{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:04:58Z","timestamp":1753891498300,"version":"3.41.2"},"reference-count":98,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"abstract":"<jats:p>Disruption of circadian rhythmicity distorts physiological and psychological processes and has major consequences on health and well-being. A chronic misalignment within the internal time-keeping system modulates alcohol consumption and contributes to stress-related psychiatric disorders which are known to trigger alcohol misuse and relapse. While there is growing evidence of the deleterious impact of circadian disruption on male physiology and behavior, knowledge about the effect in females remains limited. The present study aims to fill the gap by assessing the relationship between internal desynchronization and alcohol intake behavior in female rats. Female Wistar rats kept under standard 24-h, 22-h light-dark conditions, or chronic 6-h advanced phase shifts, were given intermittent access to 20% alcohol followed by an extended alcohol deprivation period. Alcohol consumption under altered light-dark (LD) conditions was assessed and emotional behavior during alcohol abstinence was evaluated. Internally desynchronization in female rats does not affect alcohol consumption but alters scores of emotionality during alcohol abstinence. Changes in affective-like behaviors were accompanied by reduced body weight gain and estrous irregularities under aberrant LD conditions. Our data suggest that internal desynchronization caused by environmental factors is not a major factor contributing to the onset and progression of alcohol abuse, but highlights the need of maintaining circadian hygiene as a supportive remedy during alcohol rehabilitation.<\/jats:p>","DOI":"10.3389\/fnbeh.2022.1044783","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T10:02:38Z","timestamp":1671703358000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The effects of circadian desynchronization on alcohol consumption and affective behavior during alcohol abstinence in female rats"],"prefix":"10.3389","volume":"16","author":[{"given":"Christiane","family":"Meyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Schoettner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimon","family":"Amir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/j.1521-0391.2013.12021.x","article-title":"A retrospective study of gender differences in depressive symptoms and risk of relapse in patients with alcohol dependence.","volume":"22","author":"Abulseoud","year":"2013","journal-title":"Am. J. Addict."},{"key":"B2","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.psc.2017.01.005","article-title":"Women and addiction.","volume":"40","author":"Ait-Daoud","year":"2017","journal-title":"Psychiatr. Clin. North Am."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4701563","article-title":"Pathophysiological changes in female rats with estrous cycle disorder induced by long-term heat stress.","volume":"2020","author":"An","year":"2020","journal-title":"Biomed Res. Int."},{"key":"B4","first-page":"99","article-title":"The involvement of suprachiasmatic nuclei in the regulation of estrous cycles in rodents.","volume":"3","author":"Barbacka-Surowiak","year":"2003","journal-title":"Reprod. Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/B978-0-12-812202-0.00013-0","article-title":"Chapter 13 \u2013 Circadian rhythms and addiction","volume":"2019","author":"Barko","year":"2019","journal-title":"Neural Mech. Addict."},{"key":"B6","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1124\/pr.115.011163","article-title":"Sex differences in animal models: Focus on addiction.","volume":"68","author":"Becker","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.262","article-title":"Timing of light exposure affects mood and brain circuits.","volume":"7","author":"Bedrosian","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0237-16.2016","article-title":"Circadian forced desynchrony of the master clock leads to phenotypic manifestation of depression in rats","volume":"3","author":"Ben-Hamo","year":"2016","journal-title":"eNeuro"},{"key":"B9","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1080\/07420528.2021.1989448","article-title":"Sex differences in the response to circadian disruption in diurnal sand rats.","volume":"39","author":"Bilu","year":"2022","journal-title":"Chronobiol. Int."},{"key":"B10","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/J.BBR.2004.04.017","article-title":"Regular voluntary exercise reduces anxiety-related behaviour and impulsiveness in mice.","volume":"155","author":"Binder","year":"2004","journal-title":"Behav. Brain Res."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781316257081.010","article-title":"A chronobiological perspective on allostasis and its application to shift work","author":"Boulos","year":"2004","journal-title":"Allostasis, homeostasis, and the costs of physiological adaptation"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/biology8010018","article-title":"Telling the time with a broken clock: Quantifying circadian disruption in animal models.","volume":"8","author":"Brown","year":"2019","journal-title":"Biology"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/FNBEH.2021.639790\/BIBTEX","article-title":"The influence of moderate physical activity on brain monoaminergic responses to binge-patterned alcohol ingestion in female mice.","volume":"15","author":"Buhr","year":"2021","journal-title":"Front. Behav. