{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:04:04Z","timestamp":1787501044502,"version":"build-2736575974"},"reference-count":79,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100003631","name":"National Research Council for Economics, Humanities and Social Science","doi-asserted-by":"publisher","award":["NSC 102-2325-B-003-001"],"award-info":[{"award-number":["NSC 102-2325-B-003-001"]}],"id":[{"id":"10.13039\/501100003631","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003631","name":"National Research Council for Economics, Humanities and Social Science","doi-asserted-by":"publisher","award":["NSC 102-2321-B-003-004"],"award-info":[{"award-number":["NSC 102-2321-B-003-004"]}],"id":[{"id":"10.13039\/501100003631","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 103-2325-B-003-003"],"award-info":[{"award-number":["MOST 103-2325-B-003-003"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 103-2321-B-003-003"],"award-info":[{"award-number":["MOST 103-2321-B-003-003"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 103-2320-B-436-001"],"award-info":[{"award-number":["MOST 103-2320-B-436-001"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006397","name":"National Taiwan Normal University","doi-asserted-by":"publisher","award":["103T3040B07"],"award-info":[{"award-number":["103T3040B07"]}],"id":[{"id":"10.13039\/501100006397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006397","name":"National Taiwan Normal University","doi-asserted-by":"publisher","award":["NTNU103-07-C"],"award-info":[{"award-number":["NTNU103-07-C"]}],"id":[{"id":"10.13039\/501100006397","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mackay Junior College of Medicine, Nursing and Management","award":["MKC103R05"],"award-info":[{"award-number":["MKC103R05"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"DOI":"10.3389\/fnbeh.2015.00312","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T02:18:13Z","timestamp":1448417893000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Administration of NaHS Attenuates Footshock-Induced Pathologies and Emotional and Cognitive Dysfunction in Triple Transgenic Alzheimer\u2019s Mice"],"prefix":"10.3389","volume":"9","author":[{"given":"Hei-Jen","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu Mei","family":"Hsieh-Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,11,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.neuropharm.2010.11.018","article-title":"Activation patterns of cells in selected brain stem nuclei of more and less stress responsive rats in two animal models of PTSD - predator exposure and submersion stress","volume":"62","author":"Adamec","year":"2012","journal-title":"Neuropharmacology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"L896","DOI":"10.1152\/ajplung.00053.2006","article-title":"Role of substance P in hydrogen sulfide-induced pulmonary inflammation in mice","volume":"291","author":"Bhatia","year":"2006","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/path.2885","article-title":"Compounding artifacts with uncertainty and an amyloid cascade hypothesis that is \u2018too big to fail\u2019","volume":"224","author":"Castellani","year":"2011","journal-title":"J. Pathol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1097\/fbp.0b013e3283654258","article-title":"Antidepressant-like and anxiolytic-like effects of hydrogen sulfide in behavioral models of depression and anxiety","volume":"24","author":"Chen","year":"2013","journal-title":"Behav. Pharmacol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.pneurobio.2013.06.004","article-title":"Decoding Alzheimer\u2019s disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies","volume":"108","author":"Chen","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.ajpath.2013.10.002","article-title":"High activities of BACE1 in brains with mild cognitive impairment","volume":"184","author":"Cheng","year":"2014","journal-title":"Am. J. Pathol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1037\/a0014818","article-title":"Goal-directed responding is sensitive to lesions to the prelimbic cortex or basolateral nucleus of the amygdala but not to their disconnection","volume":"123","author":"Coutureau","year":"2009","journal-title":"Behav. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"390","DOI":"10.2174\/1567205011310040005","article-title":"Age-related mitochondrial alterations without neuronal loss in the hippocampus of a transgenic model of Alzheimer\u2019s disease","volume":"10","author":"Cuadrado-Tejedor","year":"2013","journal-title":"Curr. Alzheimer Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/978-1-4939-2627-5_14","article-title":"Chronic mild stress assay leading to early onset and propagation of Alzheimer\u2019s disease phenotype in mouse models","volume":"1303","author":"Cuadrado-Tejedor","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.clim.2006.03.005","article-title":"Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse","volume":"120","author":"Cuzzocrea","year":"2006","journal-title":"Clin. Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.npep.2014.03.002","article-title":"Aminoguanidine treatment ameliorates inflammatory responses and memory impairment induced by amyloid-beta 25\u201335 injection in rats","volume":"48","author":"Diaz","year":"2014","journal-title":"Neuropeptides"},{"key":"B12","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1093\/toxsci\/65.1.18","article-title":"Cytochrome oxidase inhibition induced by acute hydrogen sulfide inhalation: correlation with tissue sulfide concentrations in the rat brain, liver, lung and nasal epithelium","volume":"65","author":"Dorman","year":"2002","journal-title":"Toxicol. Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.biopsych.2009.06.015","article-title":"Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer\u2019s disease transgenic mice","volume":"67","author":"Espa\u00f1a","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1016\/s0006-291x(02)00422-9","article-title":"Brain hydrogen sulfide is severely decreased in Alzheimer\u2019s disease","volume":"293","author":"Eto","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B15","doi-asserted-by":"publisher","first-page":"296","DOI":"10.7555\/jbr.27.20120100","article-title":"Hydrogen sulfide protects against amyloid beta-peptide induced neuronal injury via attenuating inflammatory responses in a rat model","volume":"27","author":"Fan","year":"2013","journal-title":"J. Biomed. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.freeradbiomed.2013.11.014","article-title":"Antisense oligonucleotide against GSK-3beta in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: involvement of transcription factor Nrf2 and implications for Alzheimer disease","volume":"67","author":"Farr","year":"2014","journal-title":"Free Radic Biol. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/nrneurol.2013.223","article-title":"Alzheimer disease therapy\u2013moving from amyloid-beta to tau","volume":"9","author":"Giacobini","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"9047","DOI":"10.1523\/jneurosci.2797-06.2006","article-title":"Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer\u2019s disease","volume":"26","author":"Green","year":"2006","journal-title":"J. Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"922","DOI":"10.4088\/jcp.08m04606","article-title":"Lithium trial in Alzheimer\u2019s disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study","volume":"70","author":"Hampel","year":"2009","journal-title":"J. Clin. Psychiatry"},{"key":"B20","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/nan.12050","article-title":"Immunolesion-induced loss of cholinergic projection neurones promotes beta-amyloidosis and tau hyperphosphorylation in the hippocampus of triple-transgenic mice","volume":"40","author":"Hartig","year":"2014","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuint.2014.01.004","article-title":"Hydrogen sulfide improves spatial memory impairment and decreases production of Abeta in APP\/PS1 transgenic mice","volume":"67","author":"He","year":"2014","journal-title":"Neurochem. Int."},{"key":"B22","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3233\/JAD-2012-121438","article-title":"3xTg-AD mice exhibit an activated central stress axis during early-stage pathology","volume":"33","author":"Hebda-Bauer","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1523\/jneurosci.4236-05.2006","article-title":"Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice","volume":"26","author":"Heneka","year":"2006","journal-title":"J. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1111\/j.1471-4159.2006.04283.x","article-title":"Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia","volume":"100","author":"Hu","year":"2007","journal-title":"J. Neurochem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"813672","DOI":"10.1155\/2014\/813672","article-title":"Multifunctional effects of mangosteen pericarp on cognition in C57BL\/6J and triple transgenic Alzheimer\u2019s mice","volume":"2014","author":"Huang","year":"2014","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e39656","DOI":"10.1371\/journal.pone.0039656","article-title":"Exendin-4 protected against cognitive dysfunction in hyperglycemic mice receiving an intrahippocampal lipopolysaccharide injection","volume":"7","author":"Huang","year":"2012","journal-title":"PLoS One"},{"key":"B27","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.nlm.2009.07.010","article-title":"The interaction between acute oligomer Abeta(1\u201340) and stress severely impaired spatial learning and memory","volume":"93","author":"Huang","year":"2010","journal-title":"Neurobiol. Learn. Mem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.brainres.2010.11.043","article-title":"Long-term social isolation exacerbates the impairment of spatial working memory in APP\/PS1 transgenic mice","volume":"1371","author":"Huang","year":"2011","journal-title":"Brain Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1002\/syn.21729","article-title":"Distribution of AMPA receptor subunit glur1 in the bed nucleus of the stria terminalis and effect of stress","volume":"68","author":"Hubert","year":"2014","journal-title":"Synapse"},{"key":"B30","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1097\/00002093-200401000-00004","article-title":"Mild cognitive impairment is associated with characteristic neuropsychiatric symptoms","volume":"18","author":"Hwang","year":"2004","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"B31","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/nrn2967","article-title":"Amyloid-beta and tau\u2013a toxic pas de deux in Alzheimer\u2019s disease","volume":"12","author":"Ittner","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1093\/brain\/awq116","article-title":"Midlife psychological stress and risk of dementia: a 35-year longitudinal population study","volume":"133","author":"Johansson","year":"2010","journal-title":"Brain"},{"key":"B33","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1126\/science.1079469","article-title":"Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis","volume":"300","author":"Kayed","year":"2003","journal-title":"Science"},{"key":"B34","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1113\/expphysiol.2011.057455","article-title":"Hydrogen sulfide: its production and functions","volume":"96","author":"Kimura","year":"2011","journal-title":"Exp. Physiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3389\/fnmol.2014.00065","article-title":"Physiological and pathological phosphorylation of tau by