Neurol."},{"key":"B13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.53841\/bpscpf.1995.1.79.21","article-title":"The use of analog scales and personal questionnaires for interviewing people with learning disabilities","volume":"79","author":"Dagnan","year":"1995","journal-title":"Clin. Psychol. Forum"},{"key":"B14","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.pmn.2009.09.003","article-title":"Pain in children with down syndrome: assessment and intervention by parents","volume":"11","author":"Davies","year":"2010","journal-title":"Pain Manag. Nurs."},{"key":"B15","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1007\/s11481-012-9386-8","article-title":"Central mechanisms of pain revealed through functional and structural MRI","volume":"8","author":"Davis","year":"2013","journal-title":"J. Neuroimmune Pharmacol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.pain.2006.04.031","article-title":"The evaluation of acute pain in individuals with cognitive impairment: a differential effect of the level of impairment","volume":"124","author":"Defrin","year":"2006","journal-title":"Pain"},{"key":"B17","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.pain.2003.12.003","article-title":"A quantitative somatosensory testing of pain threshold in individuals with mental retardation","volume":"108","author":"Defrin","year":"2004","journal-title":"Pain"},{"key":"B18","doi-asserted-by":"publisher","first-page":"3442","DOI":"10.1016\/j.ridd.2013.07.016","article-title":"Does format matter for comprehension of a facial affective scale and a numeric scale for pain by adults with down syndrome?","volume":"34","author":"de Knegt","year":"2013","journal-title":"Res. Dev. Disabil."},{"key":"B19","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.ejpain.2009.10.013","article-title":"Pain expression in children with an intellectual disability","volume":"14","author":"Dubois","year":"2010","journal-title":"Eur. J. Pain"},{"key":"B20","doi-asserted-by":"publisher","first-page":"CD003968","DOI":"10.1002\/14651858.CD003968.pub3","article-title":"Psychological therapies for the management of chronic and recurrent pain in children and adolescents","volume":"12","author":"Eccleston","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"B21","volume-title":"Investigators Guide to the Facial Action Coding System.","author":"Ekman","year":"1978"},{"key":"B22","author":"European Cooperation in the Field of Scientific and Technical Research (COST)","year":"2015","journal-title":"TD-1005 Pain in Cognitive Impairment, Especially Dementia."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1111\/j.1532-5415.1998.tb06644.x","article-title":"Treatment of pain in cognitively impaired compared with cognitively intact older patients with hip-fracture","volume":"46","author":"Feldt","year":"1998","journal-title":"J. Am. Geriatr. Soc."},{"key":"B24","volume-title":"Psychophysics: Methods, Theory and Application.","author":"Gescheider","year":"1985"},{"key":"B25","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.jspd.2013.05.011","article-title":"Lumbar spondylolysis and spondylolisthesis in down syndrome: a cross-sectional study at one institution","volume":"1","author":"Hansdorfer","year":"2013","journal-title":"Spine Deform."},{"key":"B26","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1111\/j.1365-2788.2007.01009.x","article-title":"Interhemispheric transmission time in persons with down syndrome","volume":"51","author":"Heath","year":"2007","journal-title":"J. Intellect. Disabil. Res."},{"key":"B27","first-page":"50","article-title":"Adults with down\u2019s syndrome: the prevalence of complications and health care in the community","volume":"7","author":"Henderson","year":"2007","journal-title":"Br. J. Gen. Pract."},{"key":"B28","first-page":"347","article-title":"Parents\u2019 ability to perceive pain experienced by their child with down syndrome","volume":"17","author":"Hennequin","year":"2003","journal-title":"J. Orofac. Pain"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1016\/s0140-6736(00)03259-1","article-title":"Pain expression and stimulus localization in individuals with down\u2019s syndrome","volume":"356","author":"Hennequin","year":"2000","journal-title":"Lancet"},{"key":"B30","first-page":"1","article-title":"International association for the study of pain: classification of chronic pain","volume-title":"Classification of Chronic Pain","author":"International Association for the Study of Pain.","year":"1986","edition":"2nd Edn."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1111\/j.1651-2227.1995.tb13577.x","article-title":"Procedural pain in a paediatric surgical emergency unit","volume":"84","author":"Jylli","year":"1995","journal-title":"Acta Paediatr."