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.ajog.2019.06.051","article-title":"The impact of occupational shift work and working hours during pregnancy on health outcomes: A systematic review and meta-analysis.","volume":"221","author":"Cai","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1177\/0748730411429447","article-title":"Forced desynchronization of activity rhythms in a model of chronic jet lag in mice.","volume":"27","author":"Casiraghi","year":"2012","journal-title":"J. Biol. Rhythms"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1111\/j.1530-0277.2007.00476.x","article-title":"Repeated light-dark phase shifts modulate voluntary ethanol intake in male and female high alcohol-drinking (HAD1) rats.","volume":"31","author":"Clark","year":"2007","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1177\/0192623315570339","article-title":"Vaginal cytology of the laboratory rat and mouse: Review and criteria for the staging of the estrous cycle using stained vaginal smears.","volume":"43","author":"Cora","year":"2015","journal-title":"Toxicol. Pathol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3758\/s13415-018-00653-4","article-title":"A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive\u2013compulsive disorder: Mapping the way forward.","volume":"19","author":"de Brouwer","year":"2019","journal-title":"Cogn. Affect. Behav. Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.cub.2004.04.034","article-title":"Forced desynchronization of dual circadian oscillators within the rat suprachiasmatic nucleus.","volume":"14","author":"de La Iglesia","year":"2004","journal-title":"Curr. Biol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5720842","article-title":"Neural mechanisms of circadian regulation of natural and drug reward.","volume":"2017","author":"Depoy","year":"2017","journal-title":"Neural Plast."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.21769\/bioprotoc.1822","article-title":"Sucrose preference test to measure stress-induced anhedonia.","volume":"6","author":"Eagle","year":"2016","journal-title":"Bio Protoc."},{"key":"B22","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/J.ALCOHOL.2009.06.003","article-title":"Reduced alcohol consumption in mice with access to a running wheel.","volume":"43","author":"Ehringer","year":"2009","journal-title":"Alcohol"},{"key":"B23","first-page":"274","article-title":"Alcohol\u2019s effects on female reproductive function.","volume":"26","author":"Emanuele","year":"2002","journal-title":"Alcohol Res. Health"},{"key":"B24","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1111\/adb.12589","article-title":"Sex hormones in alcohol consumption: A systematic review of evidence.","volume":"24","author":"Erol","year":"2019","journal-title":"Addict. Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/BF02245751","article-title":"Characterisation of the phenomenon of \u201cone-trial tolerance\u201d to the anxiolytic effect of chlordiazepoxide in the elevated plus-maze.","volume":"102","author":"File","year":"1990","journal-title":"Psychopharmacology"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2019.106128","article-title":"The epidemiology of alcohol use disorders cross-nationally: Findings from the world mental health surveys.","volume":"102","author":"Glantz","year":"2020","journal-title":"Addict. Behav."},{"key":"B27","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/0031-9384(70)90246-5","article-title":"The effect of constant light on the estrous cycle and behavior of the female rat.","volume":"5","author":"Hardy","year":"1970","journal-title":"Physiol. Behav."},{"key":"B28","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1369-1600.2009.00194.x","article-title":"Acute withdrawal, protracted abstinence and negative affect in alcoholism: Are they linked?","volume":"15","author":"Heilig","year":"2010","journal-title":"Addict. Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/S0091-3057(98)00008-2","article-title":"Responses of Swiss\u2013webster mice to repeated plus-maze experience: Further evidence for a qualitative shift in emotional state?","volume":"60","author":"Holmes","year":"1998","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B30","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/S0149-7634(99)00030-5","article-title":"Influence of spatial and temporal manipulations on the anxiolytic efficacy of chlordiazepoxide in mice previously exposed to the elevated plus-maze.","volume":"23","author":"Holmes","year":"1999","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.35946\/arcr.v40.3.03","article-title":"Sex and gender effects in recovery from alcohol use disorder.","volume":"40","author":"Holzhauer","year":"2019","journal-title":"Alcohol Res. Curr. Rev."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00272","article-title":"Chronic jet lag simulation decreases hippocampal neurogenesis and enhances depressive behaviors and cognitive deficits in adult male rats.","volume":"13","author":"Horsey","year":"2020","journal-title":"Front. Behav. Neurosci."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21341-w","article-title":"Binge Alcohol exposure causes neurobehavioral deficits and GSK3\u03b2 activation in the hippocampus of adolescent rats.","volume":"8","author":"Ji","year":"2018","journal-title":"Sci. Rep."