{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T16:32:47Z","timestamp":1754152367263,"version":"3.41.2"},"reference-count":82,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The study aims to evaluate symptomatic differences through psychometric tools comparing patients in the early stages of psychotic development with those exhibiting a more established symptomatology. Our hypothesis was that the early phase in adolescent patients is accompanied by quantitatively and qualitatively distinct symptomatology compared to adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed 116 participants\u2013consisting of 14 to 65 years old patients with psychotic or mood symptoms\u2013using psychometric tools and a clinical interview. The tools explored psychotic, depressive and anxiety dimensions, to provide a multifaceted assessment of the recruited individuals and help at categorizing them into diagnostic subclasses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We compared patients with psychotic symptoms (early-onset and lifetime) to patients with mood disorders (unipolar depression or bipolar disorder without psychotic symptoms). Psychotic symptoms intensity was significantly higher in the early-onset group compared to the lifetime group and was markedly greater than in the two other groups. It was also observed that the intensity of anxiety and depressive symptoms in the psychosis group were significantly higher in the early-onset subgroup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that the clinical presentation of early-onset patients, typically striking in its symptomatology, is reflected by elevated scores on scales not routinely used for psychotic symptoms. This may be attributed to the pervasive destructuring of personality and reality characteristic of early psychotic experiences.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnbeh.2025.1614730","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T05:30:31Z","timestamp":1753162231000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-domain destructuring in the early phases of psychosis: a multicentric phenomenological and psychometric case-control study"],"prefix":"10.3389","volume":"19","author":[{"given":"Ottone","family":"Baccaredda Boy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe Pierpaolo","family":"Merola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Patti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo","family":"Bozza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Flaccomio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Faldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Pitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Papini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Pecoraro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Noschese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Di Matteo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Brugnolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ballerini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Mauceri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Tavano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Peroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Ciabattini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Gori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Pisano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"De Cesaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valdo","family":"Ricca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1093\/schbul\/sbp148","article-title":"How prevalent are anxiety disorders in schizophrenia? A meta-analysis and critical review on a significant association.","volume":"37","author":"Achim","year":"2011","journal-title":"Schizophr. Bull."},{"key":"B2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1093\/schbul\/sbw152","article-title":"The role of cognition and social functioning as predictors in the transition to psychosis for youth with attenuated psychotic symptoms.","volume":"43","author":"Addington","year":"2017","journal-title":"Schizophr. Bull."},{"key":"B3","first-page":"165","article-title":"RStudio: Integrated development environment for R.","volume":"770","author":"Allaire","year":"2012","journal-title":"Boston MA"},{"key":"B4","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.comppsych.2016.05.001","article-title":"Self-continuity across time in schizophrenia: An exploration of phenomenological and narrative continuity in the past and future.","volume":"69","author":"All\u00e9","year":"2016","journal-title":"Compr. Psychiatry"},{"journal-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013","key":"B5","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"B6","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12991-022-00383-5","article-title":"Aberrant salience relationship with first rank symptoms.","volume":"21","author":"Ballerini","year":"2022","journal-title":"Ann. Gen. Psychiatry"},{"key":"B7","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1111\/eip.12509","article-title":"Factor structure of the cannabis experiences questionnaire in a first-episode psychosis sample.","volume":"13","author":"Birnbaum","year":"2019","journal-title":"Early