{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:17:56Z","timestamp":1792135076880,"version":"4.4.0"},"reference-count":173,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"abstract":"<jats:p>Typically, the development of anorexia nervosa (AN) is attributed to psycho-social causes. Several researchers have recently challenged this view and suggested that <jats:italic>hypothermia and hyperactivity<\/jats:italic> (HyAc) are central to AN. The following hypothesis will attempt to clarify their role in AN. Anorexia nervosa patients (ANs) have significantly lower core temperatures (T<jats:sub>core<\/jats:sub>) compared to healthy controls (HCs). This reduced temperature represents a reset T<jats:sub>core<\/jats:sub> that needs to be maintained. However, ANs cannot maintain this T<jats:sub>core<\/jats:sub> due primarily to a reduced basal metabolic rate (BMR); BMR usually supplies heat to sustain T<jats:sub>core<\/jats:sub>. Therefore, to generate the requisite heat, ANs revert to the <jats:italic>behavioral-thermoregulatory strategy<\/jats:italic> of <jats:italic>HyAc<\/jats:italic>. The majority of ANs (~89%) are reportedly HyAc. Surprisingly, engagement in HyAc is <jats:italic>not<\/jats:italic> motivated by a conscious awareness of low T<jats:sub>core<\/jats:sub>, but rather by the innocuous sensation of \u201ccold- hands\u201d frequently reported by ANs. That is, local hand-thermoreceptors signal the brain to initiate HyAc, which boosts perfusion of the hands and alters the sensation of \u201ccold-discomfort\u201d to one of \u201ccomfort.\u201d This \u201crewarding\u201d consequence encourages repetition\/habit formation. Simultaneously, hyperactivity increases the availability of heat to assist with the preservation of T<jats:sub>core<\/jats:sub>. Additionally, HyAc induces the synthesis of specific <jats:italic>brain neuromodulators<\/jats:italic> that <jats:italic>suppress food<\/jats:italic> intake and further <jats:italic>promote<\/jats:italic> HyAc; this outcome helps preserve low weight and perpetuates this vicious cycle. Based on this hypothesis and supported by rodent research, external heat availability should reduce the compulsion to be HyAc to thermoregulate. A reduction in HyAc should <jats:italic>decrease the production<\/jats:italic> of brain neuromodulators that suppress appetite. If verified, hopefully, this hypothesis will assist with the development of novel treatments to aid in the resolution of this intractable condition.<\/jats:p>","DOI":"10.3389\/fnbeh.2021.700645","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T05:13:06Z","timestamp":1628226786000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["The Central Role of Hypothermia and Hyperactivity in Anorexia Nervosa: A Hypothesis"],"prefix":"10.3389","volume":"15","author":[{"given":"Lucille Lakier","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1080\/23328940.2015.1095270","article-title":"Current understanding on the neurophysiology of behavioral thermoregulation","volume":"2","author":"Almeida","year":"2015","journal-title":"Temperature (Austin)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1146\/annurev.pharmtox.44.101802.121410","article-title":"CRF and CRF receptors: role in stress responsivity and other behaviors","volume":"44","author":"Bale","year":"2004","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"145915","DOI":"10.1016\/j.brainres.2018.08.018","article-title":"Orexin\/hypocretin and dysregulated eating: promotion of foraging behavior","volume":"1731","author":"Barson","year":"2020","journal-title":"Brain Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.eatbeh.2016.11.005","article-title":"Measurement of fidgeting in patients with anorexia nervosa using a novel shoe-based monitor","volume":"24","author":"Belak","year":"2017","journal-title":"Eat. Behav."},{"key":"B6","doi-asserted-by":"crossref","DOI":"10.7208\/chicago\/9780226169743.001.0001","volume-title":"Holy Anorexia.","author":"Bell","year":"1985"},{"key":"B7","doi-asserted-by":"publisher","first-page":"R880","DOI":"10.1152\/ajpregu.1997.273.3.R880","article-title":"Local constriction of arteriovenous anastomoses in the cooled finger","volume":"273","author":"Bergersen","year":"1997","journal-title":"Am. J. Physiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/B978-0-444-64074-1.00040-9","article-title":"Acral coldness - severely reduced blood flow to fingers and toes","volume":"157","author":"Bergersen","year":"2018","journal-title":"Handb. Clin. Neurol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1037\/a0034921","article-title":"Effective treatment of eating disorders: results at multiple sites","volume":"127","author":"Bergh","year":"2013","journal-title":"Behav. Neurosci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"110320","DOI":"10.1016\/j.mce.2018.10.018","article-title":"Neuroendocrinology of reward in anorexia nervosa and bulimia nervosa: Beyond leptin and ghrelin","volume":"497","author":"Berner","year":"2019","journal-title":"Mol. Cell. Endocrinol."},{"key":"B11","first-page":"105","article-title":"The evolution of the concept of anorexia nervosa","volume-title":"Handbook of Eating Disorders. Part 1: Anorexia and Bulimia Nervosa","author":"Beumont","year":"1987"},{"key":"B12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/1098-108x(199401)15:1<21::aid-eat2260150104>3.0.co;2-k","article-title":"Excessive physical activity in dieting disorder patients: proposals for a supervised exercise program","volume":"15","author":"Beumont","year":"1994","journal-title":"Int. J. Eat. Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1002\/eat.10246","article-title":"Randomized controlled trial of warming in anorexia nervosa","volume":"35","author":"Birmingham","year":"2004","journal-title":"Int. J. Eat. Dis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/0031-9384(90)90324-w","article-title":"Suppression of food deprivation-induced high-rate wheel running in rats","volume":"48","author":"Boer","year":"1990","journal-title":"Physiol. Behav."