{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:28:04Z","timestamp":1780759684207,"version":"3.54.1"},"reference-count":98,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021713","name":"Universidad de Almer\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Compulsive behavior has been proposed as a transdiagnostic trait observed in different neuropsychiatric disorders, such as obsessive-compulsive disorder, autism, and schizophrenia. Research Domain Criteria (RDoC) strategy could help to disentangle the neuropsychological basis of compulsivity for developing new therapeutic and preventive approaches. In preclinical research, the selection of high-drinker (HD) vs. low-drinker (LD) animals by schedule-induced polydipsia (SIP) is considered a putative model of compulsivity, which includes a well-differentiated behavioral pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The purpose of this research was to assess the cognitive control and the negative valence system domains in a phenotype of compulsive HD rats. After the selection of animals as HD or LD, we assessed behavioral inflexibility by probabilistic spatial reversal learning (PSRL), motor and cognitive impulsivity by variable delay-to-signal (VDS), and risky decision-making by rodent gambling task (rGT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HD rats performed fewer reversals and showed less probability of pressing the same lever that was previously reinforced on PSRL, more premature responses after the exposure to longer delays on VDS, and more disadvantageous risky choices on rGT. Moreover, HD animals performed more perseverative responses under the punishment period on rGT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These results highlight that HD compulsive phenotype exhibits behavioral inflexibility, insensitivity to positive feedback, waiting impulsivity, risky decision-making, and frustrative non-reward responsiveness. Moreover, these findings demonstrate the importance of mapping different behavioral domains to prevent, treat, and diagnose compulsive spectrum disorders correctly.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnbeh.2023.1175137","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:36:53Z","timestamp":1684417013000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Behavioral domains in compulsive rats: implications for understanding compulsive spectrum disorders"],"prefix":"10.3389","volume":"17","author":[{"given":"Elena","family":"Mart\u00edn-Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Olmedo-C\u00f3rdoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngeles","family":"Prados-Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Cruz-Garz\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Mora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Moreno-Montoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1523\/ENEURO.0094-17.2017","article-title":"Deep-brain stimulation of the subthalamic nucleus selectively decreases risky choice in risk-preferring rats","volume":"4","author":"Adams","year":"2017","journal-title":"ENeuro"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e0234729","DOI":"10.1371\/journal.pone.0234729","article-title":"Sex-dependent effects of chronic intermittent voluntary alcohol consumption on attentional, not motivational, measures during probabilistic learning and reversal","volume":"15","author":"Aguirre","year":"2020","journal-title":"PLoS ONE"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnhum.2021.635932","article-title":"The SEEKING drive and its fixation: a neuro-psycho-evolutionary approach to the pathology of addiction","volume":"15","author":"Alcaro","year":"2021","journal-title":"Front. Hum. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1007\/s00213-019-05296-y","article-title":"Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat: behavioural and computational evidence","volume":"236","author":"Alsi\u00f6","year":"2019","journal-title":"Psychopharmacology"},{"key":"B5","doi-asserted-by":"crossref","unstructured":"Washington, DCAmerican Psychiatric PressDiagnostic and Statistical Manual of Mental Disorders, 5th Edn.2013","DOI":"10.1176\/appi.books.9780890425596"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1038\/npp.2014.303","article-title":"Evidence Accumulation in obsessive-compulsive disorder: the role of uncertainty and monetary reward on perceptual decision-making thresholds","volume":"40","author":"Banca","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1038\/npp.2009.233","article-title":"Serotonin modulates sensitivity to reward and negative feedback in a probabilistic reversal learning task in rats","volume":"35","author":"Bari","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1038\/npp.2014.335","article-title":"Markers of serotonergic function in the orbitofrontal cortex and dorsal raph\u00e9 nucleus predict individual variation in spatial-discrimination serial reversal learning","volume":"40","author":"Barlow","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/mp.2015.140","article-title":"From impulses