{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:44:46Z","timestamp":1790761486456,"version":"4.1.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009670","name":"National Alliance for Research on Schizophrenia and Depression","doi-asserted-by":"publisher","award":["2007"],"award-info":[{"award-number":["2007"]}],"id":[{"id":"10.13039\/100009670","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Post-traumatic stress disorder (PTSD) is associated with hippocampal system structural and functional impairments. Neurobiological models of PTSD posit that contextual memory for traumatic events is impaired due to hippocampal system dysfunction whilst memory of sensory details is enhanced due to amygdalar impact on sensory cortices. If hippocampal system dysfunction is a core feature of PTSD, then non-traumatic hippocampal-dependent cognitive functions such as scene construction, spatial processing, and memory should also be impaired in individuals with PTSD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty-six trauma survivors, half diagnosed with PTSD, performed two tasks that involved spatial processing. The first was a scene construction task which requires conjuring-up spatially coherent multimodal scenarios, completed by all participants. Twenty-six participants (PTSD: <jats:italic>n<\/jats:italic> = 13) also completed a navigation task in a virtual environment, and underwent structural T1, T2 and diffusion-tensor MRI to quantify gray and white matter integrity. We examined the relationship between spatial processing, neural integrity, and symptom severity in a multiple factor analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, patients with PTSD showed impaired performance in both tasks compared to controls. Scenes imagined by patients were less vivid, less detailed, and generated less sense of presence; importantly they had disproportionally reduced spatial coherence between details. Patients also made more errors during virtual navigation. Two components of the multiple factor analysis captured group differences. The first component explained 25% of the shared variance: participants that constructed less spatially coherent scenes also made more navigation errors and had reduced white matter integrity to long association tracts and tracts connecting the hippocampus, thalamus, and cingulate. The second component explained 20% of the variance: participants who generated fewer scene details, with less spatial coherence between them, had smaller hippocampal, parahippocampal and isthmus cingulate volumes. These participants also had increased white matter integrity to the right hippocampal cingulum bundle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that patients with PTSD are impaired at imagining even neutral spatially coherent scenes and navigating through a complex spatial environment. Patients that showed reduced spatial processing more broadly had reduced hippocampal systems volumes and abnormal white matter integrity to tracts implicated in multisensory integration.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnbeh.2022.888358","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T14:09:42Z","timestamp":1656511782000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Scene Construction and Spatial Processing in Post-traumatic Stress Disorder"],"prefix":"10.3389","volume":"16","author":[{"given":"Hannah","family":"Marlatte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Beaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Adler-Luzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Abo-Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asaf","family":"Gilboa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1002\/hipo.10215","article-title":"Recollective qualities modulate hippocampal activation during autobiographical memory retrieval.","volume":"14","author":"Addis","year":"2004","journal-title":"Hippocampus"},{"key":"B2","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.csda.2013.11.006","article-title":"An ExPosition of multivariate analysis with the singular value decomposition in R.","volume":"72","author":"Beaton","year":"2014","journal-title":"Comput. Stat. Data Analys."},{"key":"B3","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.psyneuen.2014.11.007","article-title":"White matter abnormalities in Gulf War veterans with posttraumatic stress disorder: A pilot study.","volume":"51","author":"Bierer","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"B4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/jts.2490080106","article-title":"The development of a clinician-administered PTSD scale.","volume":"8","author":"Blake","year":"1995","journal-title":"J. Traum. Stress"},{"key":"B5","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1080\/09658210701256423","article-title":"Autobiographical memory for trauma: update on four controversies.","volume":"15","author":"Brewin","year":"2007","journal-title":"Memory"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1037\/a0018113","article-title":"Intrusive images in psychological disorders: characteristics, neural mechanisms, and treatment implications.","volume":"117","author":"Brewin","year":"2010","journal-title":"Psychol. Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1080\/09658211.2013.807842","article-title":"Episodic and semantic components of autobiographical memories and imagined future events in post-traumatic stress disorder.","volume":"22","author":"Brown","year":"2014","journal-title":"Memory"},{"key":"B8","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jbtep.2011.11.004","article-title":"Overgeneralized autobiographical memory and future thinking in combat veterans with posttraumatic stress disorder.","volume":"44","author":"Brown","year":"2013","journal-title":"J. Behav. Ther. Exp. Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.116.4.837","article-title":"Impaired specific autobiographical memory as a risk factor for posttraumatic stress after trauma.","volume":"116","author":"Bryant","year":"2007","journal-title":"J. Abnorm. Psychol."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-9-39","article-title":"Insular cortex involvement in declarative memory deficits in patients with post-traumatic stress disorder.","volume":"9","author":"Chen","year":"2009","journal-title":"BMC Psychiatry"},{"key":"B11","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.neurobiolaging.2008.06.015","article-title":"Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer\u2019s disease.","volume":"31","author":"Choo","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"B12","doi-asserted-by":"crossref","DOI":"10.1159\/000107570","article-title":"Scientific study of the dissociative disorders.","volume":"76","author":"Dalenberg","year":"2007","journal-title":"Psychother. Psychosomat."},{"key":"B13","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/da.22044","article-title":"White matter integrity and its relationship to PTSD and childhood trauma\u2014A systematic review and meta-analysis.","volume":"30","author":"Daniels","year":"2013","journal-title":"Depress. Anxiety"},{"key":"B14","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.cpr.2013.05.002","article-title":"Pretrauma risk factors for posttraumatic stress disorder: A systematic review of the literature.","volume":"33","author":"DiGangi","year":"2013","journal-title":"Clin. Psychol. Rev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0165-0327(01)00351-2","article-title":"Are the neural substrates of memory the final common pathway in posttraumatic stress disorder (PTSD)?","volume":"70","author":"Elzinga","year":"2002","journal-title":"J. Affect. Disord."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2740","DOI":"10.1038\/npp.2012.146","article-title":"White matter integrity in highly traumatized adults with and without post-traumatic stress disorder.","volume":"37","author":"Fani","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"B17","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1521\/jscp.24.3.401.65616","article-title":"Hope and the meaningful life: theoretical and empirical associations between goal\u2013directed thinking and life meaning.","volume":"24","author":"Feldman","year":"2005","journal-title":"J. Soc. Clin. Psychol."},{"key":"B18","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer.","volume":"62","author":"Fischl","year":"2012","journal-title":"Neuroimage"},{"key":"B19","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1196\/annals.1364.010","article-title":"Toward a psychobiology of posttraumatic self-dysregulation: reexperiencing, hyperarousal, dissociation, and emotional numbing.","volume":"1071","author":"Frewen","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1002\/jts.21840","article-title":"Finalizing PTSD in DSM-5: getting here from there and where to go next.","volume":"26","author":"Friedman","year":"2013","journal-title":"J. Traum. Stress"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1038\/nn958","article-title":"Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma.","volume":"5","author":"Gilbertson","year":"2002","journal-title":"Nat. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.biopsych.2006.12.023","article-title":"Configural cue performance in identical twins discordant for posttraumatic stress disorder: theoretical implications for the role of hippocampal function.","volume":"62","author":"Gilbertson","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"B23","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/978-1-4899-7522-5_10","article-title":"Functional neuroanatomy of PTSD: developmental cytoarchitectonic trends, memory systems, and control processes","author":"Gilboa","year":"2015","journal-title":"Future Directions in"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1093\/cercor\/bhh082","article-title":"Remembering our past: functional neuroanatomy of recollection of recent and very remote personal events.","volume":"14","author":"Gilboa","year":"2004","journal-title":"Cereb. Cortex"},{"key":"B25","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.neuropsychologia.2009.10.013","article-title":"Greater superior than inferior parietal lobule activation with increasing rotation angle during mental rotation: an fMRI study.","volume":"48","author":"Gogos","year":"2010","journal-title":"Neuropsychologia"},{"key":"B26","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.jbtep.2014.03.001","article-title":"Overgeneral memory in asylum seekers and refugees.","volume":"45","author":"Graham","year":"2014","journal-title":"J. Behav. Ther. Exp. Psychiatry"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006x.71.3.419","article-title":"Posttraumatic stress disorder following assault: the role of cognitive processing, trauma memory, and appraisals.","volume":"71","author":"Halligan","year":"2003","journal-title":"J. Consult. Clin. Psychol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1073\/pnas.0610561104","article-title":"Patients with hippocampal amnesia cannot imagine new experiences.","volume":"104","author":"Hassabis","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B29","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.tics.2007.05.001","article-title":"Deconstructing episodic memory with construction.","volume":"11","author":"Hassabis","year":"2007","journal-title":"Trends Cogn. Sci."