{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:30:33Z","timestamp":1759617033552,"version":"3.41.2"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"DOI":"10.3389\/fnbeh.2019.00296","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T14:52:44Z","timestamp":1580741564000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Prepulse Inhibition of the Startle Reflex as a Predictor of Vulnerability to Develop Locomotor Sensitization to Cocaine"],"prefix":"10.3389","volume":"13","author":[{"given":"M. Carmen","family":"Arenas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Carmen","family":"Blanco-Gand\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Mi\u00f1arro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Manzanedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.neuroscience.2011.06.001","article-title":"Reduced locomotor responses to cocaine in gherlin-deficient mice","volume":"192","author":"Abizaid","year":"2011","journal-title":"Neuroscience"},{"key":"B2","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.neuropharm.2017.01.026","article-title":"Intermittent intake of rapid cocaine injections promotes robust psychomotor sensitization, increased incentive motivation for the drug and mGlu2\/3 receptor dysregulation","volume":"117","author":"Allain","year":"2017","journal-title":"Neuropharmacology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.bbr.2008.09.001","article-title":"Effects of rat sex differences and lighting on locomotor exploration of a circular open field with free-standing central corners and without peripheral walls","volume":"196","author":"Alstott","year":"2009","journal-title":"Behav. Brain Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"507","DOI":"10.33588\/rn.6511.2017298","article-title":"Effects of cocaine on prepulse inhibition of the startle response","volume":"65","author":"Arenas","year":"2017","journal-title":"Rev. Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.1007\/s00213-018-4959-8","article-title":"Baseline prepulse inhibition of the startle reflex predicts the sensitivity to the conditioned rewarding effects of cocaine in male and female mice","volume":"235","author":"Arenas","year":"2018","journal-title":"Psychopharmacology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"8798","DOI":"10.1523\/JNEUROSCI.0984-18.2018","article-title":"The role of cholinergic midbrain neurons in startle and prepulse inhibition","volume":"38","author":"Azzopardi","year":"2018","journal-title":"J. Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2217\/17520363.3.1.1","article-title":"Role of biomarkers and endophenotypes in prevention and treatment of psychopathological disorders","volume":"3","author":"Beauchaine","year":"2009","journal-title":"Biomark. Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.conb.2013.01.025","article-title":"Addiction: failure of control over maladaptive incentive habits","volume":"23","author":"Belin","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.neuropharm.2016.03.048","article-title":"Depletion of nucleus accumbens dopamine leads to impaired reward and aversion processing in mice: relevance to motivation pathologies","volume":"109","author":"Bergamini","year":"2016","journal-title":"Neuropharmacology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s00213-005-0056-x","article-title":"The effects of dopamine agonists on prepulse inhibition in healthy men depend on baseline PPI values","volume":"182","author":"Bitsios","year":"2005","journal-title":"Psychopharmacology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1007\/s00213-017-4630-9","article-title":"Changes in gene expression and sensitivity of cocaine reward produced by a continuous fat diet","volume":"234","author":"Blanco-Gand\u00eda","year":"2017","journal-title":"Psychopharmacology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/0031-9384(75)90188-2","article-title":"Sex differences in open-field behavior in the rat: the inductive and activational role of gonadal hormones","volume":"14","author":"Blizard","year":"1975","journal-title":"Physiol. Behav."},{"key":"B13","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.physbeh.2013.05.012","article-title":"Factors influencing behavior in the forced swim test","volume":"118","author":"Bogdanova","year":"2013","journal-title":"Physiol. Behav."},{"key":"B14","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/7854_2010_61","article-title":"Prepulse inhibition of the startle reflex: a window on the brain in schizophrenia","volume":"4","author":"Braff","year":"2010","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1124\/pr.115.011668","article-title":"Evaluation of the \u201cPipeline\u201d for development of medications for cocaine use disorder: a review of translational preclinical, human laboratory, and clinical trial research","volume":"68","author":"Czoty","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3565","DOI":"10.1046\/j.1460-9568.1998.00368.x","article-title":"Drug-induced reinstatement of heroin-and cocaine-seeking behaviour following long-term extinction is associated with expression of behavioural sensitization","volume":"10","author":"De Vries","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2648","DOI":"10.1038\/sj.npp.1301657","article-title":"Contributions of dopamine D1, D2, and D3 receptor subtypes to the disruptive effects of cocaine on prepulse inhibition in mice","volume":"33","author":"Doherty","year":"2008","journal-title":"Neuropsychopharmacology"},{"volume-title":"European Drug Report 2019: Trends and Developments, Publications Office of the European Union.","year":"2019","key":"B18"},{"key":"B20","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ejphar.2018.01.052","article-title":"Antagonism of corticotropin-releasing factor CRF1 receptors blocks the enhanced response to cocaine after social stress","volume":"823","author":"Ferrer-P\u00e9rez","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3389\/fnbeh.2019.00148","article-title":"Social housing conditions modulate the long-lasting increase in cocaine reward induced by intermittent social defeat","volume":"13","author":"Ferrer-P\u00e9rez","year":"2019","journal-title":"Front. Behav. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"168","DOI":"10.3109\/00952990.2013.772618","article-title":"Probability and predictors of transition from abuse to dependence on alcohol, cannabis, and cocaine: results from the national epidemiologic survey on alcohol and related conditions","volume":"39","author":"Fl\u00f3rez-Salamanca","year":"2013","journal-title":"Am. J. Drug Alcohol Abuse"},{"key":"B22","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.medcli.2013.11.023","article-title":"Diez a\u00f1os de asistencias urgentes a consumidores de coca\u00edna en Espa\u00f1a","volume":"143","author":"Galicia","year":"2014","journal-title":"Med. Clin."},{"key":"B23","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.bbr.2018.12.025","article-title":"Role of N-methyl-D-aspartate receptors in the long-term effects of repeated social defeat stress on the rewarding and psychomotor properties of cocaine in mice","volume":"361","author":"Garc\u00eda-Pardo","year":"2019","journal-title":"Behav. Brain Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"555","DOI":"10.4321\/S0211-57352015000300008","article-title":"Cocaine: a review of addiction and treatment","volume":"35","author":"Gonz\u00e1lez-Llona","year":"2015","journal-title":"Rev. Asoc. Esp. Neuropsiq."},{"key":"B25","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1176\/appi.ajp.160.4.636","article-title":"The endophenotype concept in psychiatry: etymology and strategic intentions","volume":"160","author":"Gottesman","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e0167483","DOI":"10.1371\/journal.pone.0167483","article-title":"Maternal separation impairs cocaine-induced behavioural sensitization in adolescent mice","volume":"11","author":"Gracia-Rubio","year":"2016","journal-title":"PLoS One"},{"key":"B27","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.psc.2010.01.004","article-title":"Substance abuse in women","volume":"33","author":"Greenfield","year":"2010","journal-title":"Psychiatr. Clin. North Am."},{"key":"B28","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1001\/archpsyc.1989.01810020024005","article-title":"A comparison of male and female cocaine abusers","volume":"46","author":"Griffin","year":"1989","journal-title":"Arch. Gen. Psychiatry"},{"key":"B29","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1002\/mds.26556","article-title":"The pedunculopontine tegmental nucleus: a functional hypothesis from the comparative literature","volume":"31","author":"Gut","year":"2016","journal-title":"Mov. Disord."},{"key":"B30","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1111\/j.1601-183x.2006.00270.x","article-title":"Hypolocomotion, anxiety and serotoninsyndrome-like behavior contribute to the complex phenotype ofserotonin transporter knockout mice","volume":"6","author":"Kalueff","year":"2007","journal-title":"Genes Brain Behav."},{"key":"B31","doi-asserted-by":"publisher","first-page":"388","DOI":"10.15585\/mmwr.mm6817a3","article-title":"Drug overdose deaths involving cocaine and psychostimulants with abuse potential\u2014United States, 2003\u20132017","volume":"68","author":"Kariisa","year":"2019","journal-title":"Morb. Mortal Wkly. Rep."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1007\/s00213-019-5164-0","article-title":"The transition to cocaine addiction: the importance of pharmacokinetics for preclinical models","volume":"236","author":"Kawa","year":"2019","journal-title":"Psychopharmacology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0740-5472(93)90100-g","article-title":"Gender differences in cocaine use and treatment response","volume":"10","author":"Kosten","year":"1993","journal-title":"J. Subst. Abus. Treat."},{"key":"B34","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.cobeha.2016.11.011","article-title":"Altered dopamine transmission as a familial risk trait for addictions","volume":"13","author":"Leyton","year":"2017","journal-title":"Curr. Opin. Behav. Sci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/s0166-4328(99)00109-6","article-title":"Previous exposure to amphetamine increases incentive to obtain the drug: long-lasting effects revealed by the progressive ratio schedule","volume":"107","author":"Lorrain","year":"2000","journal-title":"Behav. Brain Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.neuropharm.2018.09.043","article-title":"Repeated cannabidiol treatment reduces cocaine intake and modulates neural proliferation and CB1R expression in the mouse hippocampus","volume":"143","author":"Luj\u00e1n","year":"2018","journal-title":"Neuropharmacology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.neuron.2011.01.017","article-title":"Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling","volume":"69","author":"L\u00fcscher","year":"2011","journal-title":"Neuron"},{"key":"B38","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s00213-014-3642-y","article-title":"Higher sensitivity to the conditioned rewarding effects of cocaine and MDMA in High-Novelty-Seekers mice exposed to a cocaine binge during adolescence","volume":"232","author":"Mateos-Garc\u00eda","year":"2015","journal-title":"Psychopharmacology"},{"key":"B39","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s00213-012-2819-5","article-title":"Baseline prepulse inhibition expression predicts the propensity of developing sensitization to the motor stimulant effects of amphetamine in C57BL\/6 mice","volume":"225","author":"Peleg-Raibstein","year":"2013","journal-title":"Psychopharmacology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.tips.2008.07.005","article-title":"Animal models of anxiety: do I need multiple tests?","volume":"29","author":"Ramos","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"B410","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0165-0173(93)90013-P","article-title":"The neural basis of drug craving: an incentive-sensitization theory of addiction","volume":"18","author":"Robinson","year":"1993","journal-title":"Brain Res. Rev."