{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T01:09:50Z","timestamp":1776301790439,"version":"3.50.1"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"abstract":"<jats:p>This functional magnetic resonance imaging (fMRI) study examined resting-state (RS) connectivity in adolescent and adult patients with anorexia nervosa (AN) using symptom provocation paradigms. Differential food reward mechanisms were investigated through separate assessments of responses to food images and low-caloric\/high-caloric food consumption. Thirteen young (\u2264 21\u2009years) and seventeen adult (&amp;gt; 21\u2009years) patients with AN and age-matched controls underwent two stimulus-driven fMRI sessions involving RS scans before and after the presentation of food-related stimuli and food consumption. Graph theory and machine learning were used for analyzing the fMRI and clinical data. Healthy controls (HCs) showed widespread developmental changes, while young participants with AN exhibited cerebellum differences for high-calorie food. Young individuals with AN displayed increased connectivity during the consumption of potato chips compared to zucchini, with no differences in adults with AN. Multiparametric machine learning accurately distinguished young individuals with AN from healthy controls based on RS connectivity following food visual stimulation (\u201canticipatory\u201d) and consumption (\u201cconsummatory\u201d). This study highlights the differential food reward mechanisms and minimal developmental changes in RS connectivity from youth to adulthood in individuals with AN compared to healthy controls. Young individuals with AN demonstrated heightened reactivity to high-caloric foods, while adults showed decreased responsiveness, potentially due to desensitization. These findings shed light on aberrant eating behaviors in individuals with AN and contribute to our understanding of the chronicity of the disease.<\/jats:p>","DOI":"10.3389\/fnbeh.2024.1451691","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T11:07:00Z","timestamp":1729768020000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impaired maturation of resting-state connectivity in anorexia nervosa from adolescence to adulthood: differential mechanisms of consummatory vs. anticipatory responses through a symptom provocation paradigm"],"prefix":"10.3389","volume":"18","author":[{"given":"Andrea","family":"Mendez-Torrijos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mageshwar","family":"Selvakumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke","family":"Kreitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Roesch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnd","family":"D\u00f6rfler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Paslakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Krehbiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Steins-L\u00f6ber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Kratz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Horndasch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Hess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1007\/s12311-013-0471-1","article-title":"Intrinsic connectivity networks within cerebellum and beyond in eating disorders","volume":"12","author":"Amianto","year":"2013","journal-title":"Cerebellum"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0149-7634(95)00033-b","article-title":"Food reward: brain substrates of wanting and liking","volume":"20","author":"Berridge","year":"1996","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.physbeh.2009.02.044","article-title":"'Liking' and 'wanting' food rewards: brain substrates and roles in eating disorders","volume":"97","author":"Berridge","year":"2009","journal-title":"Physiol. Behav."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/mrm.1910340409","article-title":"Functional connectivity in the motor cortex of resting human brain using echo-planar mri","volume":"34","author":"Biswal","year":"1995","journal-title":"Magn. Reson. Med."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"346","DOI":"10.3389\/fnbeh.2014.00346","article-title":"Increased resting state functional connectivity in the fronto-parietal and default mode network in anorexia nervosa. Front","volume":"8","author":"Boehm","year":"2014","journal-title":"Behav. Neurosci."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"5064","DOI":"10.1007\/s00330-017-4914-9","article-title":"Evaluating anorexia-related brain atrophy using MP2RAGE-based morphometry","volume":"27","author":"Boto","year":"2017","journal-title":"Eur. Radiol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e34000","DOI":"10.1371\/journal.pone.0034000","article-title":"Thinking about eating food activates visual cortex with reduced bilateral cerebellar activation in females with anorexia nervosa: an fMRI study","volume":"7","author":"Brooks","year":"2012","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nmeth.4642","article-title":"Statistics versus machine learning","volume":"15","author":"Bzdok","year":"2018","journal-title":"Nat. Methods"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1542\/peds.2014-0194","article-title":"Eating disorders in children and adolescents: state of the art review","volume":"134","author":"Campbell","year":"2014","journal-title":"Pediatrics"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/1471-2105-12-253","article-title":"Sparse PLS discriminant analysis: biologically relevant feature selection and graphical displays for multiclass problems","volume":"12","author":"Cao","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"ref11","author":"Chen","year":"2016"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1079\/bjn20051389","article-title":"Age and gender differences in children's food preferences","volume":"93","author":"Cooke","year":"2005","journal-title":"Br. J. Nutr."