{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:07:16Z","timestamp":1785323236076,"version":"3.55.0"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"abstract":"<jats:p>The present study aimed to investigate the effects of a short period of normobaric hypoxic exposure on spatial learning and memory, and brain-derived neurotrophic factor (BDNF) levels in the rat hippocampus. Hypoxic conditions were set at 12.5% O<jats:sub>2<\/jats:sub>. We compared all variables between normoxic trials (Norm), after 24 h (Hypo-24 h), and after 72 h of hypoxic exposure (Hypo-72 h). Spatial learning and memory were evaluated by using a water-finding task in an open field. Time to find water drinking fountains was significantly extended in Hypo 24 h (36.2 \u00b1 21.9 s) compared to those in Norm (17.9 \u00b1 12.8 s; <jats:italic>P<\/jats:italic> &amp;lt; 0.05), whereas no statistical differences between Norm and Hypo-72 h (22.7 \u00b1 12.3 s). Moreover, hippocampal BDNF level in Hypo-24 h was significantly lower compared to Norm (189.4 \u00b1 28.4 vs. 224.9 \u00b1 47.7 ng\/g wet tissue, <jats:italic>P<\/jats:italic> &amp;lt; 0.05), whereas no statistically differences in those between Norm and Hypo-72 h (228.1 \u00b1 39.8 ng\/g wet tissue). No significant differences in the changes in corticosterone and adrenocorticotropic hormone levels were observed across the three conditions. When data from Hypo-24 h and Hypo-72 h of hypoxia were pooled, there was a marginal negative relationship between the time to find drinking fountains and BDNF (<jats:italic>P<\/jats:italic> &amp;lt; 0.1), and was a significant negative relationship between the locomotor activities and BDNF (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). These results suggest that acute hypoxic exposure (24 h) may impair spatial learning and memory; however, it recovered after 72 h of hypoxic exposure. These changes in spatial learning and memory may be associated with changes in the hippocampal BDNF levels in rats.<\/jats:p>","DOI":"10.3389\/fnbeh.2024.1330596","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T04:29:31Z","timestamp":1707193771000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Influence of short-term hypoxic exposure on spatial learning and memory function and brain-derived neurotrophic factor in rats\u2014A practical implication to human's lost way"],"prefix":"10.3389","volume":"18","author":[{"given":"Masataka","family":"Kiuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Uno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Horiuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1089\/ham.2013.1138","article-title":"Cerebral blood flow at high altitude","volume":"15","author":"Ainslie","year":"2014","journal-title":"High Alt. 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