{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:44:56Z","timestamp":1790793896111,"version":"4.1.0"},"reference-count":107,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T00:00:00Z","timestamp":1533600000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006303","name":"Associa\u00e7\u00e3o Fundo de Incentivo \u00e0 Pesquisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006303","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["470099\/2012-7"],"award-info":[{"award-number":["470099\/2012-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/26364-4"],"award-info":[{"award-number":["2015\/26364-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"DOI":"10.3389\/fnbeh.2018.00159","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T04:33:26Z","timestamp":1533616406000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":58,"title":["Maternal Deprivation Increases Anxiety- and Depressive-Like Behaviors in an Age-Dependent Fashion and Reduces Neuropeptide Y Expression in the Amygdala and Hippocampus of Male and Female Young Adult Rats"],"prefix":"10.3389","volume":"12","author":[{"given":"Alexandra S.","family":"Miragaia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme S.","family":"de Oliveira Wertheimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda C.","family":"Consoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Cabbia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz M.","family":"Longo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E. N.","family":"Girardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Suchecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,8,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/0003-3472(70)90083-7","article-title":"Rhythmicity in the maternal behaviour of Rattus norvegicus.","volume":"18","author":"Ader","year":"1970","journal-title":"Anim. Behav."},{"key":"B2","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/sj.mp.4000473","article-title":"Environment and vulnerability to major psychiatric illness: a case control study of early parental loss in major depression, bipolar disorder and schizophrenia.","volume":"4","author":"Agid","year":"1999","journal-title":"Mol. Psychiatry"},{"key":"B3","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0006-8993(00)02285-X","article-title":"Behavioral characterization of neuropeptide Y knockout mice.","volume":"868","author":"Bannon","year":"2000","journal-title":"Brain Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.neuropharm.2011.09.011","article-title":"Stress during development alters anxiety-like behavior and hippocampal neurotransmission in male and female rats.","volume":"62","author":"Barbosa Neto","year":"2012","journal-title":"Neuropharmacology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1017\/S003329171200147X","article-title":"Global prevalence of anxiety disorders: a systematic review and meta-regression.","volume":"43","author":"Baxter","year":"2013","journal-title":"Psychol. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1007\/s10802-014-9940-3","article-title":"Factors predicting depression across multiple domains in a national longitudinal sample of Canadian youth.","volume":"43","author":"Bellamy","year":"2015","journal-title":"J. Abnorm. Child Psychol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1111\/jcpp.12560","article-title":"Parental death during childhood and depression in young adults \u2013 A national cohort study.","volume":"57","author":"Berg","year":"2016","journal-title":"J. Child Psychol. Psychiatry"},{"key":"B8","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/BF00181937","article-title":"The effects of chronic antidepressant treatment in an animal model of anxiety.","volume":"95","author":"Bodnoff","year":"1988","journal-title":"Psychopharmacology (Berl.)"},{"key":"B9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.psyneuen.2016.10.028","article-title":"Maternal care and affective behavior in female offspring: implication of the neurosteroid\/GABAergic system.","volume":"76","author":"Borrow","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.psyneuen.2014.01.004","article-title":"17\u03b2 Estradiol increases resilience and improves hippocampal synaptic function in helpless ovariectomized rats.","volume":"42","author":"Bredemann","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1080\/10253890.2018.1456525","article-title":"Association of 24 h maternal deprivation with a saline injection in the neonatal period alters adult stress response and brain monoamines in a sex-dependent fashion.","author":"Cabbia","year":"2018","journal-title":"Stress"},{"key":"B12","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/S0169-328X(98)00137-5","article-title":"Alterations in neuropeptide Y and Y1 receptor mRNA expression in brains from an animal model of depression: region specific adaptation after fluoxetine treatment.","volume":"59","author":"Caberlotto","year":"1998","journal-title":"Brain Res. Mol. Brain Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0304-3940(99)00234-7","article-title":"Alterations in neuropeptide Y levels and Y1 binding sites in the flinders sensitive line rats, a genetic animal model of depression.","volume":"265","author":"Caberlotto","year":"1999","journal-title":"Neurosci. Lett."