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116575","article-title":"Precuneus stimulation alters the neural dynamics of autobiographical memory retrieval.","volume":"210","author":"Hebscher","year":"2020","journal-title":"Neuroimage"},{"key":"B31","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.neuropsychologia.2017.03.029","article-title":"The precuneus and hippocampus contribute to individual differences in the unfolding of spatial representations during episodic autobiographical memory.","volume":"110","author":"Hebscher","year":"2018","journal-title":"Neuropsychologia"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.43114","article-title":"A causal role for the precuneus in network-wide theta and gamma oscillatory activity during complex memory retrieval.","volume":"8","author":"Hebscher","year":"2019","journal-title":"Elife"},{"key":"B33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1023\/A:1015439106231","article-title":"Neurocognitive functioning in posttraumatic stress disorder.","volume":"12","author":"Horner","year":"2002","journal-title":"Neuropsychol. Rev."},{"key":"B34","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.cpr.2005.12.004","article-title":"Is posttraumatic stress disorder associated with specific deficits in episodic memory?","volume":"26","author":"Isaac","year":"2006","journal-title":"Clin. Psychol. Rev."},{"key":"B35","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.brat.2006.02.004","article-title":"The organisation and content of trauma memories in survivors of road traffic accidents.","volume":"45","author":"Jones","year":"2007","journal-title":"Behav. Res. Ther."},{"key":"B36","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.jad.2020.01.047","article-title":"White matter microstructural alterations in posttraumatic stress disorder: an ROI and whole-brain based meta-analysis.","volume":"266","author":"Ju","year":"2020","journal-title":"J. Affect. Disord."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/j.neubiorev.2006.03.004","article-title":"A meta-analysis of structural brain abnormalities in PTSD.","volume":"30","author":"Karl","year":"2006","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B38","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.biopsych.2007.06.022","article-title":"Evidence for acquired pregenual anterior cingulate gray matter loss from a twin study of combat-related posttraumatic stress disorder.","volume":"63","author":"Kasai","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"B39","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1038\/npp.2015.94","article-title":"Treatment outcome-related white matter differences in veterans with posttraumatic stress disorder.","volume":"40","author":"Kennis","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/jts.21848","article-title":"National estimates of exposure to traumatic events and PTSD prevalence using DSM-IV and DSM-5 criteria.","volume":"26","author":"Kilpatrick","year":"2013","journal-title":"J. Traum. Stress"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1002\/aur.2558","article-title":"Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder.","volume":"14","author":"Kitamura","year":"2021","journal-title":"Autism Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.neubiorev.2019.09.024","article-title":"Impaired hippocampus-dependent associative learning as a mechanism underlying PTSD: A meta-analysis.","volume":"107","author":"Lambert","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.01021","article-title":"Shared and distinct neural bases of large-and small-scale spatial ability: a coordinate-based activation likelihood estimation meta-analysis.","volume":"12","author":"Li","year":"2019","journal-title":"Front. Neurosci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.biopsych.2017.09.006","article-title":"Smaller hippocampal volume in posttraumatic stress disorder: a multisite ENIGMA-PGC study: subcortical volumetry results from posttraumatic stress disorder consortia.","volume":"83","author":"Logue","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"B45","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/s1052-5149(03)00104-7","article-title":"Positron emission tomography imaging in depression: a neural systems perspective.","volume":"13","author":"Mayberg","year":"2003","journal-title":"Neuroimag. Clin."},{"key":"B46","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/s0272-7358(98)00036-1","article-title":"Experimental approaches to cognitive abnormality in posttraumatic stress disorder.","volume":"18","author":"McNally","year":"1998","journal-title":"Clin. Psychol. Rev."},{"key":"B47","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/0005-7967(95)00007-k","article-title":"Autobiographical memory disturbance in combat-related posttraumatic stress disorder.","volume":"33","author":"McNally","year":"1995","journal-title":"Behav. Res. Ther."},{"key":"B48","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1196\/annals.1401.006","article-title":"The role of the orbitofrontal cortex in anxiety disorders.","volume":"1121","author":"Milad","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.brat.2012.03.009","article-title":"Overgeneral autobiographical memory recollection in Iranian combat veterans with posttraumatic stress disorder.","volume":"50","author":"Moradi","year":"2012","journal-title":"Behav. Res. Ther."},{"key":"B50","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.pscychresns.2015.09.006","article-title":"Evidence for disrupted gray matter structural connectivity in posttraumatic stress disorder.","volume":"234","author":"Mueller","year":"2015","journal-title":"Psychiatry Res. Neuroimag."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1037\/tra0000027","article-title":"A meta-analytic review of overgeneral memory: the role of trauma history, mood, and the presence of posttraumatic stress disorder.","volume":"8","author":"Ono","year":"2016","journal-title":"Psychol. Traum."