{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:26:50Z","timestamp":1784165210587,"version":"3.55.0"},"reference-count":85,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Exposure to traumatic events and stressful life experiences are associated with a wide range of adverse mental and physical health outcomes. Studies have found post-traumatic stress disorder (PTSD), depression, and anxiety sensitivity occurrence to be common in addition to inflammatory diseases like asthma, especially in women. Moreover, overlapping neurobiological mechanisms have been linked to both PTSD and asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the current study, n\u2009=\u2009508 women reported on presence of lifetime asthma diagnosis and symptoms of trauma-related psychopathology including PTSD and depression. A separate group of female participants (n\u2009=\u200964) reported on asthma, PTSD, depression and anxiety sensitivity, and underwent functional MRI scans during a fearful faces task, and their anterior insula responses were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, PTSD and depression severity were significantly higher in those with asthma versus those without asthma. There was a positive association between anterior insula response to social threat cues and depression symptoms only among individuals without a lifetime presence of asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These findings provide continued evidence on the interactions between stress, neural mechanisms involved in interoception and salience detection, and trauma-related psychopathology.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnbeh.2023.1268877","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T06:19:52Z","timestamp":1698733192000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between dimensions of trauma-related psychopathology and asthma in trauma-exposed women"],"prefix":"10.3389","volume":"17","author":[{"given":"Esther R.-H.","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa R.","family":"Roeckner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Fani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Merrill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles F.","family":"Gillespie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Ely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bekh","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Michopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Powers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Jovanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1080\/02770903.2017.1418885","article-title":"The relationship between asthma and depression in a community-based sample","volume":"55","author":"Akula","year":"2018","journal-title":"J. Asthma"},{"key":"ref2","first-page":"1630","article-title":"Trauma exposure, posttraumatic stress disorder and depression in an African-American primary care population","volume":"98","author":"Alim","year":"2006","journal-title":"J. Natl. Med. Assoc."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.bbi.2021.06.001","article-title":"Asthma and posttraumatic stress disorder (PTSD): emerging links, potential models and mechanisms","volume":"97","author":"Allgire","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jpsychires.2014.09.007","article-title":"Association between mental disorders and subsequent adult onset asthma","volume":"59","author":"Alonso","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1080\/16506070801969005","article-title":"Associations between dimensions of anxiety sensitivity and PTSD symptom clusters in active-duty police officers","volume":"37","author":"Asmundson","year":"2008","journal-title":"Cogn. Behav. Ther."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3109\/02770903.2011.641048","article-title":"Anxiety sensitivity, asthma control, and quality of life in adults with asthma","volume":"49","author":"Avallone","year":"2012","journal-title":"J. Asthma"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.biopsych.2013.11.027","article-title":"Major depressive disorder is associated with abnormal interoceptive activity and functional connectivity in the insula","volume":"76","author":"Avery","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s10865-008-9164-5","article-title":"The association between anxiety sensitivity and atopy in adult asthmatics","volume":"31","author":"Barone","year":"2008","journal-title":"J. Behav. Med."},{"key":"ref9001","doi-asserted-by":"publisher","DOI":"10.1037\/t00742-000","article-title":"Beck Depression Inventory\u2013II (BDI-II) [Database record]","author":"Beck","year":"1996","journal-title":"APA PsycTests"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1017\/S0033291715001981","article-title":"The epidemiology of traumatic event exposure worldwide: results from the World Mental Health Survey Consortium","volume":"46","author":"Benjet","year":"2016","journal-title":"Psychol. Med."