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/S0006-3223(00)01084-2","article-title":"Variations in maternal care in infancy regulate the development of stress reactivity.","volume":"48","author":"Caldji","year":"","journal-title":"Biol. Psychiatry"},{"key":"B15","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S0893-133X(99)00110-4","article-title":"The effects of early rearing environment on the development of GABAA and central benzodiazepine receptor levels and novelty-induced fearfulness in the rat.","volume":"22","author":"Caldji","year":"","journal-title":"Neuropsychopharmacology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"5335","DOI":"10.1073\/pnas.95.9.5335","article-title":"Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat.","volume":"95","author":"Caldji","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B17","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1126\/science.1083968","article-title":"Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.","volume":"301","author":"Caspi","year":"2003","journal-title":"Science"},{"key":"B18","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/S0031-9384(03)00149-5","article-title":"Variations in maternal care in the rat as a mediating influence for the effects of environment on development.","volume":"79","author":"Champagne","year":"2003","journal-title":"Physiol. Behav."},{"key":"B19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3758\/BF03327174","article-title":"Maternal factors regulate stress responsiveness in the neonatal rat.","volume":"20","author":"Cirulli","year":"1992","journal-title":"Psychobiology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/npp.2011.230","article-title":"The neuropeptide Y (NPY)-ergic system is associated with behavioral resilience to stress exposure in an animal model of post-traumatic stress disorder.","volume":"37","author":"Cohen","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/S0006-3223(02)01909-1","article-title":"The relevance of differential response to trauma in an animal model of posttraumatic stress disorder.","volume":"53","author":"Cohen","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"B22","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0014-2999(01)01628-4","article-title":"Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test.","volume":"436","author":"Cryan","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00213-005-0093-5","article-title":"Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment.","volume":"182","author":"Cryan","year":"","journal-title":"Psychopharmacology (Berl.)"},{"key":"B24","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.neubiorev.2005.03.008","article-title":"Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test.","volume":"29","author":"Cryan","year":"","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6503162","article-title":"Coping with the forced swim stressor: towards understanding an adaptive mechanism.","volume":"2016","author":"de Kloet","year":"2016","journal-title":"Neural Plast."},{"key":"B26","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/BF02245592","article-title":"Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants.","volume":"121","author":"Detke","year":"1995","journal-title":"Psychopharmacology (Berl.)"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1111\/j.1530-0277.1998.tb03979.x","article-title":"Neuropeptide Y levels in ethanol-naive alcohol-preferring and nonpreferring rats and in Wistar rats after ethanol exposure.","volume":"22","author":"Ehlers","year":"1998","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0920-9964(97)00149-7","article-title":"The effects of an early stressful life event on sensorimotor gating in adult rats.","volume":"30","author":"Ellenbroek","year":"1998","journal-title":"Schizophr. Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.neubiorev.2009.09.002","article-title":"Disruptions of the mother-infant relationship and stress-related behaviours: altered corticosterone secretion does not explain everything.","volume":"34","author":"Faturi","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00319","article-title":"Neonatal stress-induced affective changes in adolescent Wistar rats: early signs of schizophrenia-like behavior.","volume":"8","author":"Girardi","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.beproc.2004.03.018","article-title":"Influence of the estrous cycle on the behavior of rats in the elevated T-maze.","volume":"67","author":"Gouveia","year":"2004","journal-title":"Behav. Processes."},{"key":"B32","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.brainres.2009.02.033","article-title":"Neuropeptide Y modulates the antidepressant activity of imipramine in olfactory bulbectomized rats: involvement of NPY Y1 receptors.","volume":"1266","author":"Goyal","year":"2009","journal-title":"Brain Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/0018-506X(74)90014-2","article-title":"Behavior of lactating rats in a dual-chambered maternity cage.","volume":"5","author":"Grota","year":"1974","journal-title":"Horm. Behav."