},{"key":"B32","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/0168-5597(89)90013-0","article-title":"Short-latency somatosensory evoked potentials following median nerve stimulation in down\u2019s syndrome","volume":"74","author":"Kakigi","year":"1989","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/1472-6874-14-107","article-title":"Evaluation of a group based cognitive behavioral therapy programme for menstrual pain management in young women with intellectual disabilities: protocol for a mixed methods controlled clinical trial","volume":"14","author":"Kennedy","year":"2014","journal-title":"BMC Womens Health"},{"key":"B34","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1866-1955-6-8","article-title":"Differences in age-related effects on brain volume in down syndrome as compared to Williams syndrome and typical development","volume":"6","author":"Koran","year":"2014","journal-title":"J. Neurodev. Disord."},{"key":"B35","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.brainresbull.2011.05.006","article-title":"APP\/SOD1 overexpressing mice present reduced neuropathic pain sensitivity","volume":"85","author":"Kotulska","year":"2011","journal-title":"Brain Res. Bull."},{"key":"B36","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1111\/j.1365-2788.2005.00749.x","article-title":"Health issues and quality of life in women with intellectual disability","volume":"49","author":"Kyrkou","year":"2005","journal-title":"J. Intellect. Disabil. Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1097\/00002508-199903000-00004","article-title":"Pain measurement in persons with intellectual disability","volume":"15","author":"LaChapelle","year":"1999","journal-title":"Clin. J. Pain"},{"key":"B38","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.pain.2006.06.013","article-title":"Genuine, suppressed and faked facial expressions of pain in children","volume":"126","author":"Larochette","year":"2006","journal-title":"Pain"},{"key":"B39","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1468-3156.2007.00437.x","article-title":"Managing chronic pain in people with learning disabilities: a case study","volume":"35","author":"Lewis","year":"2007","journal-title":"Br. J. Learn. Disabil."},{"key":"B40","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1111\/j.1469-8749.1970.tb01943.x","article-title":"Spectrographic analysis of vocal response to pain stimuli in infants with down\u2019s syndrome","volume":"12","author":"Lind","year":"1970","journal-title":"Dev. Med. Child Neurol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1093\/brain\/awg102","article-title":"Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation","volume":"126","author":"Lorenz","year":"2003","journal-title":"Brain"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1097\/00001756-199904060-00039","article-title":"A murine model for down syndrome shows reduced responsiveness to pain","volume":"10","author":"Mart\u00ednez-Cu\u00e9","year":"1999","journal-title":"Neuroreport"},{"key":"B43","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/0304-3959(95)00171-9","article-title":"A new analoge scale for assessing children\u2019s pain","volume":"64","author":"McGrath","year":"1996","journal-title":"Pain"},{"key":"B44","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/j.1365-2788.2006.00915.x","article-title":"Lifestyle and health behaviors of adults with an intellectual disability","volume":"51","author":"McGuire","year":"2007","journal-title":"J. Intellect. Disabil. Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/j.1365-2788.2010.01254.x","article-title":"Chronic pain among people with an intellectual disability: under-recognised and under-treated?","volume":"54","author":"McGuire","year":"2010","journal-title":"J. Intellect. Disabil. Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1097\/YCO.0b013e32835fd74c","article-title":"Pain in people with an intellectual disability","volume":"26","author":"McGuire","year":"2013","journal-title":"Curr. Opin. Psychiatry"},{"key":"B47","volume-title":"Feeling Better: A Cognitive Behavioral Pain Management Programme for People with an Intellectual Disability.","author":"McManus","year":"2010"},{"key":"B48","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1111\/jir.12018","article-title":"Cognitive behavioral therapy for chronic pain in people with an intellectual disability using components of the feeling better programme: a case series","volume":"58","author":"McManus","year":"2014","journal-title":"J. Intellect. Disabil. Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1097\/00002508-200403000-00005","article-title":"Expression of pain in children with autism","volume":"20","author":"Nader","year":"2004","journal-title":"Clin. J. Pain"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1176\/appi.ajp.158.10.1659","article-title":"Neuroanatomy of down\u2019s syndrome: a high-resolution MRI study","volume":"158","author":"Pinter","year":"2001","journal-title":"Am. J. Psychiatry"},{"key":"B51","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.cortex.2014.10.012","article-title":"Anomalous brain functional connectivity contributing to poor adaptive behavior in down syndrome","volume":"64","author":"Pujol","year":"2015","journal-title":"Cortex"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1016\/j.pain.2013.06.011","article-title":"How do children with autism spectrum disorders express pain? A comparison with developmentally delayed and typically developing children","volume":"154","author":"Rattaz","year":"2013","journal-title":"Pain"},{"key":"B53","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/s0891-4222(00)00053-6","article-title":"Lifestyle related risk factors for poor health in residential settings for people with intellectual disabilities","volume":"21","author":"Robertson","year":"2000","journal-title":"Res. Dev. Disabil."