{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:32:40Z","timestamp":1783441960680,"version":"3.54.6"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"abstract":"<jats:p>Male rats escalate intravenous self-administration of entactogen psychostimulants, 3,4-methylenedioxymethcathinone (methylone) and 3,4-methylenedioxymethamphetamine (MDMA) under extended access conditions, as with typical psychostimulants. Here, we investigated whether female rats escalate self-administration of methylone, 3,4-methylenedioxypentedrone (pentylone), and MDMA and then studied consequences of MDMA and pentylone self-administration on GABA<jats:sub>A<\/jats:sub> receptor and kappa opioid receptor (KOR) signaling in the central nucleus of the amygdala (CeA), a brain area critically dysregulated by extended access self-administration of alcohol or cocaine. Adult female Wistar rats were trained to self-administer methylone, pentylone, MDMA (0.5 mg\/kg\/infusion), or saline-vehicle using a fixed-ratio 1 response contingency in 6-h sessions (long-access: LgA) followed by progressive ratio (PR) dose-response testing. The effects of pentylone-LgA, MDMA-LgA and saline on basal GABAergic transmission (miniature post-synaptic inhibitory currents, mIPSCs) and the modulatory role of KOR at CeA GABAergic synapses were determined in acute brain slices using whole-cell patch-clamp. Methylone-LgA and pentylone-LgA rats similarly escalated their drug intake (both obtained more infusions compared to MDMA-LgA rats), however, pentylone-LgA rats reached higher breakpoints in <jats:italic>PR<\/jats:italic> tests. At the cellular level, baseline CeA GABA transmission was markedly elevated in pentylone-LgA and MDMA-LgA rats compared to saline-vehicle. Specifically, pentylone-LgA was associated with increased CeA mIPSC frequency (GABA release) and amplitude (post-synaptic GABAA receptor function), while mIPSC amplitudes (but not frequency) was larger in MDMA-LgA rats compared to saline rats. In addition, pentylone-LgA and MDMA-LgA profoundly disrupted CeA KOR signaling such as both KOR agonism (1 mM U50488) and KOR antagonism (200 nM nor-binaltorphimine) decreased mIPSC frequency suggesting recruitment of non-canonical KOR signaling pathways. This study confirms escalated self-administration of entactogen psychostimulants under LgA conditions in female rats which is accompanied by increased CeA GABAergic inhibition and altered KOR signaling. Collectively, our study suggests that CeA GABA and KOR mechanisms play a critical role in entactogen self-administration like those observed with escalation of alcohol or cocaine self-administration.<\/jats:p>","DOI":"10.3389\/fnbeh.2021.780500","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T07:47:24Z","timestamp":1639640844000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Self-Administration of Entactogen Psychostimulants Dysregulates Gamma-Aminobutyric Acid (GABA) and Kappa Opioid Receptor Signaling in the Central Nucleus of the Amygdala of Female Wistar Rats"],"prefix":"10.3389","volume":"15","author":[{"given":"Sophia","family":"Khom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques D.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia A.","family":"Vandewater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanabel","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Roberto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Taffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.pbb.2017.10.008","article-title":"High ambient temperature facilitates the acquisition of 3,4-methylenedioxymethamphetamine (MDMA) self-administration.","volume":"163","author":"Aarde","year":"2017","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1038\/s41386-018-0294-3","article-title":"Dynorphin-kappa opioid receptor activity in the central amygdala modulates binge-like alcohol drinking in mice.","volume":"44","author":"Anderson","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2014.00045","article-title":"Acute morphine alters GABAergic transmission in the central amygdala during naloxone-precipitated morphine withdrawal: role of cyclic AMP.","volume":"8","author":"Bajo","year":"2014","journal-title":"Front. Integr. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1111\/j.1369-1600.2010.00269.x","article-title":"Neuroadaptation of GABAergic transmission in the central amygdala during chronic morphine treatment.","volume":"16","author":"Bajo","year":"2011","journal-title":"Addict. Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1038\/npp.2011.304","article-title":"The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue.","volume":"37","author":"Baumann","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1038\/npp.2015.260","article-title":"Abuse of new psychoactive substances: threats and solutions.","volume":"41","author":"Baumann","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1038\/s41380-020-0690-z","article-title":"Kappa opioid receptor and dynorphin signaling in the central amygdala regulates alcohol intake. Mol","volume":"26","author":"Bloodgood","year":"2020","journal-title":"Psychiatry"},{"key":"B8","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1111\/adb.12069","article-title":"Acquisition of MDMA self-administration: pharmacokinetic factors and MDMA-induced serotonin release.","volume":"19","author":"Bradbury","year":"2014","journal-title":"Addict. Biol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00213-010-1806-y","article-title":"Kinase cascades and ligand-directed signaling at the kappa opioid receptor.","volume":"210","author":"Bruchas","year":"2010","journal-title":"Psychopharmacology (Berl.)