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Consequently, they have the potential to aid in the treatment of psychological disorders. The impact of <jats:italic>Lactobacillus<\/jats:italic> supplementation on the stress responses triggering psychological disorders has not been systematically reviewed. Therefore, the aim of this meta-analysis is to summarize the body of research assessing the effects of <jats:italic>Lactobacillus<\/jats:italic>-based probiotics in rodents that underwent an experimental stress treatment or not. The duration of immobility in a Forced Swim Test (FST) was the outcome used to measure changes induced by various treatments. Four online databases were systematically searched for relevant studies published in English. Fourteen studies meeting the criteria were included in the meta-analysis. The effects of probiotic supplementation and stress treatment on the duration of immobility in the FST were analyzed using a generalized linear mixed model. Publication bias was evaluated by funnel plots. Our analysis shows that <jats:italic>Lactobacillus<\/jats:italic>-based probiotic supplements significantly reduce immobility in the FST (<jats:italic>P<\/jats:italic> &amp;lt; 0.001) in stressed rodents. However, probiotics did not affect the rodents that did not undergo the stress treatment (<jats:italic>P<\/jats:italic> = 0.168). These findings provide a better understanding of the potential of <jats:italic>Lactobacillus<\/jats:italic>-based probiotics for the management of stress-induced behavior.<\/jats:p>","DOI":"10.3389\/fnbeh.2021.642757","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T05:37:56Z","timestamp":1623821876000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":39,"title":["Lactobacillus-Based Probiotics Reduce the Adverse Effects of Stress in Rodents: A Meta-analysis"],"prefix":"10.3389","volume":"15","author":[{"given":"Claire","family":"Mindus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nienke","family":"van Staaveren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Harlander-Matauschek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1016\/j.psyneuen.2012.03.024","article-title":"Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats","volume":"37","author":"Ait-Belgnaoui","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"730","DOI":"10.3389\/fpsyt.2018.00730","article-title":"Bifidobacterium and Lactobacillus counts in the gut microbiota of patients with bipolar disorder and healthy controls","volume":"9","author":"Aizawa","year":"2019","journal-title":"Front. 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