},{"key":"B41","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1146\/annurev.psych.54.101601.145237","article-title":"Addiction","volume":"54","author":"Robinson","year":"2003","journal-title":"Annu. Rev. Psychol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"3137","DOI":"10.1098\/rstb.2008.0093","article-title":"Review. The incentive sensitization theory of addiction: some current issues","volume":"363","author":"Robinson","year":"2008","journal-title":"Philos Trans. R. Soc. Lond. B. Biol. Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3389\/fnbeh.2016.00148","article-title":"The functional networks of prepulse inhibition: neuronal connectivity analysis based on FDG-PET in awake and unrestrained rats","volume":"10","author":"Rohleder","year":"2016","journal-title":"Front. Behav. Neurosci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1124\/pr.116.012484","article-title":"The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis","volume":"68","author":"Scofield","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"B45","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.euroneuro.2013.06.005","article-title":"Schizophrenia and dopamine receptors","volume":"23","author":"Seeman","year":"2013","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1034\/j.1601-183x.2002.10303.x","article-title":"Strain and sex differences in repeated ethanol treatment-induced motor activity in quasi-congenic mice","volume":"1","author":"Sershen","year":"2002","journal-title":"Genes Brain Behav."},{"key":"B47","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1615\/critrevneurobiol.v17.i2.20","article-title":"Cortical mechanisms of cocaine sensitization","volume":"17","author":"Steketee","year":"2005","journal-title":"Crit. Rev. Neurobiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1124\/pr.109.001933","article-title":"Drug wanting: behavioral sensitization and relapse to drug-seeking behavior","volume":"63","author":"Steketee","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1177\/0269881116661075","article-title":"Sensoriomotor gating of the startle reflex: what we said 25 years ago, what has happened since then, and what comes next","volume":"30","author":"Swerdlow","year":"2016","journal-title":"J. Psychopharmacol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/7854_2015_5012","article-title":"Animal models of deficient sensorimotor gating in schizophrenia: are they still relevant?","volume":"28","author":"Swerdlow","year":"2016","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/sj.npp.1300086","article-title":"Amphetamine effects on prepulse inhibition across-species: replication and parametric extension","volume":"28","author":"Swerdlow","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s00213-008-1446-7","article-title":"Amphetamine effects on startle gating in normal women and female rats","volume":"204","author":"Talledo","year":"2009","journal-title":"Psychopharmacology"},{"key":"B53","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.bbr.2004.09.002","article-title":"Age and gender differences in behavioral and morphological outcome after6-hydroxydopamine-induced lesion of the substantia nigra in rats","volume":"158","author":"Tam\u00e1s","year":"2005","journal-title":"Behav. Brain Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1176\/appi.ajp.2018.17101174","article-title":"Neuroscience of addiction: relevance to prevention and treatment","volume":"175","author":"Volkow","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"B56","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1056\/nejmra1511480","article-title":"Neurobiologic advances from the brain disease model of addiction","volume":"374","author":"Volkow","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.cell.2015.07.046","article-title":"The brain on drugs: from reward to addiction","volume":"162","author":"Volkow","year":"2015","journal-title":"Cell"},{"key":"B57","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1001\/archpsyc.63.9.999","article-title":"High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors","volume":"63","author":"Volkow","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"B58","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1176\/ajp.156.9.1440","article-title":"Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels","volume":"156","author":"Volkow","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"B59","doi-asserted-by":"publisher","first-page":"8.42.1","DOI":"10.1002\/cpns.41","article-title":"A guide to robust statistical methods in neuroscience","volume":"82","author":"Wilcox","year":"2018","journal-title":"Curr. Protoc. Neurosci."}],"container-title":["Frontiers in Behavioral Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnbeh.2019.00296\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T04:31:55Z","timestamp":1665721915000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnbeh.2019.00296\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,3]]},"references-count":60,"alternative-id":["10.3389\/fnbeh.2019.00296"],"URL":"https:\/\/doi.org\/10.3389\/fnbeh.2019.00296","relation":{},"ISSN":["1662-5153"],"issn-type":[{"type":"electronic","value":"1662-5153"}],"subject":[],"published":{"date-parts":[[2020,2,3]]},"article-number":"296"}}