},{"key":"B52","doi-asserted-by":"publisher","first-page":"S101","DOI":"10.1186\/s12913-016-1423-5","article-title":"Is traumatic memory special? A comparison of traumatic memory characteristics with memory for other emotional life experiences.","volume":"15","author":"Porter","year":"2001","journal-title":"Appl. Cogn. Psychol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1176\/jnp.23.1.jnp16","article-title":"Does PTSD impair cognition beyond the effect of trauma?","volume":"23","author":"Qureshi","year":"2011","journal-title":"J. Neuropsychiatr. Clin. Neurosci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.biopsych.2006.06.004","article-title":"Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research\u2014past, present, and future.","volume":"60","author":"Rauch","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1037\/a0013165","article-title":"Memory in posttraumatic stress disorder: properties of voluntary and involuntary, traumatic and nontraumatic autobiographical memories in people with and without posttraumatic stress disorder symptoms.","volume":"137","author":"Rubin","year":"2008","journal-title":"J. Exp. Psychol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/nrn2213","article-title":"Remembering the past to imagine the future: the prospective brain.","volume":"8","author":"Schacter","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1177\/2167702616688878","article-title":"Posttraumatic stress disorder and autobiographical memories in everyday life.","volume":"5","author":"Sch\u00f6nfeld","year":"2017","journal-title":"Clin. Psychol. Sci."},{"key":"B58","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1080\/09658210701256571","article-title":"Overgeneral memory and suppression of trauma memories in post-traumatic stress disorder.","volume":"15","author":"Sch\u00f6nfeld","year":"2007","journal-title":"Memory"},{"key":"B59","doi-asserted-by":"publisher","first-page":"S62","DOI":"10.1016\/j.neuroimage.2010.05.024","article-title":"Patterns of altered cortical perfusion and diminished subcortical integrity in posttraumatic stress disorder: an MRI study.","volume":"54","author":"Schuff","year":"2011","journal-title":"Neuroimage"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1037\/a0038039","article-title":"A quantitative meta-analysis of neurocognitive functioning in posttraumatic stress disorder.","volume":"141","author":"Scott","year":"2015","journal-title":"Psychol. Bull."},{"key":"B61","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1196\/annals.1364.007","article-title":"Amygdala, medial prefrontal cortex, and hippocampal function in PTSD.","volume":"1071","author":"Shin","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.nlm.2015.01.007","article-title":"Impaired allocentric spatial processing in posttraumatic stress disorder.","volume":"119","author":"Smith","year":"2015","journal-title":"Neurobiol. Learn. Memory"},{"key":"B63","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.neubiorev.2020.12.029","article-title":"Visual mental imagery engages the left fusiform gyrus, but not the early visual cortex: a meta-analysis of neuroimaging evidence.","volume":"122","author":"Spagna","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B64","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.janxdis.2007.03.008","article-title":"Autobiographical memory and the self-memory system in posttraumatic stress disorder.","volume":"22","author":"Sutherland","year":"2008","journal-title":"J. Anxiety Disord."},{"key":"B66","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1196\/annals.1364.031","article-title":"The relationship between hippocampal volume and declarative memory in a population of combat veterans with and without PTSD.","volume":"1071","author":"Tischler","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/BF02102887","article-title":"Dissociation and the fragmentary nature of traumatic memories: overview and exploratory study.","volume":"8","author":"Van der Kolk","year":"1995","journal-title":"J. Traum. Stress"},{"key":"B68","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1017\/S0033291715000707","article-title":"Smaller hippocampal volume as a vulnerability factor for the persistence of post-traumatic stress disorder.","volume":"45","author":"van Rooij","year":"2015","journal-title":"Psychol. Med."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1037\/a0038322","article-title":"Mental simulation and meaning in life.","volume":"108","author":"Waytz","year":"2015","journal-title":"J. Pers. Soc. Psychol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cortex.2013.02.004","article-title":"Structural network underlying visuospatial imagery in humans.","volume":"56","author":"Whittingstall","year":"2014","journal-title":"Cortex"},{"key":"B71","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1017\/S1355617709990476","article-title":"Hippocampal volume and declarative memory function in combat-related PTSD.","volume":"15","author":"Woodward","year":"2009","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.pnpbp.2010.06.016","article-title":"Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: a meta-analysis.","volume":"34","author":"Woon","year":"2010","journal-title":"Prog. NeuroPsychopharmacol. Biol. Psychiatry"},{"key":"B73","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/j.1601-5215.2011.00580.x","article-title":"Increased white matter integrity of posterior cingulate gyrus in the evolution of post-traumatic stress disorder.","volume":"24","author":"Zhang","year":"2012","journal-title":"Acta Neuropsychiatr."}],"container-title":["Frontiers in Behavioral Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnbeh.2022.888358\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T14:09:59Z","timestamp":1656511799000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnbeh.2022.888358\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,29]]},"references-count":72,"alternative-id":["10.3389\/fnbeh.2022.888358"],"URL":"https:\/\/doi.org\/10.3389\/fnbeh.2022.888358","relation":{},"ISSN":["1662-5153"],"issn-type":[{"value":"1662-5153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,29]]},"article-number":"888358"}}