{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:09:52Z","timestamp":1790640592190,"version":"4.1.0"},"reference-count":87,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Motor impulsivity and risk-related impulsive choice have been proposed as vulnerability factors for drug abuse, due to their high prevalence in drug abusers. However, how these two facets of impulsivity are associated to drug abuse remains unclear. Here, we investigated the predictive value of both motor impulsivity and risk-related impulsive choice on characteristics of drug abuse including initiation and maintenance of drug use, motivation for the drug, extinction of drug-seeking behavior following drug discontinuation and, finally, propensity to relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the Roman High- (RHA) and Low- Avoidance (RLA) rat lines, which display innate phenotypical differences in motor impulsivity, risk-related impulsive choice, and propensity to self-administer drugs. Individual levels of motor impulsivity and risk-related impulsive choice were measured using the rat Gambling task. Then, rats were allowed to self-administer cocaine (0.3 mg\/kg\/infusion; 14 days) to evaluate acquisition and maintenance of cocaine self-administration, after which motivation for cocaine was assessed using a progressive ratio schedule of reinforcement. Subsequently, rats were tested for their resistance to extinction, followed by cue-induced and drug-primed reinstatement sessions to evaluate relapse. Finally, we evaluated the effect of the dopamine stabilizer aripiprazole on reinstatement of drug-seeking behaviors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that motor impulsivity and risk-related impulsive choice were positively correlated at baseline. Furthermore, innate high levels of motor impulsivity were associated with higher drug use and increased vulnerability to cocaine-primed reinstatement of drug-seeking. However, no relationships were observed between motor impulsivity and the motivation for the drug, extinction or cue-induced reinstatement of drug-seeking. High levels of risk-related impulsive choice were not associated to any aspects of drug abuse measured in our study. Additionally, aripiprazole similarly blocked cocaine-primed reinstatement of drug-seeking in both high- and low-impulsive animals, suggesting that aripiprazole acts as a D<jats:sub>2\/3<\/jats:sub>R antagonist to prevent relapse independently of the levels of impulsivity and propensity to self-administer drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Altogether, our study highlights motor impulsivity as an important predictive factor for drug abuse and drug-primed relapse. On the other hand, the involvement of risk-related impulsive choice as a risk factor for drug abuse appears to be limited.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnbeh.2023.1200392","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T12:46:19Z","timestamp":1685709979000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Motor impulsivity but not risk-related impulsive choice is associated to drug intake and drug-primed relapse"],"prefix":"10.3389","volume":"17","author":[{"given":"Chlo\u00e9","family":"Arrondeau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginna","family":"Urue\u00f1a-M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Bell\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Marchessaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Goutaudier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Ginovart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","DOI":"10.1111\/adb.13168","article-title":"Interactions between impulsivity and MDPV self-administration in rats.","volume":"27","author":"Abbott","year":"2022","journal-title":"Addict. Biol."},{"key":"B2","year":"2013","journal-title":"Diagnostic and statistical manual of mental disorders: DSM-5"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1038\/sj.npp.1300922","article-title":"Administration of the D2 dopamine receptor antagonist sulpiride into the shell, but not the core, of the nucleus accumbens attenuates cocaine priming-induced reinstatement of drug seeking.","volume":"31","author":"Anderson","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.pbb.2009.05.013","article-title":"Impulsivity predicts the escalation of cocaine self-administration in rats.","volume":"93","author":"Anker","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2020.109861","article-title":"From sign-tracking to attentional bias: implications for gambling and substance use disorders.","volume":"99","author":"Anselme","year":"2020","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B6","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1002\/0471234311.ch20","article-title":"Epidemiology of drug dependence","author":"Anthony","year":"2002","journal-title":"Textbook in psychiatric epidemiology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1503\/jpn.140045","article-title":"Disadvantageous decision-making on a rodent gambling task is associated with increased motor impulsivity in a population of male rats.","volume":"40","author":"Barrus","year":"2015","journal-title":"J. Psychiatry Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1523\/JNEUROSCI.2225-15.2016","article-title":"Dopamine D 3 receptors modulate the ability of win-paired cues to increase risky choice in a rat gambling task.","volume":"36","author":"Barrus","year":"2016","journal-title":"J. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.pneurobio.2010.08.007","article-title":"Nucleus accumbens and impulsivity.","volume":"92","author":"Basar","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.bbr.2012.07.028","article-title":"Sex differences in attentional processes in adult rats as measured by performance on the 5-choice serial reaction time task.","volume":"235","author":"Bayless","year":"2012","journal-title":"Behav. Brain Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/0010-0277(94)90018-3","article-title":"Insensitivity to future consequences following damage to human prefrontal cortex.","volume":"50","author":"Bechara","year":"1994","journal-title":"Cognition"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1016\/S0028-3932(02)00016-7","article-title":"Decision-making and addiction (part II): myopia for the future or hypersensitivity to reward?","volume":"40","author":"Bechara","year":"2002","journal-title":"Neuropsychologia"},{"key":"B13","doi-asserted-by":"publisher","first-page":"395","DOI":"10.31887\/DCNS.2016.18.4\/jbecker","article-title":"Sex differences in addiction.","volume":"18","author":"Becker","year":"2016","journal-title":"Dialogues Clin. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/gbb.12265","article-title":"In search of predictive endophenotypes in addiction: insights from preclinical research: vulnerability traits in addiction.","volume":"15","author":"Belin","year":"2016","journal-title":"Genes Brain Behav."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1126\/science.1158136","article-title":"High impulsivity predicts the switch to compulsive cocaine-taking.","volume":"320","author":"Belin","year":"2008","journal-title":"Science"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2022.173508","article-title":"Concurrent measures of impulsive action and choice are partially related and differentially modulated by dopamine D1- and D2-like receptors in a rat model of impulsivity.","volume":"222","author":"Bell\u00e9s","year":"2023","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B17","doi-asserted-by":"publisher","first-page":"3543","DOI":"10.1007\/s00213-021-05971-z","article-title":"Early environmental enrichment and impoverishment differentially affect addiction-related behavioral traits, cocaine-taking, and dopamine D2\/3 receptor signaling in a rat model of vulnerability to drug abuse.","volume":"238","author":"Bell\u00e9s","year":"","journal-title":"Psychopharmacology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1093\/ijnp\/pyaa084","article-title":"Dopamine D2\/3 receptor availabilities and evoked dopamine release in striatum differentially predict impulsivity and novelty preference in roman high- and low-avoidance rats.","volume":"24","author":"Bell\u00e9s","year":"","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/npp.2009.162","article-title":"Dissociable control of impulsivity in rats by dopamine D2\/3 receptors in the core and shell subregions of the nucleus accumbens.","volume":"35","author":"Besson","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/0003-3472(65)90038-2","article-title":"Selection for high rates and low rates of avoidance conditioning in the rat.","volume":"13","author":"Bignami","year":"1965","journal-title":"Anim. Behav."},{"key":"B21","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1002\/dev.22037","article-title":"Sex and age differences in locomotor and anxiety-like behaviors in rats: from adolescence to adulthood.","volume":"63","author":"Bishnoi","year":"2020","journal-title":"De. Psychobiol."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00665","article-title":"Iowa gambling task (IGT): twenty years after \u2013 gambling disorder and IGT.","volume":"4","author":"Brevers","year":"2013","journal-title":"Front. Psychol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1038\/npp.2011.323","article-title":"Trait impulsive choice predicts resistance to extinction and propensity to relapse to cocaine seeking: a bidirectional investigation.","volume":"37","author":"Broos","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"B24","first-page":"1346","article-title":"Aripiprazole, alcohol and substance abuse: a review.","volume":"16","author":"Brunetti","year":"2012","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1038\/npp.2013.44","article-title":"Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2\/3 receptor availability in the rat striatum: possible relevance to the attention-deficit hyperactivity syndrome.","volume":"38","author":"Caprioli","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1021\/acschemneuro.7b00087","article-title":"Classics in chemical neuroscience: aripiprazole.","volume":"8","author":"Casey","year":"2017","journal-title":"ACS Chem. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00503","article-title":"Impulsive action and impulsive choice are differentially expressed in rats depending on the age at exposure to a gambling task.","volume":"9","author":"Cho","year":"2018","journal-title":"Front. Psychiatry"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1007\/s10899-017-9683-5","article-title":"Pathological Gambling and motor impulsivity: a systematic review with meta-analysis.","volume":"33","author":"Chowdhury","year":"2017","journal-title":"J. Gambl. Stud."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12738","article-title":"Impaired decision making following escalation of cocaine self-administration predicts vulnerability to relapse in rats.","volume":"25","author":"Cocker","year":"2020","journal-title":"Addict. Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.neubiorev.2020.01.018","article-title":"Mapping sign-tracking and goal-tracking onto human behaviors.","volume":"111","author":"Colaizzi","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2018.0145","article-title":"Neural circuitry and mechanisms of waiting impulsivity: relevance to addiction.","volume":"374","author":"Dalley","year":"2019","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1126\/science.1137073","article-title":"Nucleus accumbens D2\/3 receptors predict trait impulsivity and cocaine reinforcement.","volume":"315","author":"Dalley","year":"2007","journal-title":"Science"},{"key":"B33","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1007\/s40263-015-0278-3","article-title":"Update on the mechanism of action of aripiprazole: translational insights into antipsychotic strategies beyond dopamine receptor antagonism.","volume":"29","author":"de Bartolomeis","year":"2015","journal-title":"CNS Drugs"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1126\/science.1099020","article-title":"Evidence for addiction-like behavior in the rat.","volume":"305","author":"Deroche-Gamonet","year":"2004","journal-title":"Science"},{"key":"B35","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.biopsych.2007.07.011","article-title":"Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats.","volume":"63","author":"Diergaarde","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"B36","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1111\/j.1369-1600.2011.00376.x","article-title":"Poor impulse control predicts inelastic demand for nicotine but not alcohol in rats: impulsivity, demand elasticity.","volume":"17","author":"Diergaarde","year":"2012","journal-title":"Addict. Biol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1037\/bne0000281","article-title":"Differential involvement of D2 and D3 receptors during reinstatement of cocaine-seeking behavior in the Roman high- and low-avoidance rats.","volume":"133","author":"Dimiziani","year":"2019","journal-title":"Behav. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.biopsych.2010.06.015","article-title":"Drug addiction endophenotypes: impulsive versus sensation-seeking personality traits.","volume":"68","author":"Ersche","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B39","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1007\/PL00005481","article-title":"Varieties of impulsivity.","volume":"146","author":"Evenden","year":"1999","journal-title":"Psychopharmacology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1038\/npp.2008.43","article-title":"The roman high- and low-avoidance rat lines differ in the acquisition, maintenance, extinction, and reinstatement of intravenous cocaine self-administration.","volume":"34","author":"Fattore","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"B41","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.bbr.2014.02.013","article-title":"Ventral medial prefrontal cortex inactivation impairs impulse control but does not affect delay-discounting in rats.","volume":"264","author":"Feja","year":"2014","journal-title":"Behav. Brain Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.biopsych.2006.04.010","article-title":"Aripiprazole blocks reinstatement of cocaine seeking in an animal model of relapse.","volume":"61","author":"Feltenstein","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"B43","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s00213-009-1671-8","article-title":"Repeated aripiprazole administration attenuates cocaine seeking in a rat model of relapse.","volume":"207","author":"Feltenstein","year":"2009","journal-title":"Psychopharmacology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1111\/adb.12388","article-title":"Risk-preferring rats make worse decisions and show increased incubation of craving after cocaine self-administration: cocaine enhances risky choice.","volume":"22","author":"Ferland","year":"2017","journal-title":"Addict. Biol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.bbr.2007.07.022","article-title":"Individual differences in the attribution of incentive salience to a reward-related cue: influence on cocaine sensitization.","volume":"186","author":"Flagel","year":"2008","journal-title":"Behav. Brain Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/S0893-133X(02)00342-1","article-title":"Differential effects of the 5-HT2A receptor antagonist M100,907 and the 5-HT2C receptor antagonist SB242,084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding.","volume":"27","author":"Fletcher","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41386-019-0527-0","article-title":"Risky decision-making predicts dopamine release dynamics in nucleus accumbens shell.","volume":"45","author":"Freels","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"B48","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1023\/A:1021405031412","article-title":"Effects of cocaine and morphine in rats from two psychogenetically selected lines: a behavioral and brain dialysis study.","volume":"27","author":"Giorgi","year":"1997","journal-title":"Behav. Genet."