{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:02:57Z","timestamp":1751515377877,"version":"3.41.0"},"reference-count":195,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"abstract":"<jats:p>Women experience depression at nearly 2-fold higher rates than men, with middle-age during the menopausal transition being particularly vulnerable. Preclinical studies commonly focus on young adult or aged subjects and\/or rely upon a few behavioral tasks. Given the highly variable and heterogenous nature of depression, the current study implemented a behavioral battery to assess whether estradiol (E2, endogenously expressed in women and rats) would improve depressive measures using the Research Domain Criteria (RDoC) for negative valence, anhedonia, sociability, and anxiety in early middle-aged, ovariectomized (OVX) female rats. F344-cdf rats were OVX and injected daily with E2 (3 \u03bcg\/ml, or oil). Behavioral testing began after 14 days of injections, which continued throughout the study. E2 improved the depressive profile when using a composite metric for negative valence (immobility on the forced swim task, FST), anhedonia (duration to initiate grooming following sucrose splash and latency to initiate grooming with sucrose), sociability (time interacting toward a novel conspecific), and novelty-induced anxiety (time spent investigating marbles). Interestingly, FST immobility significantly and positively correlated with sucrose preference to show they were opposingly related: higher immobility on FST corresponded to more sucrose ingested. Also, time spent in a chamber with a novel conspecific was less informative than time directed at the conspecific. Other tasks, such as the marble bury test showed some hoarding behavior. These nuances revealed difficulties in assessing behaviors within and across studies, but overall showed that E2 improved the depressive-like syndrome (DLS) in middle-aged females based upon the RDoC.<\/jats:p>","DOI":"10.3389\/fnbeh.2025.1553501","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T05:52:55Z","timestamp":1751435575000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic 17\u03b2-estradiol treatment improves negative valence, anhedonic profile, and social interactions in ovariectomized, middle-aged female rats"],"prefix":"10.3389","volume":"19","author":[{"given":"Cheryl D.","family":"Conrad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dylan N.","family":"Peay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Sladkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinah L.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan E.","family":"Donnay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda M.","family":"Acu\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kennedy E.","family":"Whittaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.jad.2021.06.040","article-title":"Differential effects of estradiol on neural and emotional stress response in postmenopausal women with remitted Major Depressive Disorder","volume":"293","author":"Albert","year":"2021","journal-title":"J. Affect. Disord."},{"key":"B2","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1146\/annurev-clinpsy-050718-095557","article-title":"Estrogen, stress, and depression: cognitive and biological interactions","volume":"15","author":"Albert","year":"2019","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1503\/jpn.150205","article-title":"Why is depression more prevalent in women?","volume":"40","author":"Albert","year":"2015","journal-title":"J. Psychiatry Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.yfrne.2014.05.004","article-title":"Sex differences in anxiety and depression clinical perspectives","volume":"35","author":"Altemus","year":"2014","journal-title":"Front. Neuroendocrinol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1097\/00131746-200105000-00006","article-title":"Treatment of depression in women: a summary of the expert consensus guidelines","volume":"7","author":"Altshuler","year":"2001","journal-title":"J. Psychiatr. Pract."},{"key":"B6","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"key":"B7","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ynstr.2017.03.003","article-title":"Animal models in psychiatric research: The RDoC system as a new framework for endophenotype-oriented translational neuroscience","volume":"7","author":"Anderzhanova","year":"2017","journal-title":"Neurobiol. Stress"},{"key":"B8","doi-asserted-by":"publisher","first-page":"50978","DOI":"10.3791\/50978-v","article-title":"Marble burying and nestlet shredding as tests of repetitive, compulsive-like behaviors in mice","volume":"82","author":"Angoa-Pe\u00e9ez","year":"2013","journal-title":"J. Vis. Exp."},{"key":"B9","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1037\/0735-7044.120.2.249","article-title":"Anxiogenic-like effect of chronic corticosterone in the light-dark emergence task in mice","volume":"120","author":"Ardayfio","year":"2006","journal-title":"Behav. Neurosci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3389\/fnagi.2017.00111","article-title":"Aging impairs hippocampal- dependent recognition memory and LTP and prevents the associated RyR Up-regulation","volume":"9","author":"Arias-Cavieres","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.neubiorev.2021.06.014","article-title":"The forced swim test: Historical, conceptual and methodological considerations and its relationship with individual behavioral traits","volume":"128","author":"Armario","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B12","first-page":"883","article-title":"\u201cAnimal models and endophenotypes of anxiety and stress disorders,\u201d","volume-title":"Neuropsychopharmacology: 5th Generation of Progress","author":"Bakshi","year":"2002"},{"key":"B13","doi-asserted-by":"publisher","first-page":"648830","DOI":"10.3389\/fnbeh.2021.648830","article-title":"Comparative assessment of familiarity\/novelty preferences in rodents","volume":"15","author":"Beery","year":"2021","journal-title":"Front. Behav. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1210\/en.2011-1925","article-title":"A lack of ovarian function increases neuroinflammation in aged mice","volume":"153","author":"Benedusi","year":"2012","journal-title":"Endocrinology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"311","DOI":"10.3389\/fnagi.2016.00311","article-title":"Comparison of the antidepressant-like effects of estradiol and that of selective serotonin reuptake inhibitors in middle-aged ovariectomized rats","volume":"8","author":"Benmansour","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.neubiorev.2005.03.013","article-title":"Novelty reward as a measure of anhedonia","volume":"29","author":"Bevins","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B17","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0306-4530(98)00068-7","article-title":"Estradiol facilitates performance as working memory load increases","volume":"24","author":"Bimonte","year":"1999","journal-title":"Psychoneuroendocrinology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/j.1460-9568.2006.04867.x","article-title":"Progesterone reverses the spatial memory enhancements initiated by tonic and cyclic oestrogen therapy in middle-aged ovariectomized female rats","volume":"24","author":"Bimonte-Nelson","year":"2006","journal-title":"Eur. J. Neurosci"},{"key":"B19","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.neulet.2017.08.019","article-title":"A standardization of the Novelty-Suppressed Feeding Test protocol in rats","volume":"658","author":"Blasco-Serra","year":"2017","journal-title":"Neurosci. Lett."