},{"key":"B54","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.expneurol.2004.11.017","article-title":"Abnormal APP, cholinergic and cognitive function in Ts65Dn down\u2019s model mice","volume":"193","author":"Seo","year":"2005","journal-title":"Exp. Neurol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.jpainsymman.2004.04.012","article-title":"Pain in community-dwelling persons with dementia: frequency, intensity and congruence between patient and caregiver report","volume":"28","author":"Shega","year":"2004","journal-title":"J. Pain Symptom Manage."},{"key":"B56","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1136\/ip.7.1.56","article-title":"Injury in young people with intellectual disability: descriptive epidemiology","volume":"7","author":"Sherrard","year":"2001","journal-title":"Inj. Prev."},{"key":"B57","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1001\/archpsyc.1973.04200040086014","article-title":"Somatosensory evoked responses in down syndrome","volume":"29","author":"Straumanis","year":"1973","journal-title":"Arch. Gen. Psychiatry"},{"key":"B58","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1093\/brain\/awh101","article-title":"Age-related cortical gray matter reductions in non-demented down\u2019s syndrome adults determined by MRI with voxel-based morphometry","volume":"127","author":"Teipel","year":"2004","journal-title":"Brain"},{"key":"B59","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s10519-006-9047-x","article-title":"Neuroanatomy of down syndrome in vivo: a model of preclinical Alzheimer\u2019s disease","volume":"36","author":"Teipel","year":"2006","journal-title":"Behav. Genet."},{"key":"B70","volume-title":"Pain Assessment and Management in Intellectually Disabled Children.","author":"Valkenburg","year":"2012"},{"key":"B61","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1016\/j.pain.2011.05.001","article-title":"The COMFORT-behavior scale is useful to assess pain and distress in 0- to 3-year old children with down\u2019s syndrome","volume":"152","author":"Valkenburg","year":"2011","journal-title":"Pain"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12823","article-title":"Pain sensitivity of children with down syndrome and their siblings: quantitative sensory testing versus parental reports","author":"Valkenburg","year":"2015","journal-title":"Dev. Med. Child Neurol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1002\/(sici)1096-8628(19990625)89:2100::aid-ajmg83.3.co;2-e","article-title":"Health care concerns and guidelines for adults with down syndrome","volume":"89","author":"van Allen","year":"1999","journal-title":"Am. J. Med. Genet."},{"key":"B64","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.neubiorev.2009.01.005","article-title":"Keeping pain in mind: a motivational account of attention to pain","volume":"34","author":"Van Damme","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1016\/j.pain.2011.02.031","article-title":"Chronic pain in adults with an intellectual disability: prevalence, impact and health service utilization based on caregiver report","volume":"152","author":"Walsh","year":"2011","journal-title":"Pain"},{"key":"B66","doi-asserted-by":"publisher","first-page":"357","DOI":"10.3917\/enf.604.0357","article-title":"Reconnaissance des \u00e9motions et \u00e9valuation de la douleur chez des enfants et adolescents porteurs de trisomie 21","volume":"60","author":"Zabalia","year":"2008","journal-title":"Enfance"},{"key":"B67","doi-asserted-by":"publisher","first-page":"5540","DOI":"10.1523\/JNEUROSCI.5791-10.2011","article-title":"Brain mechanisms supporting the modulation of pain by mindfulness meditation","volume":"31","author":"Zeidan","year":"2011","journal-title":"J. Neurosci."},{"key":"B68","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1002\/mrdd.20163","article-title":"Alzheimer\u2019s disease in down syndrome: neurobiology and risk","volume":"13","author":"Zigman","year":"2007","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"B69","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ejpain.2008.02.009","article-title":"The prevalence of pain in nursing home residents with dementia measured using an observational pain scale","volume":"13","author":"Zwakhalen","year":"2009","journal-title":"Eur. J. Pain"}],"container-title":["Frontiers in Behavioral Neuroscience"],"original-title":[],"deposited":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T17:20:39Z","timestamp":1691860839000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fnbeh.2015.00194\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,30]]},"references-count":68,"URL":"https:\/\/doi.org\/10.3389\/fnbeh.2015.00194","relation":{},"ISSN":["1662-5153"],"issn-type":[{"value":"1662-5153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,30]]}}}