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Behav. Neurosci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Human epidemiological studies suggest that heavy alcohol consumption may lead to earlier onset of Alzheimer\u2019s Disease (AD), especially in individuals with a genetic predisposition for AD. Alcohol-related brain damage (ARBD) during a critical developmental timepoint, such as adolescence, interacts with AD-related pathologies to accelerate disease progression later in life. The current study investigates if voluntary exercise in mid-adulthood can recover memory deficits caused by the interactions between adolescence ethanol exposure and AD-transgenes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male and female TgF344-AD and wildtype F344 rats were exposed to an intragastric gavage of water (control) or 5 g\/kg of 20% ethanol (adolescent intermittent ethanol; AIE) for a 2 day on\/off schedule throughout adolescence (PD27-57). At 6 months old, rats either remained in their home cage (stationary) or were placed in a voluntary wheel running apparatus for 4 weeks and then underwent several behavioral tests. The number of cholinergic neurons in the basal forebrain and measure of neurogenesis in the hippocampus were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Voluntary wheel running recovers spatial working memory deficits selectively in female TgF344-AD rats exposed to AIE and improves pattern separation impairment seen in control TgF344-AD female rats. There were sex-dependent effects on brain pathology: Exercise improves the integration of recently born neurons in AIE-exposed TgF344-AD female rats. Exercise led to a decrease in amyloid burden in the hippocampus and entorhinal cortex, but only in male AIE-exposed TgF344-AD rats. Although the number of basal forebrain cholinergic neurons was not affected by AD-transgenes in either sex, AIE did reduce the number of basal forebrain cholinergic neurons in female rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These data provide support that even after symptom onset, AIE and AD related cognitive decline and associated neuropathologies can be rescued with exercise in unique sex-specific ways.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnbeh.2024.1448691","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T05:27:17Z","timestamp":1722490037000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Exercise leads to sex-specific recovery of behavior and pathological AD markers following adolescent ethanol exposure in the TgF344-AD model"],"prefix":"10.3389","volume":"18","author":[{"given":"Nicole L.","family":"Reitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polliana T.","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Savage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1001\/jama.292.12.1447","article-title":"Walking and dementia in physically capable elderly men.","volume":"292","author":"Abbott","year":"2004","journal-title":"JAMA"},{"key":"B2","doi-asserted-by":"publisher","first-page":"4217","DOI":"10.1523\/JNEUROSCI.0496-05.2005","article-title":"Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer\u2019s disease.","volume":"25","author":"Adlard","year":"2005","journal-title":"J. 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