to maladaptive actions: the insula is a neurobiological gate for the development of compulsive behavior","volume":"21","author":"Belin-Rauscent","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"B10","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3109\/13651501.2013.855792","article-title":"Characterizing impulsivity profile in patients with obsessive-compulsive disorder","volume":"18","author":"Benatti","year":"2014","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"B11","volume-title":"Negative Valence Systems: Workshop Proceedings","author":"Blanchard","year":"2011"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1016\/j.psychres.2012.06.010","article-title":"Behavioral and cognitive impulsivity in obsessive-compulsive disorder and eating disorders","volume":"200","author":"Boisseau","year":"2012","journal-title":"Psychiatry Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1037\/h0077619","article-title":"Schedule-induced polydipsia suppresses pituitary-adrenal activity in rats","volume":"93","author":"Brett","year":"1979","journal-title":"J. Comp. Physiol. Psychol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0031-9384(81)90003-2","article-title":"The pituitary-adrenal response to \u201cminimized\u201d schedule-induced drinking","volume":"26","author":"Brett","year":"1981","journal-title":"Physiol. Behav."},{"key":"B15","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s12640-009-9149-3","article-title":"Impulsivity as long-term sequelae after chlorpyrifos intoxication: time course and individual differences","volume":"19","author":"Cardona","year":"2011","journal-title":"Neurotox. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00213-006-0547-4","article-title":"Vulnerability of long-term neurotoxicity of chlorpyrifos: effect on schedule-induced polydipsia and a delay discounting task","volume":"189","author":"Cardona","year":"2006","journal-title":"Psychopharmacology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0028-3932(01)00077-X","article-title":"Decision-making heterogeneity in obsessive-compulsive disorder: ventromedial prefrontal cortex function predicts different treatment outcomes","volume":"40","author":"Cavedini","year":"2002","journal-title":"Neuropsychologia"},{"key":"B18","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1080\/13546805.2011.614152","article-title":"The somatic marker affecting decisional processes in obsessive-compulsive disorder","volume":"17","author":"Cavedini","year":"2012","journal-title":"Cogn. Neuropsychiatry"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.biopsych.2010.02.012","article-title":"Executive dysfunctions in obsessive-compulsive patients and unaffected relatives: searching for a new intermediate phenotype","volume":"67","author":"Cavedini","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1176\/ajp.2006.163.7.1282","article-title":"Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania","volume":"163","author":"Chamberlain","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"B21","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1176\/ajp.2007.164.2.335","article-title":"Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder","volume":"164","author":"Chamberlain","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"B22","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.neubiorev.2009.02.002","article-title":"Trichotillomania: neurobiology and treatment","volume":"33","author":"Chamberlain","year":"2009","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B23","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/7854_2020_198","article-title":"Cognitive inflexibility in OCD and related disorders","volume":"49","author":"Chamberlain","year":"2021","journal-title":"Curr. Top. Behav. Neurosci"},{"key":"B24","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.bbr.2003.09.020","article-title":"Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity","volume":"146","author":"Chudasama","year":"2003","journal-title":"Behav. Brain Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3389\/fpsyt.2018.00043","article-title":"Behavioral phenotyping of dopamine transporter knockout rats: compulsive traits, motor stereotypies, and anhedonia","volume":"9","author":"Cinque","year":"2018","journal-title":"Front. Psychiatry"},{"key":"B26","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1126\/science.1094987","article-title":"Cognitive inflexibility following prefrontal serotonin depletion","volume":"304","author":"Clarke","year":"2004","journal-title":"Science"},{"key":"B27","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1093\/cercor\/bhj120","article-title":"Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific","volume":"17","author":"Clarke","year":"2007","journal-title":"Cereb. Cortex"},{"key":"B28","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1988"},{"key":"B29","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1590\/S0004-282X2011000500013","article-title":"Decision-making impairment in obsessive-compulsive disorder as measured by the Iowa Gambling task","volume":"69","author":"da Rocha","year":"2011","journal-title":"Arq. Neuropsiquiatr."