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1111\/add.13386","article-title":"Gender-specific effects of comorbid depression and anxiety on the propensity to drink in negative emotional states.","volume":"111","author":"Karpyak","year":"2016","journal-title":"Addiction"},{"key":"B35","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/J.BRAINRES.2009.03.038","article-title":"Brain stress systems in the amygdala and addiction.","volume":"1293","author":"Koob","year":"2009","journal-title":"Brain Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/S2215-0366(16)00104-8","article-title":"Neurobiology of addiction: A neurocircuitry analysis.","volume":"3","author":"Koob","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"B37","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/alcalc\/agq035","article-title":"Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption.","volume":"45","author":"Kovanen","year":"2010","journal-title":"Alcohol Alcohol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1080\/07399330290107449","article-title":"Effects of shiftwork on sleep and menstrual function in nurses.","volume":"23","author":"Labyak","year":"2002","journal-title":"Health Care Women Int."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1007\/S11357-012-9502-Y\/FIGURES\/12","article-title":"Voluntary exercise can strengthen the circadian system in aged mice.","volume":"35","author":"Leise","year":"2013","journal-title":"Age"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10060405","article-title":"Incubation of negative affect during protracted alcohol withdrawal is age-, but not sex-selective.","volume":"10","author":"Leonardo Jimenez Chavez","year":"2020","journal-title":"Brain Sci."},{"key":"B41","first-page":"163","article-title":"Differences between male and female rats in alcohol drinking, negative affects and neuronal activity after acute and prolonged abstinence.","volume":"11","author":"Li","year":"2019","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1038\/s41596-018-0011-z","article-title":"Sucrose preference test for measurement of stress-induced anhedonia in mice.","volume":"13","author":"Liu","year":"2018","journal-title":"Nat. Protoc."},{"key":"B43","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1093\/humrep\/det417","article-title":"Moderate alcohol intake and menstrual cycle characteristics.","volume":"29","author":"Lyngs\u00f8","year":"2014","journal-title":"Hum. Reprod."},{"key":"B44","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S0376-8716(98)00095-7","article-title":"The comorbidity of alcohol dependence and affective disorders: Treatment implications.","volume":"52","author":"Lynskey","year":"1998","journal-title":"Drug Alcohol Depend."},{"key":"B45","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.cpr.2017.10.012","article-title":"Sex and gender differences in substance use disorders.","volume":"66","author":"McHugh","year":"2018","journal-title":"Clin. Psychol. Rev."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002954","article-title":"Heavy and binge alcohol drinking and parenting status in the United States from 2006 to 2018: An analysis of nationally representative cross-sectional surveys.","volume":"16","author":"McKetta","year":"2019","journal-title":"PLoS Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.alcohol.2017.08.014","article-title":"An alcohol withdrawal test battery measuring multiple behavioral symptoms in mice.","volume":"68","author":"Metten","year":"2018","journal-title":"Alcohol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079824","article-title":"Fischer rats consume 20% ethanol in a long-term intermittent-access two-bottle-choice paradigm.","volume":"8","author":"Mill","year":"2013","journal-title":"PLoS One"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/srep33500","article-title":"SCOP\/PHLPP1\u03b2 in the basolateral amygdala regulates circadian expression of mouse anxiety-like behavior.","volume":"6","author":"Nakano","year":"2016","journal-title":"Sci. Rep."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/J.NEUBIOREV.2011.12.012","article-title":"The use of a running wheel to measure activity in rodents: Relationship to energy balance, general activity, and reward.","volume":"36","author":"Novak","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B51","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.physbeh.2016.01.003","article-title":"Decreased emotional reactivity of rats exposed to repeated phase shifts of light-dark cycle.","volume":"156","author":"Okuliarova","year":"2016","journal-title":"Physiol. Behav."},{"key":"B52","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/S00213-003-1425-Y","article-title":"A 5-HT1A agonist and a 5-HT2c antagonist reduce social interaction deficit induced by multiple ethanol withdrawals in rats.","volume":"167","author":"Overstreet","year":"2003","journal-title":"Psychopharmacology"},{"key":"B53","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1038\/npp.2013.138","article-title":"The role of clock in ethanol-related behaviors.","volume":"38","author":"Ozburn","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"B54","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/J.ALCOHOL.2008.04.006","article-title":"Wheel running, voluntary ethanol consumption, and hedonic substitution.","volume":"42","author":"Ozburn","year":"2008","journal-title":"Alcohol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00343","article-title":"Mood disorders and severity of addiction in alcohol-dependent patients could be mediated by sex differences.","volume":"10","author":"Palma-\u00c1lvarez","year":"2019","journal-title":"Front. Psychiatry"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1111\/ejn.12195","article-title":"Depression-related behaviours displayed by female C57BL\/6J mice during abstinence from chronic ethanol consumption are rescued by wheel-running.","volume":"37","author":"Pang","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.alcohol.2014.09.034","article-title":"Circadian clock genes: Effects on dopamine, reward and addiction.","volume":"49","author":"Parekh","year":"2015","journal-title":"Alcohol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s00702-012-0810-2","article-title":"Clock gene variants in mood and anxiety disorders.","volume":"119","author":"Partonen","year":"2012","journal-title":"J. Neural Transm."