{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:13:48Z","timestamp":1773296028671,"version":"3.50.1"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:00:00Z","timestamp":1555372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/07125-6, 2015\/00658-1"],"award-info":[{"award-number":["2014\/07125-6, 2015\/00658-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"DOI":"10.3389\/fnbeh.2019.00073","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T05:31:28Z","timestamp":1555392688000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Paradoxical Effect of LTB4 on the Regulation of Stress-Induced Corticosterone Production"],"prefix":"10.3389","volume":"13","author":[{"given":"Gisele A.","family":"Locachevic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgana K. B.","family":"Prado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina F.","family":"Zoccal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla A. T.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Sorgi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariza","family":"Bortolanza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula F.","family":"Peti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoela V.","family":"Foga\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco S.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Del Bel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00facia H.","family":"Faccioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,4,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S157","DOI":"10.1007\/bf02637069","article-title":"Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression","volume":"31","author":"Adams","year":"1996","journal-title":"Lipids"},{"key":"B3","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.phrs.2017.04.028","article-title":"Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in major depressive disorder","volume":"121","author":"Alcocer-G\u00f3mez","year":"2017","journal-title":"Pharmacol. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.bbi.2013.10.017","article-title":"NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder","volume":"36","author":"Alcocer-G\u00f3mez","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"B4","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.neuroscience.2009.03.004","article-title":"Blocking central leukotriene synthesis affects vasopressin release during sepsis","volume":"160","author":"Athayde","year":"2009","journal-title":"Neuroscience"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1172\/JCI23949","article-title":"Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production","volume":"115","author":"Bafica","year":"2005","journal-title":"J. Clin. Invest."},{"key":"B6","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.biopsych.2012.09.021","article-title":"Inflammatory T helper 17 cells promote depression like behavior in mice","volume":"73","author":"Beurel","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"B7","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/372179a0","article-title":"Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene","volume":"372","author":"Chen","year":"1994","journal-title":"Nature"},{"key":"B8","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.jsgi.2005.02.003","article-title":"Effect of pro-inflammatory cytokines on expression and activity of 11\u03b2-hydroxysteroid dehydrogenase type 2 in cultured human term placental trophoblast and human choriocarcinoma JEG-3 cells","volume":"12","author":"Chisaka","year":"2005","journal-title":"J. Soc. Gynecol. Investig."},{"key":"B9","doi-asserted-by":"publisher","first-page":"174657","DOI":"10.1155\/2009\/174657","article-title":"The 5-lipoxygenase as a common pathway for pathological brain and vascular aging","volume":"2009","author":"Chu","year":"2009","journal-title":"Cardiovasc. Psychiatry Neurol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"5995","DOI":"10.1073\/pnas.1118355109","article-title":"Chronic stress, glucocorticoid receptor resistance, inflammation and disease risk","volume":"109","author":"Cohen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B11","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1006\/brbi.2000.0613","article-title":"Cytokine-induced sickness behavior: where do we stand?","volume":"15","author":"Dantzer","year":"2001","journal-title":"Brain Behav. Immun."},{"key":"B12","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"ra10","DOI":"10.1126\/scisignal.2005568","article-title":"Leukotriene B4-mediated sterile inflammation favors susceptibility to sepsis in murine type 1 diabetes","volume":"8","author":"Filgueiras","year":"2015","journal-title":"Sci. Signal."},{"key":"B14","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1084\/jem.184.2.717","article-title":"Functional role of interleukin 1\u03b2 (IL-1\u03b2) in IL-l\u03b2-converting enzyme-mediated apoptosis","volume":"184","author":"Friedlander","year":"1996","journal-title":"J. Exp. