{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:08:57Z","timestamp":1790446137825,"version":"4.1.0"},"reference-count":69,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004189","name":"Max-Planck-Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000006","name":"Office of Naval Research","doi-asserted-by":"publisher","award":["N00014-14-1-0245"],"award-info":[{"award-number":["N00014-14-1-0245"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"DOI":"10.3389\/fnbeh.2016.00197","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T23:14:54Z","timestamp":1476918894000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":89,"title":["A Foxp2 Mutation Implicated in Human Speech Deficits Alters Sequencing of Ultrasonic Vocalizations in Adult Male Mice"],"prefix":"10.3389","volume":"10","author":[{"given":"Jonathan","family":"Chabout","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhra","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheel R.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Radden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Dunson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon E.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich D.","family":"Jarvis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.bandl.2012.10.002","article-title":"Mouse vocal communication system: are ultrasounds learned or innate?","volume":"124","author":"Arriaga","year":"2013","journal-title":"Brain Lang."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e50672","DOI":"10.3791\/50672","article-title":"Transsynaptic tracing from peripheral targets with pseudorabies virus followed by cholera toxin and biotinylated dextran amines double labeling","volume":"103","author":"Arriaga","year":"2015","journal-title":"J. Vis. Exp."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e46610","DOI":"10.1371\/journal.pone.0046610","article-title":"Of mice, birds, and men: the mouse ultrasonic song system has some features similar to humans and song-learning birds","volume":"7","author":"Arriaga","year":"2012","journal-title":"PloS ONE"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1007\/s00439-012-1193-z","article-title":"The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders","volume":"131","author":"Bacon","year":"2012","journal-title":"Hum. Genet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/j.1469-8749.1995.tb11932.x","article-title":"Genetic basis of specific language impairment: evidence from a twin study","volume":"37","author":"Bishop","year":"1995","journal-title":"Dev. Med. Child Neurol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1002\/cne.21881","article-title":"Conservation and diversity of Foxp2 expression in muroid rodents: functional implications","volume":"512","author":"Campbell","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.ns0105s09","article-title":"Transneuronal circuit analysis with pseudorabies viruses","author":"Card","year":"2001","journal-title":"Curr. Protoc. Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"23305","DOI":"10.1038\/srep23305","article-title":"Knockout of Foxp2 disrupts vocal development in mice","volume":"6","author":"Castellucci","year":"2016","journal-title":"Sci. Rep."},{"key":"B9","doi-asserted-by":"crossref","DOI":"10.3791\/54137","volume-title":"Eliciting Analyzing Male Mouse Ultrasonic Vocalization (USV) Songs","author":"Chabout","year":"in press"},{"issue":"76","key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2015.00076","article-title":"Male mice song syntax depends on social contexts and influences female preferences","volume":"9","author":"Chabout","year":"2015","journal-title":"Front. Behav. Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/gb-2013-14-4-204","article-title":"Neurogenomics of speech and language disorders: the road ahead","volume":"14","author":"Deriziotis","year":"2013","journal-title":"Genome Biol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1196\/annals.1298.022","article-title":"Neural mechanisms of vocal sequence generation in the songbird","volume":"1016","author":"Fee","year":"2004","journal-title":"Ann. N.Y Acad. Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1002\/cne.10654","article-title":"Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain","volume":"460","author":"Ferland","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1146\/annurev.neuro.26.041002.131144","article-title":"Deciphering the genetic basis of speech and language disorders","volume":"26","author":"Fisher","year":"2003","journal-title":"Annu. Rev. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrg1747","article-title":"The eloquent ape: genes, brains and the evolution of language","volume":"7","author":"Fisher","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"B16","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.tig.2009.03.002","article-title":"FOXP2 as a molecular window into speech and language","volume":"25","author":"Fisher","year":"2009","journal-title":"Trends Genet."},{"key":"B17","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/ng0298-168","article-title":"Localisation of a gene implicated in a severe speech and language disorder","volume":"18","author":"Fisher","year":"1998","journal-title":"Nat. Genet."},{"key":"B18","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.conb.2014.07.003","article-title":"What can mice tell us about Foxp2 function?","volume":"28","author":"French","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1002\/dvg.20305","article-title":"Generation of mice with a conditional Foxp2 null allele","volume":"45","author":"French","year":"2007","journal-title":"Genesis"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1038\/mp.2011.105","article-title":"An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning","volume":"17","author":"French","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"B21","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.1073\/pnas.0712298105","article-title":"Ultrasonic vocalization impairment of Foxp2 (R552H) knockin mice related to speech-language disorder and abnormality of Purkinje cells","volume":"105","author":"Fujita","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B22","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1002\/cne.22760","article-title":"FoxP2 expression in the cerebellum and inferior olive: development of the transverse stripe-shaped expression pattern in the mouse cerebellar cortex","volume":"520","author":"Fujita","year":"2012","journal-title":"J. Comp. Neurol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.1007\/s00429-015-1079-7","article-title":"FoxP2 protein levels regulate cell morphology changes and migration patterns in the vertebrate developing telencephalon","volume":"221","author":"Garcia-Calero","year":"2016","journal-title":"Brain Struct. Funct."