Interv. Psychiatry"},{"article-title":"Der Verlust der Nat\u00fcrlichen Selbstverst\u00e4ndlichkeit: Ein Beitrag zur Psychopathologie Symptomarmer Schizophrenien. Enke Stuttgart","year":"2012","author":"Blankenburg","key":"B8"},{"key":"B9","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1007\/pl00010688","article-title":"Symptom dimensions in the course of childhood-onset schizophrenia.","volume":"8","author":"Bunk","year":"1999","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1007\/s00787-020-01618-0","article-title":"Depressive symptoms and their relationship with negative and other psychotic symptoms in early onset psychosis.","volume":"30","author":"Calderon-Mediavilla","year":"2021","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e69","DOI":"10.1192\/j.eurpsy.2021.2246","article-title":"Proportion and predictors of remission and recovery in first-episode psychosis: Systematic review and meta-analysis.","volume":"64","author":"Catalan","year":"2021","journal-title":"Eur. Psychiatr."},{"key":"B12","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1037\/a0019913","article-title":"The aberrant salience inventory: A new measure of psychosis proneness.","volume":"22","author":"Cicero","year":"2010","journal-title":"Psychol. Assess."},{"key":"B13","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.psychres.2017.04.010","article-title":"Depressive symptoms and suicidal behavior after first-episode psychosis: A comprehensive systematic review.","volume":"253","author":"Coentre","year":"2017","journal-title":"Psychiatry Res."},{"journal-title":"Die beginnende Schizophrenie. Vers. Einer Gestalt. Wahns","year":"1958","author":"Conrad","key":"B14"},{"journal-title":"Repertorio Delle Scale di Valutazione in Psichiatria. S.E.E. Societ\u00e0 Editrice Europea, Firenze","year":"2002","author":"Conti","key":"B15"},{"key":"B16","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1017\/S1121189X00001342","article-title":"The community assessment psychic experience (CAPE): Evaluation study of the Italian version.","volume":"17","author":"Daneluzzo","year":"2008","journal-title":"Epidemiol. Psychiatr. Sci."},{"key":"B17","first-page":"39","article-title":"Psychopathological characteristics of patients with first-episode psychosis and chronic schizophrenia: A descriptive comparison.","volume":"28","author":"Del Bello","year":"2016","journal-title":"Psychiatr. Danub."},{"key":"B18","first-page":"499","article-title":"Translation and validation of a French version of the Young Mania Rating Scale (YMRS).","volume":"29","author":"Favre","year":"2003","journal-title":"L\u2019Encephale"},{"key":"B19","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1002\/wps.20959","article-title":"The lived experience of psychosis: A bottom-up review co-written by experts by experience and academics.","volume":"21","author":"Fusar-Poli","year":"2022","journal-title":"World Psychiatry"},{"key":"B20","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1017\/S0033291713000184","article-title":"Lessons learned from the psychosis high-risk state: Towards a general staging model of prodromal intervention.","volume":"44","author":"Fusar-Poli","year":"2014","journal-title":"Psychol. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1708\/2098.22680","article-title":"The clinical, psychopathological and neurobiological features of salience.","volume":"50","author":"Godini","year":"2015","journal-title":"Riv. Psichiatr."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1214474","DOI":"10.3389\/fpsyg.2023.1214474","article-title":"Selfhood and alterity: Schizophrenic experience between Blankenburg and Tatossian.","volume":"14","author":"Guardascione","year":"2023","journal-title":"Front. Psychol."},{"key":"B23","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-68405-0","author":"Guy","year":"1982","journal-title":"The AMDP-System: Manual for the Assessment and Documentation of Psychopathology."},{"key":"B24","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating.","volume":"32","author":"Hamilton","year":"1959","journal-title":"Br. J. Med. Psychol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/acps.12080","article-title":"Anxiety and depression in psychosis: A systematic review of associations with positive psychotic symptoms.","volume":"128","author":"Hartley","year":"2013","journal-title":"Acta Psychiatr. Scand."},{"key":"B26","doi-asserted-by":"publisher","first-page":"553578","DOI":"10.3389\/fpsyt.2020.553578","article-title":"Pluripotential risk and clinical staging: Theoretical considerations and preliminary data from a transdiagnostic risk identification approach.","volume":"11","author":"Hartmann","year":"2021","journal-title":"Front. Psychiatry"},{"key":"B27","doi-asserted-by":"publisher","first-page":"526","DOI":"10.4088\/JCP.11m07162","article-title":"Minimum clinically important difference in the positive and negative syndrome scale with data from the clinical antipsychotic trials of intervention effectiveness (CATIE).","volume":"73","author":"Hermes","year":"2012","journal-title":"J. Clin. Psychiatry"},{"key":"B28","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/wps.20822","article-title":"The clinical significance of duration of untreated psychosis: An umbrella review and random-effects meta-analysis.","volume":"20","author":"Howes","year":"2021","journal-title":"World Psychiatry"},{"key":"B29","first-page":"646","article-title":"The concept of basic symptoms in schizophrenic and schizoaffective psychoses.","volume":"80","author":"Huber","year":"1989","journal-title":"Recenti Prog. Med."