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1126\/science.294.5548.1871","article-title":"Prostaglandins and leukotrienes: advances in eicosanoid biology","volume":"294","author":"Funk","year":"2001","journal-title":"Science"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3613","DOI":"10.1007\/s00216-016-9445-8","article-title":"Plasma eicosanoid profiles determined by high-performance liquid chromatography coupled with tandem mass spectrometry in stimulated peripheral blood from healthy individuals and sickle cell anemia patients in treatment","volume":"408","author":"Galv\u00e3o","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/s0959-4388(99)00061-6","article-title":"The broken mouse: the role of development, plasticity and environment in the interpretation of phenotypic changes in knockout mice","volume":"10","author":"Gingrich","year":"2000","journal-title":"Curr. Opin. Neurobiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.yfrne.2008.10.001","article-title":"Interleukin-1 (IL-1): a central regulator of stress responses","volume":"30","author":"Goshen","year":"2009","journal-title":"Front. Neuroendocrinol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.pbb.2014.07.002","article-title":"Effects of aspirin on immobile behavior and endocrine and immune changes in the forced swimming test: comparison to fluoxetine and imipramine","volume":"124","author":"Guan","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B20","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.ejphar.2009.03.076","article-title":"Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain","volume":"612","author":"Guo","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"5866","DOI":"10.1021\/cr200246d","article-title":"Lipoxygenase and leukotriene pathways: biochemistry, biology and roles in disease","volume":"111","author":"Haeggstr\u00f6m","year":"2011","journal-title":"Chem. Rev."},{"key":"B22","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.molmed.2008.08.005","article-title":"Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology","volume":"14","author":"Harizi","year":"2008","journal-title":"Trends Mol. Med."},{"key":"B62","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jpsychires.2015.08.007","article-title":"The relationship between cortisol, stress and psychiatric illness: new insights using hair analysis","volume":"70","author":"Herane Vives","year":"2015","journal-title":"J. Psychiatr. Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/0090-6980(85)90005-x","article-title":"Involvement of 5-lipoxygenase metabolites in ACTH-stimulated corticosteroidogenesis in rat adrenal glands","volume":"30","author":"Hirai","year":"1985","journal-title":"Prostaglandins"},{"key":"B24","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.bbi.2007.01.010","article-title":"Depressive disorders and immunity: 20 years of progress and discovery","volume":"21","author":"Irwin","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"283","DOI":"10.5498\/wjp.v6.i3.283","article-title":"Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness?","volume":"6","author":"Jeon","year":"2016","journal-title":"World J. Psychiatry"},{"key":"B26","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.tips.2015.01.005","article-title":"The 12\/15-lipoxygenase as an emerging therapeutic target for Alzheimer\u2019s disease","volume":"36","author":"Joshi","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.jpsychires.2012.12.011","article-title":"The involvement of 5-lipoxygenase activating protein in anxiety-like behavior","volume":"47","author":"Joshi","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1210\/jc.2002-021378","article-title":"Placental 11\u03b2-hydroxysteroid dehydrogenase-2 and fetal cortisol\/cortisone shuttle in small preterm infants","volume":"88","author":"Kajantie","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B29","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1176\/ajp.152.6.833","article-title":"Stressful life events, genetic liability, and onset of an episode of major depression in women","volume":"152","author":"Kendler","year":"1995","journal-title":"Am. J. Psychiatry"},{"key":"B30","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0960-0760(99)00074-6","article-title":"The type I and type II 11\u03b2-hydroxysteroid dehydrogenase enzymes","volume":"69","author":"Krozowski","year":"1999","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"786319","DOI":"10.1155\/2015\/786319","article-title":"Erythropoietin exacerbates inflammation and increases the mortality of histoplasma capsulatum-infected mice","volume":"2015","author":"Locachevic","year":"2015","journal-title":"Mediators Inflamm."},{"key":"B32","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1006\/cyto.1997.0238","article-title":"Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression","volume":"9","author":"Maes","year":"1997","journal-title":"Cytokine"},{"key":"B33","doi-asserted-by":"publisher","first-page":"8544","DOI":"10.4049\/jimmunol.181.12.8544","article-title":"Leukotrienes are potent adjuvant during fungal infection: effects on memory T cells","volume":"181","author":"Medeiros","year":"2008","journal-title":"J. Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: from evolutionary imperative to modern treatment target","volume":"16","author":"Miller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/sj.mp.4001805","article-title":"The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine","volume":"11","author":"M\u00fcller","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"B36","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/ng.3283","article-title":"NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells","volume":"47","author":"Paugh","year":"2015","journal-title":"Nat. Genet."