},{"key":"B30","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.bbr.2008.05.015","article-title":"Decision-making impairment is related to serotonin transporter promoter polymorphism in a sample of patients with obsessive-compulsive disorder","volume":"195","author":"da Rocha","year":"2008","journal-title":"Behav. Brain Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.neuron.2011.01.020","article-title":"Impulsivity, compulsivity, and top-down cognitive control","volume":"69","author":"Dalley","year":"2011","journal-title":"Neuron"},{"key":"B32","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/0031-9384(88)90187-4","article-title":"Schedule-induced polydipsia experience decreases plasma corticosterone levels but increases plasma prolactin levels","volume":"43","author":"Dantzer","year":"1988","journal-title":"Physiol. Behav."},{"key":"B33","doi-asserted-by":"publisher","first-page":"106464","DOI":"10.1016\/j.addbeh.2020.106464","article-title":"The role of experiential avoidance in transdiagnostic compulsive behavior: a structural model analysis","volume":"108","author":"Den Ouden","year":"2020","journal-title":"Addict. Behav."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1747-5341-6-3","article-title":"Obsessionality and compulsivity : a phenomenology of obsessive-compulsive disorder","volume":"6","author":"Denys","year":"2011","journal-title":"Philos. Ethics Humanit. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.bbr.2018.10.003","article-title":"Effects of cognitive judgement bias and acute antidepressant treatment on sensitivity to feedback and cognitive flexibility in the rat version of the probabilistic reversal-learning test","volume":"359","author":"Drozd","year":"2019","journal-title":"Behav. Brain Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"107162","DOI":"10.1016\/j.nlm.2020.107162","article-title":"Instrumental learning in a mouse model for obsessive-compulsive disorder: impaired habit formation in Sapap3 mutants","volume":"168","author":"Ehmer","year":"2020","journal-title":"Neurobiol. Learn. Mem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1600-0447.2006.00835.x","article-title":"Impulsiveness in obsessive-compulsive disorder: results from a family study","volume":"115","author":"Ettelt","year":"2007","journal-title":"Acta Psychiatr. Scand."},{"key":"B38","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1126\/science.133.3447.195","article-title":"Production of polydipsia in Normal rats by an intermittent food schedule","volume":"133","author":"Falk","year":"1961","journal-title":"Science."},{"key":"B39","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1901\/jeab.1966.9-37","article-title":"Schedule-induced polydipsia as a function of fixed interval length","volume":"9","author":"Falk","year":"1966","journal-title":"J. Exp. Anal. Behav."},{"key":"B40","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/0031-9384(71)90209-5","article-title":"The nature and determinants of adjunctive behavior","volume":"6","author":"Falk","year":"1971","journal-title":"Physiol. Behav."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1038\/npp.2008.43","article-title":"The Roman high- and low-avoidance rat lines differ in the acquisition, maintenance, extinction, and reinstatement of intravenous cocaine self-administration","volume":"34","author":"Fattore","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"B42","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1093\/ijnp\/pyx088","article-title":"Mapping compulsivity in the dsm-5 obsessive compulsive and related disorders: cognitive domains, neural circuitry, and treatment","volume":"21","author":"Fineberg","year":"2018","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1017\/S1092852913000801","article-title":"New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity","volume":"19","author":"Fineberg","year":"2014","journal-title":"CNS Spectr."},{"key":"B44","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1017\/S1092852914000662","article-title":"The neuropsychology of obsessive-compulsive personality disorder: a new analysis","volume":"20","author":"Fineberg","year":"2015","journal-title":"CNS Spectr."},{"key":"B45","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1097\/YIC.0000000000000314","article-title":"Clinical advances in obsessive-compulsive disorder: a position statement by the international college of obsessive-compulsive spectrum disorders","volume":"35","author":"Fineberg","year":"2020","journal-title":"Int. Clin. Psychopharmacol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.euroneuro.2016.04.001","article-title":"Compulsivity-A new trans-diagnostic research domain for the Roadmap for Mental Health Research in Europe (ROAMER) and Research Domain Criteria (RDoC) initiatives","volume":"26","author":"Fineberg","year":"2016","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1111\/ejn.15087","article-title":"Environment-dependent behavioral traits and experiential factors shape addiction vulnerability","volume":"53","author":"Fouyssac","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.yhbeh.2014.07.003","article-title":"Behavioral and neuroendocrine consequences of juvenile stress combined with adult immobilization in male rats","volume":"66","author":"Fuentes","year":"2014","journal-title":"Horm. Behav."