},{"key":"B15","doi-asserted-by":"publisher","first-page":"E132","DOI":"10.1152\/ajpendo.00241.2006","article-title":"Energy expenditure adjusted for body composition differentiates constitutional thinness from both normal subjects and anorexia nervosa","volume":"292","author":"Bossu","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1152\/jappl.1998.85.6.2054","article-title":"Influence of localized auxiliary heating on hand comfort during cold exposure","volume":"85","author":"Brajkovic","year":"1998","journal-title":"J. Appl. Physiol. (1985)"},{"key":"B17","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1080\/17461391.2012.740504","article-title":"Eating disorders in athletes: overview of prevalence, risk factors and recommendations for prevention and treatment","volume":"13","author":"Bratland-Sanda","year":"2013","journal-title":"Eur. J. Sport Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"E584","DOI":"10.1210\/jc.2011-2246","article-title":"Young women with cold-activated brown adipose tissue have higher bone mineral density and lower pref-1 than women without brown adipose tissue: a study in women with anorexia nervosa, women recovered from anorexia nervosa and normal-weight women","volume":"97","author":"Bredella","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B19","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1002\/eat.20857","article-title":"Changes of orexin A plasma levels in girls with anorexia nervosa during eight weeks of realimentation","volume":"44","author":"Bronsky","year":"2011","journal-title":"Int. J. Eat. Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/ejcn.2016.223","article-title":"Cold-induced thermogenesis in humans","volume":"71","author":"Brychta","year":"2017","journal-title":"Eur. J. Clin. Nutr."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1126\/science.173.4002.1103","article-title":"Physiological role of pleasure","volume":"173","author":"Cabanac","year":"1971","journal-title":"Science"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1007\/s00421-014-2894-x","article-title":"Three-dimensional interactions of mean body and local skin temperatures in the control of hand and foot blood flows","volume":"114","author":"Caldwell","year":"2014","journal-title":"Eur. J. Appl. Physiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e41851","DOI":"10.1371\/journal.pone.0041851","article-title":"Hyperactivity in anorexia nervosa: Warming up not just burning-off calories","volume":"7","author":"Carrera","year":"2012","journal-title":"PLoS One"},{"key":"B24","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40337-018-0190-6","article-title":"Hyperactivity in anorexia nervosa: to warm or not to warm. that is the question (a translational research one)","volume":"6","author":"Carrera","year":"2018","journal-title":"J. Eat. Dis."},{"key":"B25","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1002\/(sici)1098-108x(199812)24:4<381::aid-eat5>3.0.co;2-q","article-title":"Behavioral activation and lack of concern, core symptoms of anorexia nervosa","volume":"24","author":"Casper","year":"1998","journal-title":"Int. J. Eat. Dis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jad.2005.12.039","article-title":"The \u201cdrive for activity\u201d and \"restlessness\" in anorexia nervosa: potential pathways","volume":"92","author":"Casper","year":"2006","journal-title":"J. Affect. Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1002\/eat.22575","article-title":"Restless activation and drive for activity in anorexia nervosa may reflect a disorder of energy homeostasis","volume":"49","author":"Casper","year":"2016","journal-title":"Int. J. Eat. Dis."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.3389\/fpsyg.2018.02303","article-title":"Not the function of eating, but spontaneous activity and energy expenditure, reflected in \"restlessness\" and a \"drive for activity\" appear to be dysregulated in anorexia nervosa: treatment implications","volume":"9","author":"Casper","year":"2018","journal-title":"Front. Psychol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.3390\/nu12072060","article-title":"Might starvation-induced adaptations in muscle mass, muscle morphology and muscle function contribute to the increased urge for movement and to spontaneous physical activity in anorexia nervosa","volume":"12","author":"Casper","year":"2020","journal-title":"Nutrients"},{"key":"B30","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1176\/ajp.134.9.974","article-title":"On the course of anorexia nervosa","volume":"134","author":"Casper","year":"1977","journal-title":"Am. J. Psychiatry"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1093\/ajcn\/53.5.1143","article-title":"Total daily energy expenditure and activity level in anorexia nervosa","volume":"53","author":"Casper","year":"1991","journal-title":"Am. J. Clin. Nutr."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e01556","DOI":"10.1002\/brb3.1556","article-title":"Increased urge for movement, physical and mental restlessness, fundamental symptoms of restricting anorexia nervosa","volume":"10","author":"Casper","year":"2020","journal-title":"Brain Behav."},{"key":"B33","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/eat.20884","article-title":"Heat makes a difference in activity-based anorexia: a translational approach to treatment development in anorexia nervosa","volume":"45","author":"Cerrato","year":"2012","journal-title":"Int. J. Eat. Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"357","DOI":"10.3389\/fphys.2017.00357","article-title":"Orexin system: the key for a healthy life","volume":"8","author":"Chieffi","year":"2017","journal-title":"Front. Physiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/erv.2388","article-title":"Thermal imaging of body surface temperature distribution in women with anorexia nervosa","volume":"24","author":"Chudecka","year":"2016","journal-title":"Eur. Eat. Disord. Rev."