},{"key":"B59","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.alcohol.2014.08.013","article-title":"Clock genes in human alcohol abuse and comorbid conditions.","volume":"49","author":"Partonen","year":"2015","journal-title":"Alcohol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2019.100149","article-title":"Sex differences in stress-related alcohol use.","volume":"10","author":"Peltier","year":"2019","journal-title":"Neurobiol. Stress"},{"key":"B61","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.alcohol.2015.04.003","article-title":"Clock genes\u00d7stress\u00d7reward interactions in alcohol and substance use disorders.","volume":"49","author":"Perreau-Lenz","year":"2015","journal-title":"Alcohol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1111\/ACER.12519","article-title":"Oral self-administration of EtOH: Sex-dependent modulation by running wheel access in C57BL\/6J mice.","volume":"38","author":"Piza-Palma","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.pbb.2016.08.001","article-title":"Sex, strain, and estrous cycle influences on alcohol drinking in rats.","volume":"152","author":"Priddy","year":"2017","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B64","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","article-title":"The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: A review.","volume":"463","author":"Prut","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.alcohol.2006.06.007","article-title":"Chronic daily ethanol and withdrawal: 6. Effects on rat sympathoadrenal activity during \u201cabstinence\u201d.","volume":"38","author":"Rasmussen","year":"2006","journal-title":"Alcohol"},{"key":"B66","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3758\/BF03203466","article-title":"Analysis of the circadian rhythm of body temperature.","volume":"24","author":"Refinetti","year":"1992","journal-title":"Behav. Res. Methods Instrum. Comput."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1016\/S0140-6736(09)60746-7","article-title":"Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders.","volume":"373","author":"Rehm","year":"2009","journal-title":"Lancet"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1111\/adb.12674","article-title":"Circadian disruption favors alcohol consumption and differential \u0394FosB accumulation in corticolimbic structures.","volume":"24","author":"Res\u00e9ndiz-Flores","year":"2019","journal-title":"Addict. Biol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1159\/000507573","article-title":"Shiftwork and alcohol consumption: A systematic review of the literature.","volume":"27","author":"Richter","year":"2021","journal-title":"Eur. Addict. Res."},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3390\/genes13040701","article-title":"The impact of sex, circadian disruption, and the clock\u039419\/\u039419 genotype on alcohol drinking in mice.","volume":"13","author":"Rizk","year":"2022","journal-title":"Genes"},{"key":"B71","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/BF02253596","article-title":"Effects of diazepam on behavioural and antinociceptive responses to the elevated plus-maze in male mice depend upon treatment regimen and prior maze experience.","volume":"106","author":"Rodgers","year":"1992","journal-title":"Psychopharmacology"},{"key":"B72","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.alcohol.2010.03.002","article-title":"Effects of repeated light-dark phase shifts on voluntary ethanol and water intake in male and female Fischer and Lewis rats.","volume":"44","author":"Rosenwasser","year":"2010","journal-title":"Alcohol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.physbeh.2015.05.011","article-title":"Photoperiodic modulation of voluntary ethanol intake in C57BL\/6 mice.","volume":"147","author":"Rosenwasser","year":"2015","journal-title":"Physiol. Behav."},{"key":"B74","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.alcohol.2014.07.010","article-title":"Circadian activity rhythms and voluntary ethanol intake in male and female ethanol-preferring rats: Effects of long-term ethanol access.","volume":"48","author":"Rosenwasser","year":"2014","journal-title":"Alcohol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1111\/J.1460-9568.2008.06451.X","article-title":"Chronic stress-induced alterations in amygdala responsiveness and behavior \u2013 modulation by trait anxiety and corticotropin-releasing factor systems.","volume":"28","author":"Sandi","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11040522","article-title":"Brain sciences review behavior testing in rodents: Highlighting potential confounds affecting variability and reproducibility section on neuroadaptation and protein metabolism.","volume":"11","author":"Sar\u00e9","year":"2021","journal-title":"Brain Sci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/acer.13571","article-title":"Ovarian hormones contribute to high levels of binge-like drinking by female mice.","volume":"42","author":"Satta","year":"2018","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.psyneuen.2007.04.003","article-title":"Attenuation of estrous cycle-dependent marble burying in female rats by acute treatment with progesterone and antidepressants.","volume":"32","author":"Schneider","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.922080","article-title":"Characterization of affective behaviors and motor functions in mice with a striatal-specific deletion of bmal1 and per2.","volume":"13","author":"Schoettner","year":"2022","journal-title":"Front. Physiol."