},{"key":"B24","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/gbb.12274","article-title":"Ultrasonic vocalizations of adult male Foxp2-mutant mice: behavioral contexts of arousal and emotion","volume":"15","author":"Gaub","year":"2016","journal-title":"Genes Brain Behav"},{"key":"B25","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1111\/j.1601-183X.2010.00570.x","article-title":"The structure of innate vocalizations in Foxp2-deficient mouse pups","volume":"9","author":"Gaub","year":"2010","journal-title":"Genes Brain Behav."},{"key":"B26","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.conb.2012.11.006","article-title":"Decoding the genetics of speech and language","volume":"23","author":"Graham","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e17460","DOI":"10.1371\/journal.pone.0017460","article-title":"Development of social vocalizations in mice","volume":"6","author":"Grimsley","year":"2011","journal-title":"PloS ONE"},{"key":"B28","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.cub.2008.01.060","article-title":"Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits","volume":"18","author":"Groszer","year":"2008","journal-title":"Curr. Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e321","DOI":"10.1371\/journal.pbio.0050321","article-title":"Incomplete and inaccurate vocal imitation after knockdown of FoxP2 in songbird basal ganglia nucleus Area, X","volume":"5","author":"Haesler","year":"2007","journal-title":"PLoS Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"3164","DOI":"10.1523\/JNEUROSCI.4369-03.2004","article-title":"FoxP2 expression in avian vocal learners and non-learners","volume":"24","author":"Haesler","year":"2004","journal-title":"J. Neurosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/nature00974","article-title":"An ultra-sparse code underlies the generation of neural sequences in a songbird","volume":"419","author":"Hahnloser","year":"2002","journal-title":"Nature"},{"key":"B32","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1471-2202-13-40","article-title":"Mice do not require auditory input for the normal development of their ultrasonic vocalizations","volume":"13","author":"Hammerschmidt","year":"2012","journal-title":"BMC Neurosci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"8808","DOI":"10.1038\/srep08808","article-title":"Mice lacking the cerebral cortex develop normal song: insights into the foundations of vocal learning","volume":"5","author":"Hammerschmidt","year":"2015","journal-title":"Sci. Rep."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.neuron.2015.08.005","article-title":"Spinal locomotor circuits develop using hierarchical rules based on motorneuron position and identity","volume":"87","author":"Hinckley","year":"2015","journal-title":"Neuron"},{"key":"B35","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.neuroscience.2009.12.055","article-title":"The forkhead transcription factors, Foxp1 and Foxp2, identify different subpopulations of projection neurons in the mouse cerebral cortex","volume":"166","author":"Hisaoka","year":"2010","journal-title":"Neuroscience"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1371\/journal.pbio.0030386","article-title":"Ultrasonic songs of male mice","volume":"3","author":"Holy","year":"2005","journal-title":"PLoS Biol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1111\/j.1469-8749.1990.tb16948.x","article-title":"An extended family with a dominantly inherited speech disorder","volume":"32","author":"Hurst","year":"1990","journal-title":"Dev. Med. Child Neurol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/S0896-6273(00)80594-2","article-title":"For whom the bird sings: context-dependent gene expression","volume":"21","author":"Jarvis","year":"1998","journal-title":"Neuron"},{"key":"B39","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.conb.2015.06.011","article-title":"Shaping action sequences in basal ganglia circuits","volume":"33","author":"Jin","year":"2015","journal-title":"Curr. Opin. Neurobiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"e17721","DOI":"10.1371\/journal.pone.0017721","article-title":"Cross fostering experiments suggest that mice songs are innate","volume":"6","author":"Kikusui","year":"2011","journal-title":"PLoS ONE"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1111\/j.1460-9568.2007.05368.x","article-title":"The pallial basal ganglia pathway modulates the behaviorally driven gene expression of the motor pathway","volume":"25","author":"Kubikova","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/35097076","article-title":"A forkhead-domain gene is mutated in a severe speech and language disorder","volume":"413","author":"Lai","year":"2001","journal-title":"Nature"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1093\/brain\/awg247","article-title":"FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder","volume":"126","author":"Lai","year":"2003","journal-title":"Brain"},{"key":"B44","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1080\/136828200247133","article-title":"Prevalence and natural history of primary speech and language delay: findings from a systematic review of the literature","volume":"35","author":"Law","year":"2000","journal-title":"Int. J. Lang. Commun. Disord."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1038\/nn1138","article-title":"Language fMRI abnormalities associated with FOXP2 gene mutation","volume":"6","author":"Li\u00e9geois","year":"2003","journal-title":"Nat. Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1038\/ncomms3082","article-title":"Rudimentary substrates for vocal learning in a suboscine","volume":"4","author":"Liu","year":"2013","journal-title":"Nat. Commun."