},{"key":"B36","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.neuropharm.2011.10.014","article-title":"Central control of thermogenesis","volume":"63","author":"Clapham","year":"2012","journal-title":"Neuropharmacology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1177\/1359105308088520","article-title":"The role of exercise dependence for the relationship between exercise behavior and eating pathology: mediator or moderator","volume":"13","author":"Cook","year":"2008","journal-title":"J. Health Psychol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0022-3999(67)90064-5","article-title":"The possible significance of some behavioural correlates of weight and carbohydrate intake","volume":"11","author":"Crisp","year":"1967","journal-title":"J. Psychosom. Res."},{"key":"B39","first-page":"209","article-title":"The psychopathology of anorexia nervosa: getting the \"heat\" out of the system","volume":"62","author":"Crisp","year":"1984","journal-title":"Res. Publ. Assoc. Res. Nerv. Ment. Dis."},{"key":"B40","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3810\/psm.2009.10.1725","article-title":"Features and management of compulsive exercising in eating disorders","volume":"37","author":"Dalle Grave","year":"2009","journal-title":"Phys. Sportsmed."},{"key":"B41","doi-asserted-by":"publisher","first-page":"417","DOI":"10.4103\/0019-5154.119946","article-title":"Acrocyanosis: An overview","volume":"58","author":"Das","year":"2013","journal-title":"Indian J. Dermatol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1111\/j.0954-6820.1979.tb06042.x","article-title":"Temperature regulation in anorexia nervosa patients during prolonged exercise","volume":"205","author":"Davies","year":"1979","journal-title":"Acta Med. Scand."},{"key":"B43","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1177\/070674379704200207","article-title":"Eating disorders and hyperactivity: A psychobiological perspective","volume":"42","author":"Davis","year":"1997","journal-title":"Can. J. Psychiatry"},{"key":"B44","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1017\/s0033291700029044","article-title":"The role of physical activity in the development and maintenance of eating disorders","volume":"24","author":"Davis","year":"1994","journal-title":"Psychol. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"4","DOI":"10.2174\/1874467210666170302104053","article-title":"The CRF family of neuropeptides and their receptors - mediators of the central stress response","volume":"11","author":"Dedic","year":"2018","journal-title":"Curr. Mol. Pharmacol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s40337-018-0219-x","article-title":"Compulsive exercise in eating disorders: proposal for a definition and a clinical assessment","volume":"6","author":"Dittmer","year":"2018","journal-title":"J. Eat. Dis."},{"key":"B47","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1126\/science.160.3830.895","article-title":"Showering as a coolant for rats exposed to heat","volume":"160","author":"Epstein","year":"1968","journal-title":"Science"},{"key":"B48","doi-asserted-by":"publisher","first-page":"57432","DOI":"10.3791\/57432","article-title":"Control of eating behavior using a novel feedback system","volume":"135","author":"Esfandiari","year":"2018","journal-title":"J. Vis. Exp."},{"key":"B49","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.psyneuen.2017.06.015","article-title":"Differentiating constitutional thinness from anorexia nervosa in DSM 5 era","volume":"84","author":"Estour","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1002\/cphy.c150040","article-title":"Neurophysiology of skin thermal sensations","volume":"6","author":"Filingeri","year":"2016","journal-title":"Compr. Physiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1152\/japplphysiol.00158.2018","article-title":"Thermosensory micromapping of warm and cold sensitivity across glabrous and hairy skin of male and female hands and feet","volume":"125","author":"Filingeri","year":"2018","journal-title":"J. Appl. Physiol. (1985)"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00421-010-1602-8","article-title":"Functional architecture of behavioural thermoregulation","volume":"111","author":"Flouris","year":"2011","journal-title":"Eur. J. Appl. Physiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1152\/japplphysiol.00197.2006","article-title":"Influence of body heat content on hand function during prolonged cold exposures","volume":"101","author":"Flouris","year":"2006","journal-title":"J. Appl. Physiol. (1985)"},{"key":"B54","first-page":"1","article-title":"Body composition, cardiovascular and renal function in adolescent patients with anorexia nervosa","volume":"268","author":"Fohlin","year":"1977","journal-title":"Acta Paediatr. Scand. Suppl."},{"key":"B55","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/j.1651-2227.1978.tb16307.x","article-title":"Limb circulation in anorexia nervosa","volume":"67","author":"Freyschuss","year":"1978","journal-title":"Acta Paediatr. Scand."},{"key":"B56","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/BF00300220","article-title":"Nitrergic innervation and nitrergic cells in arteriovenous anastomoses","volume":"277","author":"Funk","year":"1994","journal-title":"Cell Tissue Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/eat.22482","article-title":"A systematic review of approaches to refeeding in patients with anorexia nervosa","volume":"49","author":"Garber","year":"2016","journal-title":"Int. J. Eat. Dis."},{"key":"B58","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1242\/jeb.048397","article-title":"The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives","volume":"214","author":"Garland","year":"2011","journal-title":"J. Exp. Biol."},{"key":"B59","first-page":"355","article-title":"Cutaneous arteriovenous anastomoses present in the tail but absent from the ear of the rat","volume":"124","author":"Gemmell","year":"1977","journal-title":"J. Anat."},{"key":"B60","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1037\/0033-295X.110.4.745","article-title":"Adapted to flee famine: adding an evolutionary perspective on anorexia nervosa","volume":"110","author":"Guisinger","year":"2003","journal-title":"Psychol. Rev."