},{"key":"B20","doi-asserted-by":"publisher","first-page":"15731","DOI":"10.1073\/pnas.1511593112","article-title":"Obesity diminishes synaptic markers, alters microglial morphology, and impairs cognitive function","volume":"112","author":"Bocarsly","year":"2015","journal-title":"PNAS"},{"key":"B21","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/BF00181937","article-title":"The effects of chronic antidepressant treatment in an animal model of anxiety","volume":"95","author":"Bodnoff","year":"1988","journal-title":"Psychopharmacology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1038\/sj.npp.1301410","article-title":"Chronic unpredictable stress induces a cognitive deficit and anxiety-like behavior in rats that is prevented by chronic antidepressant drug treatment","volume":"33","author":"Bondi","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1101\/lm.053509.121","article-title":"Sex differences in cognition following variations in endocrine status","volume":"29","author":"Bowman","year":"2022","journal-title":"Learn. Mem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3389\/fnbeh.2019.00055","article-title":"Deficits in social behavior precede cognitive decline in middle-aged mice","volume":"13","author":"Boyer","year":"2019","journal-title":"Front. Behav. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"106917","DOI":"10.1016\/j.phrs.2023.106917","article-title":"A systematic mapping review of the evolution of the rat Forced Swim Test: protocols and outcome parameters","volume":"196","author":"Brandwein","year":"2023","journal-title":"Pharmacol. Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.bbr.2005.12.001","article-title":"Factor analysis of Forced Swimming test, Sucrose Preference test and Open Field test on enriched, social and isolated reared rats","volume":"169","author":"Brenes-S\u00e1enz","year":"2006","journal-title":"Behav. Brain Res"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1038\/s41386-020-0609-z","article-title":"Fast-acting antidepressant-like effects of Reelin evaluated in the repeated-corticosterone chronic stress paradigm","volume":"45","author":"Brymer","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1586\/14737175.7.11s.S35","article-title":"Nomenclature and endocrinology of menopause and perimenopause","volume":"7","author":"Burger","year":"2007","journal-title":"Expert Rev. Neurother."},{"key":"B29","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.physbeh.2009.06.010","article-title":"Estradiol and the control of food intake","volume":"99","author":"Butera","year":"2010","journal-title":"Physiol. Behav."},{"key":"B30","doi-asserted-by":"publisher","first-page":"114026","DOI":"10.1016\/j.bbr.2022.114026","article-title":"Age-related loss of recognition memory and its correlation with hippocampal and perirhinal cortex changes in female Sprague Dawley rats","volume":"435","author":"Canatelli-Mallat","year":"2022","journal-title":"Behav. Brain Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.euroneuro.2023.07.012","article-title":"Biological markers of sex-based differences in major depressive disorder and in antidepressant response","volume":"76","author":"Carvalho Silva","year":"2023","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"392434","DOI":"10.1155\/2013\/392434","article-title":"17 beta -Estradiol attenuates poststroke depression and increases neurogenesis in female ovariectomized rats","volume":"2013","author":"Cheng","year":"2013","journal-title":"Biomed Res. Int."},{"key":"B33","doi-asserted-by":"crossref","DOI":"10.4324\/9780203771587","volume-title":"Statistical Power Analysis for the Behavioral Sciences.","author":"Cohen","year":"2013"},{"key":"B34","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1001\/archpsyc.63.4.385","article-title":"Risk for new onset of depression during the menopausal transition: the Harvard study of moods and cycles","volume":"63","author":"Cohen","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"B35","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/S1074-7427(02)00018-7","article-title":"Sex differences in spatial and non-spatial Y-maze performance after chronic stress","volume":"79","author":"Conrad","year":"2003","journal-title":"Neurobiol. Learn. Mem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1037\/a0025770","article-title":"Chronic stress and a cyclic regimen of estradiol administration separately facilitate spatial memory: relationship with hippocampal CA1 spine density and dendritic complexity","volume":"126","author":"Conrad","year":"2012","journal-title":"Behav. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"105600","DOI":"10.1016\/j.yhbeh.2024.105600","article-title":"Corticosterone disrupts spatial working memory during retention testing when highly taxed, which positively correlates with depressive-like behavior in middle-aged, ovariectomized female rats","volume":"164","author":"Conrad","year":"2024","journal-title":"Horm. Behav."},{"key":"B38","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/S0165-6147(02)02017-5","article-title":"Assessing antidepressant activity in rodents: recent developments and future needs","volume":"23","author":"Cryan","year":"2002","journal-title":"TIPS"},{"key":"B39","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.pnpbp.2015.04.004","article-title":"Animal models of major depression and their clinical implications","volume":"64","author":"Czeh","year":"2016","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B40","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.bbr.2010.11.045","article-title":"Agomelatine reverses the decrease in hippocampal cell survival induced by chronic mild stress","volume":"218","author":"Dagyte","year":"2011","journal-title":"Behav. Brain Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1210\/en.2005-0998","article-title":"Estradiol replacement enhances working memory in middle-aged rats when initiated immediately after ovariectomy but not after a long-term period of ovarian hormone deprivation","volume":"147","author":"Daniel","year":"2006","journal-title":"Endocrinology"},{"key":"B42","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/0031-9384(94)90316-6","article-title":"Effects of chronic mild stress on performance in behavioural tests relevant to anxiety and depression","volume":"56","author":"D'Aquila","year":"1994","journal-title":"Physiol. Behav"},{"key":"B43","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.neuron.2009.04.017","article-title":"Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety\/depression","volume":"62","author":"David","year":"2009","journal-title":"Neuron"},{"key":"B44","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0014-2999(03)01278-0","article-title":"Defensive burying in rodents: ethology, neurobiology and psychopharmacology","volume":"463","author":"De Boer","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3758\/s13415-018-00653-4","article-title":"A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: mapping the way forward","volume":"19","author":"de Brouwer","year":"2019","journal-title":"Cogn. Affect. Behav. Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/BF02245592","article-title":"Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants","volume":"121","author":"Detke","year":"1995","journal-title":"Psychopharmacology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"3571","DOI":"10.1210\/en.2012-1340","article-title":"Minireview: translational animal models of human menopause: challenges and emerging opportunities","volume":"153","author":"Diaz Brinton","year":"2012","journal-title":"Endocrinology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.neulet.2018.09.059","article-title":"Depression-like behaviors induced by chronic corticosterone exposure via drinking water: time-course analysis","volume":"687","author":"Ding","year":"2018","journal-title":"Neurosci. Lett."},{"key":"B49","doi-asserted-by":"publisher","first-page":"100896","DOI":"10.1016\/j.yfrne.2020.100896","article-title":"Do different types of stress differentially alter behavioural and neurobiological outcomes associated with depression in rodent models? A systematic review","volume":"61","author":"Du Preez","year":"2021","journal-title":"Front. Neuroendocrinol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/s41398-020-01000-3","article-title":"The type of stress matters: repeated injection and permanent social isolation stress in male mice have a differential effect on anxiety- and depressive-like behaviours, and associated biological alterations","volume":"10","author":"Du Preez","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"B51","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.neubiorev.2005.03.017","article-title":"Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test","volume":"29","author":"Dulawa","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B52","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nm.4050","article-title":"Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants","volume":"22","author":"Duman","year":"2016","journal-title":"Nat. Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1176\/appi.ajp.2020.19080848","article-title":"Hormonal treatments for major depressive disorder: state of the art","volume":"177","author":"Dwyer","year":"2020","journal-title":"Am. J. Psychiatry"},{"key":"B54","doi-asserted-by":"publisher","first-page":"3829","DOI":"10.1210\/jc.2013-1808","article-title":"Menopause effects on verbal memory: findings from a longitudinal community cohort","volume":"98","author":"Epperson","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B55","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1038\/sj.npp.1300097","article-title":"Antidepressant-like effect of different estrogenic compounds in the forced swimming test","volume":"28","author":"Estrada-Camarena","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1111\/jnc.16083","article-title":"Unmoving and uninflamed: characterizing neuroinflammatory dysfunction in the Wistar-Kyoto rat model of depression","volume":"168","author":"Farinha-Ferreira","year":"2024","journal-title":"J. Neurochem."},{"key":"B57","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1556\/APhysiol.100.2013.2.8","article-title":"Anxiolytic-like effect of quinpirole in combination with a low dose of 17beta-estradiol in ovariectomized rats","volume":"100","author":"Fedotova","year":"2013","journal-title":"Acta Physiol. Hung."},{"key":"B58","doi-asserted-by":"publisher","first-page":"847821","DOI":"10.1155\/2014\/847821","article-title":"Effects of SCH-23390 in combination with a low dose of 17beta-estradiol on anxiety-like behavior in ovariectomized rats","volume":"2014","author":"Fedotova","year":"2014","journal-title":"Biomed Res. Int."},{"key":"B59","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1476-5381.1978.tb07001.x","article-title":"Can social interaction be used to measure anxiety?","volume":"62","author":"File","year":"1978","journal-title":"Br. J. Pharmacol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0014-2999(03)01273-1","article-title":"A review of 25 years of the social interaction test","volume":"463","author":"File","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.neurol.2018.01.365","article-title":"Is major depression a cognitive disorder?","volume":"174","year":"2018","journal-title":"Rev. Neurol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.cobeha.2018.03.011","article-title":"Estradiol and hippocampal memory in female and male rodents","volume":"23","author":"Frick","year":"2018","journal-title":"Curr Opin Behav Sci"},{"key":"B63","doi-asserted-by":"publisher","first-page":"53109","DOI":"10.3791\/53109-v","article-title":"An unpredictable chronic mild stress protocol for instigating depressive symptoms, behavioral changes and negative health outcomes in rodents","volume":"106","author":"Frisbee","year":"2015","journal-title":"J. Vis. Exp."},{"key":"B64","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1037\/0735-7044.118.2.306","article-title":"Estrogen and\/or progesterone administered systemically or to the amygdala can have anxiety-, fear-, and pain-reducing effects in ovariectomized rats","volume":"118","author":"Frye","year":"2004","journal-title":"Behav. Neurosci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"e2998","DOI":"10.21769\/BioProtoc.2998","article-title":"Shock-probe defensive burying test to measure active versus passive coping style in response to an aversive stimulus in rats","volume":"8","author":"Fucich","year":"2018","journal-title":"Bio. Protoc."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0166-4328(01)00170-X","article-title":"Estradiol alleviates depressive-like symptoms in a novel animal model of post-partum depression","volume":"122","author":"Galea","year":"2001","journal-title":"Behav. Brain Res."},{"key":"B67","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.yhbeh.2016.11.011","article-title":"The effects of long-term estradiol treatment on social behavior and gene expression in adult female rats","volume":"87","author":"Garcia","year":"2017","journal-title":"Horm. Behav."