Cdk5","volume":"7","author":"Kimura","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1097\/wnr.0b013e32834e7ec2","article-title":"Chronic stress affects PERIOD2 expression through glycogen synthase kinase-3beta phosphorylation in the central clock","volume":"23","author":"Kinoshita","year":"2012","journal-title":"Neuroreport"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1073\/pnas.97.4.1456","article-title":"Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein","volume":"97","author":"Lin","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1016\/j.euroneuro.2012.10.007","article-title":"Footshock-induced responses in ventral subiculum neurons are mediated by locus coeruleus noradrenergic afferents","volume":"23","author":"Lipski","year":"2013","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"16074","DOI":"10.1073\/pnas.1110444108","article-title":"Glucocorticoids are critical regulators of dendritic spine development and plasticity in vivo","volume":"108","author":"Liston","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B40","first-page":"2246","article-title":"[Plasma levels of endogenous hydrogen sulfide and homocysteine in patients with Alzheimer\u2019s disease and vascular dementia and the significance thereof]","volume":"88","author":"Liu","year":"2008","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.3233\/JAD-2010-101002","article-title":"Hydrogen sulfide protects amyloid-beta induced cell toxicity in microglia","volume":"22","author":"Liu","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"B42","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3233\/JAD-141959","article-title":"A phase II trial of tideglusib in Alzheimer\u2019s disease","volume":"45","author":"Lovestone","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"B43","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/msj.20160","article-title":"Amyloid-beta oligomers: possible roles as key neurotoxins in Alzheimer\u2019s disease","volume":"77","author":"Lublin","year":"2010","journal-title":"Mt. Sinai J. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1172\/jci64516","article-title":"Inhibition of GSK3beta-mediated BACE1 expression reduces Alzheimer-associated phenotypes","volume":"123","author":"Ly","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0197-4580(02)00057-x","article-title":"Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis","volume":"24","author":"Lyness","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"B46","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1177\/1745691613506907","article-title":"The brain on stress: toward an integrative approach to brain, body and behavior","volume":"8","author":"McEwen","year":"2013","journal-title":"Perspect. Psychol. Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"849","DOI":"10.3233\/JAD-131843","article-title":"Tau oligomers and fibrils induce activation of microglial cells","volume":"37","author":"Morales","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"B48","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.neuron.2008.10.047","article-title":"Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis","volume":"60","author":"O\u2019Connor","year":"2008","journal-title":"Neuron"},{"key":"B49","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/s0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer\u2019s disease with plaques and tangles: intracellular abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"B50","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.neulet.2013.12.071","article-title":"The dual role of astrocyte activation and reactive gliosis","volume":"565","author":"Pekny","year":"2014","journal-title":"Neurosci. Lett."},{"key":"B51","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1192\/bjp.bp.113.134239","article-title":"Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study","volume":"204","author":"Pietrzak","year":"2014","journal-title":"Br. J. Psychiatry"},{"key":"B52","doi-asserted-by":"publisher","first-page":"11737","DOI":"10.1073\/pnas.0905257106","article-title":"Persistence of fear memory across time requires the basolateral amygdala complex","volume":"106","author":"Poulos","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1002\/anie.201410456","article-title":"Multitarget drug discovery for Alzheimer\u2019s disease: triazinones as BACE-1 and GSK-3beta inhibitors","volume":"54","author":"Prati","year":"2014","journal-title":"Angew. Chem. Int. Ed Engl."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1093\/brain\/awv004","article-title":"Early behavioral changes in familial Alzheimer\u2019s disease in the dominantly inherited Alzheimer network","volume":"138","author":"Ringman","year":"2015","journal-title":"Brain"},{"key":"B55","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1111\/j.1471-4159.2004.02857.x","article-title":"Alzheimer\u2019s disease beta-secretase BACE1 is not a neuron-specific enzyme","volume":"92","author":"Rossner","year":"2005","journal-title":"J. Neurochem."},{"key":"B56","doi-asserted-by":"publisher","first-page":"3634","DOI":"10.3791\/3634","article-title":"Isolation and culture of hippocampal neurons from prenatal mice","volume":"65","author":"Seibenhener","year":"2012","journal-title":"J. Vis. Exp."},{"key":"B57","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.neuint.2013.05.005","article-title":"In vitro mitochondrial failure and oxidative stress mimic biochemical features of Alzheimer disease","volume":"63","author":"Selvatici","year":"2013","journal-title":"Neurochem. Int."},{"key":"B58","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jchemneu.2005.07.003","article-title":"Systemic inflammation induces apoptosis with variable vulnerability of different brain regions","volume":"30","author":"Semmler","year":"2005","journal-title":"J. Chem. Neuroanat."