},{"key":"ref9002","volume-title":"Childhood Trauma Questionnaire: A retrospective self-report manual","author":"Bernstein","year":"1998"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1001\/archpsyc.1991.01810270028003","article-title":"Traumatic events and posttraumatic stress disorder in an urban population of young adults","volume":"48","author":"Breslau","year":"1991","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1001\/archpsyc.1997.01830230082012","article-title":"Sex differences in posttraumatic stress disorder","volume":"54","author":"Breslau","year":"1997","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/S0006-3223(00)00933-1","article-title":"A second look at comorbidity in victims of trauma: the posttraumatic stress disorder\u2013major depression connection","volume":"48","author":"Breslau","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.nicl.2012.11.003","article-title":"Altered emotional interference processing in the amygdala and insula in women with Post-Traumatic Stress Disorder","volume":"2","author":"Bruce","year":"2013","journal-title":"NeuroImage"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3389\/fncel.2015.00040","article-title":"Inflammation and neuronal plasticity: a link between childhood trauma and depression pathogenesis","volume":"9","author":"Cattaneo","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/j.bbi.2007.03.009","article-title":"Stress and inflammation in exacerbations of asthma","volume":"21","author":"Chen","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1016\/j.jaip.2018.10.046","article-title":"Association between asthma and depression: a National Cohort Study","volume":"7","author":"Choi","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"210067","DOI":"10.1183\/16000617.0067-2021","article-title":"Sex and gender in asthma","volume":"30","author":"Chowdhury","year":"2021","journal-title":"Eur. Respir. Rev."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.psychres.2012.01.008","article-title":"Posttraumatic stress disorder following asthma attack (post-asthma attack PTSD) and psychiatric co-morbidity: the impact of alexithymia and coping","volume":"197","author":"Chung","year":"2012","journal-title":"Psychiatry Res."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3121\/cmr.2.3.155","article-title":"Categorizing asthma severity: an overview of National Guidelines","volume":"2","author":"Colice","year":"2004","journal-title":"Clin. Med. Res."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1001\/archinte.164.4.394","article-title":"Posttraumatic stress disorder in female veterans: association with self-reported health problems and functional impairment","volume":"164","author":"Dobie","year":"2004","journal-title":"Arch. Intern. Med."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1002\/da.23022","article-title":"Neural function during emotion processing and modulation associated with treatment response in a randomized clinical trial for posttraumatic stress disorder","volume":"37","author":"Duval","year":"2020","journal-title":"Depress. Anxiety"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/S1081-1206(10)61135-0","article-title":"Impact of depressive symptoms on adult asthma outcomes","volume":"94","author":"Eisner","year":"2005","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref9003","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/BF01115465","article-title":"Measuring facial movement","volume":"1","author":"Ekman","year":"1976","journal-title":"Environ. Psychol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.janxdis.2010.11.003","article-title":"Testing whether posttraumatic stress disorder and major depressive disorder are similar or unique constructs","volume":"25","author":"Elhai","year":"2011","journal-title":"J. Anxiety Disord."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1891\/jcop.20.2.201","article-title":"Anxiety sensitivity as a moderator of the relation between trauma exposure frequency and posttraumatic stress symptomatology","volume":"20","author":"Feldner","year":"2006","journal-title":"J. Cogn. Psychother."},{"key":"ref9004","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1023\/A:1007781909213","article-title":"Comparison of the PTSD symptom scale\u2013interview version and the clinician\u2010administered PTSD scale","volume":"13","author":"Foa","year":"2000","journal-title":"J. Trauma. Stress."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.biopsych.2010.04.028","article-title":"Exaggerated and disconnected insular-amygdalar blood oxygenation level-dependent response to threat-related emotional faces in women with intimate-partner violence posttraumatic stress disorder","volume":"68","author":"Fonzo","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.jad.2013.01.045","article-title":"Exposure to interpersonal trauma, attachment insecurity, and depression severity","volume":"149","author":"Fowler","year":"2013","journal-title":"J. Affect. Disord."