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/hbm.22202","article-title":"Increased resting state functional connectivity in the default mode network in recovered anorexia nervosa","volume":"35","author":"Cowdrey","year":"2014","journal-title":"Hum. Brain Mapp."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"463","DOI":"10.3945\/ajcn.112.046011","article-title":"Liking compared with wanting for high-and low-calorie foods in anorexia nervosa: aberrant food reward even after weight restoration","volume":"97","author":"Cowdrey","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"NeuroImage"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1097\/NEN.0b013e3182588293","article-title":"Neuroanatomic connectivity of the human ascending arousal system critical to consciousness and its disorders","volume":"71","author":"Edlow","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1503\/jpn.140249","article-title":"Elevated cognitive control over reward processing in recovered female patients with anorexia nervosa","volume":"40","author":"Ehrlich","year":"2015","journal-title":"J. Psychiatry Neurosci."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1093\/cercor\/bhs261","article-title":"In the zone or zoning out? Tracking behavioral and neural fluctuations during sustained attention","volume":"23","author":"Esterman","year":"2013","journal-title":"Cereb. Cortex"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.biopsych.2012.04.025","article-title":"Disruption of visuospatial and somatosensory functional connectivity in anorexia nervosa","volume":"72","author":"Favaro","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1017\/S0033291713002389","article-title":"Alterations in brain structure in adults with anorexia nervosa and the impact of illness duration","volume":"44","author":"Fonville","year":"2014","journal-title":"Psychol. Med."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e932","DOI":"10.1038\/tp.2016.199","article-title":"Altered structural and effective connectivity in anorexia and bulimia nervosa in circuits that regulate energy and reward homeostasis","volume":"6","author":"Frank","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1176\/appi.ajp.162.7.1256","article-title":"Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder","volume":"162","author":"Frazier","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1002\/eat.22099","article-title":"Neurocircuit function in eating disorders","volume":"46","author":"Friederich","year":"2013","journal-title":"Int. J. Eat. Disord."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s40337-016-0118-y","article-title":"Functional brain alterations in anorexia nervosa: a scoping review","volume":"4","author":"Fuglset","year":"2016","journal-title":"J. Eat. Disord."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.neubiorev.2016.09.032","article-title":"A systematic review of resting-state functional-MRI studies in anorexia nervosa: evidence for functional connectivity impairment in cognitive control and visuospatial and body-signal integration","volume":"71","author":"Gaudio","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1503\/jpn.140310","article-title":"Abnormal functional global and local brain connectivity in female patients with anorexia nervosa","volume":"41","author":"Geisler","year":"2016","journal-title":"J. Psychiatry Neurosci."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1159\/000319360","article-title":"Influence of satiety and subjective valence rating on cerebral activation patterns in response to visual stimulation with high-calorie stimuli among restrictive anorectic and control women","volume":"62","author":"Gizewski","year":"2010","journal-title":"Neuropsychobiology"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1002\/hbm.20249","article-title":"Analysis of functional image analysis contest (FIAC) data with brainvoyager QX: from single-subject to cortically aligned group general linear model analysis and self-organizing group independent component analysis","volume":"27","author":"Goebel","year":"2006","journal-title":"Hum. Brain Mapp."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1097\/WCO.0b013e328306f2c5","article-title":"Resting-state functional connectivity in neuropsychiatric disorders","volume":"21","author":"Greicius","year":"2008","journal-title":"Curr. Opin. Neurol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1073\/pnas.0135058100","article-title":"Functional connectivity in the resting brain: a network analysis of the default mode hypothesis","volume":"100","author":"Greicius","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.brat.2018.08.006","article-title":"Evidence of prefrontal hyperactivation to food-cue reversal learning in adolescents with anorexia nervosa","volume":"111","author":"Hildebrandt","year":"2018","journal-title":"Behav. Res. Ther."