},{"key":"B68","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3758\/s13415-024-01171-2","article-title":"Rodent tests of depression and anxiety: construct validity and translational relevance","volume":"24","author":"Gencturk","year":"2024","journal-title":"Cogn. Affect. Behav. Neurosci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1124\/jpet.109.162123","article-title":"Estrogen treatment blocks 8-hydroxy-2-dipropylaminotetralin- and apomorphine-induced disruptions of prepulse inhibition: involvement of dopamine D1 or D2 or serotonin 5-HT1A, 5-HT2A, or 5-HT7 receptors","volume":"333","author":"Gogos","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B70","doi-asserted-by":"publisher","first-page":"e12652","DOI":"10.1111\/jne.12652","article-title":"Differential effects of chronic 17beta-oestradiol treatment on rat behaviours relevant to depression","volume":"30","author":"Gogos","year":"2018","journal-title":"J. Neuroendocrinol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.3389\/fpsyg.2019.01319","article-title":"Estradiol fluctuation, sensitivity to stress, and depressive symptoms in the menopause transition: a pilot study","volume":"10","author":"Gordon","year":"2019","journal-title":"Front. Psychol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1097\/GME.0000000000000528","article-title":"Estradiol variability, stressful life events, and the emergence of depressive symptomatology during the menopausal transition","volume":"23","author":"Gordon","year":"2016","journal-title":"Menopause"},{"key":"B73","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.bbr.2004.05.013","article-title":"Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats","volume":"156","author":"Gregus","year":"2005","journal-title":"Behav. Brain Res"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1134\/S1819712422010068","article-title":"Ovariectomy as a model of anxiety-depressive disorders","volume":"16","author":"Grigoryan","year":"2022","journal-title":"Neurochem. J."},{"key":"B75","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/s41583-019-0221-6","article-title":"The future of rodent models in depression research","volume":"20","author":"Gururajan","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"B76","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1002\/jeab.686","article-title":"Social preference in rats","volume":"115","author":"Hackenberg","year":"2021","journal-title":"J. Exp. Anal. Behav."},{"key":"B77","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S0031-9384(02)00860-0","article-title":"Stress-induced social avoidance: a new model of stress-induced anxiety?","volume":"77","author":"Haller","year":"2002","journal-title":"Physiol. Behav."},{"key":"B78","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.bbr.2008.10.015","article-title":"Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks","volume":"198","author":"Harrison","year":"2009","journal-title":"Behav. Brain Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3389\/fnins.2016.00517","article-title":"Benefits of hormone therapy estrogens depend on estrogen type: 17\u03b2-estradiol and conjugated equine estrogens have differential effects on cognitive, anxiety-like, and depressive-like behaviors and increase tryptophan hydroxylase-2 mRNA levels in dorsal raphe nucleus subregions","volume":"10","author":"Hiroi","year":"2016","journal-title":"Front. Neurosci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1006\/hbeh.1993.1012","article-title":"Social recognition in ovariectomized and estradiol-treated female rats","volume":"27","author":"Hlinak","year":"1993","journal-title":"Horm. Behav."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0166-4328(02)00089-X","article-title":"Individual response profiles of male Wistar rats in animal models for anxiety and depression","volume":"136","author":"Ho","year":"2002","journal-title":"Behav. Brain Res."},{"key":"B82","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.biopsych.2019.04.028","article-title":"Sex differences in vulnerability and resilience to stress across the life span","volume":"86","author":"Hodes","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"B83","doi-asserted-by":"publisher","first-page":"16362","DOI":"10.1523\/JNEUROSCI.1392-15.2015","article-title":"Sex differences in nucleus accumbens transcriptome profiles associated with susceptibility versus resilience to subchronic variable stress","volume":"35","author":"Hodes","year":"2015","journal-title":"J. Neurosci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"e0185129","DOI":"10.1371\/journal.pone.0185129","article-title":"Re-evaluation of the interrelationships among the behavioral tests in rats exposed to chronic unpredictable mild stress","volume":"12","author":"Hu","year":"2017","journal-title":"PLoS ONE"},{"key":"B85","doi-asserted-by":"publisher","first-page":"102283","DOI":"10.1016\/j.jchemneu.2023.102283","article-title":"Protective mechanism of the EZH2\/microRNA-15a-5p\/CXCL10 axis in rats with depressive-like behaviors","volume":"132","author":"Huang","year":"2023","journal-title":"J. Chem. Neuroanat."},{"key":"B86","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.neubiorev.2006.11.004","article-title":"Neotic preferences in laboratory rodents: Issues, assessment and substrates","volume":"31","author":"Hughes","year":"2007","journal-title":"Neurosci. Biobehav. Rev"},{"key":"B87","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.bbr.2011.03.038","article-title":"Sex differences and phase of light cycle modify chronic stress effects on anxiety and depressive-like behavior","volume":"222","author":"Huynh","year":"2011","journal-title":"Behav. Brain Res."},{"key":"B88","doi-asserted-by":"publisher","first-page":"373","DOI":"10.3390\/ijms22010373","article-title":"The role of estrogen receptors and their signaling across psychiatric disorders","volume":"22","author":"Hwang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B89","doi-asserted-by":"publisher","first-page":"e10404","DOI":"10.1371\/journal.pone.0010404","article-title":"Association between repeated unpredictable chronic mild stress (UCMS) procedures with a high fat diet: a model of fluoxetine resistance in mice","volume":"5","author":"Isingrini","year":"2010","journal-title":"PLoS ONE"},{"key":"B90","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1176\/appi.ajp.2020.20030305","article-title":"The critical relationship between anxiety and depression","volume":"177","author":"Kalin","year":"2020","journal-title":"Am. J. Psychiatry"},{"key":"B91","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/0091-3057(82)90053-3","article-title":"Animal model of depression: pharmacological sensitivity of a hedonic deficit","volume":"16","author":"Katz","year":"1982","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B92","volume-title":"Design and Analysis","author":"Keppel","year":"1991"},{"key":"B93","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/S0165-0327(02)00426-3","article-title":"Epidemiology of women and depression","volume":"74","author":"Kessler","year":"2003","journal-title":"J. Affect. Disord."},{"key":"B94","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/YCO.0b013e32816ebc8c","article-title":"Age of onset of mental disorders: a review of recent literature","volume":"20","author":"Kessler","year":"2007","journal-title":"Curr. Opin. Psychiatry"},{"key":"B95","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"B96","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.bbr.2011.10.047","article-title":"17beta-estradiol replacement in young, adult and middle-aged female ovariectomized rats promotes improvement of spatial reference memory and an antidepressant effect and alters monoamines and BDNF levels in memory- and depression-related brain areas","volume":"227","author":"Kiss","year":"2012","journal-title":"Behav. Brain Res."