."},{"key":"B10","doi-asserted-by":"publisher","first-page":"29803","DOI":"10.1074\/jbc.M705540200","article-title":"Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase.","volume":"282","author":"Bruchas","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/509282a","article-title":"Policy: NIH to balance sex in cell and animal studies.","volume":"509","author":"Clayton","year":"2014","journal-title":"Nature"},{"key":"B12","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1177\/0269881107082286","article-title":"High ambient temperature increases intravenous methamphetamine self-administration on fixed and progressive ratio schedules in rats.","volume":"22","author":"Cornish","year":"2008","journal-title":"J. Psychopharmacol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.ejphar.2003.09.060","article-title":"Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats.","volume":"482","author":"Cornish","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.neuropharm.2015.01.003","article-title":"Intravenous self-administration of mephedrone, methylone and MDMA in female rats.","volume":"92","author":"Creehan","year":"2015","journal-title":"Neuropharmacology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1038\/sj.npp.1301220","article-title":"Enduring deficits in sustained visual attention during withdrawal of intravenous methylenedioxymethamphetamine self-administration in rats: results from a comparative study with d-amphetamine and methamphetamine.","volume":"32","author":"Dalley","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.neuropharm.2018.01.020","article-title":"\u201cEcstasy\u201d to addiction: mechanisms and reinforcing effects of three synthetic cathinone analogs of MDMA.","volume":"133","author":"Dolan","year":"2018","journal-title":"Neuropharmacology"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/164_2020_421","article-title":"KOR control over addiction processing: an exploration of the mesolimbic dopamine pathway","author":"Estave","year":"2020","journal-title":"Handbook of Experimental Pharmacology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.biopsych.2014.09.008","article-title":"The central amygdala as an integrative hub for anxiety and alcohol use disorders.","volume":"77","author":"Gilpin","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"B19","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.neuropharm.2013.10.005","article-title":"Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala.","volume":"77","author":"Gilpin","year":"2014","journal-title":"Neuropharmacology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1021\/acschemneuro.0c00797","article-title":"Eutylone and its structural isomers interact with monoamine transporters and induce locomotor stimulation.","volume":"12","author":"Glatfelter","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1124\/jpet.111.184119","article-title":"4-Methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse.","volume":"339","author":"Hadlock","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aar4309","article-title":"G protein signaling-biased agonism at the \u03ba-opioid receptor is maintained in striatal neurons.","volume":"11","author":"Ho","year":"2018","journal-title":"Sci. Signal."},{"key":"B23","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.neuropharm.2017.09.002","article-title":"Locomotor and reinforcing effects of pentedrone, pentylone and methylone in rats.","volume":"134","author":"Javadi-Paydar","year":"2018","journal-title":"Neuropharmacology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1073\/pnas.1915143117","article-title":"Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats.","volume":"117","author":"Kallupi","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B25","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.biopsych.2013.04.028","article-title":"Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction.","volume":"74","author":"Kallupi","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1111\/j.1476-5381.2011.01499.x","article-title":"Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats.","volume":"164","author":"Kehr","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz1050","article-title":"Alcohol dependence potentiates substance P\/neurokinin-1 receptor signaling in the rat central nucleus of amygdala.","volume":"6","author":"Khom","year":"","journal-title":"Sci. Adv."},{"key":"B28","doi-asserted-by":"publisher","first-page":"6842","DOI":"10.1523\/JNEUROSCI.0733-20.2020","article-title":"Alcohol dependence and withdrawal impair serotonergic regulation of GABA transmission in the rat central nucleus of the amygdala.","volume":"40","author":"Khom","year":"","journal-title":"J. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1093\/alcalc\/agab034","article-title":"Sex differences in acute alcohol sensitivity of na\u00efve and alcohol dependent central amygdala GABA synapses.","volume":"56","author":"Kirson","year":"2021","journal-title":"Alcohol Alcohol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s00213-006-0353-z","article-title":"Escalation of methamphetamine self-administration in rats: a dose-effect function.","volume":"186","author":"Kitamura","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"B31","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.neuron.2008.06.012","article-title":"A role for brain stress systems in addiction.","volume":"59","author":"Koob","year":"2008","journal-title":"Neuron"},{"key":"B32","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1124\/pharmrev.120.000083","article-title":"Drug addiction: hyperkatifeia\/negative reinforcement as a framework for medications development.","volume":"73","author":"Koob","year":"2021","journal-title":"Pharmacol. Rev."},{"key":"B33","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.neubiorev.2018.09.008","article-title":"Addiction and stress: an allostatic view.","volume":"106","author":"Koob","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B34","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/S2215-0366(16)00104-8","article-title":"Neurobiology of addiction: a neurocircuitry analysis.","volume":"3","author":"Koob","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"B35","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1515\/revneuro-2012-0066","article-title":"Compulsive drug use and its neural substrates.","volume":"23","author":"Lesscher","year":"2012","journal-title":"Rev. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1038\/npp.2014.320","article-title":"The central amygdala nucleus is critical for incubation of methamphetamine craving.","volume":"40","author":"Li","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1021\/acschemneuro.5b00092","article-title":"Structure-activity relationship studies of functionally selective kappa opioid receptor agonists that modulate ERK 1\/2 phosphorylation while preserving G protein over \u03b2arrestin2 signaling bias.","volume":"6","author":"Lovell","year":"2015","journal-title":"ACS Chem. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.173935","article-title":"Alpha-pyrrolidinopentiophenone and mephedrone self-administration produce differential neurochemical changes following short- or long-access conditions in rats.","volume":"897","author":"Marusich","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3791\/4389","article-title":"Performing vaginal lavage, crystal violet staining, and vaginal cytological evaluation for mouse estrous cycle staging identification.","volume":"2012","author":"McLean","year":"2012","journal-title":"J. Vis. Exp."},{"key":"B40","doi-asserted-by":"publisher","year":"2011","journal-title":"Guide for the Care and Use of Laboratory Animals","DOI":"10.17226\/12910"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1111\/adb.12398","article-title":"Escalation of intravenous self-administration of methylone and mephedrone under extended access conditions.","volume":"22","author":"Nguyen","year":"","journal-title":"Addict. Biol."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1101\/177899","article-title":"Withdrawal-induced escalated oxycodone self-administration is mediated by kappa opioid receptor function","author":"Nguyen","year":"","journal-title":"bioRxiv"},{"key":"B43","doi-asserted-by":"publisher","first-page":"3797","DOI":"10.1111\/bph.15520","article-title":"Paradoxical changes in brain reward status during oxycodone self-administration in a novel test of the negative reinforcement hypothesis","volume":"178","author":"Nguyen","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.neuropharm.2018.06.026","article-title":"Prophylactic vaccination protects against the development of oxycodone self-administration.","volume":"138","author":"Nguyen","year":"2018","journal-title":"Neuropharmacology"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.23785","article-title":"Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress.","volume":"6","author":"Polter","year":"2017","journal-title":"Elife"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108512","article-title":"Moderate adolescent chronic intermittent ethanol exposure sex-dependently disrupts synaptic transmission and kappa opioid receptor function in the basolateral amygdala of adult rats.","volume":"188","author":"Przybysz","year":"2021","journal-title":"Neuropharmacology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0165-0270(95)00153-0","article-title":"Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy","volume":"66","author":"Richardson","year":"1996","journal-title":"J. Neurosci. Methods"},{"key":"B48","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.biopsych.2009.11.007","article-title":"Corticotropin releasing factor-induced amygdala gamma-aminobutyric acid release plays a key role in alcohol dependence.","volume":"67","author":"Roberto","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a039339","article-title":"The role of the central amygdala in alcohol