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.genhosppsych.2009.05.003","article-title":"Trauma exposure and stress-related disorders in inner city primary care patients","volume":"31","author":"Gillespie","year":"2009","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s00737-021-01141-4","article-title":"Trauma exposure and stress-related disorders in a large, urban, predominantly African-American, female sample","volume":"24","author":"Gluck","year":"2021","journal-title":"Arch. Womens Ment. Health"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1017\/S0033291704002739","article-title":"Asthma and depressive and anxiety disorders among young persons in the community","volume":"34","author":"Goodwin","year":"2004","journal-title":"Psychol. Med."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.psyneuen.2008.03.008","article-title":"The link between childhood trauma and depression: Insights from HPA axis studies in humans","volume":"33","author":"Heim","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1001\/archfami.9.9.802","article-title":"Traumatic life events in primary care patients: a study in an ethnically diverse sample","volume":"9","author":"Holman","year":"2000","journal-title":"Arch. Fam. Med."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.psychres.2019.04.014","article-title":"Post-traumatic stress disorder and asthma risk: a nationwide longitudinal study","volume":"276","author":"Hung","year":"2019","journal-title":"Psychiatry Res."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3389\/fimmu.2017.00021","article-title":"Role of inflammation in human fatigue: relevance of multidimensional assessments and potential neuronal mechanisms","volume":"8","author":"Karshikoff","year":"2017","journal-title":"Front. Immunol."},{"key":"ref9005","first-page":"115","article-title":"Asthma and mood disorders","volume":"1","author":"Kewalramani","year":"2008","journal-title":"Int J Child Health Hum Dev."},{"key":"ref9006","article-title":"Bronchial asthma and psychological stress","volume":"58","author":"Kilaru","year":"2010","journal-title":"Rinsho Byori."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1002\/da.20788","article-title":"Neural correlates of anxiety sensitivity during masked presentation of affective faces","volume":"28","author":"Killgore","year":"2011","journal-title":"Depress. Anxiety"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"4022","DOI":"10.1162\/jocn_a_00077","article-title":"Behavioral interpretations of intrinsic connectivity networks","volume":"23","author":"Laird","year":"2011","journal-title":"J. Cogn. Neurosci."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/da.10062","article-title":"Anxiety sensitivity and PTSD among female victims of intimate partner violence","volume":"16","author":"Lang","year":"2002","journal-title":"Depress. Anxiety"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12890-016-0355-5","article-title":"Childhood asthma, asthma severity indicators, and related conditions along an urban-rural gradient: a cross-sectional study","volume":"17","author":"Lawson","year":"2017","journal-title":"BMC Pulm. Med."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"102964","DOI":"10.1016\/j.nicl.2022.102964","article-title":"Intrusive experiences in posttraumatic stress disorder: treatment response induces changes in the directed functional connectivity of the anterior insula","volume":"34","author":"Leroy","year":"2022","journal-title":"NeuroImage"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3978\/j.issn.2224-4336.2013.10.05","article-title":"Epidemiological survey and analysis of asthma in children aged 0-14 years old in urban and rural areas of Chengdu region","volume":"2","author":"Li","year":"2013","journal-title":"Translat. Pediatr."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1093\/ije\/dys123","article-title":"The association of asthma and wheezing with major depressive episodes: an analysis of 245 727 women and men from 57 countries","volume":"41","author":"Loerbroks","year":"2012","journal-title":"Int. J. Epidemiol."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1002\/jts.22131","article-title":"Exposure to childhood abuse and later substance use: indirect effects of emotion dysregulation and exposure to trauma","volume":"29","author":"Mandavia","year":"2016","journal-title":"J. Trauma. Stress."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.comppsych.2017.07.011","article-title":"The role of anxiety sensitivity in reactivity to trauma cues in treatment-seeking adults with substance use disorders","volume":"78","author":"McHugh","year":"2017","journal-title":"Compr. Psychiatry"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1097\/PSY.0000000000001136","article-title":"Anterior insula activation during cardiac Interoception relates to depressive symptom severity in HIV-positive and HIV-negative postmenopausal women","volume":"84","author":"McIntosh","year":"2022","journal-title":"Psychosom. Med."