},{"key":"B61","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1002\/j.1550-8528.1997.tb00677.x","article-title":"Anorexia nervosa (apepsia hysterica, anorexia hysterica). 1868","volume":"5","author":"Gull","year":"1997","journal-title":"Obes. Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/erv.2377","article-title":"High levels of physical activity in anorexia nervosa: a systematic review","volume":"23","author":"Gummer","year":"2015","journal-title":"Eur. Eat. Disord. Rev."},{"key":"B63","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/eat.22095","article-title":"A rat in the labyrinth of anorexia nervosa: Contributions of the activity-based anorexia rodent model to the understanding of anorexia nervosa","volume":"46","author":"Gutierrez","year":"2013","journal-title":"Int. J. Eat. Dis."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1080\/17470210500417688","article-title":"High ambient temperature reduces rate of body-weight loss produced by wheel running","volume":"59","author":"Gutierrez","year":"2006","journal-title":"Q. J. Exp. Psychol. (Hove)"},{"key":"B65","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3389\/fpsyg.2020.00207","article-title":"Editorial: New perspectives to unlock the current impasse in treating anorexia nervosa","volume":"11","author":"Gutierrez","year":"2020","journal-title":"Front. Psychol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1017\/S0033291717003944","article-title":"Anorexia nervosa treatments and occam\u2019s razor","volume":"48","author":"Gutierrez","year":"2018","journal-title":"Psychol. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.eatbeh.2013.05.006","article-title":"Climate might be considered as a risk factor for anorexia nervosa? a hypothesis worth another look","volume":"14","author":"Gutierrez","year":"2013","journal-title":"Eat. Behav."},{"key":"B68","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.psyneuen.2008.10.003","article-title":"High ambient temperature reverses hypothalamic MC4 receptor overexpression in an animal model of anorexia nervosa","volume":"34","author":"Gutierrez","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"B69","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/BF03339752","article-title":"Heat in the treatment of patients with anorexia nervosa","volume":"6","author":"Gutierrez","year":"2001","journal-title":"Eat. Weight Disord."},{"key":"B70","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3758\/bf03196278","article-title":"Activity-based anorexia: Ambient temperature has been a neglected factor","volume":"9","author":"Gutierrez","year":"2002","journal-title":"Psychon. Bull. Rev."},{"key":"B72","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1054\/npep.1999.0047","article-title":"The role of corticotropin-releasing factor and urocortin in the modulation of ingestive behavior","volume":"33","author":"Heinrichs","year":"1999","journal-title":"Neuropeptides"},{"key":"B73","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.resp.2004.03.014","article-title":"Natural hypometabolism during hibernation and daily torpor in mammals","volume":"141","author":"Heldmaier","year":"2004","journal-title":"Respir. Physiol. Neurobiol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1249\/MSS.0000000000001865","article-title":"The transcriptional signature of a runner\u2019s high","volume":"51","author":"Hicks","year":"2019","journal-title":"Med. Sci. Sports and Exerc."},{"key":"B75","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.physbeh.2005.03.017","article-title":"Voluntary access to a warm plate reduces hyperactivity in activity-based anorexia","volume":"85","author":"Hillebrand","year":"2005","journal-title":"Physiol. Behav."},{"key":"B76","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1210\/jcem-62-2-319","article-title":"The responses of plasma adrenocorticotropin and cortisol to corticotropin-releasing hormone (CRH) and cerebrospinal fluid immunoreactive CRH in anorexia nervosa patients","volume":"62","author":"Hotta","year":"1986","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B77","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1093\/icb\/icr059","article-title":"Heat for nothing or activity for free? evidence and implications of activity-thermoregulatory heat substitution","volume":"51","author":"Humphries","year":"2011","journal-title":"Int. Comp. Biol."},{"key":"B78","first-page":"5","article-title":"Plasma levels of leptin and orexin A in the restrictive type of anorexia nervosa","volume-title":"Regl. Pept.","author":"Janas-Kozik","year":"2011"},{"key":"B79","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1136\/bjsports-2015-095735","article-title":"2016 update on eating disorders in athletes: A comprehensive narrative review with a focus on clinical assessment and management","volume":"50","author":"Joy","year":"2016","journal-title":"Br. J. Sports Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.jtherbio.2017.07.003","article-title":"Modelling hand skin temperature in relation to body composition","volume":"69","author":"Katic","year":"2017","journal-title":"J. Therm. Biol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"R1800","DOI":"10.1152\/ajpregu.00805.2004","article-title":"Dorsomedial hypothalamic corticotropin-releasing factor mediation of exercise-induced anorexia","volume":"288","author":"Kawaguchi","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.physbeh.2007.11.037","article-title":"Neurobiology of anorexia and bulimia nervosa","volume":"94","author":"Kaye","year":"2008","journal-title":"Physiol. Behav."},{"key":"B83","first-page":"433","article-title":"Contribution of CNS neuropeptide (NPY, CRH and beta-endorphin) alterations to psychophysiological abnormalities in anorexia nervosa","volume":"25","author":"Kaye","year":"1989","journal-title":"Psychopharmacol. Bull."