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/imhj.10052","article-title":"Brain and behavior interface: stress and the developing brain.","volume":"24","author":"Gunnar","year":"2003","journal-title":"Infant Mental Health J."},{"key":"B35","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.npep.2004.05.002","article-title":"The NPY system in stress, anxiety and depression.","volume":"38","author":"Heilig","year":"2004","journal-title":"Neuropeptides"},{"key":"B36","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1007\/BF00441953","article-title":"Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models.","volume":"98","author":"Heilig","year":"1989","journal-title":"Psychopharmacology (Berl.)"},{"key":"B37","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/0014-2999(88)90182-3","article-title":"Antidepressant drugs increase the concentration of neuropeptide Y (NPY)-like immunoreactivity in the rat brain.","volume":"147","author":"Heilig","year":"1988","journal-title":"Eur. J. Pharmacol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0022-3956(03)00101-8","article-title":"Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism.","volume":"38","author":"Heilig","year":"2004","journal-title":"J. Psychiatr. Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.neuroimage.2014.10.020","article-title":"Duration of early adversity and structural brain development in post-institutionalized adolescents.","volume":"105","author":"Hodel","year":"2015","journal-title":"Neuroimage"},{"key":"B40","doi-asserted-by":"publisher","first-page":"192","DOI":"10.2307\/1166146","article-title":"Hidden regulators in attachment, separation, and loss.","volume":"59","author":"Hofer","year":"1994","journal-title":"Monogr. Soc. Res. Child Dev."},{"key":"B41","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1007\/s002130100701","article-title":"Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment.","volume":"158","author":"Huot","year":"2001","journal-title":"Psychopharmacology (Berl.)"},{"key":"B42","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/S0893-133X(02)00363-9","article-title":"Early life stress changes concentrations of neuropeptide Y and corticotropin-releasing hormone in adult rat brain. Lithium treatment modifies these changes.","volume":"27","author":"Husum","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1016\/S0028-3908(00)00009-5","article-title":"Involvement of hippocampal neuropeptide Y in mediating the chronic actions of lithium, electroconvulsive stimulation and citalopram.","volume":"39","author":"Husum","year":"2000","journal-title":"Neuropharmacology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/S0028-3908(02)00038-2","article-title":"Early maternal deprivation alters hippocampal levels of neuropeptide Y and calcitonin-gene related peptide in adult rats.","volume":"42","author":"Husum","year":"2002","journal-title":"Neuropharmacology"},{"key":"B45","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.psyneuen.2016.09.013","article-title":"17\u03b2-Estradiol augments antidepressant efficacy of escitalopram in ovariectomized rats: neuroprotective and serotonin reuptake transporter modulatory effects.","volume":"74","author":"Ibrahim","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"B46","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1210\/en.2010-0658","article-title":"Stress vulnerability during adolescent development in rats.","volume":"152","author":"Jankord","year":"2011","journal-title":"Endocrinology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.euroneuro.2006.06.011","article-title":"Electroconvulsive stimuli selectively affect behavior and neuropeptide Y (NPY) and NPY Y(1) receptor gene expressions in hippocampus and hypothalamus of Flinders Sensitive Line rat model of depression.","volume":"17","author":"Jim\u00e9nez-Vasquez","year":"2007","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0165-3806(01)00264-4","article-title":"Early maternal separation alters neuropeptide Y concentrations in selected brain regions in adult rats.","volume":"131","author":"Jim\u00e9nez-Vasquez","year":"2001","journal-title":"Brain Res. Dev. Brain Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/0269881110367448","article-title":"The role of central noradrenergic dysregulation in anxiety disorders: evidence from clinical studies.","volume":"25","author":"Kalk","year":"2011","journal-title":"J. Psychopharmacol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1111\/j.1460-9568.2008.06306.x","article-title":"Behavioural profile of a new mouse model for NPY deficiency.","volume":"28","author":"Karl","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.npep.2013.10.014","article-title":"Role of neuropeptides in anxiety, stress, and depression: from animals to humans.","volume":"47","author":"Kormos","year":"2013","journal-title":"Neuropeptides"},{"key":"B52","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1126\/science.156.3772.258","article-title":"Maternal and environmental influences on the adrenocortical response to stress in weanling