},{"key":"B49","doi-asserted-by":"publisher","first-page":"113111","DOI":"10.1016\/j.physbeh.2020.113111","article-title":"Effects of partial reinforcement on autoshaping in inbred Roman high- and low-avoidance rats","volume":"225","author":"Fuentes-Verdugo","year":"2020","journal-title":"Physiol. Behav."},{"key":"B50","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/s41386-020-0599-x","article-title":"Effects of exposure to chronic uncertainty and a sensitizing regimen of amphetamine injections on locomotion, decision-making, and dopamine receptors in rats","volume":"45","author":"Fugariu","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1017\/S1092852918000846","article-title":"Impulsivity and decision-making in obsessive-compulsive disorder after effective deep brain stimulation or treatment as usual","volume":"23","author":"Grassi","year":"2018","journal-title":"CNS Spectr."},{"key":"B52","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1017\/S1092852919000993","article-title":"Addicted to compulsion: assessing three core dimensions of addiction across obsessive-compulsive disorder and gambling disorder","volume":"25","author":"Grassi","year":"2020","journal-title":"CNS Spectr."},{"key":"B53","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1556\/2006.4.2015.039","article-title":"Think twice: impulsivity and decision making in obsessive-compulsive disorder","volume":"4","author":"Grassi","year":"2015","journal-title":"J. Behav. Addict."},{"key":"B54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mpr.1406","article-title":"ROAMER: roadmap for mental health research in Europe","volume":"23","author":"Haro","year":"2014","journal-title":"Int. J. Methods Psychiatr. Res"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1523\/ENEURO.0341-21.2021","article-title":"Serotonin 2c antagonism in the lateral orbitofrontal cortex ameliorates cue-enhanced risk preference and restores sensitivity to reinforcer devaluation in male rats","volume":"8","author":"Hathaway","year":"2021","journal-title":"ENeuro"},{"key":"B56","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.bbr.2011.04.017","article-title":"Schedule-induced polydipsia in the Spontaneously Hypertensive Rat and its relation to impulsive behaviour","volume":"223","author":"Ibias","year":"2011","journal-title":"Behav. Brain Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1176\/appi.ajp.2010.09091379","article-title":"Research Domain Criteria (RDoC): toward a new classification framework for research on mental disorders","volume":"167","author":"Insel","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"B58","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.jad.2015.01.060","article-title":"Further evidence of a dissociation between decision-making under ambiguity and decision-making under risk in obsessive-compulsive disorder","volume":"176","author":"Kim","year":"2015","journal-title":"J. Affect. Disord."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1744-859X-11-25","article-title":"Poor performance on the Iowa gambling task in children with obsessive-compulsive disorder","volume":"11","author":"Kodaira","year":"2012","journal-title":"Ann. Gen. Psychiatry"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1523\/JNEUROSCI.1931-17.2018","article-title":"Pronounced hyperactivity, cognitive dysfunctions, and BDNF dysregulation in dopamine transporter knock-out rats","volume":"38","author":"Leo","year":"2018","journal-title":"J. Neurosci"},{"key":"B61","doi-asserted-by":"publisher","first-page":"491","DOI":"10.3758\/BF03196044","article-title":"Acquisition of schedule-induced polydipsia by rats in proximity to upcoming food delivery","volume":"32","author":"L\u00f3pez-Crespo","year":"2004","journal-title":"Learn. Behav."},{"key":"B62","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s00213-007-1059-6","article-title":"Individual differences in schedule-induced polydipsia and the role of gabaergic and dopaminergic systems","volume":"197","author":"L\u00f3pez-Grancha","year":"2008","journal-title":"Psychopharmacology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.yhbeh.2005.05.019","article-title":"Differences in corticosterone level due to inter-food interval length: implications for schedule-induced polydipsia","volume":"49","author":"L\u00f3pez-Grancha","year":"2006","journal-title":"Horm. Behav."},{"key":"B64","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s10608-015-9714-4","article-title":"Shared and distinct cognitive\/affective mechanisms in intrusive cognition: an examination of worry and obsessions","volume":"40","author":"Macatee","year":"2016","journal-title":"Cognit. Ther. Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/npp.2008.173","article-title":"Removing obstacles in neuroscience drug discovery: the future path for animal models","volume":"34","author":"Markou","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"B66","doi-asserted-by":"publisher","first-page":"215","DOI":"10.2174\/1570159X21666221121091454","article-title":"Differential neurobiological markers in phenotype-stratified rats modeling high or low vulnerability to compulsive behavior: a narrative review","author":"Mart\u00edn-Gonz\u00e1lez","year":"","journal-title":"Curr. Neuropharmacol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"105170","DOI":"10.1016\/j.yhbeh.2022.105170","article-title":"Socioemotional deficit and HPA axis time response in high compulsive rats selected by schedule-induced polydipsia","volume":"142","author":"Mart\u00edn-Gonz\u00e1lez","year":"","journal-title":"Horm. Behav."},{"key":"B68","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s00213-017-4819-y","article-title":"Do psychoactive drugs have a therapeutic role in compulsivity? Studies on schedule-induced polydipsia","volume":"235","author":"Mart\u00edn-Gonz\u00e1lez","year":"2018","journal-title":"Psychopharmacology"},{"key":"B69","volume-title":"Handbook of Biological Statistics, 2nd Edn","author":"McDonald","year":"2009"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1007\/s00213-017-4561-5","article-title":"Tryptophan depletion affects compulsive behaviour in rats: strain dependent effects and associated neuromechanisms","volume":"234","author":"Merch\u00e1n","year":"2017","journal-title":"Psychopharmacology"},{"key":"B71","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.pnpbp.2019.03.016","article-title":"Behavioral and biological markers for predicting compulsive-like drinking in schedule-induced polydipsia","volume":"93","author":"Merch\u00e1n","year":"2019","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B72","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/0166-4328(88)90134-9","article-title":"The relationship between schedule-induced polydipsia and pituitary-adrenal activity: pharmacological and behavioral manipulations","volume":"28","author":"Mittleman","year":"1988","journal-title":"Behav. Brain Res."},{"key":"B73","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/s41386-019-0550-1","article-title":"Reward sensitivity deficits in a rat model of compulsive eating behavior","volume":"45","author":"Moore","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"B74","doi-asserted-by":"publisher","first-page":"112592","DOI":"10.1016\/j.bbr.2020.112592","article-title":"Increased amygdala and decreased hippocampus volume after schedule-induced polydipsia in high drinker compulsive rats","volume":"390","author":"Mora","year":"2020","journal-title":"Behav. Brain Res."},{"key":"B75","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.neuropharm.2018.09.004","article-title":"Reduced cortical serotonin 5-HT2A receptor binding and glutamate activity in high compulsive drinker rats","volume":"143","author":"Mora","year":"2018","journal-title":"Neuropharmacology"},{"key":"B76","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1017\/S003329170999033X","article-title":"Inhibition of thoughts and actions in obsessive-compulsive disorder: extending the endophenotype?","volume":"40","author":"Morein-Zamir","year":"2010","journal-title":"Psychol. Med."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1038\/npp.2009.224","article-title":"Impulsivity characterization in the roman high-and low-avoidance rat strains: behavioral and neurochemical differences","volume":"35","author":"Moreno","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"B78","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1007\/s00213-011-2570-3","article-title":"Schedule-induced polydipsia as a model of compulsive behavior: neuropharmacological and neuroendocrine bases","volume":"219","author":"Moreno","year":"2012","journal-title":"Psychopharmacology"},{"key":"B79","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1042\/ETLS20220005","article-title":"Negative valence system as a relevant domain in compulsivity: review in a preclinical model of compulsivity","volume":"6","author":"Moreno-Montoya","year":"2022","journal-title":"Emerg. Top. Life Sci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1093\/schbul\/sbw141","article-title":"Behavioral biomarkers of schizophrenia in high drinker rats: a potential endophenotype of compulsive neuropsychiatric disorders","volume":"43","author":"Navarro","year":"2017","journal-title":"Schizophr. Bull."},{"key":"B81","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s00213-014-3699-7","article-title":"Activation of serotonin 5-HT2 A receptors inhibits high compulsive drinking on schedule-induced polydipsia","volume":"232","author":"Navarro","year":"2015","journal-title":"Psychopharmacology"},{"key":"B82","doi-asserted-by":"publisher","first-page":"113217","DOI":"10.1016\/j.expneurol.2020.113217","article-title":"Unilateral parietal brain injury increases risk-taking on a rat gambling task","volume":"327","author":"Ozga-Hess","year":"2020","journal-title":"Exp. Neurol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1017\/S0033291709991255","article-title":"The neuropsychology of the schizo-obsessive subtype of schizophrenia: a new analysis","volume":"40","author":"Patel","year":"2010","journal-title":"Psychol. Med."