},{"key":"B37","doi-asserted-by":"publisher","first-page":"950981","DOI":"10.1155\/2013\/950981","article-title":"Celecoxib improves host defense through prostaglandin inhibition during Histoplasma capsulatum infection","volume":"2013","author":"Pereira","year":"2013","journal-title":"Mediators Inflamm."},{"key":"B38","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.micinf.2007.01.006","article-title":"Inhibition of leukotriene biosynthesis abrogates the host control of Mycobacterium tuberculosis","volume":"9","author":"Peres","year":"2007","journal-title":"Microbes Infect."},{"key":"B39","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1002\/jms.3998","article-title":"High-resolution multiple reaction monitoring method for quantification of steroidal hormones in plasma","volume":"53","author":"Peti","year":"2018","journal-title":"J. Mass Spectrom."},{"key":"B40","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0031-9384(88)90097-2","article-title":"Plasma corticosterone levels during repeated presentation of two intensities of restraint stress: chronic stress and habituation","volume":"43","author":"Pitman","year":"1988","journal-title":"Physiol. Behav."},{"key":"B41","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.bbr.2004.04.008","article-title":"Strain differences in sucrose preference and in the consequences of unpredictable chronic mild stress","volume":"155","author":"Pothion","year":"2004","journal-title":"Behav. Brain Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"17658","DOI":"10.1038\/s41598-017-17993-9","article-title":"Leukotriene B4 is essential for lung host defence and alpha-defensin-1 production during Achromobacter xylosoxidans infection","volume":"7","author":"Prado","year":"2017","journal-title":"Sci. Rep."},{"key":"B43","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.bbalip.2014.08.012","article-title":"5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease","volume":"1851","author":"R\u00e5dmark","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"B44","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.it.2005.11.006","article-title":"Cytokines sing the blues: inflammation and the pathogenesis of depression","volume":"27","author":"Raison","year":"2006","journal-title":"Trends Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/s1074-5521(97)90258-1","article-title":"A combinatorial approach for determining protease specificities: application to interleukin-1\u03b2 converting enzyme (ICE)","volume":"4","author":"Rano","year":"1997","journal-title":"Chem. Biol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.steroids.2016.09.010","article-title":"Glucocorticoid resistance in chronic diseases","volume":"115","author":"Rodriguez","year":"2016","journal-title":"Steroids"},{"key":"B47","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1164\/ajrccm.161.supplement_1.ltta-1","article-title":"The discovery of the leukotrienes","volume":"161","author":"Samuelsson","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1095\/biolreprod.107.064717","article-title":"Effect of the interaction between lipoxygenase pathway and progesterone on the regulation of hydroxysteroid 11-beta dehydrogenase 2 in cultured human term placental trophoblasts","volume":"78","author":"Sato","year":"2008","journal-title":"Biol. Reprod."},{"key":"B49","doi-asserted-by":"publisher","first-page":"e31701","DOI":"10.1371\/journal.pone.0031701","article-title":"5-lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection","volume":"7","author":"Secatto","year":"2012","journal-title":"PLoS One"},{"key":"B50","doi-asserted-by":"publisher","first-page":"e85083","DOI":"10.1371\/journal.pone.0085083","article-title":"The leukotriene B4\/BLT1 axis is a key determinant in susceptibility and resistance to histoplasmosis","volume":"9","author":"Secatto","year":"2014","journal-title":"PLoS One"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1182\/blood-2004-08-3323","article-title":"Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase","volume":"106","author":"Serezani","year":"2005","journal-title":"Blood"},{"key":"B52","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/0306-9877(91)90272-z","article-title":"The macrophage theory of depression","volume":"35","author":"Smith","year":"1991","journal-title":"Med. Hypotheses"},{"key":"B53","doi-asserted-by":"crossref","first-page":"383","DOI":"10.31887\/DCNS.2006.8.4\/ssmith","article-title":"The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress","volume":"8","author":"Smith","year":"2006","journal-title":"Dialogues Clin. Neurosci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1210\/jcem.80.3.7883847","article-title":"Type 2 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid and activity in human placenta and fetal membranes: its relationship to birth weight and putative role in fetal adrenal