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e0191059","DOI":"10.1371\/journal.pone.0191059","article-title":"Neural processing of food and emotional stimuli in adolescent and adult anorexia nervosa patients","volume":"13","author":"Horndasch","year":"2018","journal-title":"PLoS One"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"4952","DOI":"10.1002\/hbm.24750","article-title":"Automated brain extraction of multisequence MRI using artificial neural networks","volume":"40","author":"Isensee","year":"2019","journal-title":"Hum. Brain Mapp."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.pscychresns.2010.11.008","article-title":"Amygdala hyperreactivity in restrictive anorexia nervosa","volume":"191","author":"Joos","year":"2011","journal-title":"Psychiatry Res."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/ped.13730","article-title":"Childhood dietary intake: comparison between anorexia nervosa and healthy leanness","volume":"61","author":"Kanayama","year":"2019","journal-title":"Pediatr. Int."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"651547","DOI":"10.3389\/fpsyg.2022.651547","article-title":"Inhibitory control development: a network neuroscience perspective","volume":"13","author":"Kang","year":"2022","journal-title":"Front. Psychol."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"334","DOI":"10.3389\/fnins.2018.00334","article-title":"A new analysis of resting state connectivity and graph theory reveals distinctive short-term modulations due to whisker stimulation in rats","volume":"12","author":"Kreitz","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref8001","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s001120170107","article-title":"Perzentile f\u00fcr den Body-mass-Index f\u00fcr das Kindes- und Jugendalter unter Heranziehung verschiedener deutscher Stichproben","volume":"149","author":"Kromeyer-Hauschild","year":"2001","journal-title":"Monatsschr Kinderheilkd."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3233\/Fi-2010-288","article-title":"Boruta - A system for feature selection","volume":"101","author":"Kursa","year":"2010","journal-title":"Fundam. Inf."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v036.i11","article-title":"Feature selection with the Boruta package","volume":"36","author":"Kursa","year":"2010","journal-title":"J. Stat. Softw."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.3174\/ajnr.A3263","article-title":"Resting-state fMRI: a review of methods and clinical applications","volume":"34","author":"Lee","year":"2013","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"104480","DOI":"10.1016\/j.appet.2019.104480","article-title":"Basal ganglia volume and shape in anorexia nervosa","volume":"144","author":"Leppanen","year":"2020","journal-title":"Appetite"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1111\/j.1369-1600.2009.00146.x","article-title":"Clinical study: attentional bias in alcohol-dependent patients: the role of chronicity and executive functioning","volume":"14","author":"Loeber","year":"2009","journal-title":"Addict. Biol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.pscychresns.2016.02.001","article-title":"Brain parcellation choice affects disease-related topology differences increasingly from global to local network levels","volume":"249","author":"Lord","year":"2016","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.bpsc.2021.03.006","article-title":"Recovery-associated resting-state activity and connectivity alterations in anorexia nervosa","volume":"6","author":"Lotter","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1006\/nimg.1997.0315","article-title":"Functional connectivity in single and multislice echoplanar imaging using resting-state fluctuations","volume":"7","author":"Lowe","year":"1998","journal-title":"NeuroImage"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroimage.2012.12.008","article-title":"Volumetric parcellation methodology of the human hypothalamus in neuroimaging: normative data and sex differences","volume":"69","author":"Makris","year":"2013","journal-title":"NeuroImage"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1017\/S1092852918000767","article-title":"Snack food as a modulator of human resting-state functional connectivity","volume":"23","author":"Mendez-Torrijos","year":"2018","journal-title":"CNS Spectr."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12888-021-03497-4","article-title":"Altered functional connectivity in adolescent anorexia nervosa is related to age and cortical thickness","volume":"21","author":"Myrvang","year":"2021","journal-title":"BMC Psychiatry"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.jpsychires.2009.04.003","article-title":"The epidemiology of eating disorders in six European countries: results of the ESEMeD-WMH project","volume":"43","author":"Preti","year":"2009","journal-title":"J. Psychiatr. Res."