},{"key":"B97","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.yhbeh.2015.06.009","article-title":"Trajectories and phenotypes with estrogen exposures across the lifespan: what does Goldilocks have to do with it?","volume":"74","author":"Koebele","year":"2015","journal-title":"Horm. Behav."},{"key":"B98","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.maturitas.2016.01.015","article-title":"Modeling menopause: the utility of rodents in translational behavioral endocrinology research","volume":"87","author":"Koebele","year":"2016","journal-title":"Maturitas"},{"key":"B99","doi-asserted-by":"publisher","first-page":"104656","DOI":"10.1016\/j.yhbeh.2019.104656","article-title":"A long-term cyclic plus tonic regimen of 17beta-estradiol improves the ability to handle a high spatial working memory load in ovariectomized middle-aged female rats","volume":"118","author":"Koebele","year":"2020","journal-title":"Horm. Behav."},{"key":"B100","first-page":"711","article-title":"Gender differences in presentation of chronic major depression","volume":"31","author":"Kornstein","year":"1995","journal-title":"Psychopharmacol. Bull."},{"key":"B101","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.physbeh.2012.01.004","article-title":"Estrogen effects on the forced swim test differ in two outbred rat strains","volume":"106","author":"Koss","year":"2012","journal-title":"Physiol. Behav."},{"key":"B102","doi-asserted-by":"publisher","first-page":"104694","DOI":"10.1016\/j.yhbeh.2020.104694","article-title":"Temporal and bidirectional influences of estradiol on voluntary wheel running in adult female and male rats","volume":"120","author":"Krentzel","year":"2020","journal-title":"Horm. Behav."},{"key":"B103","doi-asserted-by":"publisher","first-page":"e0158150","DOI":"10.1371\/journal.pone.0158150","article-title":"Behavioral phenotyping of juvenile long-evans and sprague-dawley rats: implications for preclinical models of autism spectrum disorders","volume":"11","author":"Ku","year":"2016","journal-title":"PLoS ONE"},{"key":"B104","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3389\/fnbeh.2018.00134","article-title":"Chronic social stress leads to reduced gustatory reward salience and effort valuation in mice","volume":"12","author":"Kukel'ova","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"B105","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.neubiorev.2016.07.002","article-title":"Social functioning in major depressive disorder","volume":"69","author":"Kupferberg","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B106","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1186\/1471-2164-11-675","article-title":"Age and sex dependent changes in liver gene expression during the life cycle of the rat","volume":"11","author":"Kwekel","year":"2010","journal-title":"BMC Genom."},{"key":"B107","doi-asserted-by":"publisher","first-page":"863","DOI":"10.3389\/fpsyg.2013.00863","article-title":"Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs","volume":"4","author":"Lakens","year":"2013","journal-title":"Front. Psychol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.euroneuro.2020.04.007","article-title":"Similarities and dissimilarities in the effects of benzodiazepines and specific serotonin reuptake inhibitors (SSRIs) in the defensive marble burying test: a systematic review and meta-analysis","volume":"36","author":"Langer","year":"2020","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1111\/j.1365-2826.2008.01772.x","article-title":"Behavioural assays to model cognitive and affective dimensions of depression and anxiety in rats","volume":"20","author":"Lapiz-Bluhm","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"177555","DOI":"10.1016\/j.ejphar.2025.177555","article-title":"Efficacy of mangiferin, kaempferol, and diosgenin on models of depression: a systematic review and network meta-analysis of rodent studies","volume":"997","author":"Lei","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/s12974-023-02889-5","article-title":"Supraphysiologic doses of 17beta-estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolism","volume":"20","author":"Li","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"B112","doi-asserted-by":"publisher","first-page":"150443","DOI":"10.1016\/j.bbrc.2024.150443","article-title":"Ameliorative effect of alpha-tocopherol and tocotrienol-rich palm oil extract on menopause-associated mood disorder in ovariectomized mice","volume":"734","author":"Liang","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B113","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.bbr.2004.09.004","article-title":"Structure of the rat behaviour in the forced swimming test","volume":"158","author":"Lino-de-Oliveira","year":"2005","journal-title":"Behav. Brain Res."},{"key":"B114","doi-asserted-by":"publisher","first-page":"3337","DOI":"10.1210\/en.2011-2176","article-title":"Intrahypothalamic estradiol modulates hypothalamus-pituitary-adrenal-axis activity in female rats","volume":"153","author":"Liu","year":"2012","journal-title":"Endocrinology"},{"key":"B115","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1038\/s41596-018-0011-z","article-title":"Sucrose preference test for measurement of stress-induced anhedonia in mice","volume":"13","author":"Liu","year":"2018","journal-title":"Nat. Protoc."},{"key":"B116","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1097\/00008877-199711000-00010","article-title":"The forced swimming test as a model for core and component behavioral effects of antidepressant drugs","volume":"8","author":"Lucki","year":"1997","journal-title":"Behav. Pharmacol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.yhbeh.2014.08.011","article-title":"Estradiol and cognitive function: past, present and future","volume":"66","author":"Luine","year":"2014","journal-title":"Horm. Behav."},{"key":"B118","doi-asserted-by":"publisher","first-page":"3000605221075816","DOI":"10.1177\/03000605221075816","article-title":"Validity of chronic restraint stress for modeling anhedonic-like behavior in rodents: a systematic review and meta-analysis","volume":"50","author":"Mao","year":"2022","journal-title":"J. Int. Med. Res."},{"key":"B119","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jad.2004.09.008","article-title":"Gender differences in depression: findings from the STAR*D study","volume":"87","author":"Marcus","year":"2005","journal-title":"J. Affect. Disord."},{"key":"B120","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.physbeh.2007.06.020","article-title":"Social recognition memory: influence of age, sex, and ovarian hormonal status","volume":"92","author":"Markham","year":"2007","journal-title":"Physiol. Behav."