rats.","volume":"156","author":"Levine","year":"1967","journal-title":"Science"},{"key":"B53","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1002\/dev.420240803","article-title":"Time course of the effect of maternal deprivation on the hypothalamic-pituitary-adrenal axis in the infant rat.","volume":"24","author":"Levine","year":"1991","journal-title":"Dev. Psychobiol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1126\/science.277.5332.1659","article-title":"Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress.","volume":"277","author":"Liu","year":"1997","journal-title":"Science"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2014.00013","article-title":"Age- and sex-dependent effects of early life stress on hippocampal neurogenesis.","volume":"5","author":"Loi","year":"2014","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1111\/jcpp.12208","article-title":"Risk-taking and sensation-seeking propensity in postinstitutionalized early adolescents.","volume":"55","author":"Loman","year":"2014","journal-title":"J. Child Psychol. Psychiatry"},{"key":"B57","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1126\/science.290.5489.131","article-title":"Molecular and neuronal substrate for the selective attenuation of anxiety.","volume":"290","author":"L\u00f6w","year":"2000","journal-title":"Science"},{"key":"B58","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1097\/00008877-199711000-00010","article-title":"The forced swimming test as a model for core and component behavioral effects of antidepressant drugs.","volume":"8","author":"Lucki","year":"1997","journal-title":"Behav. Pharmacol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S0031-9384(01)00593-5","article-title":"Estrous cycle influences the response of female rats in the elevated plus-maze test.","volume":"74","author":"Marcondes","year":"2001","journal-title":"Physiol. Behav."},{"key":"B60","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/0031-9384(95)02069-1","article-title":"Repeated maternal separation of preweanling rats attenuates behavioral responses to primary and conditioned incentives in adulthood.","volume":"59","author":"Matthews","year":"1996","journal-title":"Physiol. Behav."},{"key":"B61","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1080\/15622970701561383","article-title":"Gender-related qualitative differences in baseline and post-stress anxiety responses are not reflected in the incidence of criterion-based PTSD-like behaviour patterns.","volume":"10","author":"Mazor","year":"2009","journal-title":"World J Biol Psychiatry"},{"key":"B62","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1159\/000125287","article-title":"Neonatal handling alters adrenocortical negative feedback sensitivity and hippocampal type II glucocorticoid receptor binding in the rat.","volume":"50","author":"Meaney","year":"1989","journal-title":"Neuroendocrinology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.neuroscience.2004.08.009","article-title":"Variations of maternal care differentially influence \u2018fear\u2019 reactivity and regional patterns of cFos immunoreactivity in response to the shock-probe burying test.","volume":"129","author":"Menard","year":"2004","journal-title":"Neuroscience"},{"key":"B64","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1159\/000054862","article-title":"Diazepam increases the number of punished responses in a conflict-operant paradigm during late proestrus and estrus in the Wistar rat.","volume":"43","author":"Molina-Hern\u00e1ndez","year":"2001","journal-title":"Neuropsychobiology"},{"key":"B65","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.1016\/j.peptides.2006.05.017","article-title":"Estrus variation in anxiolytic-like effects of intra-lateral septal infusions of the neuropeptide Y in Wistar rats in two animal models of anxiety-like behavior.","volume":"27","author":"Molina-Hern\u00e1ndez","year":"2006","journal-title":"Peptides"},{"key":"B66","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1037\/h0077599","article-title":"Mother rats interact differently with male and female offspring.","volume":"93","author":"Moore","year":"1979","journal-title":"J. Comp. Physiol. Psychol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1017\/S1461145705005158","article-title":"Neuropeptide Y and corticotropin-releasing hormone in CSF mark response to antidepressive treatment with citalopram.","volume":"8","author":"Nikisch","year":"2005","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003675","article-title":"Opposite effects of early maternal deprivation on neurogenesis in male versus female rats.","volume":"4","author":"Oomen","year":"2009","journal-title":"PLoS One"},{"key":"B69","doi-asserted-by":"publisher","first-page":"6635","DOI":"10.1523\/JNEUROSCI.0247-10.2010","article-title":"Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthood.","volume":"30","author":"Oomen","year":"2010","journal-title":"J. Neurosci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1055\/s-0035-1565241","article-title":"The effects of antidepressants on neuropeptide Y in patients with depression and anxiety.","volume":"49","author":"Ozsoy","year":"2016","journal-title":"Pharmacopsychiatry"},{"key":"B71","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1177\/070674370605100204","article-title":"Descriptive