},{"key":"B84","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1210\/jcem-64-2-203","article-title":"Elevated cerebrospinal fluid levels of immunoreactive corticotropin-releasing hormone in anorexia nervosa: relation to state of nutrition, adrenal function and intensity of depression","volume":"64","author":"Kaye","year":"1987","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B85","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/74271","article-title":"Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2","volume":"24","author":"Kishimoto","year":"2000","journal-title":"Nat. Genet."},{"key":"B86","doi-asserted-by":"publisher","first-page":"E551","DOI":"10.1152\/ajpendo.00126.2003","article-title":"Orexin A (hypocretin 1) injected into hypothalamic paraventricular nucleus and spontaneous physical activity in rats","volume":"286","author":"Kiwaki","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B87","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.npep.2013.10.014","article-title":"Role of neuropeptides in anxiety, stress and depression: From animals to humans","volume":"47","author":"Kormos","year":"2013","journal-title":"Neuropeptides"},{"key":"B88","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.psychres.2013.08.050","article-title":"The expression of excessive exercise co-segregates with the risk of developing an eating disorder in women","volume":"210","author":"Kostrzewa","year":"2013","journal-title":"Psychiatry Res."},{"key":"B89","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1007\/s13679-017-0288-1","article-title":"Spontaneous physical activity defends against obesity","volume":"6","author":"Kotz","year":"2017","journal-title":"Curr. Obes. Rep."},{"key":"B90","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/0010-440x(78)90072-x","article-title":"Hyperactivity in anorexia nervosa: a fundamental clinical feature","volume":"19","author":"Kron","year":"1978","journal-title":"Compr. Psychiatry"},{"key":"B91","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1177\/1358863X11398519","article-title":"Acrocyanosis: the flying dutchman","volume":"16","author":"Kurklinsky","year":"2011","journal-title":"Vasc. Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/s0167-0115(01)00340-8","article-title":"Effects of restricted feeding on the activity of hypothalamic orexin (OX)-A containing neurons and OX2 receptor mRNA level in the paraventricular nucleus of rats","volume":"104","author":"Kurose","year":"2002","journal-title":"Regul. Pept."},{"key":"B93","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1136\/pgmj.52.603.45","article-title":"Study of EEG sleep characteristics in patients with anorexia nervosa before and after restoration of matched population mean weight consequent on ingestion of a \"normal\" diet","volume":"52","author":"Lacey","year":"1976","journal-title":"Postgrad. Med. J."},{"key":"B94","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/BF00452416","article-title":"Bone marrow hypoplasia in anorexia nervosa","volume":"124","author":"Lampert","year":"1976","journal-title":"Eur. J. Pediatr."},{"key":"B95","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s10571-006-9010-7","article-title":"Feast or famine: the sympathetic nervous system response to nutrient intake","volume":"26","author":"Landsberg","year":"2006","journal-title":"Cell. Mol. Neurobiol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/j.1467-789X.2012.01040.x","article-title":"Core temperature: a forgotten variable in energy expenditure and obesity","volume":"13","author":"Landsberg","year":"2012","journal-title":"Obes. Rev."},{"key":"B97","first-page":"287","article-title":"Do the obese have lower body temperatures? a new look at a forgotten variable in energy balance","volume":"120","author":"Landsberg","year":"2009","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"key":"B98","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/j.1365-2796.2007.01842.x","article-title":"Nonexercise activity thermogenesis\u2013liberating the life-force","volume":"262","author":"Levine","year":"2007","journal-title":"J. Int. Med."},{"key":"B99","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/j.1365-201X.2005.01467.x","article-title":"NEAT\u2013non-exercise activity thermogenesis\u2013egocentric geocentric environmental factors vs. biological regulation","volume":"184","author":"Levine","year":"2005","journal-title":"Acta Physiol. Scand."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1093\/ajcn\/72.6.1451","article-title":"Energy expenditure of nonexercise activity","volume":"72","author":"Levine","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"B101","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1249\/MSS.0000000000001499","article-title":"Biological\/genetic regulation of physical activity level: consensus from GenBioPAC","volume":"50","author":"Lightfoot","year":"2018","journal-title":"Med. Sci. Sports Exerc."},{"key":"B102","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1113\/jphysiol.1993.sp019491","article-title":"Fluctuations in blood flow to acral skin in humans: connection with heart rate and blood pressure variability","volume":"460","author":"Lossius","year":"1993","journal-title":"J. Physiol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1136\/bmj.281.6245.906","article-title":"Altered thresholds for thermoregulatory sweating and vasodilatation in anorexia nervosa","volume":"281","author":"Luck","year":"1980","journal-title":"Br. Med. J."},{"key":"B104","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1042\/cs0610559","article-title":"Increased cutaneous vasoreactivity to cold in anorexia nervosa","volume":"61","author":"Luck","year":"1981","journal-title":"Clin. Sci."},{"key":"B105","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1186\/1471-244X-13-290","article-title":"Nutritional rehabilitation in anorexia nervosa: review of the literature and implications for treatment","volume":"13","author":"Marzola","year":"2013","journal-title":"BMC Psychiatry"},{"key":"B106","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1097\/00005792-197403000-00003","article-title":"Hypothalamic dysfunction in patients with anorexia nervosa","volume":"53","author":"Mecklenburg","year":"1974","journal-title":"Medicine"},{"key":"B107","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/erv.1122","article-title":"Compulsive exercise and eating disorders","volume":"19","author":"Meyer","year":"2011","journal-title":"Eur. Eat. Disord. Rev."