},{"key":"B121","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1177\/0269881114544778","article-title":"Analysis of sociability and preference for social novelty in the acute and subchronic phencyclidine rat","volume":"28","author":"McKibben","year":"2014","journal-title":"J. Psychopharmacol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.yhbeh.2008.04.010","article-title":"Assessment of estradiol influence on spatial tasks and hippocampal CA1 spines: evidence that the duration of hormone deprivation after ovariectomy compromises 17\u03b2-estradiol effectiveness in altering CA1 spines","volume":"54","author":"McLaughlin","year":"2008","journal-title":"Horm. Behav"},{"key":"B123","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1002\/hipo.20678","article-title":"Chronic 17\u00df-estradiol or cholesterol prevents stress-induced hippocampal CA3 dendritic retraction in ovariectomized female rats: Possible correspondence between CA1 spine properties and spatial acquisition","volume":"20","author":"McLaughlin","year":"2010","journal-title":"Hippocampus"},{"key":"B124","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1037\/pha0000112","article-title":"Chronic corticosterone administration effects on behavioral emotionality in female c57bl6 mice","volume":"25","author":"Mekiri","year":"2017","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1037\/h0077196","article-title":"Experiments on neophobia in wild and laboratory rats: a reevaluation","volume":"90","author":"Mitchell","year":"1976","journal-title":"J. Comp. Physiol. Psychol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.psyneuen.2015.08.028","article-title":"Immobility in the forced swim test is adaptive and does not reflect depression","volume":"62","author":"Molendijk","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"B127","doi-asserted-by":"publisher","first-page":"6623141","DOI":"10.1155\/2023\/6623141","article-title":"Edaravone improved behavioral abnormalities, alleviated oxidative stress inflammation, and metabolic homeostasis pathways in depression","volume":"2023","author":"Montazeri","year":"2023","journal-title":"Depress. Anxiety"},{"key":"B128","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/j.1601-1848.2004.00076.x","article-title":"Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice","volume":"3","author":"Moy","year":"2004","journal-title":"Genes Brain Behav."},{"key":"B129","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/j.1601-183X.2004.00071.x","article-title":"Automated apparatus for quantitation of social approach behaviors in mice","volume":"3","author":"Nadler","year":"2004","journal-title":"Genes Brain Behav."},{"key":"B130","doi-asserted-by":"publisher","first-page":"H1159","DOI":"10.1152\/ajpheart.00615.2017","article-title":"Sex differences in depression-like behavior and neuroinflammation in rats post-MI: role of estrogens","volume":"315","author":"Najjar","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"e70063","DOI":"10.1002\/alz.70063","article-title":"Associations among age at menopause, depressive symptoms, and cognitive function","volume":"21","author":"Nakanishi","year":"2025","journal-title":"Alzheimers Dement"},{"key":"B132","unstructured":"RDoC Matrix\n          \n          2019"},{"key":"B133","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1038\/nn.2647","article-title":"Animal models of neuropsychiatric disorders","volume":"13","author":"Nestler","year":"2010","journal-title":"Nat. Neurosci."},{"key":"B134","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s11011-017-0148-4","article-title":"Combined corticosterone treatment and chronic restraint stress lead to depression associated with early cognitive deficits in mice","volume":"33","author":"Ngoupaye","year":"2018","journal-title":"Metab. Brain Dis."},{"key":"B135","doi-asserted-by":"publisher","first-page":"2470547020923711","DOI":"10.1177\/2470547020923711","article-title":"Corticosterone Induces depressive-like behavior in female peri-pubescent rats, but Not in pre-pubescent rats","volume":"4","author":"Nickle","year":"2020","journal-title":"Chronic Stress"},{"key":"B136","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.bbrc.2019.04.049","article-title":"Anxiety and task performance changes in an aging mouse model","volume":"514","author":"Nolte","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B137","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/S0090-9556(25)08299-6","article-title":"Pharmacokinetic analysis of enterohepatic circulation of buprenorphine and its active metabolite, norbuprenorphine, in rats","volume":"22","author":"Ohtani","year":"1994","journal-title":"Drug Metab. Dispos."},{"key":"B138","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.bbr.2009.07.027","article-title":"Depression-like and anxiety-like behavioural aftermaths of impact accelerated traumatic brain injury in rats: a model of comorbid depression and anxiety?","volume":"205","author":"Pandey","year":"2009","journal-title":"Behav. Brain Res"},{"key":"B139","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.bbi.2019.01.003","article-title":"Mir363-3p attenuates post-stroke depressive-like behaviors in middle-aged female rats","volume":"78","author":"Panta","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"B140","doi-asserted-by":"publisher","first-page":"143","DOI":"10.2147\/IJWH.S7155","article-title":"Optimal management of perimenopausal depression","volume":"2","author":"Parry","year":"2010","journal-title":"Int. J. Womens. Health"},{"key":"B141","doi-asserted-by":"publisher","first-page":"112519","DOI":"10.1016\/j.bbr.2020.112519","article-title":"Chronic unpredictable intermittent restraint stress disrupts spatial memory in male, but not female rats","volume":"383","author":"Peay","year":"2020","journal-title":"Behav. Brain Res."},{"key":"B142","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.exger.2016.01.012","article-title":"A working model for the assessment of disruptions in social behavior among aged rats: the role of sex differences, social recognition, and sensorimotor processes","volume":"76","author":"Perkins","year":"2016","journal-title":"Exp. Gerontol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00213-004-2048-7","article-title":"Forced swimming test in mice: a review of antidepressant activity","volume":"177","author":"Petit-Demouliere","year":"2005","journal-title":"Psychopharmacology"},{"key":"B144","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1901\/jeab.1981.35-31","article-title":"Burying by rats in response to aversive and nonaversive stimuli","volume":"35","author":"Poling","year":"1981","journal-title":"J. Exp. Anal. Behav."