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1177\/0145445515607047","article-title":"Anxiety sensitivity and reactivity to asthma-like sensations among young adults with asthma","volume":"40","author":"McLeish","year":"2016","journal-title":"Behav. Modif."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1177\/1359105310382584","article-title":"The role of anxiety sensitivity in terms of asthma control: a pilot test among young adult asthmatics","volume":"16","author":"McLeish","year":"2011","journal-title":"J. Health Psychol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/S0006-3223(02)01475-0","article-title":"Anxiety sensitivity and panic disorder","volume":"52","author":"McNally","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1177\/21677026211000723","article-title":"Characterizing typologies of polytraumatization: a replication and extension study examining internalizing and externalizing psychopathology in an urban population","volume":"9","author":"Mekawi","year":"2021","journal-title":"Clin. Psychol. Sci."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.alit.2017.04.013","article-title":"The interplay between neuroendocrine activity and psychological stress-induced exacerbation of allergic asthma","volume":"67","author":"Miyasaka","year":"2018","journal-title":"Allergol. Int."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1176\/appi.ajp.161.8.1390","article-title":"Posttraumatic stress disorder and depression following trauma: understanding comorbidity","volume":"161","author":"O\u2019Donnell","year":"2004","journal-title":"Am. J. Psychiatr."},{"key":"ref460","first-page":"292","article-title":"Bronchial asthma and psychological stress","volume":"58","author":"Ohno","year":"2010","journal-title":"Rinsho Byori."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/j.alit.2017.06.005","article-title":"Neuropsychiatry phenotype in asthma: psychological stress-induced alterations of the neuroendocrine-immune system in allergic airway inflammation","volume":"66","author":"Ohno","year":"2017","journal-title":"Allergol. Int."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.janxdis.2012.08.004","article-title":"The physical health consequences of PTSD and PTSD symptoms: a meta-analytic review","volume":"27","author":"Pacella","year":"2013","journal-title":"J. Anxiety Disord."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"6504","DOI":"10.1038\/s41598-022-10345-2","article-title":"Role of the anterior insular cortex in restraint-stress induced fear behaviors","volume":"12","author":"Park","year":"2022","journal-title":"Sci. Rep."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.comppsych.2018.03.012","article-title":"The unique and interactive effects of anxiety sensitivity and emotion dysregulation in relation to posttraumatic stress, depressive, and anxiety symptoms among trauma-exposed firefighters","volume":"84","author":"Paulus","year":"2018","journal-title":"Compr. Psychiatry"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.jad.2012.01.044","article-title":"Amygdala response and functional connectivity during emotion regulation: a study of 14 depressed adolescents","volume":"139","author":"Perlman","year":"2012","journal-title":"J. Affect. Disord."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1037\/0022-006X.73.4.667","article-title":"Trauma, depression, coping, and mental health service seeking among impoverished women","volume":"73","author":"Rayburn","year":"2005","journal-title":"J. Consult. Clin. Psychol."},{"key":"ref9007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0005-7967(86)90143-9","article-title":"Anxiety sensitivity, anxiety frequency and the prediction of fearfulness","volume":"24","author":"Reiss","year":"1986","journal-title":"Behav Res Ther."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1136\/thoraxjnl-2018-211793","article-title":"Urbanisation and asthma in low-income and middle-income countries: a systematic review of the urban\u2013rural differences in asthma prevalence","volume":"74","author":"Rodriguez","year":"2019","journal-title":"Thorax"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"e40921","DOI":"10.1371\/journal.pone.0040921","article-title":"Are there neurophenotypes for asthma? Functional brain imaging of the interaction between emotion and inflammation in asthma","volume":"7","author":"Rosenkranz","year":"2012","journal-title":"PLoS One"},{"key":"ref9008","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1176\/appi.ps.56.2.212","article-title":"Posttraumatic stress disorder among African Americans in an Innery City Mental Health Clinic","volume":"56","author":"Schwartz","year":"2005","journal-title":"Psychiatric Services"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.biopsych.2008.05.027","article-title":"Functional activation and neural networks in women with posttraumatic stress disorder related to intimate partner violence","volume":"64","author":"Simmons","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1183\/09031936.00028010","article-title":"Association of airflow limitation with trauma exposure and post-traumatic stress disorder","volume":"37","author":"Spitzer","year":"2011","journal-title":"Eur. Respir. J."