epidemiology of major depression in Canada.","volume":"51","author":"Patten","year":"2006","journal-title":"Can. J. Psychiatry"},{"key":"B72","volume":"237","author":"Paxinos","year":"1998","journal-title":"The Rat Brain in Stereotaxic Coordinates"},{"key":"B73","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","article-title":"Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat.","volume":"14","author":"Pellow","year":"1985","journal-title":"J. Neurosci. Methods"},{"key":"B74","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0193-953X(05)70006-X","article-title":"Psychoneuroendocrinology of depression. Hypothalamic-pituitary-adrenal axis.","volume":"21","author":"Plotsky","year":"1998","journal-title":"Psychiatr. Clin. N. Am."},{"key":"B75","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants.","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch Int. Pharmacodyn. Ther."},{"key":"B76","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/mp.2017.36","article-title":"Identifying fast-onset antidepressants using rodent models.","volume":"22","author":"Ramaker","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"B77","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.bbr.2017.04.016","article-title":"Ovarian hormones modify anxiety behavior and glucocorticoid receptors after chronic social isolation stress.","volume":"328","author":"Ramos-Ortolaza","year":"2017","journal-title":"Behav. Brain Res."},{"key":"B78","first-page":"304","article-title":"\u201cMaternal behavior,\u201d in","author":"Rees","year":"2005","journal-title":"The Behavior of the Laboratory Rat: A Handbook With Tests"},{"key":"B79","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.neulet.2010.04.054","article-title":"Long-term consequences of early maternal deprivation in serotonergic activity and HPA function in adult rat.","volume":"480","author":"Rentesi","year":"2010","journal-title":"Neurosci. Lett."},{"key":"B80","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.bbr.2013.01.040","article-title":"Early maternal deprivation-induced modifications in the neurobiological, neurochemical and behavioral profile of adult rats.","volume":"244","author":"Rentesi","year":"2013","journal-title":"Behav. Brain Res."},{"key":"B81","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/1520-6394(2000)12:1+<2::AID-DA2>3.0.CO;2-4","article-title":"Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders.","volume":"1","author":"Ressler","year":"2000","journal-title":"Depress. Anxiety"},{"key":"B82","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/dev.420260504","article-title":"Maternal regulation of adrenocortical activity in the infant rat: effects of feeding.","volume":"26","author":"Rosenfeld","year":"1993","journal-title":"Dev. Psychobiol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/S0149-7634(05)80196-4","article-title":"Multifactorial regulation of the hypothalamic-pituitary-adrenal axis during development.","volume":"16","author":"Rosenfeld","year":"1992","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B84","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.psyneuen.2013.10.017","article-title":"Cerebrospinal fluid neuropeptide Y in combat veterans with and without posttraumatic stress disorder.","volume":"40","author":"Sah","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"B85","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.biopsych.2009.04.037","article-title":"Low cerebrospinal fluid neuropeptide Y concentrations in posttraumatic stress disorder.","volume":"66","author":"Sah","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"B86","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s00213-004-2015-3","article-title":"Neuropeptide expression in rats exposed to chronic mild stresses.","volume":"178","author":"Sergeyev","year":"2005","journal-title":"Psychopharmacology (Berl.)"},{"key":"B87","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.euroneuro.2013.11.007","article-title":"Intranasal neuropeptide Y reverses anxiety and depressive-like behavior impaired by single prolonged stress PTSD model.","volume":"24","author":"Serova","year":"2014","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.neuroscience.2013.01.040","article-title":"Single intranasal neuropeptide Y infusion attenuates development of PTSD-like symptoms to traumatic stress in rats.","volume":"236","author":"Serova","year":"2013","journal-title":"Neuroscience"},{"key":"B89","doi-asserted-by":"publisher","first-page":"R1332","DOI":"10.1152\/ajpregu.1997.273.4.R1332","article-title":"Long-term effects of maternal deprivation on the corticosterone response to stress in rats.","volume":"273","author":"Suchecki","year":"1997","journal-title":"Am. J. Physiol. Regul. Integr. Compar. Physiol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0166-4328(00)00148-0","article-title":"Pituitary-adrenal axis and behavioural responses of maternally deprived juvenile rats to the open field.","volume":"111","author":"Suchecki","year":"2000","journal-title":"Behav. Brain Res."