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e10251","DOI":"10.1002\/jbm4.10251","article-title":"Transdermal estrogen in women with anorexia nervosa: an exploratory pilot study","volume":"4","author":"Resulaj","year":"2020","journal-title":"JBMR Plus"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"e1005752","DOI":"10.1371\/journal.pcbi.1005752","article-title":"mixOmics: an R package for 'omics feature selection and multiple data integration","volume":"13","author":"Rohart","year":"2017","journal-title":"PLoS Comput. Biol."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1017\/S0029665112000821","article-title":"Taste, olfactory and food texture reward processing in the brain and the control of appetite","volume":"71","author":"Rolls","year":"2012","journal-title":"Proc. Nutr. Soc."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3389\/fpsyt.2017.00030","article-title":"Reduced resting-state functional connectivity in current and recovered restrictive anorexia nervosa","volume":"8","author":"Scaife","year":"2017","journal-title":"Front. Psych."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.yclnex.2019.02.001","article-title":"Alterations of brain structure and functions in anorexia nervosa","volume":"28","author":"Scharner","year":"2019","journal-title":"Clin. Nutr. Exp."},{"key":"ref55","volume-title":"Kinder-DIPS open access: Diagnostisches Interview bei psychischen St\u00f6rungen im Kindes-und Jugendalter","author":"Schneider","year":"2017"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"e0117959","DOI":"10.1371\/journal.pone.0117959","article-title":"Which foods may be addictive? The roles of processing, fat content, and glycemic load","volume":"10","author":"Schulte","year":"2015","journal-title":"PLoS One"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1172\/jci.insight.92970","article-title":"Integration of homeostatic signaling and food reward processing in the human brain","volume":"2","author":"Simon","year":"2017","journal-title":"JCI Insight"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.1002\/hbm.20673","article-title":"Changes in the interaction of resting-state neural networks from adolescence to adulthood","volume":"30","author":"Stevens","year":"2009","journal-title":"Hum. Brain Mapp."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.2174\/1570159X15666171017111532","article-title":"Neural network alterations across eating disorders: a narrative review of fMRI studies","volume":"16","author":"Steward","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S0033291724000485","article-title":"Comprehensive elucidation of resting-state functional connectivity in anorexia nervosa by a multicenter cross-sectional study","volume":"1","author":"Sudo","year":"2024","journal-title":"Psychol. Med."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.beth.2008.07.002","article-title":"Acceptance of structured diagnostic interviews for mental disorders in clinical practice and research settings","volume":"40","author":"Suppiger","year":"2009","journal-title":"Behav. Ther."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1080\/10942912.2020.1826512","article-title":"Nutritional and sensorial characteristics of zucchini (L.) as affected by freezing and the culinary treatment","volume":"23","author":"Tejada","year":"2020","journal-title":"Int. J. Food Prop."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1176\/appi.ajp.161.7.1238","article-title":"Medial prefrontal cortex activity associated with symptom provocation in eating disorders","volume":"161","author":"Uher","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"e01205","DOI":"10.1002\/brb3.1205","article-title":"Resting-state connectivity within and across neural circuits in anorexia nervosa","volume":"9","author":"Uniacke","year":"2019","journal-title":"Brain Behav."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s00787-021-01880-w","article-title":"Longitudinal study in adolescent anorexia nervosa: evaluation of cortico-striatal and default mode network resting-state brain circuits","volume":"32","author":"Via","year":"2021","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"480","DOI":"10.3390\/jcm10235480","article-title":"Volumetric alterations of the cerebral cortex in eating disorders","volume":"10","author":"Vidal","year":"2021","journal-title":"J. Clin. Med."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1093\/alcalc\/agp056","article-title":"Avoidance of alcohol-related stimuli increases during the early stage of abstinence in alcohol-dependent patients","volume":"44","author":"Vollst\u00e4dt-Klein","year":"2009","journal-title":"Alcohol Alcohol."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/30918","article-title":"Collective dynamics of 'small-world' networks","volume":"393","author":"Watts","year":"1998","journal-title":"Nature"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/j.neuroimage.2010.06.041","article-title":"Network-based statistic: identifying differences in brain networks","volume":"53","author":"Zalesky","year":"2010","journal-title":"NeuroImage"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/nrneurol.2009.198","article-title":"Disease and the brain's dark energy","volume":"6","author":"Zhang","year":"2010","journal-title":"Nat. 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