{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:33:54Z","timestamp":1791599634574,"version":"4.3.4"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Misuse of drugs and natural rewards, such as food, share common neural pathways and comparably influence behavioral consequences. Food-restriction enhances drug-taking and drug-seeking behaviors in animals, but the effect of food-restriction on cocaine self-administration and cocaine-seeking in both sexes has not been well characterized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Therefore, the present study investigated differences between food-restricted vs. <jats:italic>ad libitum-<\/jats:italic>feeding male and female Wistar rats on the acquisition of cocaine self-administration and cue-induced reinstatement of cocaine-seeking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Food access sex-dependently altered the acquisition of cocaine self-administration such that food-restricted females, but not males, displayed an escalated intake behavior over time. Only food-restricted females differed significantly between active and inactive lever pressing during the reinstatement of cocaine-seeking session.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Taken together, these results suggest that food-restriction sex-dependently improves learning of cocaine self-administration that persists to alter cocaine-seeking behavior following abstinence.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnbeh.2025.1603564","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T05:22:46Z","timestamp":1749532966000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Sex-dependent effects of food-restriction on cocaine self-administration and cocaine-seeking in rats"],"prefix":"10.3389","volume":"19","author":[{"given":"Alixandria T.","family":"Mascarin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ava M.","family":"Mac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasu","family":"Kallakuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K.","family":"Greenwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane A.","family":"Perrine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"B1","first-page":"1680","article-title":"Effect of food restriction on reproductive-related genes and reproductive hormones in adult female rats.","volume":"16","author":"Ahmed","year":"2012","journal-title":"Eur. 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