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00145","article-title":"A genetic model of impulsivity, vulnerability to drug abuse and schizophrenia-relevant symptoms with translational potential: the roman high- vs. low-avoidance rats.","volume":"13","author":"Giorgi","year":"2019","journal-title":"Front. Behav. Neurosci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.1523\/JNEUROSCI.2615-18.2018","article-title":"Compulsive alcohol seeking results from a failure to disengage dorsolateral striatal control over behavior.","volume":"39","author":"Giuliano","year":"2019","journal-title":"J. Neurosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/s41380-022-01848-5","article-title":"Hypodopaminergic state of the nigrostriatal pathway drives compulsive alcohol use.","volume":"28","author":"Goutaudier","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13022","article-title":"Dopamine neurons gate the intersection of cocaine use, decision making, and impulsivity.","volume":"26","author":"Hynes","year":"2021","journal-title":"Addict. Biol."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00068","article-title":"Sex differences in risk preference and c-Fos expression in paraventricular thalamic nucleus of rats during gambling task.","volume":"12","author":"Ishii","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/nyas.12388","article-title":"Dissecting impulsivity and its relationships to drug addictions: impulsivity subtypes and drug addiction.","volume":"1327","author":"Jentsch","year":"2014","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.neuroscience.2013.12.063","article-title":"5-HT2A and mGlu2 receptor binding levels are related to differences in impulsive behavior in the Roman Low- (RLA) and High- (RHA) avoidance rat strains.","volume":"263","author":"Klein","year":"2014","journal-title":"Neuroscience"},{"key":"B56","doi-asserted-by":"publisher","first-page":"570","DOI":"10.30773\/pi.2020.0404","article-title":"Association of prefrontal cortex thinning with high impulsivity in healthy adults.","volume":"18","author":"Lim","year":"2021","journal-title":"Psychiatry Investig."},{"key":"B57","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.bbr.2011.04.006","article-title":"Rats prone to attribute incentive salience to reward cues are also prone to impulsive action.","volume":"223","author":"Lovic","year":"2011","journal-title":"Behav. Brain Res."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2020.109864","article-title":"Maladaptive consequences of repeated intermittent exposure to uncertainty.","volume":"99","author":"Mascia","year":"2020","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B59","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/npp.2013.295","article-title":"Adolescent risk taking, cocaine self-administration, and striatal dopamine signaling.","volume":"39","author":"Mitchell","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1038\/npp.2009.224","article-title":"Impulsivity characterization in the roman high- and low-avoidance rat strains: behavioral and neurochemical differences.","volume":"35","author":"Moreno","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1038\/sj.npp.1300983","article-title":"Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models.","volume":"31","author":"Natesan","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"B62","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/sj.npp.1301414","article-title":"Differential regulation of the Mesoaccumbens dopamine circuit by Serotonin2C receptors in the ventral tegmental area and the nucleus accumbens: an in vivo microdialysis study with cocaine.","volume":"33","author":"Navailles","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.109791","article-title":"Distinct relationships between risky decision making and cocaine self-administration under short- and long-access conditions.","volume":"98","author":"Orsini","year":"2020","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B64","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.bbr.2013.01.018","article-title":"Medial prefrontal cortex lesions impair decision-making on a rodent gambling task: reversal by D1 receptor antagonist administration.","volume":"243","author":"Paine","year":"2013","journal-title":"Behav. Brain Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1097\/00001756-200312020-00019","article-title":"Increased motivation for self-administered cocaine after escalated cocaine intake.","volume":"14","author":"Paterson","year":"2003","journal-title":"NeuroReport"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2020.107984","article-title":"The role of impulsivity as predisposing behavioural trait in different aspects of alcohol self-administration in rats.","volume":"212","author":"Pattij","year":"2020","journal-title":"Drug Alcohol Depend."},{"key":"B67","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1037\/1064-1297.16.2.165","article-title":"Impulsive choice as a predictor of acquisition of IV cocaine self-administration and reinstatement of cocaine-seeking behavior in male and female rats.","volume":"16","author":"Perry","year":"2008","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1007\/s00213-021-05858-z","article-title":"Sign- and goal-tracking score does not correlate with addiction-like behavior following prolonged cocaine self-administration.","volume":"238","author":"Poho\u00f8al\u00e1","year":"2021","journal-title":"Psychopharmacology"},{"key":"B69","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1038\/npp.2013.218","article-title":"Impulsivity and risk taking in bipolar disorder and schizophrenia.","volume":"39","author":"Reddy","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"B70","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.bbr.2018.12.033","article-title":"Volumetric brain differences between the Roman rat strains: neonatal handling effects, sensorimotor gating and working memory.","volume":"361","author":"R\u00edo-\u00c1lamos","year":"2019","journal-title":"Behav. Brain Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/BF00439560","article-title":"Self-administration of cocaine on a progressive ratio schedule in rats: dose-response relationship and effect of haloperidol pretreatment.","volume":"97","author":"Roberts","year":"1989","journal-title":"Psychopharmacology"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1037\/bne0000226","article-title":"The neuroscience of cognitive-motivational styles: sign- and goal-trackers as animal models.","volume":"132","author":"Sarter","year":"2018","journal-title":"Behav. Neurosci."