},{"journal-title":"Allgemeine Psychopathologie.","year":"1913","author":"Jaspers","key":"B30"},{"key":"B31","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1471-244X-10-26","article-title":"Effectiveness of second-generation antipsychotics: A naturalistic, randomized comparison of olanzapine, quetiapine, risperidone, and ziprasidone.","volume":"10","author":"Johnsen","year":"2010","journal-title":"BMC Psychiatry"},{"key":"B32","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1176\/appi.ajp.160.1.13","article-title":"Psychosis as a state of aberrant salience: A framework linking biology, phenomenology, and pharmacology in schizophrenia.","volume":"160","author":"Kapur","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"B33","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.schres.2005.01.003","article-title":"From dopamine to salience to psychosis\u2014linking biology, pharmacology and phenomenology of psychosis.","volume":"79","author":"Kapur","year":"2005","journal-title":"Schizophr. Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/eip.12986","article-title":"Anxiety symptoms in first-episode psychosis.","volume":"15","author":"Karpov","year":"2021","journal-title":"Early Interv. Psychiatry"},{"key":"B35","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia.","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophr. Bull."},{"key":"B36","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1176\/appi.ajp.2016.16010103","article-title":"The epidemiology of first-episode psychosis in early intervention in psychosis services: Findings from the social epidemiology of psychoses in east anglia [SEPEA] study.","volume":"174","author":"Kirkbride","year":"2017","journal-title":"Am. J. Psychiatry"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1093\/schbul\/sbr145","article-title":"Disease prediction in the at-risk mental state for psychosis using neuroanatomical biomarkers: Results from the FePsy study.","volume":"38","author":"Koutsouleris","year":"2012","journal-title":"Schizophr. Bull."},{"key":"B38","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/B978-0-444-64123-6.00022-9","article-title":"*Schizophrenia spectrum and other psychotic disorders","volume":"175","author":"Lewine","year":"2020","journal-title":"Handbook of Clinical Neurology"},{"key":"B39","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1111\/eip.13022","article-title":"Aberrant salience in adolescents is related to indicators of psychopathology that are relevant in the prodromal phases of psychosis.","volume":"15","author":"Lisi","year":"2021","journal-title":"Early Interv. Psychiatry"},{"key":"B40","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1111\/j.1600-0447.2007.01067.x","article-title":"Anxiety symptoms in schizophrenia spectrum disorders: Associations with social function, positive and negative symptoms, hope and trauma history.","volume":"116","author":"Lysaker","year":"2007","journal-title":"Acta Psychiatr. Scand."},{"key":"B41","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1111\/j.1476-5381.2010.00721.x","article-title":"Adolescent cannabis use and psychosis: Epidemiology and neurodevelopmental models.","volume":"160","author":"Malone","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1038\/s41380-023-01949-9","article-title":"Cognitive impairment in schizophrenia: Aetiology, pathophysiology, and treatment.","volume":"28","author":"McCutcheon","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"B43","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.schres.2019.12.011","article-title":"Depressive symptoms during first episode psychosis and functional outcome: A systematic review and meta-analysis.","volume":"218","author":"McGinty","year":"2020","journal-title":"Schizophr. Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/wps.20514","article-title":"Beyond the \u201cat risk mental state\u201d concept: Transitioning to transdiagnostic psychiatry.","volume":"17","author":"McGorry","year":"2018","journal-title":"World Psychiatry"},{"key":"B45","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1111\/eip.13490","article-title":"The role of psychotic-like experiences in the association between aberrant salience and anxiety: A psychopathological proposal based on a case\u2013control study.","volume":"18","author":"Merola","year":"2024","journal-title":"Early Interv. Psychiatry"},{"key":"B46","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change.","volume":"134","author":"Montgomery","year":"1979","journal-title":"Br. J. Psychiatry"},{"key":"B47","doi-asserted-by":"publisher","first-page":"80","DOI":"10.36148\/2284-0249-N345","article-title":"Bridging the gap: Aberrant salience, depressive symptoms and their role in psychosis prodrome.","volume":"29","author":"Nastro","year":"2023","journal-title":"J. Psychopathol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1002\/wps.20597","article-title":"Testing a neurophenomenological model of basic self disturbance in early psychosis.","volume":"18","author":"Nelson","year":"2019","journal-title":"World Psychiatry"},{"key":"B49","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1093\/schbul\/sbaa083","article-title":"The self and its prolonged intrinsic neural timescale in schizophrenia.","volume":"47","author":"Northoff","year":"2021","journal-title":"Schizophr. Bull."