},{"key":"B108","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/erv.863","article-title":"Excessive exercise in the eating disorders: a need for less activity from patients and more from researchers.","volume":"16","author":"Meyer","year":"2008","journal-title":"Eur. Eat. Disord. Rev."},{"key":"B109","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/S2213-8587(13)70180-3","article-title":"Endocrine consequences of anorexia nervosa","volume":"2","author":"Misra","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1093\/ajcn\/66.1.133","article-title":"Increase in diet-induced thermogenesis at the start of refeeding in severely malnourished anorexia nervosa patients","volume":"66","author":"Moukaddem","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"key":"B111","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1080\/23328940.2016.1156214","article-title":"Head temperature modulates thermal behavior in the cold in humans","volume":"3","author":"Mundel","year":"2016","journal-title":"Temperature (Austin)"},{"key":"B112","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1002\/eat.22796","article-title":"Characterization and correlates of exercise among adolescents with anorexia nervosa and bulimia nervosa","volume":"50","author":"Nagata","year":"2017","journal-title":"Int. J. Eat. Dis."},{"key":"B113","doi-asserted-by":"publisher","first-page":"S207","DOI":"10.1067\/mjd.2001.103266","article-title":"Chronic idiopathic acrocyanosis","volume":"45","author":"Nousari","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1530\/eje.1.01850","article-title":"L-tri-iodothyronine is a major determinant of resting energy expenditure in underweight patients with anorexia nervosa and during weight gain","volume":"152","author":"Onur","year":"2005","journal-title":"Eur. J. Endocrinol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0031-9384(77)90125-1","article-title":"Body temperature and the activity-stress ulcer in the rat","volume":"18","author":"Pare","year":"1977","journal-title":"Physiol. Behav."},{"key":"B116","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1002\/erv.2791","article-title":"Heart rate variability as a biomarker for anorexia nervosa: A review","volume":"29","author":"Peyser","year":"2021","journal-title":"Eur. Eat. Disord. Rev."},{"key":"B117","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0165-1781(96)02982-4","article-title":"Central and peripheral noradrenalin regulation in eating disorders","volume":"62","author":"Pirke","year":"1996","journal-title":"Psychiatry Res."},{"key":"B118","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1093\/ajcn\/71.6.1495","article-title":"Basal metabolic rate in anorexia nervosa: Relation to body composition and leptin concentrations","volume":"71","author":"Polito","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"B119","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/s1471-4892(01)00117-5","article-title":"Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression","volume":"2","author":"Reul","year":"2002","journal-title":"Curr. Opin. Pharmacol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1210\/jc.2006-1319","article-title":"Hormonal and psychological factors linked to the increased thermic effect of food in malnourished fasting anorexia nervosa","volume":"92","author":"Rigaud","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B121","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0361-9230(90)90270-a","article-title":"Involvement of corticotropin-releasing factor in the anorexia induced by exercise","volume":"25","author":"Rivest","year":"1990","journal-title":"Brain Res. Bull."},{"key":"B122","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1152\/ajplegacy.1957.188.2.332","article-title":"Factors influencing survival of rats in fasting; metabolic rate and body weight loss","volume":"188","author":"Rixon","year":"1957","journal-title":"Am. J. Physiol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3390\/nu12010183","article-title":"Physical activity in eating disorders: a systematic review","volume":"12","author":"Rizk","year":"2020","journal-title":"Nutrients"},{"key":"B124","doi-asserted-by":"publisher","first-page":"R37","DOI":"10.1152\/ajpregu.00668.2006","article-title":"Thermoregulation: some concepts have changed. functional architecture of the thermoregulatory system","volume":"292","author":"Romanovsky","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1111\/apha.12231","article-title":"Skin temperature: its role in thermoregulation","volume":"210","author":"Romanovsky","year":"2014","journal-title":"Acta Physiol. (Oxf)"},{"key":"B126","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/s0306-4530(00)00036-6","article-title":"Altered energy metabolism in anorexia nervosa","volume":"26","author":"Russell","year":"2001","journal-title":"Psychoneuroendocrinology"},{"key":"B127","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1097\/00001756-200206120-00001","article-title":"Roles of orexins in regulation of feeding and wakefulness","volume":"13","author":"Sakurai","year":"2002","journal-title":"Neuroreport"},{"key":"B128","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1097\/01.mco.0000078995.96795.91","article-title":"Orexin: a link between energy homeostasis and adaptive behaviour","volume":"6","author":"Sakurai","year":"2003","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"B129","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1152\/jappl.1966.21.6.1757","article-title":"Esophageal, rectal and muscle temperature during exercise","volume":"21","author":"Saltin","year":"1966","journal-title":"J. Appl. Physiol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.neuropharm.2018.09.034","article-title":"The role of the orexin system in stress response","volume":"154","author":"Sargin","year":"2019","journal-title":"Neuropharmacology"},{"key":"B131","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.eurpsy.2015.09.008","article-title":"Physical activity in anorexia nervosa: How relevant is it to therapy response","volume":"30","author":"Sauchelli","year":"2015","journal-title":"Eur. Psychiatry"},{"key":"B132","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.psyneuen.2015.12.014","article-title":"Orexin and sleep quality in anorexia nervosa: clinical relevance and influence on treatment outcome","volume":"65","author":"Sauchelli","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"B133","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.neulet.2018.03.049","article-title":"Activity-based anorexia activates CRF immunoreactive neurons in female rats","volume":"674","author":"Scharner","year":"2018","journal-title":"Neurosci. Lett."