},{"key":"B47","doi-asserted-by":"publisher","first-page":"5573","DOI":"10.1523\/JNEUROSCI.5054-12.2013","article-title":"Engineered deafness reveals that mouse courtship vocalizations do not require auditory experience","volume":"33","author":"Mahrt","year":"2013","journal-title":"J. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1016\/j.neuron.2013.09.021","article-title":"Diminished FoxP2 levels affect dopaminergic modulation of corticostriatal signaling important to song variability","volume":"80","author":"Murugan","year":"2013","journal-title":"Neuron"},{"key":"B49","doi-asserted-by":"publisher","first-page":"e06203","DOI":"10.7554\/eLife.06203","article-title":"Female mice ultrasonically interact with males during courtship displays","volume":"4","author":"Neunuebel","year":"2015","journal-title":"Elife"},{"key":"B50","author":"NIDCD","year":"2010","journal-title":"Statistics about Voice, Speech and Language"},{"key":"B51","volume-title":"Cortical Modules Contribute to Stereotyped Vocalizations in a Tropical Rodent","author":"Okobi","year":"2013"},{"issue":"12","key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fnevo.2012.00012","article-title":"Birds, primates, and spoken language origins: behavioral phenotypes and neurobiological substrates","volume":"4","author":"Petkov","year":"2012","journal-title":"Front. Evol. Neurosci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1256846","DOI":"10.1126\/science.1256846","article-title":"Convergent transcriptional specializations in the brains of humans and song-learning birds","volume":"346","author":"Pfenning","year":"2014","journal-title":"Science"},{"key":"B54","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.conb.2014.07.002","article-title":"The role of ultrasonic vocalizations in mouse communication","volume":"28C","author":"Portfors","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"B55","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2011"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1044\/jslhr.4206.1461","article-title":"Prevalence of speech delay in 6-year-old children and comorbidity with language impairment","volume":"42","author":"Shriberg","year":"1999","journal-title":"J. Speech Lang. Hear. Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"9643","DOI":"10.1073\/pnas.0503739102","article-title":"Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene","volume":"102","author":"Shu","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B58","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1152\/jn.00901.2013","article-title":"The response of the anterior striatum during adult human vocal learning","volume":"112","author":"Simmonds","year":"2014","journal-title":"J. Neurophysiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"9264","DOI":"10.1073\/pnas.97.16.9264","article-title":"Pseudorabies virus expressing enhanced green fluorescent protein: a tool for in vitro electrophysiological analysis of transsynaptically labeled neurons in identified central nervous system circuits","volume":"97","author":"Smith","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B60","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1146\/annurev.neuro.24.1.631","article-title":"Sequential organization of multiple movements: involvement of cortical motor areas","volume":"24","author":"Tanji","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"3152","DOI":"10.1523\/JNEUROSCI.5589-03.2004","article-title":"Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction","volume":"24","author":"Teramitsu","year":"2004","journal-title":"J. Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"7390","DOI":"10.1523\/JNEUROSCI.1662-06.2006","article-title":"FoxP2 regulation during undirected singing in adult songbirds","volume":"26","author":"Teramitsu","year":"2006","journal-title":"J. Neurosci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"9498","DOI":"10.1073\/pnas.132128899","article-title":"C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity","volume":"99","author":"Thupari","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B64","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1002\/ajmg.a.36055","article-title":"Small intragenic deletion in FOXP2 associated with childhood apraxia of speech and dysarthria","volume":"161A","author":"Turner","year":"2013","journal-title":"Am. J. Med. Genet. A"},{"key":"B65","doi-asserted-by":"publisher","first-page":"3154","DOI":"10.1093\/hmg\/ddl392","article-title":"Functional genetic analysis of mutations implicated in a human speech and language disorder","volume":"15","author":"Vernes","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"B66","doi-asserted-by":"publisher","first-page":"e1002145","DOI":"10.1371\/journal.pgen.1002145","article-title":"Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain","volume":"7","author":"Vernes","year":"2011","journal-title":"PLoS Genet."},{"key":"B67","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1093\/brain\/awf058","article-title":"Behavioural analysis of an inherited speech and language disorder: comparison with acquired aphasia","volume":"125","author":"Watkins","year":"2002a","journal-title":"Brain"},{"key":"B68","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1093\/brain\/awf057","article-title":"Analysis of an inherited speech and language disorder: structural brain abnormalities","volume":"125","author":"Watkins","year":"2002b","journal-title":"Brain"},{"key":"B69","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1002\/gepi.0042","article-title":"Truncated product method for combining P-values","volume":"22","author":"Zaykin","year":"2002","journal-title":"Genet. Epidemiol."}],"container-title":["Frontiers in Behavioral Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnbeh.2016.00197\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T21:37:34Z","timestamp":1498340254000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnbeh.2016.00197\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,20]]},"references-count":69,"URL":"https:\/\/doi.org\/10.3389\/fnbeh.2016.00197","relation":{},"ISSN":["1662-5153"],"issn-type":[{"value":"1662-5153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,20]]}}}