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1038\/npp.2011.48","article-title":"Individual variation in the motivational properties of cocaine.","volume":"36","author":"Saunders","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"B74","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00213-008-1069-z","article-title":"Aripiprazole blocks acute self-administration of cocaine and is not self-administered in mice.","volume":"199","author":"S\u00f8rensen","year":"2008","journal-title":"Psychopharmacology"},{"key":"B75","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1007\/s00213-021-05887-8","article-title":"Sign tracking predicts suboptimal behavior in a rodent gambling task.","volume":"238","author":"Swintosky","year":"2021","journal-title":"Psychopharmacology"},{"key":"B76","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/0006-8993(91)91677-S","article-title":"Efferent projections of the infralimbic (area 25) region of the medial prefrontal cortex in the rat: an anterograde tracer PHA-L study.","volume":"566","author":"Takagishi","year":"1991","journal-title":"Brain Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"9010","DOI":"10.1523\/JNEUROSCI.0127-05.2005","article-title":"Sex differences in hormonal modulation of anxiety measured with light-enhanced startle: possible role for arginine vasopressin in the male.","volume":"25","author":"Toufexis","year":"2005","journal-title":"J. Neurosci."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1017\/S1461145713000205","article-title":"Innately low D2 receptor availability is associated with high novelty-seeking and enhanced behavioural sensitization to amphetamine.","volume":"16","author":"Tournier","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/7854_2011_119","article-title":"Linking ADHD, impulsivity, and drug abuse: a neuropsychological perspective","author":"Urcelay","year":"2011","journal-title":"Behavioral neuroscience of attention deficit hyperactivity disorder and its treatment current topics in behavioral neurosciences"},{"key":"B80","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1016\/j.addbeh.2006.06.032","article-title":"Cognitive impulsivity in cocaine and heroin polysubstance abusers.","volume":"32","author":"Verdejo-Garc\u00eda","year":"2007","journal-title":"Addict. Behav."},{"key":"B81","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/syn.10279","article-title":"Differential projections of the infralimbic and prelimbic cortex in the rat.","volume":"51","author":"Vertes","year":"2004","journal-title":"Synapse"},{"key":"B82","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/bcpt.12036","article-title":"Effects of aripiprazole, an atypical antipsychotic, on the motor alterations induced by acute ethanol administration in mice.","volume":"112","author":"Viana","year":"2013","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s40429-014-0035-6","article-title":"Recent translational findings on impulsivity in relation to drug abuse.","volume":"1","author":"Weafer","year":"2014","journal-title":"Curr. Addict. Rep."},{"key":"B84","doi-asserted-by":"publisher","first-page":"4321","DOI":"10.1073\/pnas.97.8.4321","article-title":"Control of cocaine-seeking behavior by drug-associated stimuli in rats: effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens.","volume":"97","author":"Weiss","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B85","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.cpr.2006.01.001","article-title":"Behavioral models of impulsivity in relation to ADHD: translation between clinical and preclinical studies.","volume":"26","author":"Winstanley","year":"2006","journal-title":"Clin. Psychol. Rev."},{"key":"B86","doi-asserted-by":"publisher","first-page":"4481","DOI":"10.1007\/s00213-015-4075-y","article-title":"Inactivation of the prelimbic or infralimbic cortex impairs decision-making in the rat gambling task.","volume":"232","author":"Zeeb","year":"2015","journal-title":"Psychopharmacology"},{"key":"B87","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1038\/npp.2009.62","article-title":"Serotonergic and dopaminergic modulation of gambling behavior as assessed using a novel rat gambling task.","volume":"34","author":"Zeeb","year":"2009","journal-title":"Neuropsychopharmacology"}],"container-title":["Frontiers in Behavioral Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnbeh.2023.1200392\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T12:46:24Z","timestamp":1685709984000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnbeh.2023.1200392\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,2]]},"references-count":87,"alternative-id":["10.3389\/fnbeh.2023.1200392"],"URL":"https:\/\/doi.org\/10.3389\/fnbeh.2023.1200392","relation":{},"ISSN":["1662-5153"],"issn-type":[{"value":"1662-5153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,2]]},"article-number":"1200392"}}