steroidogenesis","volume":"80","author":"Stewart","year":"1995","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B55","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease","volume":"481","author":"Strowig","year":"2012","journal-title":"Nature"},{"key":"B56","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1159\/000198167","article-title":"Biological mechanism of antidepressant effect of omega-3 fatty acids: how does fish oil act as a \u2018mind-body interface\u2019?","volume":"17","author":"Su","year":"2009","journal-title":"Neurosignals"},{"key":"B57","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1677\/joe.0.1630417","article-title":"Regulation of 11\u03b2-hydroxysteroid dehydrogenase type 1 gene expression by LH and interleukin-1\u03b2 in cultured rat granulosa cells","volume":"163","author":"Tetsuka","year":"1999","journal-title":"J. Endocrinol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.bbi.2012.07.013","article-title":"Restraint stress alters neutrophil and macrophage phenotypes during wound healing","volume":"28","author":"Tymen","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"B59","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.neulet.2008.03.041","article-title":"Effects of MK-886, a 5-lipoxygenase activating protein (FLAP) inhibitor and 5-lipoxygenase deficiency on the forced swimming behavior of mice","volume":"436","author":"Uz","year":"2008","journal-title":"Neurosci. Lett."},{"key":"B60","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1046\/j.1471-4159.1999.0730693.x","article-title":"Glucocorticoids stimulate inflammatory 5-lipoxygenase gene expression and protein translocation in the brain","volume":"73","author":"Uz","year":"1999","journal-title":"J. Neurochem."},{"key":"B61","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1002\/jlb.67.6.801","article-title":"Dexamethasone promotes phagocytosis and bacterial killing by human monocytes\/macrophages in vitro","volume":"67","author":"van der Goes","year":"2000","journal-title":"J. Leukoc. Biol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s002130050456","article-title":"Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation","volume":"134","author":"Willner","year":"1997","journal-title":"Psychopharmacology"},{"key":"B64","unstructured":"Depression2017"},{"key":"B65","first-page":"96","article-title":"Effects of antidepressants on serum corticosterone level and swimming time in forced swimming rats: application to screening test of antidepressants","volume":"12","author":"Yamada","year":"1987","journal-title":"Res. Comm. Psychol. Psychiatr. Behav."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1007\/s00213-015-4136-2","article-title":"Knockdown of hippocampal cysteinyl leukotriene receptor 1 prevents depressive behavior and neuroinflammation induced by chronic mild stress in mice","volume":"233","author":"Yu","year":"2016","journal-title":"Psychopharmacology"},{"key":"B67","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.autrev.2010.11.009","article-title":"The kaleidoscope of glucocorticoid effects on immune system","volume":"10","author":"Zen","year":"2011","journal-title":"Autoimmun. Rev."},{"key":"B68","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/1465-9921-11-39","article-title":"Intracerebroventricular injection of leukotriene B4 attenuates antigen-induced asthmatic response via BLT1 receptor stimulating HPA-axis in sensitized rats","volume":"11","author":"Zhang","year":"2010","journal-title":"Respir. Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"pyv006","DOI":"10.1093\/ijnp\/pyv006","article-title":"NLRP3 inflammasome mediates chronic mild stress-induced depression in mice via neuroinflammation","volume":"18","author":"Zhang","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1097\/psy.0b013e3181b05c57","article-title":"Sex-specific association of depression and a haplotype in leukotriene A4 hydrolase gene","volume":"71","author":"Zhao","year":"2009","journal-title":"Psychosom. Med."},{"key":"B71","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.toxicon.2018.06.066","article-title":"LTB4 and PGE2 modulate the release of MIP-1\u03b1 and IL-1\u03b2 by cells stimulated with Bothrops snake venoms","volume":"150","author":"Zoccal","year":"2018","journal-title":"Toxicon"},{"key":"B72","doi-asserted-by":"publisher","first-page":"10760","DOI":"10.1038\/ncomms10760","article-title":"Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality","volume":"7","author":"Zoccal","year":"2016","journal-title":"Nat. Commun."},{"key":"B73","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.pnpbp.2010.04.011","article-title":"Glucocorticoids, cytokines and brain abnormalities in depression","volume":"35","author":"Zunszain","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"}],"container-title":["Frontiers in Behavioral Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnbeh.2019.00073\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T13:07:54Z","timestamp":1607260074000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnbeh.2019.00073\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,16]]},"references-count":73,"alternative-id":["10.3389\/fnbeh.2019.00073"],"URL":"https:\/\/doi.org\/10.3389\/fnbeh.2019.00073","relation":{},"ISSN":["1662-5153"],"issn-type":[{"value":"1662-5153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,16]]},"article-number":"73"}}