},{"key":"B50","doi-asserted-by":"publisher","first-page":"e0256686","DOI":"10.1371\/journal.pone.0256686","article-title":"The community assessment of psychic experiences-positive scale (CAPE-P15) accurately classifies and differentiates psychotic experience levels in adolescents from the general population.","volume":"16","author":"N\u00fa\u00f1ez","year":"2021","journal-title":"PLoS One"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbae197","article-title":"Psychotic experiences and risk of suicidal thoughts and behaviors: A systematic review and meta-analysis of longitudinal population studies.","author":"O\u2019Hare","year":"2024","journal-title":"Schizophr. Bull."},{"key":"B52","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1080\/00273171.2018.1454822","article-title":"Cross-sectional analysis of longitudinal mediation processes.","volume":"53","author":"O\u2019Laughlin","year":"2018","journal-title":"Multivar. Behav. Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1111\/eip.12086","article-title":"Self-awareness of functional impairment in individuals at clinical high-risk for psychosis.","volume":"9","author":"Olvet","year":"2015","journal-title":"Early Interv. Psychiatry"},{"key":"B54","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1159\/000088441","article-title":"EASE: Examination of anomalous self-experience.","volume":"38","author":"Parnas","year":"2005","journal-title":"Psychopathology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/jocb.678","article-title":"Creative minds: Altered salience as a bridge between creativity and psychosis, a case control study","volume":"58","author":"Patti","year":"2024","journal-title":"J. Creat. Behav."},{"key":"B56","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s00787-017-1070-3","article-title":"Adolescents at ultra-high risk of psychosis in Italian neuropsychiatry services: Prevalence, psychopathology and transition rate.","volume":"27","author":"Pelizza","year":"2018","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"B57","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1002\/jclp.23059","article-title":"Assessing aberrant salience in young community help-seekers with early psychosis: The approved Italian version of the Aberrant Salience Inventory.","volume":"77","author":"Pelizza","year":"2021","journal-title":"J. Clin. Psychol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"39","DOI":"10.36131\/cnfioritieditore20230105","article-title":"Depressive features in individuals with first episode psychosis: Psychopathological and treatment considerations from a 2-year follow-up study.","volume":"20","author":"Pelizza","year":"2023","journal-title":"Clin. Neuropsychiatry"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1007\/s00406-021-01355-8","article-title":"Integrating trauma, self-disturbances, cognitive biases, and personality into a model for the risk of psychosis: A longitudinal study in a non-clinical sample.","volume":"272","author":"Pionke-Ubych","year":"2022","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1080\/08039488.2021.1942547","article-title":"Subjective experience of aberrant salience in young people at Ultra-High Risk (UHR) for psychosis: A cross-sectional study.","volume":"76","author":"Poletti","year":"2022","journal-title":"Nord. J. Psychiatry"},{"key":"B61","doi-asserted-by":"publisher","first-page":"152343","DOI":"10.1016\/j.comppsych.2022.152343","article-title":"Validation of the aberrant salience inventory in a general and clinical Spanish population.","volume":"118","author":"Rodr\u00edguez-Testal","year":"2022","journal-title":"Compr. Psychiatry"},{"key":"B62","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1192\/bjp.2022.203","article-title":"Negative symptoms in children and adolescents with early-onset psychosis and at clinical high-risk for psychosis: Systematic review and meta-analysis.","volume":"223","author":"Salazar de Pablo","year":"2023","journal-title":"Br. J. Psychiatry J. Ment. Sci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1093\/schbul\/sbn139","article-title":"Subjective symptoms of schizophrenia in research and the clinic: The basic symptom concept.","volume":"35","author":"Schultze-Lutter","year":"2009","journal-title":"Schizophr. Bull."},{"key":"B64","doi-asserted-by":"publisher","first-page":"136","DOI":"10.5694\/mja11.10481","article-title":"Targeted primary care-based mental health services for young Australians.","volume":"196","author":"Scott","year":"2012","journal-title":"Med. J. Aust."