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113943","article-title":"Disruption of circadian rhythms: A crucial factor in the etiology of infertility.","volume":"21","author":"Sciarra","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1111\/j.1530-0277.2008.00753.x","article-title":"Intermittent access to 20% ethanol induces high ethanol consumption in Long-Evans and Wistar rats.","volume":"32","author":"Simms","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B82","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/J.BRAINRES.2006.10.063","article-title":"Diurnal differences in dopamine transporter and tyrosine hydroxylase levels in rat brain: Dependence on the suprachiasmatic nucleus.","volume":"1129","author":"Sleipness","year":"2007","journal-title":"Brain Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0022-5193(78)90022-X","article-title":"The chi square periodogram: Its utility for analysis of circadian rhythms.","volume":"72","author":"Sokolove","year":"1978","journal-title":"J. Theor. Biol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/nm1163","article-title":"The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption.","volume":"11","author":"Spanagel","year":"2005","journal-title":"Nat. Med."},{"journal-title":"Canadian community health survey: Mental health. The daily.","year":"2013","key":"B85"},{"key":"B86","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1038\/npp.2008.90","article-title":"Abstinence following alcohol drinking produces depression-like behavior and reduced hippocampal neurogenesis in mice.","volume":"34","author":"Stevenson","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2021.173105","article-title":"Circadian rhythms and substance use disorders: A bidirectional relationship.","volume":"201","author":"Tamura","year":"2021","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B88","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ejphar.2008.03.035","article-title":"Increased marble-burying behavior in ethanol-withdrawal state: Modulation by gonadotropin-releasing hormone agonist.","volume":"587","author":"Umathe","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1097\/01.ALC.0000033120.51856.F0","article-title":"Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: Regulation by corticotropin-releasing factor.","volume":"26","author":"Valdez","year":"2002","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B90","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/ejn.14255","article-title":"Circadian disruption: What do we actually mean?","volume":"51","author":"Vetter","year":"2018","journal-title":"Eur. J. Neurosci."},{"key":"B91","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The use of the elevated plus maze as an assay of anxiety-related behavior in rodents.","volume":"2","author":"Walf","year":"2007","journal-title":"Nat. Protoc."},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3390\/APP12189220","article-title":"The impact of physical activity on the circadian system: Benefits for health, performance and Wellbeing.","volume":"12","author":"Weinert","year":"2022","journal-title":"Appl. Sci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1080\/07420528.2016.1205083","article-title":"Intensive voluntary wheel running may restore circadian activity rhythms and improves the impaired cognitive performance of arrhythmic djungarian hamsters.","volume":"33","author":"Weinert","year":"2016","journal-title":"Chronobiol. Int."},{"key":"B94","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/BF00414034","article-title":"Voluntary ethanol intake in rats following exposure to ethanol on various schedules.","volume":"29","author":"Wise","year":"1973","journal-title":"Psychopharmacologia"},{"key":"B95","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/0031-9384(88)90204-1","article-title":"Estrous correlated modulations of circadian and ultradian wheel-running activity rhythms in LEW\/Ztm rats.","volume":"43","author":"Wollnik","year":"1988","journal-title":"Physiol. Behav."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00303","article-title":"The risk factors of the alcohol use disorders-through review of its comorbidities.","volume":"12","author":"Yang","year":"2018","journal-title":"Front. Neurosci."},{"key":"B97","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1111\/gtc.12522","article-title":"Effect of different light\u2013dark schedules on estrous cycle in mice, and implications for mitigating the adverse impact of night work.","volume":"22","author":"Yoshinaka","year":"2017","journal-title":"Genes Cells"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1038\/465690a","article-title":"Males still dominate animal studies.","volume":"465","author":"Zucker","year":"2010","journal-title":"Nature"}],"container-title":["Frontiers in Behavioral Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnbeh.2022.1044783\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T10:02:44Z","timestamp":1671703364000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnbeh.2022.1044783\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,22]]},"references-count":98,"alternative-id":["10.3389\/fnbeh.2022.1044783"],"URL":"https:\/\/doi.org\/10.3389\/fnbeh.2022.1044783","relation":{},"ISSN":["1662-5153"],"issn-type":[{"type":"electronic","value":"1662-5153"}],"subject":[],"published":{"date-parts":[[2022,12,22]]},"article-number":"1044783"}}