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1176\/ajp.2007.164.2.318","article-title":"Increased amygdala and insula activation during emotion processing in anxiety-prone subjects","volume":"164","author":"Stein","year":"2007","journal-title":"Am. J. Psychiatr."},{"key":"ref9009","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.jpsychires.2013.05.031","article-title":"Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic Weathers","volume":"47","author":"Stevens","year":"2013","journal-title":"J Psychiatr Res."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.nicl.2017.11.016","article-title":"Episodic memory after trauma exposure: medial temporal lobe function is positively related to re-experiencing and inversely related to negative affect symptoms","volume":"17","author":"Stevens","year":"2018","journal-title":"NeuroImage"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1097\/PSY.0b013e3181d07873","article-title":"Right anterior insula hypoactivity during anticipation of homeostatic shifts in major depressive disorder","volume":"72","author":"Strigo","year":"2010","journal-title":"Psychosom. Med."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.anai.2014.02.015","article-title":"Asthma and depression: the cooper center longitudinal study","volume":"112","author":"Trojan","year":"2014","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.bbi.2012.09.012","article-title":"Stress, asthma, and respiratory infections: pathways involving airway immunology and microbial endocrinology","volume":"29","author":"Trueba","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1097\/WNP.0000000000000377","article-title":"Structure and function of the human insula","volume":"34","author":"Uddin","year":"2017","journal-title":"J Clin Neurophysiol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1710-1492-4-1-12","article-title":"Psychological factors in asthma","volume":"4","author":"Van Lieshout","year":"2008","journal-title":"Allergy, Asthma Clin. Immunol."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.beth.2012.03.005","article-title":"Single-session anxiety sensitivity reduction program for trauma-exposed adults: a case series documenting feasibility and initial efficacy","volume":"43","author":"Vujanovic","year":"2012","journal-title":"Behav. Ther."},{"key":"ref9010","first-page":"206","article-title":"The ptsd checklist for dsm-5 (pcl-5)","volume":"10","author":"Weathers","year":"2013"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"e0647","DOI":"10.1097\/CCE.0000000000000647","article-title":"Posttraumatic stress disorder symptom clusters in surrogate decision makers of patients experiencing chronic critical illness","volume":"4","author":"Wendlandt","year":"2022","journal-title":"Crit. Care Explorat."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"538","DOI":"10.3109\/15622970903563794","article-title":"Abnormal body perception and neural activity in the insula in depression: an fMRI study of the depressed \u201cmaterial me.\u201d","volume":"11","author":"Wiebking","year":"2010","journal-title":"World J. Biol. Psychiatry"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3389\/fnbeh.2015.00082","article-title":"Interoception in insula subregions as a possible state marker for depression\u2014an exploratory fMRI study investigating healthy, depressed and remitted participants","volume":"9","author":"Wiebking","year":"2015","journal-title":"Front. Behav. Neurosci."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1093\/scan\/nsw024","article-title":"Neural correlates of individual differences in anxiety sensitivity: an fMRI study using semantic priming","volume":"11","author":"Yang","year":"2016","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/S0022-3956(01)00032-2","article-title":"Relationship of parental trauma exposure and PTSD to PTSD, depressive and anxiety disorders in offspring","volume":"35","author":"Yehuda","year":"2001","journal-title":"J. Psychiatr. Res."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"15057","DOI":"10.1038\/nrdp.2015.57","article-title":"Post-traumatic stress disorder","volume":"1","author":"Yehuda","year":"2015","journal-title":"Nat. Rev. Dis. Primers."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1007\/s10865-020-00142-5","article-title":"Anxiety sensitivity and opioid misuse and dependence among trauma-exposed adults with chronic pain","volume":"43","author":"Zvolensky","year":"2020","journal-title":"J. Behav. 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