},{"key":"B145","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"B146","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2017.11.015","article-title":"Contrasting effects of individual versus combined estrogen and progestogen regimens as working memory load increases in middle-aged ovariectomized rats: one plus one does not equal two","volume":"64","author":"Prakapenka","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"B147","doi-asserted-by":"publisher","first-page":"13941","DOI":"10.1073\/pnas.95.23.13941","article-title":"Estrogen alters behavior and forebrain c-fos expression in ovariectomized rats subjected to the forced swim test","volume":"95","author":"Rachman","year":"1998","journal-title":"PNAS"},{"key":"B148","doi-asserted-by":"publisher","first-page":"e70019","DOI":"10.1002\/cpz1.70019","article-title":"Behavioral assays for comprehensive evaluation of cognitive and neuropsychiatric comorbidities of traumatic brain injury and chronic neurological disorders","volume":"4","author":"Reddy","year":"2024","journal-title":"Curr. Protoc."},{"key":"B149","doi-asserted-by":"publisher","first-page":"570560","DOI":"10.3389\/fendo.2020.570560","article-title":"The role of estrogen in anxiety-like behavior and memory of middle-aged female rats","volume":"11","author":"Renczes","year":"2020","journal-title":"Front. Endocrinol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"2","DOI":"10.12965\/jer.2040016.008","article-title":"The role of neuroinflammation on pathogenesis of affective disorders","volume":"16","author":"Rhie","year":"2020","journal-title":"J. Exerc. Rehabil."},{"key":"B151","doi-asserted-by":"publisher","first-page":"829274","DOI":"10.3389\/fnbeh.2022.829274","article-title":"Considerations of timing post-ovariectomy in mice and rats in studying anxiety- and depression-like behaviors associated with surgical menopause in women","volume":"16","author":"Rodriguez-Landa","year":"2022","journal-title":"Front. Behav. Neurosci."},{"key":"B152","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1097\/FBP.0b013e328337bdfc","article-title":"Estradiol valerate elicits antidepressant-like effects in middle-aged female rats under chronic mild stress","volume":"21","author":"Romano-Torres","year":"2010","journal-title":"Behav. Pharmacol."},{"key":"B153","first-page":"149","article-title":"Gender differences in depression","volume":"26","author":"Sagud","year":"2002","journal-title":"Coll. Antropol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1037\/a0020909","article-title":"Developing constructs for psychopathology research: research domain criteria","volume":"119","author":"Sanislow","year":"2010","journal-title":"J. Abnorm. Psychol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/S0306-4522(03)00213-6","article-title":"The cognitive effects of ovariectomy and estrogen replacement are modulated by aging","volume":"119","author":"Savonenko","year":"2003","journal-title":"Neuroscience"},{"key":"B156","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/S2215-0366(18)30166-4","article-title":"Associations between age and the course of major depressive disorder: a 2-year longitudinal cohort study","volume":"5","author":"Schaakxs","year":"2018","journal-title":"Lancet Psychiatry"},{"key":"B157","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1111\/j.1749-6632.2009.04982.x","article-title":"Sex hormones and mood in the perimenopause","volume":"1179","author":"Schmidt","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B158","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1001\/archgenpsychiatry.2009.36","article-title":"Cross-national associations between gender and mental disorders in the World Health Organization World Mental Health Surveys","volume":"66","author":"Seedat","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0113-20.2020","article-title":"Validation of chronic restraint stress model in young adult rats for the study of depression using longitudinal multimodal MR imaging","author":"Seewoo","year":"2020","journal-title":"eNeuro"},{"key":"B160","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.1365-2826.2006.01508.x","article-title":"The critical period hypothesis: can it explain discrepancies in the oestrogen-cognition literature?","volume":"19","author":"Sherwin","year":"2007","journal-title":"J. Neuroendocrinol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/nprot.2012.044","article-title":"Using the rat forced swim test to assess antidepressant-like activity in rodents","volume":"7","author":"Slattery","year":"2012","journal-title":"Nat. Protoc."},{"key":"B162","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1093\/ilar\/ilu026","article-title":"The ups and downs of modelling mood disorders in rodents","volume":"55","author":"Slattery","year":"2014","journal-title":"ILAR J."},{"key":"B163","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/nature10287","article-title":"Adult hippocampal neurogenesis buffers stress responses and depressive behaviour","volume":"476","author":"Snyder","year":"2011","journal-title":"Nature"},{"key":"B164","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.psc.2017.01.007","article-title":"Depression and menopause: current knowledge and clinical recommendations for a critical window","volume":"40","author":"Soares","year":"2017","journal-title":"Psychiatr. Clin. North Am."},{"key":"B165","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1093\/ijnp\/pyy037","article-title":"Relevance of rodent models of depression in clinical practice: can we overcome the obstacles in translational neuropsychiatry?","volume":"21","author":"S\u00f6derlund","year":"2018","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/nmeth.2935","article-title":"Olfactory exposure to males, including men, causes stress and related analgesia in rodents","volume":"11","author":"Sorge","year":"2014","journal-title":"Nat. Meth"},{"key":"B167","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.physbeh.2009.05.001","article-title":"Ovarian hormones modulate social recognition in female rats","volume":"98","author":"Spiteri","year":"2009","journal-title":"Physiol. Behav."},{"key":"B168","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.contraception.2012.12.011","article-title":"Ethinyl estradiol and 17beta-estradiol in combined oral contraceptives: pharmacokinetics, pharmacodynamics and risk assessment","volume":"87","author":"Stanczyk","year":"2013","journal-title":"Contraception"},{"key":"B169","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/j.jad.2024.10.098","article-title":"Bidirectional changes in depressive symptoms and social functioning in older adults attending psychological therapy services","volume":"369","author":"Steare","year":"2025","journal-title":"J. Affect. Disord."},{"key":"B170","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.nlm.2008.04.002","article-title":"Higher levels of estradiol replacement correlate with better spatial memory in surgically menopausal young and middle-aged rats","volume":"90","author":"Talboom","year":"2008","journal-title":"Neurobiol. Learn. Mem."