},{"key":"B134","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.physbeh.2010.03.016","article-title":"Neurobiology of hyperactivity and reward: agreeable restlessness in anorexia nervosa","volume":"100","author":"Scheurink","year":"2010","journal-title":"Physiol. Behav."},{"key":"B135","doi-asserted-by":"publisher","first-page":"20","DOI":"10.4161\/temp.29235","article-title":"The relative overlooking of human behavioral temperature regulation: an issue worth resolving","volume":"1","author":"Schlader","year":"2014","journal-title":"Temperature (Austin)"},{"key":"B136","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1007\/s00421-012-2544-0","article-title":"Human temperature regulation when given the opportunity to behave","volume":"113","author":"Schlader","year":"2013","journal-title":"Eur. J. Appl. Physiol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.physbeh.2009.09.002","article-title":"Characteristics of the control of human thermoregulatory behavior","volume":"98","author":"Schlader","year":"2009","journal-title":"Physiol. Behav."},{"key":"B138","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.physbeh.2011.02.002","article-title":"The independent roles of temperature and thermal perception in the control of human thermoregulatory behavior","volume":"103","author":"Schlader","year":"2011","journal-title":"Physiol. Behav."},{"key":"B139","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1249\/JES.0000000000000180","article-title":"Regulation of body temperature by autonomic and behavioral thermoeffectors","volume":"47","author":"Schlader","year":"2019","journal-title":"Exerc. Sport Sci. Rev."},{"key":"B140","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1046\/j.1525-1470.1999.00022.x","article-title":"Dermatologic findings in anorexia and bulimia nervosa of childhood and adolescence","volume":"16","author":"Schulze","year":"1999","journal-title":"Pediatr. Dermatol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1089\/thy.1995.5.481","article-title":"Thyroid hormone control of thermogenesis and energy balance","volume":"5","author":"Silva","year":"1995","journal-title":"Thyroid"},{"key":"B142","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1152\/physrev.00009.2005","article-title":"Thermogenic mechanisms and their hormonal regulation","volume":"86","author":"Silva","year":"2006","journal-title":"Physiol. Rev."},{"key":"B143","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.neubiorev.2015.11.003","article-title":"Dopamine and anorexia nervosa","volume":"60","author":"Sodersten","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B144","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/S2213-8587(15)00090-X","article-title":"Reversible biological adaptations in obesity","volume":"3","author":"Sodersten","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"596","DOI":"10.3389\/fnins.2019.00596","article-title":"Eating behavior and the evolutionary perspective on anorexia nervosa","volume":"13","author":"Sodersten","year":"","journal-title":"Front. Neurosci."},{"key":"B146","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.3389\/fpsyg.2019.02110","article-title":"Verifying feighner\u2019s hypothesis; anorexia nervosa is not a psychiatric disorder","volume":"10","author":"Sodersten","year":"","journal-title":"Front. Psychol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"651","DOI":"10.12740\/PP\/OnlineFirst\/75338","article-title":"Modern approaches to the treatment of anorexia nervosa. \"the third wave\" of cognitive behavioral therapy. [Wspolczesne kierunki w leczeniu osob chorujacych na jadlowstret psychiczny. \"Trzecia fala\" terapii poznawczo-behawioralnej]","volume":"52","author":"Starzomska","year":"2018","journal-title":"Psychiatr. Pol."},{"key":"B148","first-page":"575","article-title":"Environmental temperature and deprivation of food and water on the spontaneous activity of rats","volume":"29","author":"Stevenson","year":"1957","journal-title":"Yale J. Biol. Med."},{"key":"B149","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1475-097x.1991.tb00651.x","article-title":"Relationships between skin temperature and perfusion in the arm and leg","volume":"11","author":"Stoner","year":"1991","journal-title":"Clin. Physiol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1152\/jappl.1963.18.4.756","article-title":"Metabolic and thermal responses to muscular exertion in the cold","volume":"18","author":"Stromme","year":"1963","journal-title":"J. Appl. Physiol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.clindermatol.2011.11.011","article-title":"Eating disorders and the skin","volume":"31","author":"Strumia","year":"2013","journal-title":"Clin. Dermatol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"146085","DOI":"10.1016\/j.brainres.2018.12.036","article-title":"Orexin\/hypocretin receptor modulation of anxiolytic and antidepressive responses during social stress and decision-making: Potential for therapy","volume":"1731","author":"Summers","year":"2020","journal-title":"Brain Res."},{"key":"B153","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/297331a0","article-title":"Corticotropin releasing factor produces behavioural activation in rats","volume":"297","author":"Sutton","year":"1982","journal-title":"Nature"},{"key":"B154","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1111\/j.1651-2227.2005.tb01805.x","article-title":"Medical assessment of adolescent girls with eating disorders: an evaluation of symptoms and signs of starvation","volume":"94","author":"Swenne","year":"2005","journal-title":"Acta Paediatr."