},{"key":"B59","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s12990-015-0064-8","article-title":"Temporal dynamics of anxiety phenotypes in a dental pulp injury model","volume":"11","author":"Shang","year":"2015","journal-title":"Mol. Pain"},{"key":"B60","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/jnc.12991","article-title":"Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer\u2019s disease","volume":"133","author":"Sokolow","year":"2014","journal-title":"J. Neurochem."},{"key":"B61","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1016\/j.bbadis.2013.09.013","article-title":"Stress contributes to the development of central insulin resistance during aging: implications for Alzheimer\u2019s disease","volume":"1832","author":"Solas","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"B62","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/febs.13103","article-title":"Combining an amyloid-beta (Abeta) cleaving enzyme inhibitor with a gamma-secretase modulator results in an additive reduction of abeta production","volume":"282","author":"Str\u00f6mberg","year":"2015","journal-title":"FEBS J."},{"key":"B64","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.bbr.2015.06.042","article-title":"The effect of obestatin on anxiety-like behavior in mice","volume":"293","author":"Szak\u00e1cs","year":"2015","journal-title":"Behav. Brain Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1016\/j.ajpath.2012.06.033","article-title":"The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system","volume":"181","author":"Tai","year":"2012","journal-title":"Am. J. Pathol."},{"key":"B66","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3233\/JAD-2006-9S335","article-title":"GSK-3 is essential in the pathogenesis of Alzheimer\u2019s disease","volume":"9","author":"Takashima","year":"2006","journal-title":"J. Alzheimers Dis."},{"key":"B67","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1007\/s12640-011-9283-6","article-title":"Amyloid-beta production: major link between oxidative stress and BACE1","volume":"22","author":"Tamagno","year":"2012","journal-title":"Neurotox. Res."},{"key":"B68","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3389\/fncel.2013.00189","article-title":"Recent developments of protein kinase inhibitors as potential AD therapeutics","volume":"7","author":"Tell","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The use of the elevated plus maze as an assay of anxiety-related behavior in rodents","volume":"2","author":"Walf","year":"2007","journal-title":"Nat. Protoc."},{"key":"B70","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.pneurobio.2010.04.005","article-title":"The putative neurodegenerative links between depression and Alzheimer\u2019s disease","volume":"91","author":"Wuwongse","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1186\/1742-2094-9-202","article-title":"Hydrogen sulfide attenuates spatial memory impairment and hippocampal neuroinflammation in beta-amyloid rat model of Alzheimer\u2019s disease","volume":"9","author":"Xuan","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1002\/jnr.21998","article-title":"NMDA receptor-dependent signaling pathways that underlie amyloid beta-protein disruption of LTP in the hippocampus","volume":"87","author":"Yamin","year":"2009","journal-title":"J. Neurosci. Res"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/j.ejrad.2013.03.019","article-title":"Decreased functional connectivity of the amygdala in Alzheimer\u2019s disease revealed by resting-state fMRI","volume":"82","author":"Yao","year":"2013","journal-title":"Eur. J. Radiol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.lfs.2009.05.023","article-title":"Hydrogen sulfide inhibits MPP(+)-induced apoptosis in PC12 cells","volume":"85","author":"Yin","year":"2009","journal-title":"Life Sci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","article-title":"Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model","volume":"53","author":"Yoshiyama","year":"2007","journal-title":"Neuron"},{"key":"B76","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.neuint.2010.11.010","article-title":"Hydrogen sulfide reduces mRNA and protein levels of beta-site amyloid precursor protein cleaving enzyme 1 in PC12 cells","volume":"58","author":"Zhang","year":"2011","journal-title":"Neurochem. Int."},{"key":"B78","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1007\/s11064-013-0969-4","article-title":"Dynamic change of hydrogen sulfide after traumatic brain injury and its effect in mice","volume":"38","author":"Zhang","year":"2013","journal-title":"Neurochem. Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"L960","DOI":"10.1152\/ajplung.00388.2006","article-title":"Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-kappaB","volume":"292","author":"Zhang","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"3639","DOI":"10.1523\/jneurosci.4396-06.2007","article-title":"Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer\u2019s disease pathogenesis","volume":"27","author":"Zhao","year":"2007","journal-title":"J. Neurosci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1248\/bpb.32.1406","article-title":"Cardioprotective effect of hydrogen sulfide in ischemic reperfusion experimental rats and its influence on expression of survivin gene","volume":"32","author":"Zhuo","year":"2009","journal-title":"Biol. Pharm. Bull."}],"container-title":["Frontiers in Behavioral Neuroscience"],"original-title":[],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T20:20:46Z","timestamp":1498249246000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fnbeh.2015.00312\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,25]]},"references-count":79,"URL":"https:\/\/doi.org\/10.3389\/fnbeh.2015.00312","relation":{},"ISSN":["1662-5153"],"issn-type":[{"value":"1662-5153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,25]]}}}