},{"key":"B84","doi-asserted-by":"publisher","first-page":"217.195","DOI":"10.1016\/j.bbr.2010.10.010","article-title":"Individual differences in schedule-induced polydipsia: neuroanatomical dopamine divergences","volume":"2","author":"Pell\u00f3n","year":"2011","journal-title":"Behav. Brain Res."},{"key":"B85","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.biopsych.2013.09.007","article-title":"Capacity to delay reward differentiates obsessive-compulsive disorder and obsessive-compulsive personality disorder","volume":"75","author":"Pinto","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"B86","doi-asserted-by":"publisher","first-page":"100","DOI":"10.3389\/fnbeh.2019.00100","article-title":"Increased fear memory and glutamatergic modulation in compulsive drinker rats selected by schedule-induced polydipsia","volume":"13","author":"Prados-Pardo","year":"2019","journal-title":"Front. Behav. Neurosci."},{"key":"B87","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/S1569-7339(10)70093-X","article-title":"Role of central serotonin in impulsivity and compulsivity: comparative studies in experimental animals and humans","volume":"21","author":"Robbins","year":"2010","journal-title":"Handb. Behav. Neurosci."},{"key":"B88","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.brainres.2018.10.004","article-title":"Long-term deficits in risky decision-making after traumatic brain injury on a rat analog of the Iowa gambling task","volume":"1704","author":"Shaver","year":"2019","journal-title":"Brain Res."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-35537-7","article-title":"Trait determinants of impulsive behavior: a comprehensive analysis of 188 rats","volume":"8","author":"Soares","year":"2018","journal-title":"Sci. Rep."},{"key":"B90","doi-asserted-by":"publisher","first-page":"e0111739","DOI":"10.1371\/journal.pone.0111739","article-title":"Multidimensional measures of impulsivity in obsessive-compulsive disorder: cannot wait and stop","volume":"9","author":"Sohn","year":"2014","journal-title":"PLoS ONE"},{"key":"B91","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/0166-4328(86)90025-2","article-title":"Pituitary-adrenal correlates of schedule-induced polydipsia and wheel running in rats","volume":"19","author":"Tazi","year":"1986","journal-title":"Behav. Brain Res."},{"key":"B92","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.biopsych.2016.08.009","article-title":"Specific frontostriatal circuits for impaired cognitive flexibility and goal-directed planning in obsessive-compulsive disorder: evidence from resting-state functional connectivity","volume":"81","author":"Vaghi","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"B93","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/mp.2014.44","article-title":"Disorders of compulsivity: a common bias towards learning habits","volume":"20","author":"Voon","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"B94","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0091-3057(83)90262-9","article-title":"The effect of 6-OHDA lesions of the nucleus accumbens septum on schedule-induced drinking, wheelrunning and corticosterone levels in the rat","volume":"18","author":"Wallace","year":"1983","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B95","doi-asserted-by":"publisher","first-page":"4718","DOI":"10.1523\/JNEUROSCI.5606-03.2004","article-title":"Contrasting roles of basolateral amygdala and orbitofrontal cortex in impulsive choice","volume":"24","author":"Winstanley","year":"2004","journal-title":"J. Neurosci."},{"key":"B96","unstructured":"World Health OrganizationInternational Classification of Diseases 11th Revision2018"},{"key":"B97","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1038\/npp.2009.62","article-title":"Serotonergic and dopaminergic modulation of gambling behavior as assessed using a novel rat gambling task","volume":"34","author":"Zeeb","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"B98","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep17312","article-title":"Trait-related decision making impairment in obsessive-compulsive disorder: evidence from decision making under ambiguity but not decision making under risk","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."}],"container-title":["Frontiers in Behavioral Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnbeh.2023.1175137\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:37:02Z","timestamp":1684417022000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnbeh.2023.1175137\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,18]]},"references-count":98,"alternative-id":["10.3389\/fnbeh.2023.1175137"],"URL":"https:\/\/doi.org\/10.3389\/fnbeh.2023.1175137","relation":{},"ISSN":["1662-5153"],"issn-type":[{"value":"1662-5153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,18]]},"article-number":"1175137"}}