},{"key":"B155","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.neuron.2018.02.022","article-title":"Regulation of body temperature by the nervous system","volume":"98","author":"Tan","year":"2018","journal-title":"Neuron"},{"key":"B156","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1152\/advan.00126.2014","article-title":"Recent advances in thermoregulation","volume":"39","author":"Tansey","year":"2015","journal-title":"Adv. Physiol. Educ."},{"key":"B157","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1126\/science.112.2904.215","article-title":"Adaptation to caloric restriction","volume":"112","author":"Taylor","year":"1950","journal-title":"Science"},{"key":"B158","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1007\/s00421-014-2940-8","article-title":"Hands and feet: Physiological insulators, radiators and evaporators","volume":"114","author":"Taylor","year":"2014","journal-title":"Eur. J. Appl. Physiol."},{"key":"B159","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1159\/000110802","article-title":"Neuropeptidergic mediators of spontaneous physical activity and non-exercise activity thermogenesis","volume":"87","author":"Teske","year":"2008","journal-title":"Neuroendocrinology"},{"key":"B160","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/B978-0-12-394623-2.00006-8","article-title":"Energy expenditure: role of orexin","volume":"89","author":"Teske","year":"2012","journal-title":"Vitam. Horm."},{"key":"B161","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1046\/j.1467-789x.2000.00018.x","article-title":"Biological determinants of spontaneous physical activity","volume":"1","author":"Thorburn","year":"2000","journal-title":"Obes. Rev."},{"key":"B162","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1146\/annurev-clinpsy-050212-185546","article-title":"The genetics of eating disorders","volume":"9","author":"Trace","year":"2013","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s11920-018-0928-5","article-title":"The role of habits in anorexia nervosa: where we are and where to go from here?","volume":"20","author":"Uniacke","year":"2018","journal-title":"Curr. Psychiatry Rep."},{"key":"B164","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1080\/02640414.2019.1592800","article-title":"Dynamic sitting: measurement and associations with metabolic health","volume":"37","author":"van der Berg","year":"2019","journal-title":"J. Sports Sci."},{"key":"B165","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/nbm.768","article-title":"In-vivo non-invasive study of the thermoregulatory function of the blood vessels in the rat tail using magnetic resonance angiography","volume":"15","author":"Vanhoutte","year":"2002","journal-title":"NMR Biomed."},{"key":"B166","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1007\/BF03327745","article-title":"Exploring the association between anorexia nervosa and geographical latitude","volume":"11","author":"Vazquez","year":"2006","journal-title":"Eat. Weight Disord."},{"key":"B167","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/s0300-595x(76)80034-5","article-title":"Anorexia nervosa: behavioural and hypothalamic aspects","volume":"5","author":"Vigersky","year":"1976","journal-title":"Clin. Endocrinol. Metab."},{"key":"B168","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1017\/s0033291700039994","article-title":"Disturbances in the regulation of body temperature in anorexia nervosa","volume":"1","author":"Wakeling","year":"1970","journal-title":"Psychol. Med."},{"key":"B169","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1080\/23328940.2015.1088502","article-title":"Arterio-venous anastomoses in the human skin and their role in temperature control","volume":"3","author":"Walloe","year":"2015","journal-title":"Temperature (Austin)"},{"key":"B170","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1176\/appi.ajp.2012.12081074","article-title":"The enigmatic persistence of anorexia nervosa","volume":"170","author":"Walsh","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"B171","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1126\/science.133.3461.1338","article-title":"Behavioral thermoregulation","volume":"133","author":"Weiss","year":"1961","journal-title":"Science"},{"key":"B172","doi-asserted-by":"publisher","first-page":"11439","DOI":"10.1523\/JNEUROSCI.3459-04.2004","article-title":"Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response","volume":"24","author":"Winsky-Sommerer","year":"2004","journal-title":"J. Neurosci."},{"key":"B173","doi-asserted-by":"publisher","first-page":"131","DOI":"10.2147\/AGG.S55776","article-title":"Genetics and epigenetics of eating disorders","volume":"5","author":"Yilmaz","year":"2015","journal-title":"Ad. Genomics Genet."},{"key":"B174","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/S0300-595X(77)80073-X","article-title":"Catecholamines and intermediary metabolism","volume":"6","author":"Young","year":"","journal-title":"Clin. Endocrinol. Metab."},{"key":"B175","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1126\/science.867049","article-title":"Suppression of sympathetic nervous system during fasting","volume":"196","author":"Young","year":"","journal-title":"Science"}],"container-title":["Frontiers in Behavioral Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnbeh.2021.700645\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T05:13:17Z","timestamp":1628226797000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnbeh.2021.700645\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,6]]},"references-count":173,"alternative-id":["10.3389\/fnbeh.2021.700645"],"URL":"https:\/\/doi.org\/10.3389\/fnbeh.2021.700645","relation":{},"ISSN":["1662-5153"],"issn-type":[{"value":"1662-5153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,6]]},"article-number":"700645"}}