dependence","volume":"11","author":"Roberto","year":"2020","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"10159","DOI":"10.1523\/JNEUROSCI.3004-04.2004","article-title":"Increased GABA release in the central amygdala of ethanol-dependent rats.","volume":"24","author":"Roberto","year":"2004","journal-title":"J. Neurosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1007\/s00213-018-5075-5","article-title":"The synthetic cathinones, butylone and pentylone, are stimulants that act as dopamine transporter blockers but 5-HT transporter substrates.","volume":"236","author":"Saha","year":"2019","journal-title":"Psychopharmacology (Berl)"},{"key":"B52","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1124\/mol.115.101394","article-title":"Binding mode selection determines the action of ecstasy homologs at monoamine transporters.","volume":"89","author":"Sandtner","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.biopsych.2016.06.010","article-title":"Hypocretin neurotransmission within the central amygdala mediates escalated cocaine self-administration and stress-induced reinstatement in rats.","volume":"81","author":"Schmeichel","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"B54","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/s41593-021-00806-8","article-title":"Considering sex as a biological variable will require a global shift in science culture.","volume":"24","author":"Shansky","year":"2021","journal-title":"Nat. Neurosci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1111\/j\/1476-5381.2012.02145.x","article-title":"Pharmacological characterization of designer cathinones in vitro","volume":"168","author":"Simmler","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1124\/jpet.115.229765","article-title":"In vitro characterization of psychoactive substances at rat, mouse, and human trace amine-associated receptor 1.","volume":"357","author":"Simmler","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B57","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.neuropharm.2013.11.008","article-title":"Monoamine transporter and receptor interaction profiles of a new series of designer cathinones.","volume":"79","author":"Simmler","year":"","journal-title":"Neuropharmacology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.bcp.2014.01.024","article-title":"Pharmacological profiles of aminoindanes, piperazines, and pipradrol derivatives.","volume":"88","author":"Simmler","year":"","journal-title":"Biochem. Pharmacol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1515\/BC.2011.016","article-title":"The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, \u2018Ecstasy\u2019), methamphetamine and D-amphetamine.","volume":"392","author":"Steinkellner","year":"2011","journal-title":"Biol. Chem."},{"key":"B60","doi-asserted-by":"publisher","first-page":"3093","DOI":"10.1038\/s41380-020-00920-2","article-title":"Importance of sex and trauma context on circulating cytokines and amygdalar GABAergic signaling in a comorbid model of posttraumatic stress and alcohol use disorders","volume":"26","author":"Steinman","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12813","article-title":"Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala","volume":"25","author":"Su\u00e1rez","year":"2019","journal-title":"Addict. Biol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"3759","DOI":"10.1007\/s00213-020-05653-2","article-title":"Role of the GABAa and GABAb receptors of the central nucleus of the amygdala in compulsive cocaine-seeking behavior in male rats.","volume":"237","author":"Sun","year":"2020","journal-title":"Psychopharmacology (Berl)"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.56519","article-title":"Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.","volume":"10","author":"Uprety","year":"2021","journal-title":"Elife"},{"key":"B64","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.neuropharm.2015.08.030","article-title":"Intravenous self-administration of entactogen-class stimulants in male rats.","volume":"99","author":"Vandewater","year":"2015","journal-title":"Neuropharmacology"},{"key":"B65","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1093\/alcalc\/agx114","article-title":"Role of TLR4 in the modulation of central amygdala GABA transmission by CRF following restraint stress.","volume":"53","author":"Varodayan","year":"2018","journal-title":"Alcohol Alcohol."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044652","article-title":"Effect of ambient temperature on the thermoregulatory and locomotor stimulant effects of 4-methylmethcathinone in Wistar and Sprague-Dawley rats.","volume":"7","author":"Wright","year":"2012","journal-title":"PLoS One"}],"container-title":["Frontiers in Behavioral Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnbeh.2021.780500\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T07:47:31Z","timestamp":1639640851000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnbeh.2021.780500\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,16]]},"references-count":66,"alternative-id":["10.3389\/fnbeh.2021.780500"],"URL":"https:\/\/doi.org\/10.3389\/fnbeh.2021.780500","relation":{},"ISSN":["1662-5153"],"issn-type":[{"value":"1662-5153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,16]]},"article-number":"780500"}}