},{"key":"B65","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/S2215-0366(24)00060-9","article-title":"Staging 2.0: Refining transdiagnostic clinical staging frameworks to enhance reliability and utility for youth mental health.","volume":"11","author":"Scott","year":"2024","journal-title":"Lancet Psychiatry"},{"key":"B66","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.schres.2020.11.061","article-title":"Distinguishing schizophrenia spectrum from non-spectrum disorders among young patients with first episode psychosis and at high clinical risk: The role of basic self-disturbance and neurocognition.","volume":"228","author":"Spark","year":"2021","journal-title":"Schizophr. Res."},{"key":"B67","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/B978-0-12-813201-2.00021-1","article-title":"New paradigms to study psychosis risk: Clinical staging, pluripotency, and dynamic prediction","author":"Spooner","year":"2020","journal-title":"Risk Factors for Psychosis"},{"key":"B68","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3389\/fpsyt.2017.00045","article-title":"Comprehensive psychopathological assessment based on the Association for Methodology and Documentation in psychiatry (AMDP) system: Development, methodological foundation, application in clinical routine, and research.","volume":"8","author":"Stieglitz","year":"2017","journal-title":"Front. Psychiatry"},{"key":"B69","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s00787-017-1046-3","article-title":"Clinical high risk for psychosis in children and adolescents: A systematic review.","volume":"27","author":"Tor","year":"2018","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"B70","doi-asserted-by":"publisher","first-page":"788","DOI":"10.4103\/indianjpsychiatry.indianjpsychiatry_521_24","article-title":"Aberrant salience in acute versus chronic schizophrenia: Do medication and positive symptoms make a difference?","volume":"66","author":"Vaidya","year":"2024","journal-title":"Indian J. Psychiatry"},{"key":"B71","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1002\/wps.20423","article-title":"A critique of the \u201cultra-high risk\u201d and \u201ctransition\u201d paradigm.","volume":"16","author":"van Os","year":"2017","journal-title":"World Psychiatry"},{"key":"B72","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1002\/wps.20310","article-title":"Psychosis as a transdiagnostic and extended phenotype in the general population.","volume":"15","author":"van Os","year":"2016","journal-title":"World Psychiatry"},{"key":"B73","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.schres.2025.02.005","article-title":"Schizophrenia spectrum disorders with comorbid panic: A systematic review.","volume":"277","author":"Veras","year":"2025","journal-title":"Schizophr. Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1159\/000357759","article-title":"The phenomenology of emotion experience in first-episode psychosis.","volume":"47","author":"Vodu\u0161ek","year":"2014","journal-title":"Psychopathology"},{"key":"B75","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.schres.2019.11.035","article-title":"Comorbidity rates of depression and anxiety in first episode psychosis: A systematic review and meta-analysis.","volume":"216","author":"Wilson","year":"2020","journal-title":"Schizophr. Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/s41398-024-02800-7","article-title":"Prefrontal cortical dopamine deficit may cause impaired glucose metabolism in schizophrenia.","volume":"14","author":"Wu","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1101\/2024.08.07.24311240","author":"Yassin","year":"2024","journal-title":"Cognitive Subtypes in Youth at Clinical High Risk for Psychosis."},{"key":"B78","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: Reliability, validity and sensitivity.","volume":"133","author":"Young","year":"1978","journal-title":"Br. J. Psychiatry"},{"key":"B79","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1093\/schbul\/22.2.353","article-title":"The prodromal phase of first-episode psychosis: Past and current conceptualizations.","volume":"22","author":"Yung","year":"1996","journal-title":"Schizophr. Bull."},{"key":"B80","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1177\/070674371305800103","article-title":"The ultra-high risk concept\u2014A review.","volume":"58","author":"Yung","year":"2013","journal-title":"Can. J. Psychiatry"},{"key":"B81","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.jad.2024.07.130","article-title":"Depressive and anxiety symptoms among schizophrenia patients.","volume":"362","author":"Zhao","year":"2024","journal-title":"J. Affect. Disord."},{"key":"B82","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1037\/10316-001","article-title":"Diathesis-stress models","author":"Zuckerman","year":"1999","journal-title":"Vulnerability to Psychopathology: A Biosocial Model"}],"container-title":["Frontiers in Behavioral Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnbeh.2025.1614730\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T05:30:35Z","timestamp":1753162235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnbeh.2025.1614730\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,22]]},"references-count":82,"alternative-id":["10.3389\/fnbeh.2025.1614730"],"URL":"https:\/\/doi.org\/10.3389\/fnbeh.2025.1614730","relation":{},"ISSN":["1662-5153"],"issn-type":[{"type":"electronic","value":"1662-5153"}],"subject":[],"published":{"date-parts":[[2025,7,22]]},"article-number":"1614730"}}