},{"key":"B91","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0165-3806(93)90022-3","article-title":"Maternal regulation of the hypothalamic-pituitary-adrenal axis in the infant rat: the roles of feeding and stroking.","volume":"75","author":"Suchecki","year":"1993","journal-title":"Brain Res. Dev. Brain Res."},{"key":"B92","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s10571-011-9774-2","article-title":"Relevance of stress and female sex hormones for emotion and cognition.","volume":"32","author":"ter Horst","year":"2012","journal-title":"Cell Mol. Neurobiol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00178","article-title":"Neuropeptide Y in alcohol addiction and affective disorders.","volume":"8","author":"Thorsell","year":"2017","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B94","doi-asserted-by":"publisher","first-page":"12852","DOI":"10.1073\/pnas.220232997","article-title":"Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression.","volume":"97","author":"Thorsell","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1093\/brain\/awm033","article-title":"Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats.","volume":"130","author":"Thorsell","year":"2007","journal-title":"Brain"},{"key":"B96","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3922\/j.psns.2011.2.008","article-title":"Early life stress, HPA axis, and depression.","volume":"4","author":"Tofoli","year":"2011","journal-title":"Psychol.Neurosci."},{"key":"B97","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/j.1467-7687.2009.00852.x","article-title":"Prolonged institutional rearing is associated with atypically large amygdala volume and difficulties in emotion regulation.","volume":"13","author":"Tottenham","year":"2010","journal-title":"Dev. Sci."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/j.biopsych.2008.01.011","article-title":"Childhood parental loss and adult hypothalamic-pituitary-adrenal function.","volume":"63","author":"Tyrka","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"B99","doi-asserted-by":"publisher","first-page":"10171","DOI":"10.1523\/JNEUROSCI.18-23-10171.1998","article-title":"Maternal deprivation effect on the infant\u2019s neural stress markers is reversed by tactile stimulation and feeding but not by suppressing corticosterone.","volume":"18","author":"van Oers","year":"1998","journal-title":"J. Neurosci."},{"key":"B100","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.physbeh.2009.11.002","article-title":"Circadian phase and sex effects on depressive\/anxiety-like behaviors and HPA axis responses to acute stress.","volume":"99","author":"Verma","year":"2010","journal-title":"Physiol. Behav."},{"key":"B101","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1097\/FBP.0b013e32833a5cb0","article-title":"Raloxifene and\/or estradiol decrease anxiety-like and depressive-like behavior, whereas only estradiol increases carcinogen-induced tumorigenesis and uterine proliferation among ovariectomized rats.","volume":"21","author":"Walf","year":"2010","journal-title":"Behav. Pharmacol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0165-0173(81)90005-9","article-title":"Behavioral depression produced by an uncontrollable stressor: relationship to norepinephrine, dopamine, and serotonin levels in various regions of rat brain.","volume":"3","author":"Weiss","year":"1981","journal-title":"Brain Res. Rev."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1002\/dev.21440","article-title":"Maternal deprivation alters growth, food intake, and neuropeptide Y in the hypothalamus of adolescent male and female rats.","volume":"58","author":"Wertheimer","year":"2016","journal-title":"Dev. Psychobiol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0924-977X(98)00026-1","article-title":"Alterations of corticotropin releasing hormone (CRH) and neuropeptide Y (NPY) plasma levels in mood disorder patients with a recent suicide attempt.","volume":"9","author":"Westrin","year":"1999","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B105","year":"2018","journal-title":"World Health Organization \u2013 Depression."},{"key":"B106","doi-asserted-by":"publisher","first-page":"E525","DOI":"10.1152\/ajpendo.1988.255.4.E525","article-title":"Pituitary-adrenal response to bacterial endotoxin in developing rats.","volume":"255","author":"Witek-Janusek","year":"1988","journal-title":"Am. J. Physiol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1517\/14728222.2011.628314","article-title":"Central functions of neuropeptide Y in mood and anxiety disorders.","volume":"15","author":"Wu","year":"2011","journal-title":"Exp. Opin. Ther. Targets"}],"container-title":["Frontiers in Behavioral Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnbeh.2018.00159\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T20:52:51Z","timestamp":1661719971000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnbeh.2018.00159\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,7]]},"references-count":107,"alternative-id":["10.3389\/fnbeh.2018.00159"],"URL":"https:\/\/doi.org\/10.3389\/fnbeh.2018.00159","relation":{},"ISSN":["1662-5153"],"issn-type":[{"value":"1662-5153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,7]]},"article-number":"159"}}