},{"key":"B171","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/mp.2009.67","article-title":"Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis","volume":"15","author":"Taliaz","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"B172","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1007\/s00787-024-02573-w","article-title":"Social isolation and poor mental health in young people: testing genetic and environmental influences in a longitudinal cohort study","volume":"34","author":"Thompson","year":"2025","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"B173","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/0091-3057(81)90219-7","article-title":"Conditioned defensive burying: a new paradigm for the study of anxiolytic agents","volume":"15","author":"Treit","year":"1981","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B174","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/ejn.14720","article-title":"Neuroinflammation and depression: a review","volume":"53","author":"Troubat","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"B175","doi-asserted-by":"publisher","first-page":"112047","DOI":"10.1016\/j.bbr.2019.112047","article-title":"Psychomotor retardation in depression: a critical measure of the forced swim test","volume":"372","author":"Unal","year":"2019","journal-title":"Behav. Brain Res."},{"key":"B176","doi-asserted-by":"publisher","first-page":"e20241292","DOI":"10.1590\/0001-3765202520241292","article-title":"Vagus nerve stimulation -induced anxiolytic and neurotrophic effect in healthy rats","volume":"97","author":"Valente","year":"2025","journal-title":"An. Acad. Bras. Cienc."},{"key":"B177","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/ph9020021","article-title":"The post-ovariectomy interval affects the antidepressant-like action of citalopram combined with ethynyl-estradiol in the forced swim test in middle aged rats","volume":"9","author":"Vega-Rivera","year":"2016","journal-title":"Pharmaceuticals"},{"key":"B178","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.neuroscience.2013.06.058","article-title":"The antidepressant-like effect of ethynyl estradiol is mediated by both serotonergic and noradrenergic systems in the forced swimming test","volume":"250","author":"Vega-Rivera","year":"2013","journal-title":"Neuroscience"},{"key":"B179","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.bbr.2011.10.023","article-title":"The effects of gonadectomy on sex- and age-typical responses to novelty and ethanol-induced social inhibition in adult male and female Sprague-Dawley rats","volume":"227","author":"Vetter-O'Hagen","year":"2012","journal-title":"Behav. Brain Res."},{"key":"B180","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1210\/endo-129-5-2503","article-title":"Variations in the hypothalamic-pituitary-adrenal response to stress during the estrous cycle in the rat","volume":"129","author":"Viau","year":"1991","journal-title":"Endocrinology"},{"key":"B181","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1210\/er.2016-1007","article-title":"Estrogens, neuroinflammation, and neurodegeneration","volume":"37","author":"Villa","year":"2016","journal-title":"Endocr. Rev."},{"key":"B182","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41380-022-01762-w","article-title":"Introducing a depression-like syndrome for translational neuropsychiatry: a plea for taxonomical validity and improved comparability between humans and mice","volume":"28","author":"von M\u00fccke-Heim","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"B183","doi-asserted-by":"publisher","first-page":"247","DOI":"10.2174\/157340012800792957","article-title":"Neurobiological underpinnings of the estrogen - mood relationship","volume":"8","author":"Wharton","year":"2012","journal-title":"Curr. Psychiatry Rev."},{"key":"B184","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.jad.2019.02.029","article-title":"Assessment of perimenopausal depression: a review","volume":"249","author":"Willi","year":"2019","journal-title":"J. Affect. Disord."},{"key":"B185","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s002130050456","article-title":"Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation","volume":"134","author":"Willner","year":"1997","journal-title":"Psychopharmacology"},{"key":"B186","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1159\/000087097","article-title":"Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS","volume":"52","author":"Willner","year":"2005","journal-title":"Neuropsychobiology"},{"key":"B187","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1097\/00008877-200205000-00001","article-title":"The validity of animal models of predisposition to depression","volume":"13","author":"Willner","year":"2002","journal-title":"Behav. Pharmacol."},{"key":"B188","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S0149-7634(05)80194-0","article-title":"Chronic mild stress-induced anhedonia: a realistic animal model of depression","volume":"16","author":"Willner","year":"1992","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B189","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0165-0327(99)00176-7","article-title":"The estimated rate of depressed mood in US adults: recent evidence for a peak in later life","volume":"60","author":"Wu","year":"2000","journal-title":"J. Affect. Disord."},{"key":"B190","doi-asserted-by":"publisher","first-page":"52587","DOI":"10.3791\/52587","article-title":"The forced swim test as a model of depressive-like behavior","volume":"97","author":"Yankelevitch-Yahav","year":"2015","journal-title":"J. Vis. Exp."},{"key":"B191","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/mp.2009.94","article-title":"Sex, trauma, stress hormones and depression","volume":"15","author":"Young","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"B192","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.jpsychires.2008.07.002","article-title":"Sex differences in response to citalopram: a STAR*D report","volume":"43","author":"Young","year":"2009","journal-title":"J. Psychiatr. Res."},{"key":"B193","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jpsychires.2023.04.002","article-title":"The effect of exogenous estrogen on depressive mood in women: a systematic review and meta-analysis of randomized controlled trials","volume":"162","author":"Zhang","year":"2023","journal-title":"J. Psychiatr. Res."},{"key":"B194","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1093\/ijnp\/pyac082","article-title":"Rasd2 mediates acute fasting-induced antidepressant-like effects via doamine D2 receptor activation in ovariectomized mice","volume":"26","author":"Zhang","year":"2023","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B195","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1021\/acschemneuro.3c00590","article-title":"Antidepressant-like effect of the eburnamine-type molecule vindeburnol in rat and mouse models of ultrasound-induced depression","volume":"15","author":"Zubkov","year":"2024","journal-title":"ACS Chem. Neurosci."}],"container-title":["Frontiers in Behavioral Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnbeh.2025.1553501\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T05:52:58Z","timestamp":1751435578000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnbeh.2025.1553501\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":195,"alternative-id":["10.3389\/fnbeh.2025.1553501"],"URL":"https:\/\/doi.org\/10.3389\/fnbeh.2025.1553501","relation":{},"ISSN":["1662-5153"],"issn-type":[{"value":"1662-5153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,2]]}}}